BioMedical Science Institute

Research Output

2020

The position of the target site for engineered nucleases improves the aberrant mRNA clearance in in vivo genome editing

Lee, J. H., Yu, S., Nam, T. W., Roh, J. I., Jin, Y., Han, J. P., Cha, J. Y., Kim, Y. K., Yeom, S. C., Nam, K. T. & Lee, H. W., 2020 Dec 1, In : Scientific reports. 10, 1, 4173.

Research output: Contribution to journalArticle

Open Access
2019

Commensal-derived metabolites govern Vibrio cholerae pathogenesis in host intestine

You, J. S., Yong, J. H., Kim, G. H., Moon, S., Nam, K. T., Ryu, J. H., Yoon, M. Y. & Yoon, S. S., 2019 Sep 14, In : Microbiome. 7, 1, 132.

Research output: Contribution to journalArticle

Open Access
1 Citation (Scopus)

Development of novel biocompatible thermosensitive anti-adhesive agents using human-derived acellular dermal matrix

Jeong, J. J., Lee, D. W., Song, S. Y., Park, Y., Kim, J. H., Kim, J. I., Kim, H. G., Nam, K. T., Lee, W. J., Nam, K. H. & Lee, J. H., 2019 Feb, In : PloS one. 14, 2, e0212583.

Research output: Contribution to journalArticle

Open Access

Di-2-ethylhexylphthalate promotes thyroid cell proliferation and DNA damage through activating thyrotropin-receptor-mediated pathways in vitro and in vivo

Kim, S., Park, G. Y., Yoo, Y. J., Jeong, J. S., Nam, K. T., Jee, S. H., Lim, K. M. & Lee, Y. S., 2019 Feb, In : Food and Chemical Toxicology. 124, p. 265-272 8 p.

Research output: Contribution to journalArticle

8 Citations (Scopus)

Enrichment of short-chain ceramides and free fatty acids in the skin epidermis, liver, and kidneys of db/db mice, a type 2 diabetes mellitus model

Kim, M., Jeong, H., Lee, B., Cho, Y., Yoon, W. K., Cho, A., Kwon, G., Nam, K. T., Ha, H. & Lim, K. M., 2019 Sep, In : Biomolecules and Therapeutics. 27, 5, p. 457-465 9 p.

Research output: Contribution to journalArticle

1 Citation (Scopus)

Inactivation of Sirtuin2 protects mice from acetaminophen-induced liver injury: Possible involvement of ER stress and S6K1 activation

Lee, D. H., Lee, B., Park, J. S., Lee, Y. S., Kim, J. H., Cho, Y., Jo, Y., Kim, H. S., Lee, Y. H., Nam, K. T. & Bae, S. H., 2019 Jan 1, In : BMB reports. 52, 3, p. 190-195 6 p.

Research output: Contribution to journalArticle

Open Access
5 Citations (Scopus)

Intrinsic expression of viperin regulates thermogenesis in adipose tissues

Eom, J., Kim, J. J., Yoon, S. G., Jeong, H., Son, S., Lee, J. B., Yoo, J., Seo, H. J., Cho, Y., Kim, K. S., Choi, K. M., Kim, I. Y., Lee, H. Y., Nam, K. T., Cresswell, P., Seong, J. K. & Seo, J. Y., 2019 Aug 27, In : Proceedings of the National Academy of Sciences of the United States of America. 116, 35, p. 17419-17428 10 p.

Research output: Contribution to journalArticle

Open Access
6 Citations (Scopus)

In Vivo Albumin Traps Photosensitizer Monomers from Self-Assembled Phthalocyanine Nanovesicles: A Facile and Switchable Theranostic Approach

Li, X., Yu, S., Lee, Y., Guo, T., Kwon, N., Lee, D., Yeom, S. C., Cho, Y., Kim, G., Huang, J. D., Choi, S., Nam, K. T. & Yoon, J., 2019 Jan 23, In : Journal of the American Chemical Society. 141, 3, p. 1366-1372 7 p.

Research output: Contribution to journalArticle

28 Citations (Scopus)

Knockdown of pyruvate kinase M2 inhibits cell proliferation, metabolism, and migration in renal cell carcinoma

Dey, P., Son, J. Y., Kundu, A., Kim, K. S., Lee, Y., Yoon, K., Yoon, S., Lee, B. M., Nam, K. T. & Kim, H. S., 2019 Nov 2, In : International journal of molecular sciences. 20, 22, 5622.

Research output: Contribution to journalArticle

Open Access

Loss of Rab25 promotes the development of skin squamous cell carcinoma through the dysregulation of integrin trafficking

Jeong, H., Lim, K. M., Kim, K. H., Cho, Y., Lee, B., Knowles, B. C., Roland, J. T., Zwerner, J. P., Goldenring, J. R. & Nam, K. T., 2019 Oct 1, In : Journal of Pathology. 249, 2, p. 227-240 14 p.

Research output: Contribution to journalArticle

1 Citation (Scopus)

Lysates of a probiotic, lactobacillus rhamnosus, can improve skin barrier function in a reconstructed human epidermis model

Jung, Y. O., Jeong, H., Cho, Y., Lee, E. O., Jang, H. W., Kim, J., Nam, K. T. & Lim, K. M., 2019 Sep 1, In : International journal of molecular sciences. 20, 17, 4289.

Research output: Contribution to journalArticle

Open Access
1 Citation (Scopus)

Rab25 deficiency perturbs epidermal differentiation and skin barrier function in mice

Jeong, H., Lim, K. M., Goldenring, J. R. & Nam, K. T., 2019 Jan 1, In : Biomolecules and Therapeutics. 27, 6, p. 553-561 9 p.

Research output: Contribution to journalArticle

1 Citation (Scopus)

RAE1 mediated ZEB1 expression promotes epithelial–mesenchymal transition in breast cancer

Oh, J. H., Lee, J. Y., Yu, S., Cho, Y., Hur, S., Nam, K. T. & Kim, M. H., 2019 Dec 1, In : Scientific reports. 9, 1, 2977.

Research output: Contribution to journalArticle

Open Access
2 Citations (Scopus)

Sequential Protein-Responsive Nanophotosensitizer Complex for Enhancing Tumor-Specific Therapy

Li, X., Fan, H., Guo, T., Bai, H., Kwon, N., Kim, K. H., Yu, S., Cho, Y., Kim, H., Nam, K. T., Yoon, J., Zhang, X. B. & Tan, W., 2019 Jun 25, In : ACS Nano. 13, 6, p. 6702-6710 9 p.

Research output: Contribution to journalArticle

7 Citations (Scopus)

Sexually dimorphic leanness and hypermobility in p16Ink4a/CDKN2A-deficient mice coincides with phenotypic changes in the cerebellum

Kim, K. H., Cho, Y., Lee, J., Jeong, H., Lee, Y., Kim, S. I., Kim, C. H., Lee, H. W. & Nam, K. T., 2019 Aug 1, In : Scientific reports. 9, 1, 1 p.

Research output: Contribution to journalArticle

Open Access
1 Citation (Scopus)

Vascular Regeneration with New Sources of Endothelial Cells: Pluripotent Stem Cells and Directly Reprogrammed Cells

Lee, S., Lee, S. J. & Yoon, Y. S., 2019 Jan 4, In : Circulation Research. 124, 1, p. 29-31 3 p.

Research output: Contribution to journalComment/debate

Open Access
1 Citation (Scopus)
2018

Cardiac regeneration with human pluripotent stem cell-derived cardiomyocytes

Park, M. & Yoon, Y. S., 2018 Nov, In : Korean Circulation Journal. 48, 11, p. 974-988 15 p.

Research output: Contribution to journalReview article

5 Citations (Scopus)

ChREBP deficiency leads to diarrhea-predominant irritable bowel syndrome

Oh, A. R., Sohn, S., Lee, J., Park, J. M., Nam, K. T., Hahm, K. B., Kim, Y. B., Lee, H. J. & Cha, J. Y., 2018 Aug, In : Metabolism: Clinical and Experimental. 85, p. 286-297 12 p.

Research output: Contribution to journalArticle

4 Citations (Scopus)

Clusterin is highly expressed in tubular complexes during spontaneous pancreatitis of spontaneous hypertensive rats

Park, J. W., Nam, K. T., Shin, J. H., Kim, I. Y., Choi, K. M., Roh, K. J., Oh, S. H., Yun, Y. M., Suh, J. G., Oh, Y. S., Yoon, Y. S. & Seong, J. K., 2018 Jan 1, In : Journal of Veterinary Medical Science. 80, 10, p. 1553-1557 5 p.

Research output: Contribution to journalComment/debate

Design of Polymeric Culture Substrates to Promote Proangiogenic Potential of Stem Cells

Kwon, B. J., Wang, X., Kang, M. L., You, J., Lee, S. J., Kim, W. S., Yoon, Y. S., Park, J. C. & Sung, H. J., 2018 Feb, In : Macromolecular Bioscience. 18, 2, 1700340.

Research output: Contribution to journalReview article

Discovery of Ezrin Expression as a Potential Biomarker for Chemically Induced Ocular Irritation Using Human Corneal Epithelium Cell Line and a Reconstructed Human Cornea-like Epithelium Model

Ye, D. J., Kwon, Y. J., Baek, H. S., Shin, S., Lee, C., Yun, J. W., Nam, K. T., Lim, K. M. & Chun, Y. J., 2018 Oct 1, In : Toxicological Sciences. 165, 2, p. 335-346 12 p.

Research output: Contribution to journalArticle

Expression of LRIG1, a Negative Regulator of EGFR, Is Dynamically Altered during Different Stages of Gastric Carcinogenesis

Yu, S., Yang, M., Lim, K. M., Cho, Y., Kim, H., Lee, K., Jeong, S. H., Coffey, R. J., Goldenring, J. R. & Nam, K. T., 2018 Dec, In : American Journal of Pathology. 188, 12, p. 2912-2923 12 p.

Research output: Contribution to journalArticle

4 Citations (Scopus)

Ezrin as a complementary marker in ocular toxicity assessment using a three-dimensional reconstructed human corneal-like epithelium model, EpiOcular™

Ko, K. Y., Hong, M. H., Kim, T. S., Nam, K. T., Lee, G. Y., Yi, J. S., Ahn, I. Y., Kim, J. H. & Lee, J. K., 2018 Jul, In : Journal of Pharmacological and Toxicological Methods. 92, p. 24-33 10 p.

Research output: Contribution to journalArticle

2 Citations (Scopus)

Facile Supramolecular Approach to Nucleic-Acid-Driven Activatable Nanotheranostics That Overcome Drawbacks of Photodynamic Therapy

Li, X., Yu, S., Lee, D., Kim, G., Lee, B., Cho, Y., Zheng, B. Y., Ke, M. R., Huang, J. D., Nam, K. T., Chen, X. & Yoon, J., 2018 Jan 23, In : ACS Nano. 12, 1, p. 681-688 8 p.

Research output: Contribution to journalArticle

52 Citations (Scopus)

Generation of Human Pluripotent Stem Cell-derived Endothelial Cells and Their Therapeutic Utility

Lee, S. J., Kim, K. H. & Yoon, Y. S., 2018 Jun 1, In : Current Cardiology Reports. 20, 6, 45.

Research output: Contribution to journalReview article

6 Citations (Scopus)

High-resolution acoustophoretic 3D cell patterning to construct functional collateral cylindroids for ischemia therapy

Kang, B., Shin, J., Park, H. J., Rhyou, C., Kang, D., Lee, S. J., Yoon, Y. S., Cho, S. W. & Lee, H., 2018 Dec 1, In : Nature communications. 9, 1, 5402.

Research output: Contribution to journalArticle

20 Citations (Scopus)

Investigation of dermal toxicity of ionic liquids in monolayer-cultured skin cells and 3D reconstructed human skin models

Hwang, J. H., Park, H., Choi, D. W., Nam, K. T. & Lim, K. M., 2018 Feb, In : Toxicology in Vitro. 46, p. 194-202 9 p.

Research output: Contribution to journalArticle

14 Citations (Scopus)

Low dose exposure to Di-2-ethylhexylphthalate in Juvenile rats alters the expression of genes related with thyroid hormone regulation

Kim, M., Jeong, J. S., Kim, H., Hwang, S., Park, I. H., Lee, B. C., Yoon, S. I., Jee, S. H., Nam, K. T. & Lim, K. M., 2018 Sep, In : Biomolecules and Therapeutics. 26, 5, p. 512-519 8 p.

Research output: Contribution to journalArticle

6 Citations (Scopus)

Nanomatrix Coated Stent Enhances Endothelialization but Reduces Platelet, Smooth Muscle Cell, and Monocyte Adhesion under Physiologic Conditions

Alexander, G. C., Hwang, P. T. J., Chen, J., Kim, J., Brott, B. C., Yoon, Y. S. & Jun, H. W., 2018 Jan 8, In : ACS Biomaterials Science and Engineering. 4, 1, p. 107-115 9 p.

Research output: Contribution to journalArticle

2 Citations (Scopus)

Neuronal Nitric Oxide Synthase Is a Novel Biomarker for the Interstitial Cells of Cajal in Stress-Induced Diarrhea-Dominant Irritable Bowel Syndrome

Jang, D. E., Bae, J. H., Chang, Y. J., Lee, Y. H., Nam, K. T., Kim, I. Y., Seong, J. K., Lee, Y. C. & Yeom, S. C., 2018 Mar 1, In : Digestive diseases and sciences. 63, 3, p. 619-627 9 p.

Research output: Contribution to journalArticle

4 Citations (Scopus)
2017

Current strategies and challenges for purification of cardiomyocytes derived from human pluripotent stem cells

Ban, K., Bae, S. & Yoon, Y. S., 2017 Jan 1, In : Theranostics. 7, 7, p. 2067-2077 11 p.

Research output: Contribution to journalReview article

12 Citations (Scopus)

Direct reprogramming into endothelial cells: A new source for vascular regeneration

Lee, S., Kim, J. E., Johnson, B. A., Andukuri, A. & Yoon, Y. S., 2017 Jun, In : Regenerative Medicine. 12, 4, p. 317-320 4 p.

Research output: Contribution to journalReview article

3 Citations (Scopus)

Direct Reprogramming of Human Dermal Fibroblasts into Endothelial Cells Using ER71/ETV2

Lee, S., Park, C., Han, J. W., Kim, J. Y., Cho, K., Kim, E. J., Kim, S., Lee, S. J., Oh, S. Y., Tanaka, Y., Park, I. H., An, H. J., Shin, C. M., Sharma, S. & Yoon, Y. S., 2017 Mar 3, In : Circulation Research. 120, 5, p. 848-861 14 p.

Research output: Contribution to journalArticle

22 Citations (Scopus)

Enhanced therapeutic and long-term dynamic vascularization effects of human pluripotent stem cell-derived endothelial cells encapsulated in a nanomatrix gel

Lee, S. J., Sohn, Y. D., Andukuri, A., Kim, S., Byun, J., Han, J. W., Park, I. H., Jun, H. W. & Yoon, Y. S., 2017 Jan 1, In : Circulation. 136, 20, p. 1939-1954 16 p.

Research output: Contribution to journalArticle

24 Citations (Scopus)

Evaluation of ocular irritancy of coal-tar dyes used in cosmetics employing reconstructed human cornea-like epithelium and short time exposure tests

Lee, M., Nam, K. T., Kim, J., Lim, S. E., Yeon, S. H., Lee, B., Lee, J. Y. & Lim, K. M., 2017 Oct, In : Food and Chemical Toxicology. 108, p. 236-243 8 p.

Research output: Contribution to journalArticle

7 Citations (Scopus)

Expression levels of GABA-A receptor subunit alpha 3, Gabra3 and lipoprotein lipase, Lpl are associated with the susceptibility to acetaminophen-induced hepatotoxicity

Kim, M., Yun, J. W., Shin, K., Cho, Y., Yang, M., Nam, K. T. & Lim, K. M., 2017 Mar, In : Biomolecules and Therapeutics. 25, 2, p. 112-121 10 p.

Research output: Contribution to journalArticle

7 Citations (Scopus)

In vivo near-infrared imaging and phototherapy of tumors using a cathepsin B-activated fluorescent probe

Chen, X., Lee, D., Yu, S., Kim, G., Lee, S., Cho, Y., Jeong, H., Nam, K. T. & Yoon, J., 2017 Apr 1, In : Biomaterials. 122, p. 130-140 11 p.

Research output: Contribution to journalArticle

48 Citations (Scopus)

Low-dose bisphenol A increases bile duct proliferation in juvenile rats: A possible evidence for risk of liver cancer in the exposed population?

Jeong, J. S., Nam, K. T., Lee, B., Pamungkas, A. D., Song, D., Kim, M., Yu, W. J., Lee, J., Jee, S., Park, Y. H. & Lim, K. M., 2017 Sep, In : Biomolecules and Therapeutics. 25, 5, p. 545-552 8 p.

Research output: Contribution to journalArticle

9 Citations (Scopus)

Modified Mouse Models of Chronic Secondary Lymphedema: Tail and Hind Limb Models

Jun, H., Lee, J. Y., Kim, J. H., Noh, M., Kwon, T. W., Cho, Y. P. & Yoon, Y. S., 2017 Jan 1, In : Annals of Vascular Surgery. 43, p. 288-295 8 p.

Research output: Contribution to journalArticle

4 Citations (Scopus)

Novel vaccine potential of Rv3131, a DosR regulon-encoded putative nitroreductase, against hyper-virulent Mycobacterium tuberculosis strain K

Kwon, K. W., Kim, W. S., Kim, H., Han, S. J., Hahn, M. Y., Lee, J. S., Nam, K. T., Cho, S. N. & Shin, S. J., 2017 Mar 8, In : Scientific reports. 7, 44151.

Research output: Contribution to journalArticle

8 Citations (Scopus)

Overcoming the Roadblocks to Cardiac Cell Therapy Using Tissue Engineering

Yanamandala, M., Zhu, W., Garry, D. J., Kamp, T. J., Hare, J. M., Jun, H. W., Yoon, Y. S., Bursac, N., Prabhu, S. D., Dorn, G. W., Bolli, R., Kitsis, R. N. & Zhang, J., 2017 Aug 8, In : Journal of the American College of Cardiology. 70, 6, p. 766-775 10 p.

Research output: Contribution to journalReview article

39 Citations (Scopus)
2016

Bone marrow-derived mesenchymal stem cells improve diabetic neuropathy by direct modulation of both angiogenesis and myelination in peripheral nerves

Han, J. W., Choi, D., Lee, M. Y., Huh, Y. H. & Yoon, Y. S., 2016 Jan 1, In : Cell transplantation. 25, 2, p. 313-326 14 p.

Research output: Contribution to journalArticle

31 Citations (Scopus)

Ezetimibe, an NPC1L1 inhibitor, is a potent Nrf2 activator that protects mice from diet-induced nonalcoholic steatohepatitis

Lee, D. H., Han, D. H., Nam, K. T., Park, J. S., Kim, S. H., Lee, M., Kim, G., Min, B. S., Cha, B. S., Lee, Y. S., Sung, S. H., Jeong, H., Ji, H. W., Lee, M. J., Lee, J. S., Lee, H. Y., Chun, Y., Kim, J., Komatsu, M., Lee, Y. H. & 1 others, Bae, S. H., 2016 Oct 1, In : Free Radical Biology and Medicine. 99, p. 520-532 13 p.

Research output: Contribution to journalArticle

24 Citations (Scopus)

miR-30-HNF4γ and miR-194-NR2F2 regulatory networks contribute to the upregulation of metaplasia markers in the stomach

Sousa, J. F., Nam, K. T., Petersen, C. P., Lee, H. J., Yang, H. K., Kim, W. H. & Goldenring, J. R., 2016 Jun 1, In : Gut. 65, 6, p. 914-924 11 p.

Research output: Contribution to journalArticle

24 Citations (Scopus)

Novel Multifunctional Nanomatrix Reduces Inflammation in Dynamic Conditions in Vitro and Dilates Arteries ex Vivo

Alexander, G. C., Vines, J. B., Hwang, P., Kim, T., Kim, J. A., Brott, B. C., Yoon, Y. S. & Jun, H. W., 2016 Mar 2, In : ACS Applied Materials and Interfaces. 8, 8, p. 5178-5187 10 p.

Research output: Contribution to journalArticle

4 Citations (Scopus)

Therapeutic effects of late outgrowth endothelial progenitor cells or mesenchymal stem cells derived from human umbilical cord blood on infarct repair

Kim, S. W., Jin, H. L., Kang, S. M., Kim, S., Yoo, K. J., Jang, Y., Kim, H. O. & Yoon, Y. S., 2016 Jan 15, In : International Journal of Cardiology. 203, p. 498-507 10 p.

Research output: Contribution to journalArticle

30 Citations (Scopus)
2015

Diabetic mesenchymal stem cells are ineffective for improving limb ischemia due to their impaired angiogenic capability

Kim, H., Han, J. W., Lee, J. Y., Choi, Y. J., Sohn, Y. D., Song, M. & Yoon, Y. S., 2015 Aug 19, In : Cell transplantation. 24, 8, p. 1571-1584 14 p.

Research output: Contribution to journalArticle

24 Citations (Scopus)

Dynamic Expansion of Gastric Mucosal Doublecortin-Like Kinase 1-Expressing Cells in Response to Parietal Cell Loss Is Regulated by Gastrin

Choi, E., Petersen, C. P., Lapierre, L. A., Williams, J. A., Weis, V. G., Goldenring, J. R. & Nam, K. T., 2015 Aug 1, In : American Journal of Pathology. 185, 8, p. 2219-2231 13 p.

Research output: Contribution to journalArticle

10 Citations (Scopus)

Enhanced therapeutic neovascularization by CD31-expressing cells and embryonic stem cell-derived endothelial cells engineered with chitosan hydrogel containing VEGF-releasing microtubes

Lee, S., Valmikinathan, C. M., Byun, J., Kim, S., Lee, G., Mokarram, N., Pai, S. B., Um, E., Bellamkonda, R. V. & Yoon, Y. S., 2015 Sep 1, In : Biomaterials. 63, p. 158-167 10 p.

Research output: Contribution to journalArticle

34 Citations (Scopus)

Generation of pure lymphatic endothelial cells from human pluripotent stem cells and their therapeutic effects on wound repair

Lee, S. J., Park, C., Lee, J. Y., Kim, S., Kwon, P. J., Kim, W., Jeon, Y. H., Lee, E. & Yoon, Y. S., 2015 Jun 12, In : Scientific reports. 5, 11019.

Research output: Contribution to journalArticle

34 Citations (Scopus)