Interdisciplinary Program of Integrated OMICS for Biomedical Sciences

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2020

A molecular basis for reciprocal regulation between pheromones and hormones in response to dietary cues in C. Elegans

Park, S., Park, J. Y. & Paik, Y. K., 2020 Apr 1, In : International journal of molecular sciences. 21, 7, p. 1-12 12 p., 2366.

Research output: Contribution to journalArticle

Open Access

A novel functional cross-interaction between opioid and pheromone signaling may be involved in stress avoidance in Caenorhabditis elegans

Park, J. Y., Cheong, M. C., Cho, J. Y., Koo, H. S. & Paik, Y. K., 2020 Dec 1, In : Scientific reports. 10, 1, 7524.

Research output: Contribution to journalArticle

Open Access

A Variant of SLC1A5 Is a Mitochondrial Glutamine Transporter for Metabolic Reprogramming in Cancer Cells

Yoo, H. C., Park, S. J., Nam, M., Kang, J., Kim, K., Yeo, J. H., Kim, J. K., Heo, Y., Lee, H. S., Lee, M. Y., Lee, C. W., Kang, J. S., Kim, Y. H., Lee, J., Choi, J., Hwang, G. S., Bang, S. & Han, J. M., 2020 Feb 4, In : Cell Metabolism. 31, 2, p. 267-283.e12

Research output: Contribution to journalArticle

3 Citations (Scopus)

Discovery of Chemicals to Either Clear or Indicate Amyloid Aggregates by Targeting Memory-Impairing Anti-Parallel Aβ Dimers

Lee, J. C., Kim, H. Y., Lee, S., Shin, J., Kim, H. V., Kim, K., Baek, S., Lee, D., Jeon, H., Kim, D. W., Yang, S. H., Han, G., Park, K., Choi, J., Park, J., Moss, J. A., Janda, K. D. & Kim, Y. S., 2020 Jul 6, In : Angewandte Chemie - International Edition. 59, 28, p. 11491-11500 10 p.

Research output: Contribution to journalArticle

1 Citation (Scopus)

Diversity-oriented generation and biological evaluation of new chemical scaffolds bearing a 2,2-dimethyl-2H-chromene unit: Discovery of novel potent ANO1 inhibitors

Seo, Y., Choi, J., Lee, J. H., Kim, T. G., Park, S. H., Han, G., Namkung, W. & Kim, I., 2020 Aug, In : Bioorganic Chemistry. 101, 104000.

Research output: Contribution to journalArticle

Glucose-dependent control of leucine metabolism by leucyl-tRNA synthetase 1

Yoon, I., Nam, M., Kim, H. K., Moon, H. S., Kim, S., Jang, J., Song, J. A., Jeong, S. J., Kim, S. B., Cho, S., Kim, Y. H., Lee, J., Yang, W. S., Yoo, H. C., Kim, K., Kim, M. S., Yang, A., Cho, K., Park, H. S., Hwang, G. S. & 4 others, Hwang, K. Y., Han, J. M., Kim, J. H. & Kim, S., 2020 Jan 10, In : Science. 367, 6474, p. 205-210 6 p.

Research output: Contribution to journalArticle

8 Citations (Scopus)

Identification and validation of VEGFR2 kinase as a target of voacangine by a systematic combination of DARTS and MSI

Kim, Y., Sugihara, Y., Kim, T. Y., Cho, S. M., Kim, J. Y., Lee, J. Y., Yoo, J. S., Song, D., Han, G., Rezeli, M., Welinder, C., Appelqvist, R., Marko-Varga, G. & Kwon, H. J., 2020 Apr, In : Biomolecules. 10, 4, 508.

Research output: Contribution to journalArticle

Open Access

Identification of ALDH6A1 as a Potential Molecular Signature in Hepatocellular Carcinoma via Quantitative Profiling of the Mitochondrial Proteome

Shin, H., Cha, H. J., Lee, M. J., Na, K., Park, D., Kim, C. Y., Han, D. H., Kim, H. & Paik, Y. K., 2020 Apr 3, In : Journal of Proteome Research. 19, 4, p. 1684-1695 12 p.

Research output: Contribution to journalArticle

Investigation of memory-enhancing botanical mixture and their isolated compounds for inhibition of amyloid-β and tau aggregation

Baek, S., Park, S., Shin, J., Lee, J. S., Kim, H. Y., Han, G. & Kim, Y. S., 2020 Dec 1, In : Applied Biological Chemistry. 63, 1, 22.

Research output: Contribution to journalArticle

Open Access

O-GlcNAcylation on LATS2 disrupts the Hippo pathway by inhibiting its activity

Kima, E., Kima, E., Kang, J. G., Kang, M. J., Park, J. H., Kim, Y. J., Kim, Y. J., Kweon, T. H., Kweon, T. H., Lee, H. W., Jho, E. H., Jho, E. H., Lee, Y. H., Lee, Y. H., Kim, S. I., Yi, E. C., Yi, E. C., Park, H. W., Yang, W. H., Yang, W. H. & 3 others, Cho, J. W., Cho, J. W. & Cho, J. W., 2020 Jun 23, In : Proceedings of the National Academy of Sciences of the United States of America. 117, 25, p. 14259-14269 11 p.

Research output: Contribution to journalArticle

Open Access

SGLT2 inhibition modulates NLRP3 inflammasome activity via ketones and insulin in diabetes with cardiovascular disease

Kim, S. R., Lee, S. G., Kim, S. H., Kim, J. H., Choi, E., Cho, W., Rim, J. H., Hwang, I., Lee, C. J., Lee, M., Oh, C. M., Jeon, J. Y., Gee, H. Y., Kim, J. H., Lee, B. W., Kang, E. S., Cha, B. S., Lee, M. S., Yu, J. W., Cho, J. W. & 2 others, Kim, J. S. & Lee, Y. H., 2020 Dec 1, In : Nature communications. 11, 1, 2127.

Research output: Contribution to journalArticle

Open Access
2 Citations (Scopus)
2019

200+ Protein Concentrations in Healthy Human Blood Plasma: Targeted Quantitative SRM SIS Screening of Chromosomes 18, 13, Y, and the Mitochondrial Chromosome Encoded Proteome

Kopylov, A. T., Ponomarenko, E. A., Ilgisonis, E. V., Pyatnitskiy, M. A., Lisitsa, A. V., Poverennaya, E. V., Kiseleva, O. I., Farafonova, T. E., Tikhonova, O. V., Zavialova, M. G., Novikova, S. E., Moshkovskii, S. A., Radko, S. P., Morukov, B. V., Grigoriev, A. I., Paik, Y. K., Salekdeh, G. H., Urbani, A., Zgoda, V. G. & Archakov, A. I., 2019 Jan 4, In : Journal of Proteome Research. 18, 1, p. 120-129 10 p.

Research output: Contribution to journalArticle

6 Citations (Scopus)

A Ras destabilizer KYA1797K overcomes the resistance of EGFR tyrosine kinase inhibitor in KRAS-mutated non-small cell lung cancer

Park, J., Cho, Y. H., Shin, W. J., Lee, S. K., Lee, J. H., Kim, T., Cha, P. H., Yang, J. S., Cho, J., Min, D. S., Han, G., Lee, H. Y. & Choi, K. Y., 2019 Dec 1, In : Scientific reports. 9, 1, 648.

Research output: Contribution to journalArticle

7 Citations (Scopus)

Buffering of cytosolic calcium plays a neuroprotective role by preserving the autophagy-lysosome pathway during MPP+-induced neuronal death

Jung, S., Chung, Y., Lee, Y., Lee, Y., Cho, J. W., Shin, E. J., Kim, H. C. & Oh, Y. J., 2019 Dec 1, In : Cell Death Discovery. 5, 1, 130.

Research output: Contribution to journalArticle

Open Access

CXXC5 mediates growth plate senescence and is a target for enhancement of longitudinal bone growth

Choi, S., Kim, H. Y., Cha, P. H., Seo, S. H., Lee, C., Choi, Y., Shin, W., Heo, Y., Han, G., Lee, W. & Choi, K. Y., 2019, In : Life Science Alliance. 2, 2, e201800254.

Research output: Contribution to journalArticle

Open Access
2 Citations (Scopus)

Developing a preoperative serum metabolome-based recurrence-predicting nomogram for patients with resected pancreatic ductal adenocarcinoma

Rho, S. Y., Lee, S. G., Park, M., Lee, J., Lee, S. H., Hwang, H. K., Lee, M. J., Paik, Y. K., Lee, W. J. & Kang, C. M., 2019 Dec 1, In : Scientific reports. 9, 1, 18634.

Research output: Contribution to journalArticle

Open Access
1 Citation (Scopus)

Fluorescent 1,4-Naphthoquinones to Visualize Diffuse and Dense-Core Amyloid Plaques in APP/PS1 Transgenic Mouse Brains

Neo Shin, N., Jeon, H., Jung, Y., Baek, S., Lee, S., Yoo, H. C., Bae, G. H., Park, K., Yang, S. H., Han, J. M., Kim, I. & Kim, Y., 2019 Jun 19, In : ACS Chemical Neuroscience. 10, 6, p. 3031-3044 14 p.

Research output: Contribution to journalArticle

2 Citations (Scopus)

Fluorescent 1,4-Naphthoquinones To Visualize Diffuse and Dense-Core Amyloid Plaques in APP/PS1 Transgenic Mouse Brains

Neo Shin, N., Jeon, H., Jung, Y., Baek, S., Lee, S., Yoo, H. C., Bae, G. H., Park, K., Yang, S-H., Han, J. M., Kim, I. & Kim, Y., 2019 Apr 24, In : ACS Chemical Neuroscience.

Research output: Contribution to journalArticle

FusionPro, a versatile proteogenomic tool for identification of novel fusion transcripts and their potential translation products in cancer cells

Kim, C. Y., Na, K., Park, S., Jeong, S. K., Cho, J. Y., Shin, H., Lee, M. J., Han, G. & Paik, Y. K., 2019, In : Molecular and Cellular Proteomics. 18, 8, p. 1651-1668 18 p.

Research output: Contribution to journalArticle

Open Access
1 Citation (Scopus)

Glycoprotein 96 polymorphisms are associated with the risk of systemic lupus erythematosus: A case-control study

Lee, J. S., Im, C. H., Lee, S. J., Choi, J. Y., Han, J. M., Kim, S., Kim, D. J., Park, T., Lee, E. Y. & Song, Y. W., 2019 May, In : International Journal of Rheumatic Diseases. 22, 5, p. 905-912 8 p.

Research output: Contribution to journalArticle

Keratins regulate Hsp70-mediated nuclear localization of p38 mitogen-activated protein kinase

Lee, S. Y., Kim, S., Lim, Y., Yoon, H. N. & Ku, N. O., 2019 Sep 26, In : Journal of cell science. 132, 18

Research output: Contribution to journalArticle

Open Access

Liver disease–associated keratin 8 and 18 mutations modulate keratin acetylation and methylation

Jang, K. H., Yoon, H. N., Lee, J., Yi, H., Park, S. Y., Lee, S. Y., Lim, Y., Lee, H. J., Cho, J. W., Paik, Y. K., Hancock, W. S. & Ku, N. O., 2019 Aug 1, In : FASEB Journal. 33, 8, p. 9030-9043 14 p.

Research output: Contribution to journalArticle

1 Citation (Scopus)

Nontranslational function of leucyl-tRNA synthetase regulates myogenic differentiation and skeletal muscle regeneration

Son, K., You, J. S., Yoon, M. S., Dai, C., Kim, J. H., Khanna, N., Banerjee, A., Martinis, S. A., Han, G., Han, J. M., Kim, S. & Chen, J., 2019 May 1, In : Journal of Clinical Investigation. 129, 5, p. 2088-2093 6 p.

Research output: Contribution to journalArticle

Open Access
2 Citations (Scopus)

Novel pendrin inhibitor attenuates airway hyperresponsiveness and mucin expression in experimental murine asthma

Park, J., Lee, H. J., Song, D., Gi, M., Jo, S., Jeon, D. K., Seo, Y., Kim, B., Lee, H., Namkung, W., Han, G. & Choi, J. Y., 2019 Nov, In : Journal of Allergy and Clinical Immunology. 144, 5, p. 1425-1428.e12

Research output: Contribution to journalArticle

1 Citation (Scopus)

OAS1 and OAS3 negatively regulate the expression of chemokines and interferon-responsive genes in human macrophages

Lee, W. B., Choi, W. Y., Lee, D. H., Shim, H., Kim-Ha, J. & Kim, Y. J., 2019, In : BMB reports. 52, 2, p. 133-138 6 p.

Research output: Contribution to journalArticle

3 Citations (Scopus)

Optimization of Vinyl Sulfone Derivatives as Potent Nuclear Factor Erythroid 2-Related Factor 2 (Nrf2) Activators for Parkinson's Disease Therapy

Choi, J. W., Kim, S., Park, J. H., Kim, H. J., Shin, S. J., Kim, J. W., Woo, S. Y., Lee, C., Han, S. M., Lee, J., Pae, A. N., Han, G. & Park, K. D., 2019 Jan 24, In : Journal of Medicinal Chemistry. 62, 2, p. 811-830 20 p.

Research output: Contribution to journalArticle

11 Citations (Scopus)

Prognostic potential of the preoperative plasma complement factor B in resected pancreatic cancer: A pilot study

Kim, S. H., Lee, M. J., Hwang, H. K., Lee, S. H., Kim, H., Paik, Y. K. & Kang, C. M., 2019 Jan 1, In : Cancer Biomarkers. 24, 3, p. 335-342 8 p.

Research output: Contribution to journalArticle

1 Citation (Scopus)

Refinements of LC-MS/MS Spectral Counting Statistics Improve Quantification of Low Abundance Proteins

Lee, H. Y., Kim, E. G., Jung, H. R., Jung, J. W., Kim, H. B., Cho, J. W., Kim, K. M. & Yi, E. C., 2019 Dec 1, In : Scientific reports. 9, 1, 13653.

Research output: Contribution to journalArticle

Open Access

RNA-dependent chaperone (chaperna) as an engineered pro-region for the folding of recombinant microbial transglutaminase

Lee, J., Son, A., Kim, P., Kwon, S. B., Yu, J. E., Han, G. & Seong, B. L., 2019 Mar, In : Biotechnology and Bioengineering. 116, 3, p. 490-502 13 p.

Research output: Contribution to journalArticle

1 Citation (Scopus)

Senescent T cells predict the development of hyperglycemia in humans

Lee, Y. H., Kim, S. R., Han, D. H., Yu, H. T., Han, Y. D., Kim, J. H., Kim, S. H., Lee, C. J., Min, B. H., Kim, D. H., Kim, K. H., Cho, J. W., Lee, W. W., Shin, E. C. & Park, S., 2019 Jan 1, In : Diabetes. 68, 1, p. 156-162 7 p.

Research output: Contribution to journalArticle

6 Citations (Scopus)

Simultaneous Suppression of Multiple Programmed Cell Death Pathways by miRNA-105 in Cardiac Ischemic Injury

Shin, S., Choi, J. W., Moon, H., Lee, C. Y., Park, J. H., Lee, J., Seo, H. H., Han, G., Lim, S., Lee, S., Kim, S. W. & Hwang, K. C., 2019 Mar 1, In : Molecular Therapy - Nucleic Acids. 14, p. 438-449 12 p.

Research output: Contribution to journalArticle

4 Citations (Scopus)

Sodium-glucose cotransporter 2 inhibitors regulate ketone body metabolism via inter-organ crosstalk

Kim, J. H., Lee, M., Kim, S. H., Kim, S. R., Lee, B. W., Kang, E. S., Cha, B. S., Cho, J. W. & Lee, Y. H., 2019 Apr, In : Diabetes, Obesity and Metabolism. 21, 4, p. 801-811 11 p.

Research output: Contribution to journalArticle

6 Citations (Scopus)

Therapeutic effects of the novel Leucyl-tRNA synthetase inhibitor BC-LI-0186 in non-small cell lung cancer

Kim, E. Y., Lee, J. G., Lee, J. M., Kim, A., Yoo, H. C., Kim, K., Lee, M., Lee, C., Han, G., Han, J. M. & Chang, Y. S., 2019 May 1, In : Therapeutic Advances in Medical Oncology. 11

Research output: Contribution to journalArticle

Open Access
1 Citation (Scopus)

Trifunctional Fluorogenic Probes for Fluorescence Imaging and Isolation of Glycosidases in Cells

Hyun, J. Y., Park, S. H., Park, C. W., Kim, H. B., Cho, J. W. & Shin, I., 2019 Jun 21, In : Organic Letters. 21, 12, p. 4439-4442 4 p.

Research output: Contribution to journalArticle

3 Citations (Scopus)

β-catenin activation down-regulates cell-cell junction-related genes and induces epithelial-to-mesenchymal transition in colorectal cancers

Kim, W. K., Kwon, Y., Jang, M., Park, M., Kim, J., Cho, S., Jang, D. G., Lee, W. B., Jung, S. H., Choi, H. J., Min, B. S., Il Kim, T., Hong, S. P., Paik, Y. K. & Kim, H., 2019 Dec 1, In : Scientific reports. 9, 1, 18440.

Research output: Contribution to journalArticle

Open Access
1 Citation (Scopus)
2018

A small molecule approach to degrade RAS with EGFR repression is a potential therapy for KRAS mutation-driven colorectal cancer resistance to cetuximab

Lee, S. K., Cho, Y. H., Cha, P. H., Yoon, J. S., Ro, E. J., Jeong, W. J., Park, J., Kim, H., Il Kim, T., Min, D. S., Han, G. & Choi, K. Y., 2018 Nov 1, In : Experimental and Molecular Medicine. 50, 11, 153.

Research output: Contribution to journalArticle

3 Citations (Scopus)

ASV-ID, a Proteogenomic Workflow to Predict Candidate Protein Isoforms on the Basis of Transcript Evidence

Jeong, S. K., Kim, C. Y. & Paik, Y. K., 2018 Dec 7, In : Journal of Proteome Research. 17, 12, p. 4235-4242 8 p.

Research output: Contribution to journalArticle

2 Citations (Scopus)

Coordination of the leucine-sensing Rag GTPase cycle by leucyl-tRNA synthetase in the mTORC1 signaling pathway

Lee, M., Kim, J. H., Yoon, I., Lee, C., Sichani, M. F., Kang, J. S., Kang, J., Guo, M., Lee, K. Y., Han, G., Kim, S. & Han, J. M., 2018 Jun 5, In : Proceedings of the National Academy of Sciences of the United States of America. 115, 23, p. E5279-E5288

Research output: Contribution to journalArticle

17 Citations (Scopus)

Dysregulated autophagy contributes to caspase-dependent neuronal apoptosis

Chung, Y., Lee, J., Jung, S., Lee, Y., Cho, J. W. & Oh, Y. J., 2018 Dec 1, In : Cell Death and Disease. 9, 12, 1189.

Research output: Contribution to journalArticle

12 Citations (Scopus)

Glycosylation of hemagglutinin and neuraminidase of influenza a virus as signature for ecological spillover and adaptation among influenza reservoirs

Kim, P., Jang, Y. H., Kwon, S. B., Lee, C. M., Han, G. & Seong, B. L., 2018 Apr 7, In : Viruses. 10, 4, 183.

Research output: Contribution to journalArticle

7 Citations (Scopus)

Identification of Missing Proteins in Human Olfactory Epithelial Tissue by Liquid Chromatography-Tandem Mass Spectrometry

Hwang, H., Jeong, J. E., Lee, H. K., Yun, K. N., An, H. J., Lee, B., Paik, Y. K., Jeong, T. S., Yee, G. T., Kim, J. Y. & Yoo, J. S., 2018 Dec 7, In : Journal of Proteome Research. 17, 12, p. 4320-4324 5 p.

Research output: Contribution to journalArticle

8 Citations (Scopus)

Integrin CD11b negatively regulates mincle-induced signaling via the lyn–SIRPα–SHP1 complex

Zhang, Q., Lee, W. B., Kang, J. S., Kim, L. K. & Kim, Y. J., 2018 Feb 2, In : Experimental and Molecular Medicine. 50, 2, e439.

Research output: Contribution to journalArticle

8 Citations (Scopus)

Intermediate filaments: The sweet side of vimentin

Snider, N. T., Ku, N. O. & Omary, M. B., 2018 Mar 7, In : eLife. 7, e35336.

Research output: Contribution to journalArticle

8 Citations (Scopus)

Loss of RNA-binding protein HuR facilitates cellular senescence through posttranscriptional regulation of TIN2 mRNA

Lee, J. H., Jung, M., Hong, J., Kim, M. K. & Chung, I. K., 2018, In : Nucleic acids research. 46, 8, p. 4271-4285 15 p.

Research output: Contribution to journalArticle

6 Citations (Scopus)

OASL1 traps viral RNAs in stress granules to promote antiviral responses

Kang, J. S., Hwang, Y. S., Kim, L. K., Lee, S., Lee, W. B., Kim-Ha, J. & Kim, Y. J., 2018 Jan 1, In : Molecules and cells. 41, 3, p. 214-223 10 p.

Research output: Contribution to journalArticle

6 Citations (Scopus)

O-GlcN acylation of the tumor suppressor FOXO3 triggers aberrant cancer cell growth

Shin, H., Cha, H. J., Na, K., Lee, M. J., Cho, J. Y., Kim, C. Y., Kim, E. K., Kang, C. M., Kim, H. & Paik, Y. K., 2018 Mar 1, In : Cancer Research. 78, 5, p. 1214-1224 11 p.

Research output: Contribution to journalArticle

5 Citations (Scopus)

Specific autophagy and ESCRT components participate in the unconventional secretion of CFTR

Noh, S. H., Gee, H. Y., Kim, Y., Piao, H., Kim, J., Kang, C. M., Lee, G., Mook-Jung, I., Lee, Y., Cho, J. W. & Lee, M. G., 2018 Oct 3, In : Autophagy. 14, 10, p. 1761-1778 18 p.

Research output: Contribution to journalArticle

6 Citations (Scopus)

Structural basis for arginine glycosylation of host substrates by bacterial effector proteins

Park, J. B., Kim, Y. H., Yoo, Y., Kim, J., Jun, S. H., Cho, J. W., El Qaidi, S., Walpole, S., Monaco, S., García-García, A. A., Wu, M., Hays, M. P., Hurtado-Guerrero, R., Angulo, J., Hardwidge, P. R., Shin, J. S. & Cho, H. S., 2018 Dec 1, In : Nature communications. 9, 1, 4283.

Research output: Contribution to journalArticle

9 Citations (Scopus)

Synthesis and evaluation of biaryl derivatives for structural characterization of selective monoamine oxidase B inhibitors toward Parkinson's disease therapy

Yeon, S. K., Choi, J. W., Park, J. H., Lee, Y. R., Kim, H. J., Shin, S. J., Jang, B. K., Kim, S., Bahn, Y. S., Han, G., Lee, Y. S., Pae, A. N. & Park, K. D., 2018 Jan 1, In : Bioorganic and Medicinal Chemistry. 26, 1, p. 232-244 13 p.

Research output: Contribution to journalArticle

5 Citations (Scopus)

The HDAC6 inhibitor ACY-1215 enhances the anticancer activity of oxaliplatin in colorectal cancer cells

Lee, D. H., Won, H. R., Ryu, H. W., Han, J. M. & Kwon, S. H., 2018 Aug, In : International journal of oncology. 53, 2, p. 844-854 11 p.

Research output: Contribution to journalArticle

6 Citations (Scopus)