Research Output 2000 2019

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2019

Carvedilol improves glucose tolerance and insulin sensitivity in treatment of adrenergic overdrive in high fat diet-induced obesity in mice

Nguyen, L. V., Ta, Q. V., Dang, T. B., Nguyen, P. H., Nguyen, T., Pham, T. V. H., Nguyen, T. H. T., Baker, S., Le Tran, T., Yang, D. J., Kim, K. W. & Doan, K. V., 2019 Jan 1, In : PloS one. 14, 11, e0224674.

Research output: Contribution to journalArticle

Open Access
High Fat Diet
glucose tolerance
high fat diet
Nutrition
insulin resistance
2 Citations (Scopus)

FoxO1 regulates leptin-induced mood behavior by targeting tyrosine hydroxylase

Son, D. H., Doan, K. V., Yang, D. J., Sun, J. S., Kim, S. K., Kang, N., Kang, J. Y., Paik, J. H., DePinho, R. A., Choi, Y. H., Shin, D. M. & Kim, K. W., 2019 Feb, In : Metabolism: Clinical and Experimental. 91, p. 43-52 10 p.

Research output: Contribution to journalArticle

Tyrosine 3-Monooxygenase
Leptin
STAT3 Transcription Factor
Dopaminergic Neurons
Anti-Anxiety Agents
Open Access
AMP-Activated Protein Kinases
Osteoclasts
Cytoplasmic and Nuclear Receptors
Ligands
Osteogenesis

P110β in the ventromedial hypothalamus regulates glucose and energy metabolism

Fujikawa, T., Choi, Y. H., Yang, D. J., Shin, D. M., Donato, J., Kohno, D., Lee, C. E., Elias, C. F., Lee, S. & Kim, K. W., 2019 Apr 1, In : Experimental and Molecular Medicine. 51, 4, 52.

Research output: Contribution to journalArticle

Open Access
Energy Metabolism
Hypothalamus
Neurons
Steroidogenic Factor 1
1-Phosphatidylinositol 4-Kinase
2018
2 Citations (Scopus)

4-hydroxy-3-methoxycinnamic acid regulates orexigenic peptides and hepatic glucose homeostasis through phosphorylation of FoxO1

Kinyua, A. W., Ko, C. M., Doan, K. V., Yang, D. J., Huynh, M. K. Q., Moh, S. H., Choi, Y. H. & Kim, K. W., 2018 Feb 2, In : Experimental and Molecular Medicine. 50, 2, e437.

Research output: Contribution to journalArticle

ferulic acid
Phosphorylation
Homeostasis
Glucose
Peptides
3 Citations (Scopus)

A novel peptide, nicotinyl–isoleucine–valine–histidine (Na–IVH), promotes antioxidant gene expression and wound healing in HaCaT cells

Son, D. H., Yang, D. J., Sun, J. S., Kim, S. K., Kang, N., Kang, J. Y., Choi, Y. H., Lee, J. H., Moh, S. H., Shin, D. M. & Kim, K. W., 2018 Aug 1, In : Marine Drugs. 16, 8, 262.

Research output: Contribution to journalArticle

Niacinamide
Wound Healing
Antioxidants
Gene Expression
Reactive Oxygen Species
1 Citation (Scopus)

CCN5 knockout mice exhibit lipotoxic cardiomyopathy with mild obesity and diabetes

Kim, J., Joo, S., Eom, G. H., Lee, S. H., Lee, M. A., Lee, M., Kim, K. W., Kim, D. H., Kook, H., Kwak, T. H. & Park, W. J., 2018 Nov, In : PloS one. 13, 11, e0207228.

Research output: Contribution to journalArticle

cardiomyopathy
Medical problems
Cardiomyopathies
Knockout Mice
diabetes
4 Citations (Scopus)

Insulin Regulates Adrenal Steroidogenesis by Stabilizing SF-1 Activity

Kinyua, A. W., Doan, K. V., Yang, D. J., Huynh, M. K. Q., Choi, Y. H., Shin, D. M. & Kim, K. W., 2018 Dec 1, In : Scientific reports. 8, 1, 5025.

Research output: Contribution to journalArticle

Steroidogenic Factor 1
Insulin
Adrenal Glands
Aldosterone
Streptozocin
5 Citations (Scopus)

Peripheral cannabinoid 1 receptor blockade mitigates adipose tissue inflammation via NLRP3 inflammasome in mouse models of obesity

Han, J. H., Shin, H., Rho, J. G., Kim, J. E., Son, D. H., Yoon, J., Lee, Y. J., Park, J. H., Song, B. J., Choi, C. S., Yoon, S. G., Kim, I. Y., Lee, E. K., Seong, J. K., Kim, K. W. & Kim, W., 2018 Sep, In : Diabetes, Obesity and Metabolism. 20, 9, p. 2179-2189 11 p.

Research output: Contribution to journalArticle

rimonabant
Inflammasomes
Cannabinoid Receptors
Adipose Tissue
Obesity
6 Citations (Scopus)

Serum fibroblast growth factor 21 and new-onset metabolic syndrome: KoGES-ARIRANG study

Choi, J. R., Kim, J. Y., Park, I. H., Huh, J. H., Kim, K. W., Cha, S. K., Park, K. S., Sohn, J. H., Park, J. T. & Koh, S. B., 2018 Mar, In : Yonsei medical journal. 59, 2, p. 287-293 7 p.

Research output: Contribution to journalArticle

Serum
Prospective Studies
Population
fibroblast growth factor 21
Lipid Metabolism
4 Citations (Scopus)

TRPM3/TRPV4 regulates Ca2+-mediated RANKL/NFATc1 expression in osteoblasts

Son, A., Kang, N., Kang, J. Y., Kim, K. W., Yang, Y. M. & Shin, D. M., 2018 Nov, In : Journal of molecular endocrinology. 61, 4, p. 207-218 12 p.

Research output: Contribution to journalArticle

RANK Ligand
NFATC Transcription Factors
Osmotic Pressure
Osteoblasts
Bone Remodeling
2016
14 Citations (Scopus)

FoxO1 in dopaminergic neurons regulates energy homeostasis and targets tyrosine hydroxylase

Doan, K. V., Kinyua, A. W., Yang, D. J., Ko, C. M., Moh, S. H., Shong, K. E., Kim, H., Park, S. K., Kim, D. H., Kim, I., Paik, J. H., Depinho, R. A., Yoon, S. G., Kim, I. Y., Seong, J. K., Choi, Y. H. & Kim, K. W., 2016 Sep 29, In : Nature communications. 7, 12733.

Research output: Contribution to journalArticle

homeostasis
tyrosine
Dopaminergic Neurons
Tyrosine 3-Monooxygenase
neurons
14 Citations (Scopus)

Gallic acid inhibition of Src-Stat3 signaling overcomes acquired resistance to EGF receptor tyrosine kinase inhibitors in advanced non-small cell lung cancer

Phan, A. N. H., Hua, T. N. M., Kim, M. K., Vo, V. T. A., Choi, J. W., Kim, H. W., Rho, J. K., Kim, K. W. & Jeong, Y., 2016 Jan 1, In : Oncotarget. 7, 34, p. 54702-54713 12 p.

Research output: Contribution to journalArticle

Gallic Acid
Epidermal Growth Factor Receptor
Non-Small Cell Lung Carcinoma
Protein-Tyrosine Kinases
Lung Neoplasms
27 Citations (Scopus)

Gallic Acid Promotes Wound Healing in Normal and Hyperglucidic Conditions

Yang, D. J., Moh, S. H., Son, D. H., You, S., Kinyua, A. W., Ko, C. M., Song, M., Yeo, J., Choi, Y. H. & Kim, K. W., 2016 Jul, In : Molecules. 21, 7, 899.

Research output: Contribution to journalArticle

wound healing
Gallic Acid
Wound Healing
Skin
fibroblasts
11 Citations (Scopus)

Leptin and insulin engage specific PI3K subunits in hypothalamic SF1 neurons

Sohn, J. W., Oh, Y., Kim, K., Lee, S., Williams, K. W. & Elmquist, J. K., 2016 Aug 1, In : Molecular Metabolism. 5, 8, p. 669-679 11 p.

Research output: Contribution to journalArticle

Steroidogenic Factor 1
Leptin
Phosphatidylinositol 3-Kinases
Ventromedial Hypothalamic Nucleus
Insulin
5 Citations (Scopus)

Leucine-enkephalin promotes wound repair through the regulation of hemidesmosome dynamics and matrix metalloprotease

Yang, D. J., Lee, K. S., Ko, C. M., Moh, S. H., Song, J., Hur, L. C., Cheon, Y. W., Yang, S. H., Choi, Y. H. & Kim, K., 2016 Feb 1, In : Peptides. 76, p. 57-64 8 p.

Research output: Contribution to journalArticle

Hemidesmosomes
Leucine Enkephalin
Metalloproteases
Skin
Repair
4 Citations (Scopus)

Nutritional conditions regulate transcriptional activity of SF-1 by controlling sumoylation and ubiquitination

Lee, J., Yang, D. J., Lee, S., Hammer, G. D., Kim, K. W. & Elmquist, J. K., 2016 Jan 11, In : Scientific reports. 6, 19143.

Research output: Contribution to journalArticle

Steroidogenic Factor 1
Sumoylation
Ubiquitination
Starvation
Homeostasis
5 Citations (Scopus)

Primary cilia negatively regulate melanogenesis in melanocytes and pigmentation in a human skin model

Choi, H., Shin, J. H., Kim, E. S., Park, S. J., Bae, I. H., Jo, Y. K., Jeong, I. Y., Kim, H. J., Lee, Y., Park, H. C., Jeon, H. B., Kim, K. W., Lee, T. R. & Cho, D. H., 2016 Dec, In : PloS one. 11, 12, e0168025.

Research output: Contribution to journalArticle

melanogenesis
melanocytes
Cilia
Melanocytes
Pigmentation
13 Citations (Scopus)

SF-1 expression in the hypothalamus is required for beneficial metabolic effects of exercise

Fujikawa, T., Castorena, C. M., Pearson, M., Kusminski, C. M., Ahmed, N., Battiprolu, P. K., Kim, K. W., Lee, S., Hill, J. A., Scherer, P. E., Holland, W. L. & Elmquist, J. K., 2016 Nov 22, In : eLife. 5, NOVEMBER2016, e18206.

Research output: Contribution to journalArticle

Steroidogenic Factor 1
Ventromedial Hypothalamic Nucleus
Metabolism
Hypothalamus
Neurology
10 Citations (Scopus)

Steroidogenic factor 1 in the ventromedial nucleus of the hypothalamus regulates age-dependent obesity

Kinyua, A. W., Yang, D. J., Chang, I. & Kim, K. W., 2016 Sep, In : PloS one. 11, 9, e0162352.

Research output: Contribution to journalArticle

Steroidogenic Factor 1
hypothalamus
Hypothalamus
obesity
Obesity
2015
1 Citation (Scopus)

A novel tripeptide derived from Chlorella vulgaris regulates skin homeostasis through antioxidant activity

Han, J. G., Kulkarni, A., Jeon, J. Y., Kim, B. R., Song, M. Y., Jeong, H. Y., Yang, D. J., You, S. H., Kim, K. W., Moh, S. H. & Hwang, J. K., 2015 Jan 1, In : Science of Advanced Materials. 7, 11, p. 2476-2480 5 p.

Research output: Contribution to journalArticle

Antioxidants
Alanine
Serine
Cysteine
Skin

A novel tripeptide derived from Chlorella vulgaris regulates skin homeostasis through its antioxidant function

Han, J. G., Kulkarni, A., Jeon, J. Y., Kim, B. R., Song, M. Y., Jeong, H. Y., Yang, D. J., You, S. H., Kim, K. W., Moh, S. H. & Hwang, J. K., 2015 Jan 1, In : Science of Advanced Materials. 7, 12, p. 2545-2550 6 p.

Research output: Contribution to journalArticle

Antioxidants
Alanine
Serine
Cysteine
Skin
51 Citations (Scopus)

Gallic acid regulates body weight and glucose homeostasis through AMPK activation

Doan, K. V., Ko, C. M., Kinyua, A. W., Yang, D. J., Choi, Y. H., Oh, I. Y., Nguyen, N. M., Ko, A., Choi, J. W., Jeong, Y., Jung, M. H., Cho, W. G., Xu, S., Park, K., Park, W. J., Choi, S. Y., Kim, H. S., Moh, S. H. & Kim, K., 2015 Jan 1, In : Endocrinology. 156, 1, p. 157-168 12 p.

Research output: Contribution to journalArticle

Sirtuin 1
Gallic Acid
AMP-Activated Protein Kinases
Homeostasis
Body Weight
11 Citations (Scopus)

Insulin priming effect on estradiol-induced breast cancer metabolism and growth

Wairagu, P. M., Phan, A. N. H., Kim, M. K., Han, J., Kim, H. W., Choi, J. W., Kim, K. W., Cha, S. K., Park, K. H. & Jeong, Y., 2015 Mar 1, In : Cancer Biology and Therapy. 16, 3, p. 484-492 9 p.

Research output: Contribution to journalArticle

Estradiol
Insulin
Breast Neoplasms
Growth
Metformin
14 Citations (Scopus)

Mycosporine-like amino acids promote wound healing through focal adhesion kinase (FAK) and mitogen-activated protein kinases (MAP kinases) signaling pathway in keratinocytes

Choi, Y. H., Yang, D. J., Kulkarni, A., Moh, S. H. & Kim, K. W., 2015 Dec 1, In : Marine Drugs. 13, 12, p. 7055-7066 12 p.

Research output: Contribution to journalArticle

Focal Adhesion Protein-Tyrosine Kinases
Mitogen-Activated Protein Kinases
Keratinocytes
Wound Healing
Amino Acids
2014
23 Citations (Scopus)

Dnmt3a in sim1 neurons is necessary for normal energy homeostasis

Kohno, D., Lee, S., Harper, M. J., Kim, K. W., Sone, X., Sasaki, T., Kitamura, T., Fan, G. & Elmquist, J. K., 2014 Nov 12, In : Journal of Neuroscience. 34, 46, p. 15288-15296 9 p.

Research output: Contribution to journalArticle

Paraventricular Hypothalamic Nucleus
Hypothalamus
Homeostasis
Neurons
Tyrosine 3-Monooxygenase
15 Citations (Scopus)

Emetine enhances the tumor necrosis factor-related apoptosis-inducing ligand-induced apoptosis of pancreatic cancer cells by downregulation of myeloid cell leukemia sequence-1 protein

Han, Y., Park, S., Kinyua, A. W., Andera, L., Kim, K. I. W. & Kim, I., 2014 Jan 1, In : Oncology Reports. 31, 1, p. 456-462 7 p.

Research output: Contribution to journalArticle

Myeloid Cell Leukemia Sequence 1 Protein
Emetine
Pancreatic Neoplasms
Down-Regulation
Tumor Necrosis Factor-alpha
28 Citations (Scopus)

Prolactin-sensitive neurons express estrogen receptor-α and depend on sex hormones for normal responsiveness to prolactin

Furigo, I. C., Kim, K., Nagaishi, V. S., Ramos-Lobo, A. M., De Alencar, A., Pedroso, J. A. B., Metzger, M. & Donato, J., 2014 May 30, In : Brain Research. 1566, p. 47-59 13 p.

Research output: Contribution to journalArticle

Gonadal Steroid Hormones
Estrogen Receptors
Prolactin
Neurons
Hypothalamus
2013
41 Citations (Scopus)

Revisiting the ventral medial nucleus of the hypothalamus: The roles of SF-1 neurons in energy homeostasis

Choi, Y. H., Fujikawa, T., Lee, J., Reuter, A. & Kim, K. W., 2013 Jun 17, In : Frontiers in Neuroscience. 7 MAY, Article 71.

Research output: Contribution to journalArticle

Steroidogenic Factor 1
Middle Hypothalamus
Homeostasis
Neurons
Glucose
2012
76 Citations (Scopus)

FOXO1 in the ventromedial hypothalamus regulates energy balance

Kim, K. W., Donato, J., Berglund, E. D., Choi, Y. H., Kohno, D., Elias, C. F., DePinho, R. A. & Elmquist, J. K., 2012 Jul 2, In : Journal of Clinical Investigation. 122, 7, p. 2578-2589 12 p.

Research output: Contribution to journalArticle

Middle Hypothalamus
Hypothalamus
Steroidogenic Factor 1
Neurons
Energy Metabolism
2011
86 Citations (Scopus)

Steroidogenic factor 1 directs programs regulating diet-induced thermogenesis and leptin action in the ventral medial hypothalamic nucleus

Kim, K. W., Zhao, L., Donato, J., Kohno, D., Xu, Y., Eliasa, C. F., Lee, C., Parker, K. L. & Elmquist, J. K., 2011 Jun 28, In : Proceedings of the National Academy of Sciences of the United States of America. 108, 26, p. 10673-10678 6 p.

Research output: Contribution to journalArticle

Steroidogenic Factor 1
Thermogenesis
Leptin
Diet
High Fat Diet
2010
28 Citations (Scopus)

CNS-specific ablation of steroidogenic factor 1 results in impaired female reproductive function

Kim, K. W., Li, S., Zhao, H., Peng, B., Tobet, S. A., Elmquist, J. K., Parker, K. L. & Zhao, L., 2010 Jun 1, In : Molecular Endocrinology. 24, 6, p. 1240-1250 11 p.

Research output: Contribution to journalArticle

Steroidogenic Factor 1
Ventromedial Hypothalamic Nucleus
Female Infertility
Corpus Luteum
Gonadotropin-Releasing Hormone
76 Citations (Scopus)

PI3K signaling in the ventromedial hypothalamic nucleus is required for normal energy homeostasis

Xu, Y., Hill, J. W., Fukuda, M., Gautron, L., Sohn, J. W., Kim, K. W., Lee, C. E., Choi, M. J., Lauzon, D. A., Dhillon, H., Lowell, B. B., Zigman, J. M., Zhao, J. J. & Elmquist, J. K., 2010 Jul 7, In : Cell Metabolism. 12, 1, p. 88-95 8 p.

Research output: Contribution to journalArticle

Ventromedial Hypothalamic Nucleus
Phosphatidylinositols
Energy Metabolism
Homeostasis
Phosphotransferases
2008
55 Citations (Scopus)

Central nervous system-specific knockout of steroidogenic factor 1 results in increased anxiety-like behavior

Zhao, L., Kim, K., Ikeda, Y., Anderson, K. K., Beck, L., Chase, S., Tobet, S. A. & Parker, K. L., 2008 Jun 1, In : Molecular Endocrinology. 22, 6, p. 1403-1415 13 p.

Research output: Contribution to journalArticle

Steroidogenic Factor 1
Anxiety
Central Nervous System
Ventromedial Hypothalamic Nucleus
Knockout Mice
24 Citations (Scopus)

Steroidogenic factor 1 regulates expression of the cannabinoid receptor 1 in the ventromedial hypothalamic nucleus

Kim, K. W., Jo, Y. H., Zhao, L., Stallings, N. R., Chua, S. C. & Parker, K. L., 2008 Aug 1, In : Molecular Endocrinology. 22, 8, p. 1950-1961 12 p.

Research output: Contribution to journalArticle

Steroidogenic Factor 1
Ventromedial Hypothalamic Nucleus
Cannabinoid Receptors
Homeostasis
Neurons
2007
101 Citations (Scopus)

RGS9-2 negatively modulates L-3,4-dihydroxyphenylalanine-induced dyskinesia in experimental Parkinson's disease

Gold, S. J., Hoang, C. V., Potts, B. W., Porras, G., Pioli, E., Ki, W. K., Nadjar, A., Qin, C., LaHoste, G. J., Li, Q., Bioulac, B. H., Waugh, J. L., Gurevich, E., Neve, R. L. & Bezard, E., 2007 Dec 26, In : Journal of Neuroscience. 27, 52, p. 14338-14348 11 p.

Research output: Contribution to journalArticle

Dyskinesias
Parkinsonian Disorders
Levodopa
Corpus Striatum
Oxidopamine
2006
36 Citations (Scopus)

Neuron-specific enolase-cre mouse line with cre activity in specific neuronal populations

Kwon, C. H., Zhou, J., Li, Y., Kim, K. W., Hensley, L. L., Baker, S. J. & Parada, L. F., 2006 Mar 1, In : Genesis. 44, 3, p. 130-135 6 p.

Research output: Contribution to journalArticle

Phosphopyruvate Hydratase
Population
Neurons
Gene Deletion
Cerebral Cortex
2005
33 Citations (Scopus)

Regulation of human resistin gene expression in cell systems: An important role of stimulatory protein 1 interaction with a common promoter polymorphic site

Chung, S. S., Choi, H. H., Kim, K. W., Cho, Y. M., Lee, H. K. & Park, K. S., 2005 Jun 1, In : Diabetologia. 48, 6, p. 1150-1158 9 p.

Research output: Contribution to journalArticle

Resistin
Gene Expression
Proteins
Adipocytes
Genes
2004
113 Citations (Scopus)

Common genetic polymorphisms in the promoter of resistin gene are major determinants of plasma resistin concentrations in humans

Cho, Y. M., Youn, B. S., Chung, S. S., Kim, K. W., Lee, H. K., Yu, K. Y., Park, H. J., Shin, H. D. & Park, K. S., 2004 Mar, In : Diabetologia. 47, 3, p. 559-565 7 p.

Research output: Contribution to journalArticle

Resistin
Genetic Polymorphisms
Genes
Haplotypes
Obesity
2002
106 Citations (Scopus)

Calpain-dependent cleavage of cain/cabin1 activates calcineurin to mediate calcium-triggered cell death

Kim, M. J., Jo, D. G., Hong, G. S., Kim, B. J., Lai, M., Cho, D. H., Kim, K. W., Bandyopadhyay, A., Hong, Y. M., Kim, D. H., Cho, C., Liu, J. O., Snyder, S. H. & Jung, Y. K., 2002 Jul 23, In : Proceedings of the National Academy of Sciences of the United States of America. 99, 15, p. 9870-9875 6 p.

Research output: Contribution to journalArticle

Calpain
Calcineurin
Cell Death
Calcium
Calcimycin
24 Citations (Scopus)

Caspase cleavage product lacking amino-terminus of IκBα sensitizes resistant cells to TNF-α and TRAIL-induced apoptosis

Kim, K. W., Kim, B. J., Chung, C. W., Jo, D. G., Kim, I. K., Song, Y. H., Kwon, Y. K., Woo, H. N. & Jung, Y. K., 2002 Apr 15, In : Journal of Cellular Biochemistry. 85, 2, p. 334-345 12 p.

Research output: Contribution to journalArticle

TNF-Related Apoptosis-Inducing Ligand
Caspases
Tumor Necrosis Factor-alpha
Apoptosis
HeLa Cells
18 Citations (Scopus)

Sensitizing effects of cadmium on TNF-α- and TRAIL-mediated apoptosis of NIH3T3 cells with distinct expression patterns of p53

Kim, B. J., Kim, M. S., Kim, K. B., Kim, K., Hong, Y. M., Kim, I. K., Lee, H. W. & Jung, Y. K., 2002 Sep 1, In : Carcinogenesis. 23, 9, p. 1411-1417 7 p.

Research output: Contribution to journalArticle

TNF-Related Apoptosis-Inducing Ligand
Cadmium
Cell Death
Tumor Necrosis Factor-alpha
Apoptosis
2001
13 Citations (Scopus)

Inactivation of farnesyltransferase and geranylgeranyltransferase I by caspase-3: Cleavage of the common α subunit during apoptosis

Kim, K. W., Chung, H. H., Chung, C. W., Kim, I. K., Miura, M., Wang, S., Zhu, H., Moon, K. D., Rha, G. B., Park, J. H., Jo, D. G., Woo, H. N., Song, Y. H., Kim, B. J., Yuan, J. & Jung, Y. K., 2001 Jan 18, In : Oncogene. 20, 3, p. 358-366 9 p.

Research output: Contribution to journalArticle

Farnesyltranstransferase
Caspase 3
Apoptosis
Etoposide
Caspases
2000
91 Citations (Scopus)

Cadmium induces caspase-mediated cell death: Suppression by Bcl-2

Kim, M. S., Kim, B. J., Woo, H. N., Kim, K., Kim, K. B., Kim, I. K. & Jung, Y. K., 2000 Apr 7, In : Toxicology. 145, 1, p. 27-37 11 p.

Research output: Contribution to journalArticle

Cell death
Caspases
Cadmium
Cell Death
Apoptosis