• 1914 Citations
  • 23 h-Index
19982019

Research output per year

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Research Output

  • 1914 Citations
  • 23 h-Index
  • 48 Article
  • 2 Short survey
  • 1 Comment/debate
  • 1 Review article
2019

Activation of sonic hedgehog signaling by a Smoothened agonist restores congenital defects in mouse models of endocrine-cerebro-osteodysplasia syndrome

Shin, J. O., Song, J., Choi, H. S., Lee, J., Lee, K., Ko, H. W. & Bok, J., 2019 Nov, In : EBioMedicine. 49, p. 305-317 13 p.

Research output: Contribution to journalArticle

Open Access

Fibroblast growth factor receptor influences primary cilium length through an interaction with intestinal cell kinase

Bosakova, M. K., Nita, A., Gregor, T., Varecha, M., Gudernova, I., Fafilek, B., Barta, T., Basheer, N., Abraham, S. P., Balek, L., Tomanova, M., Kucerova, J. F., Bosak, J., Potesil, D., Zieba, J., Song, J., Konik, P., Park, S., Duran, I., Zdrahal, Z. & 8 others, Smajs, D., Jansen, G., Fu, Z., Ko, H. W., Hampl, A., Trantirek, L., Krakow, D. & Krejci, P., 2019 Jan 1, In : Proceedings of the National Academy of Sciences of the United States of America. 116, 10, p. 4316-4325 10 p.

Research output: Contribution to journalArticle

Open Access
2 Citations (Scopus)

Multilayer fabrication of unobtrusive poly(dimethylsiloxane) nanobrush for tunable cell adhesion

Chae, S. S., Jung, J. H., Choi, W. J., Park, J. K., Baik, H. K., Jung, J. & Ko, H. W., 2019 Dec 1, In : Scientific reports. 9, 1, 1834.

Research output: Contribution to journalArticle

Open Access
1 Citation (Scopus)
2018

PEGylated hyaluronic acid-coated liposome for enhanced in vivo efficacy of sorafenib via active tumor cell targeting and prolonged systemic exposure

Mo, L., Song, J. G., Lee, H., Zhao, M., Kim, H. Y., Lee, Y. J., Ko, H. W. & Han, H. K., 2018 Feb, In : Nanomedicine: Nanotechnology, Biology, and Medicine. 14, 2, p. 557-567 11 p.

Research output: Contribution to journalArticle

18 Citations (Scopus)

Sauchinone controls hepatic cholesterol homeostasis by the negative regulation of PCSK9 transcriptional network

Chae, H. S., You, B. H., Kim, D. Y., Lee, H., Ko, H. W., Ko, H. J., Choi, Y. H., Choi, S. S. & Chin, Y. W., 2018 Dec 1, In : Scientific reports. 8, 1, 6737.

Research output: Contribution to journalArticle

4 Citations (Scopus)
2017

Capsaicin prevents degeneration of dopamine neurons by inhibiting glial activation and oxidative stress in the MPTP model of Parkinson's disease

Chung, Y. C., Baek, J. Y., Kim, S. R., Ko, H. W., Bok, E., Shin, W. H., Won, S. Y. & Jin, B. K., 2017 Mar 3, In : Experimental and Molecular Medicine. 49, 3, e298.

Research output: Contribution to journalArticle

22 Citations (Scopus)

Cell Cycle-Related Kinase (CCRK) regulates ciliogenesis and Hedgehog signaling in mice

Snouffer, A., Brown, D., Lee, H., Walsh, J., Lupu, F., Norman, R., Lechtreck, K., Ko, H. W. & Eggenschwiler, J., 2017 Aug, In : PLoS Genetics. 13, 8, e1006912.

Research output: Contribution to journalArticle

9 Citations (Scopus)

Design, synthesis, and biological evaluation of structurally modified isoindolinone and quinazolinone derivatives as hedgehog pathway inhibitors

Bhattarai, D., Jung, J. H., Han, S., Lee, H., Oh, S. J., Ko, H. W. & Lee, K., 2017 Jan 1, In : European Journal of Medicinal Chemistry. 125, p. 1036-1050 15 p.

Research output: Contribution to journalArticle

9 Citations (Scopus)

Injury-stimulated Sonic hedgehog expression in microglia contributes to neuroinflammatory response in the MPTP model of Parkinson's disease

Lee, J. H., Chung, Y. C., Bok, E., Lee, H., Huh, S. H., Lee, J. E., Jin, B. K. & Ko, H. W., 2017 Jan 22, In : Biochemical and Biophysical Research Communications. 482, 4, p. 980-986 7 p.

Research output: Contribution to journalArticle

5 Citations (Scopus)

Mangosteen extract prevents dextran sulfate sodium-induced colitis in mice by suppressing NF-κB activation and inflammation

Chae, H. S., You, B. H., Song, J., Ko, H. W., Choi, Y. H. & Chin, Y. W., 2017 Aug 1, In : Journal of Medicinal Food. 20, 8, p. 727-733 7 p.

Research output: Contribution to journalArticle

5 Citations (Scopus)

Vaccinia-related kinase 3 (VRK3) sets the circadian period and amplitude by affecting the subcellular localization of clock proteins in mammalian cells

Park, N., Song, J., Jeong, S., Thi Tran, T., Ko, H. W. & Kim, E. Y., 2017 May 27, In : Biochemical and Biophysical Research Communications. 487, 2, p. 320-326 7 p.

Research output: Contribution to journalArticle

α-Mangostin ameliorates dextran sulfate sodium-induced colitis through inhibition of NF-κB and MAPK pathways

You, B. H., Chae, H. S., Song, J., Ko, H. W., Chin, Y. W. & Choi, Y. H., 2017 Aug 1, In : International Immunopharmacology. 49, p. 212-221 10 p.

Research output: Contribution to journalArticle

11 Citations (Scopus)
2016

An inactivating mutation in intestinal cell kinase, ICK, impairs hedgehog signalling and causes short rib-polydactyly syndrome

University of Washington Center for Mendelian Genomics, 2016 Jan 1, In : Human molecular genetics. 25, 18, p. 3998-4011 14 p.

Research output: Contribution to journalArticle

13 Citations (Scopus)

Ciliary smoothened-mediated noncanonical hedgehog signaling promotes tubulin acetylation

Lee, H. & Ko, H. W., 2016 Nov 25, In : Biochemical and Biophysical Research Communications. 480, 4, p. 574-579 6 p.

Research output: Contribution to journalArticle

2 Citations (Scopus)

Paclitaxel-Nanodiamond Nanocomplexes Enhance Aqueous Dispersibility and Drug Retention in Cells

Lim, D. G., Jung, J. H., Ko, H. W., Kang, E. & Jeong, S. H., 2016 Sep 14, In : ACS Applied Materials and Interfaces. 8, 36, p. 23558-23567 10 p.

Research output: Contribution to journalArticle

18 Citations (Scopus)

Sulforaphene Interferes with Human Breast Cancer Cell Migration and Invasion through Inhibition of Hedgehog Signaling

Bao, C., Kim, M. C., Chen, J., Song, J., Ko, H. W. & Lee, H. J., 2016 Jul 13, In : Journal of Agricultural and Food Chemistry. 64, 27, p. 5515-5524 10 p.

Research output: Contribution to journalArticle

8 Citations (Scopus)
2015

Drosophila peptidyl-prolyl isomerase Pin1 modulates circadian rhythms via regulating levels of PERIOD

Kang, S. W., Lee, E., Cho, E., Seo, J. H., Ko, H. W. & Kim, E. Y., 2015 Jun 14, In : Biochemical and Biophysical Research Communications. 463, 3, p. 235-240 6 p.

Research output: Contribution to journalArticle

2 Citations (Scopus)

Effects of substrate conductivity on cell morphogenesis and proliferation using tailored, atomic layer deposition-grown ZnO thin films

Choi, W. J., Jung, J., Lee, S., Chung, Y. J., Yang, C. S., Lee, Y. K., Lee, Y. S., Park, J. K., Ko, H. W. & Lee, J. O., 2015 Apr 21, In : Scientific reports. 5, 9974.

Research output: Contribution to journalArticle

16 Citations (Scopus)

Leptin elongates hypothalamic neuronal cilia via transcriptional regulation and actin destabilization

Kang, G. M., Han, Y., Ko, H. W., Kim, J., Chul Oh, B., Kwon, I. & Kim, M. S., 2015 Jul 17, In : Journal of Biological Chemistry. 290, 29, p. 18146-18155 10 p.

Research output: Contribution to journalArticle

19 Citations (Scopus)

Primary cilia in energy balance signaling and metabolic disorder

Lee, H., Song, J., Jung, J. H. & Ko, H. W., 2015 Jan 1, In : BMB reports. 48, 12, p. 647-654 8 p.

Research output: Contribution to journalShort survey

12 Citations (Scopus)

TRPV1 on astrocytes rescues nigral dopamine neurons in Parkinson's disease via CNTF

Nam, J. H., Park, E. S., Won, S. Y., Lee, Y. A., Kim, K. I., Jeong, J. Y., Baek, J. Y., Cho, E. J., Jin, M., Chung, Y. C., Lee, B. D., Kim, S. H., Kim, E. G., Byun, K., Lee, B., Woo, D. H., Lee, C. J., Kim, S. R., Bok, E., Kim, Y. S. & 8 others, Ahn, T. B., Ko, H. W., Brahmachari, S., Pletinkova, O., Troconso, J. C., Dawson, V. L., Dawson, T. M. & Jin, B. K., 2015 Dec 1, In : Brain. 138, 12, p. 3610-3622 13 p.

Research output: Contribution to journalArticle

33 Citations (Scopus)
2014

Daidzein suppresses tumor necrosis factor-α induced migration and invasion by inhibiting hedgehog/gli1 signaling in human breast cancer cells

Bao, C., Namgung, H., Lee, J., Park, H. C., Ko, J., Moon, H., Ko, H. W. & Lee, H. J., 2014 Apr 30, In : Journal of Agricultural and Food Chemistry. 62, 17, p. 3759-3767 9 p.

Research output: Contribution to journalArticle

19 Citations (Scopus)

Intestinal cell kinase, aprotein associated with endocrine-cerebro- osteodysplasia syndrome,is a key regulator of cilia length and Hedgehog signaling

Moon, H., Song, J., Shin, J. O., Lee, H., Kim, H. K., Eggenschwiller, J. T., Bok, J. & Ko, H. W., 2014 Jun 10, In : Proceedings of the National Academy of Sciences of the United States of America. 111, 23, p. 8541-8546 6 p.

Research output: Contribution to journalArticle

31 Citations (Scopus)

Leptin-promoted cilia assembly is critical for normal energy balance

Han, Y. M., Kang, G. M., Byun, K., Ko, H. W., Kim, J., Shin, M. S., Kim, H. K., Gil, S. Y., Yu, J. H., Lee, B. & Kim, M. S., 2014, In : Journal of Clinical Investigation. 124, 5, p. 2193-2197 5 p.

Research output: Contribution to journalArticle

43 Citations (Scopus)

Pax3 function is required specifically for inner ear structures with melanogenic fates

Kim, H. K., Ankamreddy, H., Lee, D. J., Kong, K. A., Ko, H. W., Kim, M. H. & Bok, J., 2014 Mar 14, In : Biochemical and Biophysical Research Communications. 445, 3, p. 608-614 7 p.

Research output: Contribution to journalArticle

12 Citations (Scopus)
2013

Localization of primary cilia in mouse retina

Kim, Y. K., Kim, J. H., Yu, Y. S., Ko, H. W. & Kim, J. H., 2013 Oct 1, In : Acta Histochemica. 115, 8, p. 789-794 6 p.

Research output: Contribution to journalArticle

5 Citations (Scopus)

Single-stranded DNA aptamer that specifically binds to the influenza virus NS1 protein suppresses interferon antagonism

Woo, H. M., Kim, K. S., Lee, J. M., Shim, H. S., Cho, S. J., Lee, W. K., Ko, H. W., Keum, Y. S., Kim, S. Y., Pathinayake, P., Kim, C. J. & Jeong, Y. J., 2013 Oct 16, In : Antiviral Research. 100, 2, p. 337-345 9 p.

Research output: Contribution to journalArticle

26 Citations (Scopus)
2012

The primary cilium as a multiple cellular signaling scaffold in development and disease

Ko, H. W., 2012 Aug 1, In : BMB reports. 45, 8, p. 427-432 6 p.

Research output: Contribution to journalShort survey

16 Citations (Scopus)
2011

Erratum: NEMO/NLK phosphorylates PERIOD to initiate a time-delay phosphorylation circuit that sets circadian clock speed (Cell (2011) 145 (357-370))

Chiu, J. C., Ko, H. W. & Edery, I., 2011 May 13, In : Cell. 145, 4, 1 p.

Research output: Contribution to journalComment/debate

1 Citation (Scopus)

Fluoxetine prevents MPTP-induced loss of dopaminergic neurons by inhibiting microglial activation

Chung, Y. C., Kim, S. R., Park, J. Y., Chung, E. S., Park, K. W., Won, S. Y., Bok, E., Jin, M., Park, E. S., Yoon, S. H., Ko, H. W., Kim, Y. S. & Jin, B. K., 2011 May 1, In : Neuropharmacology. 60, 6, p. 963-974 12 p.

Research output: Contribution to journalArticle

100 Citations (Scopus)

Intraflagellar transport protein 122 antagonizes Sonic Hedgehog signaling and controls ciliary localization of pathway components

Qin, J., Lin, Y., Norman, R. X., Ko, H. W. & Eggenschwiler, J. T., 2011 Jan 25, In : Proceedings of the National Academy of Sciences of the United States of America. 108, 4, p. 1456-1461 6 p.

Research output: Contribution to journalArticle

107 Citations (Scopus)

NEMO/NLK phosphorylates PERIOD to initiate a time-delay phosphorylation circuit that sets circadian clock speed

Chiu, J. C., Ko, H. W. & Edery, I., 2011 Apr 29, In : Cell. 145, 3, p. 357-370 14 p.

Research output: Contribution to journalArticle

110 Citations (Scopus)
2010

A hierarchical phosphorylation cascade that regulates the timing of PERIOD nuclear entry reveals novel roles for proline-directed kinases and GSK-3β/SGG in circadian clocks

Ko, H. W., Kim, E. Y., Chiu, J., Vanselow, J. T., Kramer, A. & Edery, I., 2010 Sep 22, In : Journal of Neuroscience. 30, 38, p. 12664-12675 12 p.

Research output: Contribution to journalArticle

69 Citations (Scopus)

Broad-Minded Links Cell Cycle-Related Kinase to Cilia Assembly and Hedgehog Signal Transduction

Ko, H. W., Norman, R. X., Tran, J., Fuller, K. P., Fukuda, M. & Eggenschwiler, J. T., 2010 Feb 16, In : Developmental Cell. 18, 2, p. 237-247 11 p.

Research output: Contribution to journalArticle

62 Citations (Scopus)

The role of neuroinflammation on the pathogenesis of Parkinson's disease

Chung, Y. C., Ko, H. W., Bok, E., Park, E. S., Huh, S. H., Nam, J. H. & Jin, B. K., 2010 Apr, In : BMB reports. 43, 4, p. 225-232 8 p.

Research output: Contribution to journalReview article

98 Citations (Scopus)

Two distinct modes of PERIOD recruitment onto dCLOCK reveal a novel role for TIMELESS in circadian transcription

Sun, W. C., Jeong, E. H., Jeong, H. J., Ko, H. W., Edery, I. & Kim, E. Y., 2010 Oct 27, In : Journal of Neuroscience. 30, 43, p. 14458-14469 12 p.

Research output: Contribution to journalArticle

14 Citations (Scopus)
2009

Analysis of hedgehog signaling in mouse intraflagellar transport mutants.

Ko, H. W., Liu, A. & Eggenschwiler, J. T., 2009, In : Methods in cell biology. 93, p. 347-369 23 p.

Research output: Contribution to journalArticle

5 Citations (Scopus)

Tubby-like protein 3 (TULP3) regulates patterning in the mouse embryo through inhibition of Hedgehog signaling

Norman, R. X., Ko, H. W., Huang, V., Eun, C. M., Abler, L. L., Zhang, Z., Sun, X. & Eggenschwiler, J. T., 2009 May 7, In : Human molecular genetics. 18, 10, p. 1740-1754 15 p.

Research output: Contribution to journalArticle

53 Citations (Scopus)
2008

FKBP8 cell-autonomously controls neural tube patterning through a Gli2- and Kif3a-dependent mechanism

Cho, A., Ko, H. W. & Eggenschwiler, J. T., 2008 Sep 1, In : Developmental Biology. 321, 1, p. 27-39 13 p.

Research output: Contribution to journalArticle

44 Citations (Scopus)

Natural Variation in the Splice Site Strength of a Clock Gene and Species-Specific Thermal Adaptation

Low, K. H., Lim, C., Ko, H. W. & Edery, I., 2008 Dec 26, In : Neuron. 60, 6, p. 1054-1067 14 p.

Research output: Contribution to journalArticle

63 Citations (Scopus)
2007

A DOUBLETIME kinase binding domain on the Drosophila PERIOD protein is essential for its hyperphosphorylation, transcriptional repression, and circadian clock function

Eun, Y. K., Hyuk, W. K., Yu, W., Hardin, P. E. & Edery, I., 2007 Jul 1, In : Molecular and Cellular Biology. 27, 13, p. 5014-5028 15 p.

Research output: Contribution to journalArticle

80 Citations (Scopus)

Cis-combination of the classic perS and perL mutations results in arrhythmic Drosophila with ectopic accumulation of hyperphosphorylated PERIOD protein

Hyuk, W. K., DiMassa, S., Eun, Y. K., Bae, K. & Edery, I., 2007 Dec 1, In : Journal of Biological Rhythms. 22, 6, p. 488-501 14 p.

Research output: Contribution to journalArticle

7 Citations (Scopus)
2005

Analyzing the degradation of PERIOD protein by the ubiquitin-proteasome pathway in cultured Drosophila cells

Ko, H. W. & Edery, I., 2005 Jan 1, In : Methods in Enzymology. 393, p. 394-408 15 p., 18.

Research output: Contribution to journalArticle

8 Citations (Scopus)
2002

Role for Slimb in the degradation of Drosophila Period protein phosphorylated by Doubletime

Ko, H. W., Jiang, J. & Edery, I., 2002 Dec 12, In : Nature. 420, 6916, p. 673-678 6 p.

Research output: Contribution to journalArticle

244 Citations (Scopus)
2000

NT-4/5 exacerbates free radical-induced neuronal necrosis in vitro and in vivo

Won, S. J., Park, E. C., Ryu, B. R., Ko, H. W., Sohn, S., Kwon, H. J. & Gwag, B. J., 2000 Jan 1, In : Neurobiology of Disease. 7, 4, p. 251-259 9 p.

Research output: Contribution to journalArticle

23 Citations (Scopus)

Synergetic activation of p38 mitogen-activated protein kinase and caspase-3-like proteases for execution of calyculin A-induced apoptosis but not N-methyl-D-aspartate-induced necrosis in mouse cortical neurons

Ko, H. W., Han, K. S., Kim, E. Y., Ryu, B. R., Yoon, W. J., Jung, Y. K., Kim, S. U. & Gwag, B. J., 2000 Jun 5, In : Journal of Neurochemistry. 74, 6, p. 2455-2461 7 p.

Research output: Contribution to journalArticle

40 Citations (Scopus)
1999

Necrosis and apoptosis after retinal ischemia: Involvement of NMDA- mediated excitotoxicity and p53

Joo, C. K., Choi, J. S., Ko, H. W., Park, K. Y., Sohn, S., Chun, M. H., Oh, Y. J. & Gwag, B. J., 1999 Mar 11, In : Investigative Ophthalmology and Visual Science. 40, 3, p. 713-720 8 p.

Research output: Contribution to journalArticle

137 Citations (Scopus)

Nuclear factor kappa B-mediated kainate neurotoxicity in the rat and hamster hippocampus

Won, S. J., Ko, H. W., Kim, E. Y., Park, E. C., Huh, K., Jung, N. P., Choi, I., Oh, Y. K., Shin, H. C. & Gwag, B. J., 1999 Sep 1, In : Neuroscience. 94, 1, p. 83-91 9 p.

Research output: Contribution to journalArticle

33 Citations (Scopus)

Phosphatidylinositol 3-kinase-mediated regulation of neuronal apoptosis and necrosis by insulin and IGF-I

Ryu, B. R., Ko, H. W., Jou, I., Noh, J. S. & Gwag, B. J., 1999 Jun 15, In : Journal of Neurobiology. 39, 4, p. 536-546 11 p.

Research output: Contribution to journalArticle

93 Citations (Scopus)
1998

A neuron-specific gene transfer by a recombinant defective Sindbis virus

Gwag, B. J., Kim, E. Y., Ryu, B. R., Won, S. J., Ko, H. W., Oh, Y. J., Cho, Y. G., Ha, S. J. & Sung, Y. C., 1998 Dec 10, In : Molecular Brain Research. 63, 1, p. 53-61 9 p.

Research output: Contribution to journalArticle

33 Citations (Scopus)