If you made any changes in Pure these will be visible here soon.

Research Output 2009 2019

2019
1 Citation (Scopus)

MST1 Negatively Regulates TNFα-Induced NF-κB Signaling through Modulating LUBAC Activity

Lee, I. Y., Lim, J. M., Cho, H., Kim, E., Kim, Y., Oh, H. K., Yang, W. S., Roh, K. H., Park, H. W., Mo, J. S., Yoon, J. H., Song, H. K. & Choi, E. J., 2019 Mar 21, In : Molecular Cell. 73, 6, p. 1138-1149.e6

Research output: Contribution to journalArticle

TNF Receptor-Associated Factor 2
Ubiquitin-Protein Ligases
Ubiquitin
Serine
Gene Expression
2018

Erratum to: Regulation of Hippo pathway transcription factor TEAD by p38 MAPK-induced cytoplasmic translocation (Nature Cell Biology, (2017), 19, 8, (996-1002), 10.1038/ncb3581)

Lin, K. C., Moroishi, T., Meng, Z., Jeong, H. S., Plouffe, S. W., Sekido, Y., Han, J., Park, H. W. & Guan, K. L., 2018 Sep 1, In : Nature Cell Biology. 20, 9, 1 p.

Research output: Contribution to journalComment/debate

p38 Mitogen-Activated Protein Kinases
Cell Biology
Transcription Factors
Research
45 Citations (Scopus)

RAP2 mediates mechanoresponses of the Hippo pathway

Meng, Z., Qiu, Y., Lin, K. C., Kumar, A., Placone, J. K., Fang, C., Wang, K. C., Lu, S., Pan, M., Hong, A. W., Moroishi, T., Luo, M., Plouffe, S. W., Diao, Y., Ye, Z., Park, H. W., Wang, X., Yu, F. X., Chien, S., Wang, C. Y. & 3 others, Ren, B., Engler, A. J. & Guan, K. L., 2018 Aug 30, In : Nature. 560, 7720, p. 655-660 6 p.

Research output: Contribution to journalLetter

Extracellular Matrix
Cues
Biological Phenomena
Phosphatidic Acids
Monomeric GTP-Binding Proteins
31 Citations (Scopus)

The role of hippo pathway in cancer stem cell biology

Park, J. H., Shin, J. E. & Park, H. W., 2018 Jan 1, In : Molecules and cells. 41, 2, p. 83-92 10 p.

Research output: Contribution to journalShort survey

Neoplastic Stem Cells
Cell Biology
Organ Size
Drug Resistance
Neoplasms
2017
25 Citations (Scopus)

EIF5A-PEAK1 signaling regulates YAP1/TAZ protein expression and pancreatic cancer cell growth

Strnadel, J., Choi, S., Fujimura, K., Wang, H., Zhang, W., Wyse, M., Wright, T., Gross, E., Peinado, C., Park, H. W., Bui, J., Kelber, J., Bouvet, M., Guan, K. L. & Klemke, R. L., 2017 Apr 15, In : Cancer Research. 77, 8, p. 1997-2007 11 p.

Research output: Contribution to journalArticle

Pancreatic Neoplasms
Adenocarcinoma
Growth
Informatics
Proteins
37 Citations (Scopus)

Regulation of Hippo pathway transcription factor TEAD by p38 MAPK-induced cytoplasmic translocation

Lin, K. C., Moroishi, T., Meng, Z., Jeong, H. S., Plouffe, S. W., Sekido, Y., Han, J., Park, H. W. & Guan, K. L., 2017 Aug 1, In : Nature Cell Biology. 19, 8, p. 996-1002 7 p.

Research output: Contribution to journalArticle

p38 Mitogen-Activated Protein Kinases
Transcription Factors
Organ Size
Protein-Serine-Threonine Kinases
Transducers
35 Citations (Scopus)

Regulation of the Hippo Pathway Transcription Factor TEAD

Lin, K. C., Park, H. W. & Guan, K. L., 2017 Nov 1, In : Trends in Biochemical Sciences. 42, 11, p. 862-872 11 p.

Research output: Contribution to journalReview article

Tissue homeostasis
Transcription Factors
Cell proliferation
Cell growth
Transcription
2015
212 Citations (Scopus)

Alternative Wnt Signaling Activates YAP/TAZ

Park, H. W., Kim, Y. C., Yu, B., Moroishi, T., Mo, J. S., Plouffe, S. W., Meng, Z., Lin, K. C., Yu, F. X., Alexander, C. M., Wang, C. Y. & Guan, K. L., 2015 Aug 17, In : Cell. 162, 4, p. 780-794 15 p., 8328.

Research output: Contribution to journalArticle

Catenins
rho GTP-Binding Proteins
Wnt Signaling Pathway
Organ Size
Cell Movement
126 Citations (Scopus)

A YAP/TAZ-induced feedback mechanism regulates Hippo pathway homeostasis

Moroishi, T., Park, H. W., Qin, B., Chen, Q., Meng, Z., Plouffe, S. W., Taniguchi, K., Yu, F. X., Karin, M., Pan, D. & Guan, K. L., 2015 Jun 15, In : Genes and Development. 29, 12, p. 1271-1284 14 p.

Research output: Contribution to journalArticle

Homeostasis
Proteins
Phosphotransferases
Long-Acting Thyroid Stimulator
Neurofibromin 2
178 Citations (Scopus)

Cellular energy stress induces AMPK-mediated regulation of YAP and the Hippo pathway

Mo, J. S., Meng, Z., Kim, Y. C., Park, H. W., Hansen, C. G., Kim, S., Lim, D. S. & Guan, K. L., 2015 Apr 30, In : Nature Cell Biology. 17, 4, p. 500-510 11 p.

Research output: Contribution to journalArticle

AMP-Activated Protein Kinases
Proteins
Null Lymphocytes
Organ Size
Neoplasms
258 Citations (Scopus)

Differential regulation of mTORC1 by leucine and glutamine

Jewell, J. L., Kim, Y. C., Russell, R. C., Yu, F. X., Park, H. W., Plouffe, S. W., Tagliabracci, V. S. & Guan, K. L., 2015 Jan 9, In : Science. 347, 6218, p. 194-198 5 p.

Research output: Contribution to journalArticle

Glutamine
Leucine
GTP Phosphohydrolases
Adenosine Triphosphatases
Amino Acids
143 Citations (Scopus)

MAP4K family kinases act in parallel to MST1/2 to activate LATS1/2 in the Hippo pathway

Meng, Z., Moroishi, T., Mottier-Pavie, V., Plouffe, S. W., Hansen, C. G., Hong, A. W., Park, H. W., Mo, J. S., Lu, W., Lu, S., Flores, F., Yu, F. X., Halder, G. & Guan, K. L., 2015 Oct 5, In : Nature communications. 6, 8357.

Research output: Contribution to journalArticle

deletion
phosphorylation
Phosphorylation
Tissue homeostasis
Phosphotransferases
2014
73 Citations (Scopus)

Mechanisms of CFTR Functional Variants That Impair Regulated Bicarbonate Permeation and Increase Risk for Pancreatitis but Not for Cystic Fibrosis

LaRusch, J., Jung, J., General, I. J., Lewis, M. D., Park, H. W., Brand, R. E., Gelrud, A., Anderson, M. A., Banks, P. A., Conwell, D., Lawrence, C., Romagnuolo, J., Baillie, J., Alkaade, S., Cote, G., Gardner, T. B., Amann, S. T., Slivka, A., Sandhu, B., Aloe, A. & 6 others, Kienholz, M. L., Yadav, D., Barmada, M. M., Bahar, I., Lee, M. G. & Whitcomb, D. C., 2014 Jul, In : PLoS Genetics. 10, 7, e1004376.

Research output: Contribution to journalArticle

pancreatitis
cystic fibrosis
Bicarbonates
bicarbonates
bicarbonate
43 Citations (Scopus)

Rag GTPases are cardioprotective by regulating lysosomal function

Kim, Y. C., Park, H. W., Sciarretta, S., Mo, J. S., Jewell, J. L., Russell, R. C., Wu, X., Sadoshima, J. & Guan, K. L., 2014 Jul 1, In : Nature communications. 5, 4241.

Research output: Contribution to journalArticle

GTP Phosphohydrolases
lysosomes
activation
Chemical activation
knockout mice
244 Citations (Scopus)

The Hippo signaling pathway in stem cell biology and cancer

Mo, J. S., Park, H. W. & Guan, K. L., 2014 Jun, In : EMBO Reports. 15, 6, p. 642-656 15 p.

Research output: Contribution to journalReview article

Tissue homeostasis
Cytology
Stem cells
Cell Biology
Stem Cells
2013
88 Citations (Scopus)

Dynamic modulation of ANO1/TMEM16A HCO3- permeability by Ca2+/calmodulin

Jung, J., Nam, J. H., Park, H. W., Oh, U., Yoon, J. H. & Lee, M. G., 2013 Jan 2, In : Proceedings of the National Academy of Sciences of the United States of America. 110, 1, p. 360-365 6 p.

Research output: Contribution to journalArticle

Calmodulin
Permeability
Anions
Proteins
Fluids and Secretions
144 Citations (Scopus)

Protein kinase A activates the Hippo pathway to modulate cell proliferation and differentiation

Yu, F. X., Zhang, Y., Park, H. W., Jewell, J. L., Chen, Q., Deng, Y., Pan, D., Taylor, S. S., Lai, Z. C. & Guan, K. L., 2013 Feb 1, In : Genes and Development. 27, 11, p. 1223-1232 10 p.

Research output: Contribution to journalArticle

Cyclic AMP-Dependent Protein Kinases
Cell Differentiation
Cell Proliferation
Phosphotransferases
Adenosine Kinase
65 Citations (Scopus)

Regulation of the Hippo pathway and implications for anticancer drug development

Park, H. W. & Guan, K. L., 2013 Oct 1, In : Trends in Pharmacological Sciences. 34, 10, p. 581-589 9 p.

Research output: Contribution to journalReview article

Carcinogenesis
Critical Pathways
Organ Size
Cell proliferation
Research
665 Citations (Scopus)

ULK1 induces autophagy by phosphorylating Beclin-1 and activating VPS34 lipid kinase

Russell, R. C., Tian, Y., Yuan, H., Park, H. W., Chang, Y. Y., Kim, J., Kim, H., Neufeld, T. P., Dillin, A. & Guan, K. L., 2013 Jul 1, In : Nature Cell Biology. 15, 7, p. 741-750 10 p.

Research output: Contribution to journalArticle

Autophagy
Phosphotransferases
Lipids
Starvation
Amino Acids
6 Citations (Scopus)

WNK4 inhibits plasma membrane targeting of NCC through regulation of syntaxin13 SNARE formation

Chung, W. Y., Park, H. W., Han, J. W., Lee, M. G. & Kim, J. Y., 2013 Jan 1, In : Cellular Signalling. 25, 12, p. 2469-2477 9 p.

Research output: Contribution to journalArticle

Symporters
SNARE Proteins
Vesicle-Associated Membrane Protein 2
Cell Membrane
Endosomes
2012
7 Citations (Scopus)

Expression of anion exchangers in cultured human endolymphatic sac epithelia

Lee, H. J., Yang, W. S., Park, H. W., Choi, H. S., Kim, S. H., Kim, J. Y. & Choi, J. Y., 2012 Dec 1, In : Otology and Neurotology. 33, 9, p. 1664-1671 8 p.

Research output: Contribution to journalArticle

Endolymphatic Sac
Anions
Epithelium
Epithelial Cells
Chloride-Bicarbonate Antiporters
184 Citations (Scopus)

Molecular mechanism of pancreatic and salivary gland fluid and HCO 3 - secretion

Lee, M. G., Ohana, E., Park, H. W., Yang, D. & Muallem, S., 2012 Jan 1, In : Physiological Reviews. 92, 1, p. 39-74 36 p.

Research output: Contribution to journalReview article

Acinar Cells
Salivary Glands
Electrolytes
Pancreas
Salivary Ducts
28 Citations (Scopus)

Opposite regulatory effects of TRPC1 and TRPC5 on neurite outgrowth in PC12 cells

Heo, D. K., Chung, W. Y., Park, H. W., Yuan, J. P., Lee, M. G. & Kim, J. Y., 2012 Apr 1, In : Cellular Signalling. 24, 4, p. 899-906 8 p.

Research output: Contribution to journalArticle

PC12 Cells
Neuronal Outgrowth
Transfection
Cations
Cell Differentiation
18 Citations (Scopus)

Rescue of epithelial HCO 3 - secretion in murine intestine by apical membrane expression of the cystic fibrosis transmembrane conductance regulator mutant F508del

Xiao, F., Li, J., Singh, A. K., Riederer, B., Wang, J., Sultan, A., Park, H. W., Lee, M. G., Lamprecht, G., Scholte, B. J., De Jonge, H. R. & Seidler, U., 2012 Nov 1, In : Journal of Physiology. 590, 21, p. 5317-5334 18 p.

Research output: Contribution to journalArticle

Cystic Fibrosis Transmembrane Conductance Regulator
Intestines
Colforsin
Membranes
Microvilli
20 Citations (Scopus)

Transepithelial bicarbonate secretion: Lessons from the pancreas

Park, H. W. & Lee, M. G., 2012 Oct, In : Cold Spring Harbor Perspectives in Medicine. 2, 10, a009571.

Research output: Contribution to journalArticle

Bicarbonates
Pancreas
Cystic Fibrosis Transmembrane Conductance Regulator
Fluids
Epithelium
2011
33 Citations (Scopus)

Serine-threonine kinase with-no-lysine 4 (WNK4) controls blood pressure via transient receptor potential canonical 3 (TRPC3) in the vasculature

Park, H. W., Kim, J. Y., Choi, S. K., Lee, Y. H., Zeng, W., Kim, K. H., Muallem, S. & Lee, M. G., 2011 Jun 28, In : Proceedings of the National Academy of Sciences of the United States of America. 108, 26, p. 10750-10755 6 p.

Research output: Contribution to journalArticle

Protein-Serine-Threonine Kinases
Lysine
Blood Pressure
Hypertension
Vasoconstriction
1 Citation (Scopus)

WNK4 kinase negatively regulates the surface expression of Muscarinic M3 receptor

Chung, W. Y., Park, H. W., Heo, D. K., Kim, K. H., Lee, M. G. & Kim, J. Y., 2011 Mar 1, In : Cellular Signalling. 23, 3, p. 566-571 6 p.

Research output: Contribution to journalArticle

Muscarinic M3 Receptors
Lysine
Phosphotransferases
Half-Life
Ions
2010
118 Citations (Scopus)

Dynamic regulation of CFTR bicarbonate permeability by [Cl -]i and its role in pancreatic bicarbonate secretion

Park, H. W., Nam, J. H., Kim, J. Y., Namkung, W., Yoon, J. S., Lee, J. S., Kim, K. S., Venglovecz, V., Gray, M. A., Kim, K. H. & Lee, M. G., 2010 Jan 1, In : Gastroenterology. 139, 2, p. 620-631 12 p.

Research output: Contribution to journalArticle

Cystic Fibrosis Transmembrane Conductance Regulator
Bicarbonates
Permeability
Phosphotransferases
Pancreatic Ducts
14 Citations (Scopus)

βpix up-regulates Na+/H+ exchanger 3 through a Shank2-mediated protein-protein interaction

Lee, J. S., Lee, Y. M., Kim, J. Y., Park, H. W., Grinstein, S., Orlowski, J., Kim, E., Kim, K. H. & Lee, M. G., 2010 Mar 12, In : Journal of Biological Chemistry. 285, 11, p. 8104-8113 10 p.

Research output: Contribution to journalArticle

Sodium-Hydrogen Antiporter
Up-Regulation
rho GTP-Binding Proteins
Proteins
Membranes
2009
3 Citations (Scopus)

PDZ-based adaptor proteins in epithelial anion transport and VIP receptor regulation

Gee, H. Y., Park, H. W., Kim, K. H. & Lee, M. G., 2009 Dec 1, In : Journal of Medical Investigation. 56, SUPPL. 1, p. 302-305 4 p.

Research output: Contribution to journalShort survey

Vasoactive Intestinal Peptide Receptors
Anions
Epithelial Cells
Proteins
Ion Transport
24 Citations (Scopus)

Synaptic Scaffolding Molecule Binds to and Regulates Vasoactive Intestinal Polypeptide Type-1 Receptor in Epithelial Cells

Gee, H. Y., Kim, Y. W., Jo, M. J., Namkung, W., Kim, J. Y., Park, H. W., Kim, K. S., Kim, H., Baba, A., Yang, J., Kim, E., Kim, K. H. & Lee, M. G., 2009 Jan 1, In : Gastroenterology. 137, 2

Research output: Contribution to journalArticle

Receptors, Vasoactive Intestinal Polypeptide, Type I
Vasoactive Intestinal Peptide
Guanylate Kinases
HEK293 Cells
Epithelial Cells