• 3318 Citations
  • 22 h-Index
20092019

Research output per year

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Research Output

  • 3318 Citations
  • 22 h-Index
  • 24 Article
  • 4 Review article
  • 2 Short survey
  • 1 Comment/debate
2019

MST1 Negatively Regulates TNFα-Induced NF-κB Signaling through Modulating LUBAC Activity

Lee, I. Y., Lim, J. M., Cho, H., Kim, E., Kim, Y., Oh, H. K., Yang, W. S., Roh, K. H., Park, H. W., Mo, J. S., Yoon, J. H., Song, H. K. & Choi, E. J., 2019 Mar 21, In : Molecular Cell. 73, 6, p. 1138-1149.e6

Research output: Contribution to journalArticle

6 Citations (Scopus)
2018

Erratum to: Regulation of Hippo pathway transcription factor TEAD by p38 MAPK-induced cytoplasmic translocation (Nature Cell Biology, (2017), 19, 8, (996-1002), 10.1038/ncb3581)

Lin, K. C., Moroishi, T., Meng, Z., Jeong, H. S., Plouffe, S. W., Sekido, Y., Han, J., Park, H. W. & Guan, K. L., 2018 Sep 1, In : Nature Cell Biology. 20, 9, p. 1098 1 p.

Research output: Contribution to journalComment/debate

RAP2 mediates mechanoresponses of the Hippo pathway

Meng, Z., Qiu, Y., Lin, K. C., Kumar, A., Placone, J. K., Fang, C., Wang, K. C., Lu, S., Pan, M., Hong, A. W., Moroishi, T., Luo, M., Plouffe, S. W., Diao, Y., Ye, Z., Park, H. W., Wang, X., Yu, F. X., Chien, S., Wang, C. Y. & 3 others, Ren, B., Engler, A. J. & Guan, K. L., 2018 Aug 30, In : Nature. 560, 7720, p. 655-660 6 p.

Research output: Contribution to journalArticle

68 Citations (Scopus)

The role of hippo pathway in cancer stem cell biology

Park, J. H., Shin, J. E. & Park, H. W., 2018, In : Molecules and cells. 41, 2, p. 83-92 10 p.

Research output: Contribution to journalShort survey

46 Citations (Scopus)
2017

EIF5A-PEAK1 signaling regulates YAP1/TAZ protein expression and pancreatic cancer cell growth

Strnadel, J., Choi, S., Fujimura, K., Wang, H., Zhang, W., Wyse, M., Wright, T., Gross, E., Peinado, C., Park, H. W., Bui, J., Kelber, J., Bouvet, M., Guan, K. L. & Klemke, R. L., 2017 Apr 15, In : Cancer Research. 77, 8, p. 1997-2007 11 p.

Research output: Contribution to journalArticle

30 Citations (Scopus)

Regulation of Hippo pathway transcription factor TEAD by p38 MAPK-induced cytoplasmic translocation

Lin, K. C., Moroishi, T., Meng, Z., Jeong, H. S., Plouffe, S. W., Sekido, Y., Han, J., Park, H. W. & Guan, K. L., 2017 Aug 1, In : Nature Cell Biology. 19, 8, p. 996-1002 7 p.

Research output: Contribution to journalArticle

57 Citations (Scopus)

Regulation of the Hippo Pathway Transcription Factor TEAD

Lin, K. C., Park, H. W. & Guan, K. L., 2017 Nov, In : Trends in Biochemical Sciences. 42, 11, p. 862-872 11 p.

Research output: Contribution to journalReview article

54 Citations (Scopus)
2015

Alternative Wnt Signaling Activates YAP/TAZ

Park, H. W., Kim, Y. C., Yu, B., Moroishi, T., Mo, J. S., Plouffe, S. W., Meng, Z., Lin, K. C., Yu, F. X., Alexander, C. M., Wang, C. Y. & Guan, K. L., 2015 Aug 17, In : Cell. 162, 4, p. 780-794 15 p., 8328.

Research output: Contribution to journalArticle

250 Citations (Scopus)

A YAP/TAZ-induced feedback mechanism regulates Hippo pathway homeostasis

Moroishi, T., Park, H. W., Qin, B., Chen, Q., Meng, Z., Plouffe, S. W., Taniguchi, K., Yu, F. X., Karin, M., Pan, D. & Guan, K. L., 2015 Jun 15, In : Genes and Development. 29, 12, p. 1271-1284 14 p.

Research output: Contribution to journalArticle

140 Citations (Scopus)

Cellular energy stress induces AMPK-mediated regulation of YAP and the Hippo pathway

Mo, J. S., Meng, Z., Kim, Y. C., Park, H. W., Hansen, C. G., Kim, S., Lim, D. S. & Guan, K. L., 2015 Apr 30, In : Nature Cell Biology. 17, 4, p. 500-510 11 p.

Research output: Contribution to journalArticle

207 Citations (Scopus)

Differential regulation of mTORC1 by leucine and glutamine

Jewell, J. L., Kim, Y. C., Russell, R. C., Yu, F. X., Park, H. W., Plouffe, S. W., Tagliabracci, V. S. & Guan, K. L., 2015 Jan 9, In : Science. 347, 6218, p. 194-198 5 p.

Research output: Contribution to journalArticle

304 Citations (Scopus)

MAP4K family kinases act in parallel to MST1/2 to activate LATS1/2 in the Hippo pathway

Meng, Z., Moroishi, T., Mottier-Pavie, V., Plouffe, S. W., Hansen, C. G., Hong, A. W., Park, H. W., Mo, J. S., Lu, W., Lu, S., Flores, F., Yu, F. X., Halder, G. & Guan, K. L., 2015 Oct 5, In : Nature communications. 6, 8357.

Research output: Contribution to journalArticle

171 Citations (Scopus)
2014

Mechanisms of CFTR Functional Variants That Impair Regulated Bicarbonate Permeation and Increase Risk for Pancreatitis but Not for Cystic Fibrosis

LaRusch, J., Jung, J., General, I. J., Lewis, M. D., Park, H. W., Brand, R. E., Gelrud, A., Anderson, M. A., Banks, P. A., Conwell, D., Lawrence, C., Romagnuolo, J., Baillie, J., Alkaade, S., Cote, G., Gardner, T. B., Amann, S. T., Slivka, A., Sandhu, B., Aloe, A. & 6 others, Kienholz, M. L., Yadav, D., Barmada, M. M., Bahar, I., Lee, M. G. & Whitcomb, D. C., 2014 Jul, In : PLoS Genetics. 10, 7, e1004376.

Research output: Contribution to journalArticle

81 Citations (Scopus)

Rag GTPases are cardioprotective by regulating lysosomal function

Kim, Y. C., Park, H. W., Sciarretta, S., Mo, J. S., Jewell, J. L., Russell, R. C., Wu, X., Sadoshima, J. & Guan, K. L., 2014 Jul 1, In : Nature communications. 5, 4241.

Research output: Contribution to journalArticle

46 Citations (Scopus)

The Hippo signaling pathway in stem cell biology and cancer

Mo, J. S., Park, H. W. & Guan, K. L., 2014 Jun, In : EMBO Reports. 15, 6, p. 642-656 15 p.

Research output: Contribution to journalReview article

284 Citations (Scopus)
2013

Dynamic modulation of ANO1/TMEM16A HCO3- permeability by Ca2+/calmodulin

Jung, J., Nam, J. H., Park, H. W., Oh, U., Yoon, J. H. & Lee, M. G., 2013 Jan 2, In : Proceedings of the National Academy of Sciences of the United States of America. 110, 1, p. 360-365 6 p.

Research output: Contribution to journalArticle

97 Citations (Scopus)

Protein kinase A activates the Hippo pathway to modulate cell proliferation and differentiation

Yu, F. X., Zhang, Y., Park, H. W., Jewell, J. L., Chen, Q., Deng, Y., Pan, D., Taylor, S. S., Lai, Z. C. & Guan, K. L., 2013 Feb 1, In : Genes and Development. 27, 11, p. 1223-1232 10 p.

Research output: Contribution to journalArticle

170 Citations (Scopus)

Regulation of the Hippo pathway and implications for anticancer drug development

Park, H. W. & Guan, K. L., 2013 Oct, In : Trends in Pharmacological Sciences. 34, 10, p. 581-589 9 p.

Research output: Contribution to journalReview article

74 Citations (Scopus)

ULK1 induces autophagy by phosphorylating Beclin-1 and activating VPS34 lipid kinase

Russell, R. C., Tian, Y., Yuan, H., Park, H. W., Chang, Y. Y., Kim, J., Kim, H., Neufeld, T. P., Dillin, A. & Guan, K. L., 2013 Jul, In : Nature Cell Biology. 15, 7, p. 741-750 10 p.

Research output: Contribution to journalArticle

748 Citations (Scopus)

WNK4 inhibits plasma membrane targeting of NCC through regulation of syntaxin13 SNARE formation

Chung, W. Y., Park, H. W., Han, J. W., Lee, M. G. & Kim, J. Y., 2013 Dec, In : Cellular Signalling. 25, 12, p. 2469-2477 9 p.

Research output: Contribution to journalArticle

6 Citations (Scopus)
2012

Expression of anion exchangers in cultured human endolymphatic sac epithelia

Lee, H. J., Yang, W. S., Park, H. W., Choi, H. S., Kim, S. H., Kim, J. Y. & Choi, J. Y., 2012 Dec, In : Otology and Neurotology. 33, 9, p. 1664-1671 8 p.

Research output: Contribution to journalArticle

7 Citations (Scopus)

Molecular mechanism of pancreatic and salivary gland fluid and HCO 3 - secretion

Lee, M. G., Ohana, E., Park, H. W., Yang, D. & Muallem, S., 2012 Jan, In : Physiological Reviews. 92, 1, p. 39-74 36 p.

Research output: Contribution to journalReview article

202 Citations (Scopus)

Opposite regulatory effects of TRPC1 and TRPC5 on neurite outgrowth in PC12 cells

Heo, D. K., Chung, W. Y., Park, H. W., Yuan, J. P., Lee, M. G. & Kim, J. Y., 2012 Apr, In : Cellular Signalling. 24, 4, p. 899-906 8 p.

Research output: Contribution to journalArticle

29 Citations (Scopus)

Rescue of epithelial HCO 3 - secretion in murine intestine by apical membrane expression of the cystic fibrosis transmembrane conductance regulator mutant F508del

Xiao, F., Li, J., Singh, A. K., Riederer, B., Wang, J., Sultan, A., Park, H., Lee, M. G., Lamprecht, G., Scholte, B. J., De Jonge, H. R. & Seidler, U., 2012 Nov, In : Journal of Physiology. 590, 21, p. 5317-5334 18 p.

Research output: Contribution to journalArticle

20 Citations (Scopus)

Transepithelial bicarbonate secretion: Lessons from the pancreas

Park, H. W. & Lee, M. G., 2012 Oct, In : Cold Spring Harbor Perspectives in Medicine. 2, 10, a009571.

Research output: Contribution to journalArticle

21 Citations (Scopus)
2011

Serine-threonine kinase with-no-lysine 4 (WNK4) controls blood pressure via transient receptor potential canonical 3 (TRPC3) in the vasculature

Park, H. W., Kim, J. Y., Choi, S. K., Lee, Y. H., Zeng, W., Kim, K. H., Muallem, S. & Lee, M. G., 2011 Jun 28, In : Proceedings of the National Academy of Sciences of the United States of America. 108, 26, p. 10750-10755 6 p.

Research output: Contribution to journalArticle

33 Citations (Scopus)

WNK4 kinase negatively regulates the surface expression of Muscarinic M3 receptor

Chung, W. Y., Park, H. W., Heo, D. K., Kim, K. H., Lee, M. G. & Kim, J. Y., 2011 Mar, In : Cellular Signalling. 23, 3, p. 566-571 6 p.

Research output: Contribution to journalArticle

1 Citation (Scopus)
2010

Dynamic regulation of CFTR bicarbonate permeability by [Cl -]i and its role in pancreatic bicarbonate secretion

Park, H. W., Nam, J. H., Kim, J. Y., Namkung, W., Yoon, J. S., Lee, J. S., Kim, K. S., Venglovecz, V., Gray, M. A., Kim, K. H. & Lee, M. G., 2010, In : Gastroenterology. 139, 2, p. 620-631 12 p.

Research output: Contribution to journalArticle

123 Citations (Scopus)

βpix up-regulates Na+/H+ exchanger 3 through a Shank2-mediated protein-protein interaction

Lee, J. S., Lee, Y. M., Kim, J. Y., Park, H. W., Grinstein, S., Orlowski, J., Kim, E., Kim, K. H. & Lee, M. G., 2010 Mar 12, In : Journal of Biological Chemistry. 285, 11, p. 8104-8113 10 p.

Research output: Contribution to journalArticle

16 Citations (Scopus)
2009

PDZ-based adaptor proteins in epithelial anion transport and VIP receptor regulation

Gee, H. Y., Park, H. W., Kim, K. H. & Lee, M. G., 2009, In : Journal of Medical Investigation. 56, SUPPL. 1, p. 302-305 4 p.

Research output: Contribution to journalShort survey

3 Citations (Scopus)

Synaptic Scaffolding Molecule Binds to and Regulates Vasoactive Intestinal Polypeptide Type-1 Receptor in Epithelial Cells

Gee, H. Y., Kim, Y. W., Jo, M. J., Namkung, W., Kim, J. Y., Park, H. W., Kim, K. S., Kim, H., Baba, A., Yang, J., Kim, E., Kim, K. H. & Lee, M. G., 2009 Aug, In : Gastroenterology. 137, 2, p. 607-617.e4

Research output: Contribution to journalArticle

24 Citations (Scopus)