• 9316 Citations
  • 45 h-Index
1990 …2020

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2020

Evaluation of the Interaction between Bax and Hsp70 in Cells by Using a FRET System Consisting of a Fluorescent Amino Acid and YFP as a FRET Pair

Park, S. H., Ko, W., Park, S. H., Lee, H. S. & Shin, I., 2020 Jan 15, In : ChemBioChem. 21, 1-2, p. 59-63 5 p.

Research output: Contribution to journalArticle

2019

A lysosomal chloride ion-selective fluorescent probe for biological applications

Park, S. H., Hyun, J. Y. & Shin, I., 2019, In : Chemical Science. 10, 1, p. 56-66 11 p.

Research output: Contribution to journalArticle

10 Citations (Scopus)

Analysis of Protein-Protein Interaction in a Single Live Cell by Using a FRET System Based on Genetic Code Expansion Technology

Park, S. H., Ko, W., Lee, H. S. & Shin, I., 2019 Mar 13, In : Journal of the American Chemical Society. 141, 10, p. 4273-4281 9 p.

Research output: Contribution to journalArticle

4 Citations (Scopus)

An Inhibitor of the Interaction of Survivin with Smac in Mitochondria Promotes Apoptosis

Park, S. H., Shin, I., Park, S. H., Kim, N. D. & Shin, I., 2019 Nov 18, In : Chemistry - An Asian Journal. 14, 22, p. 4035-4041 7 p.

Research output: Contribution to journalArticle

1 Citation (Scopus)

A pH-sensitive excited state intramolecular proton transfer fluorescent probe for imaging mitochondria and Helicobacter pylori

Hong, K. I., Park, S. H., Lee, S. M., Shin, I. & Jang, W. D., 2019 May 1, In : Sensors and Actuators, B: Chemical. 286, p. 148-153 6 p.

Research output: Contribution to journalArticle

7 Citations (Scopus)

Identification of Novel Resorcinol Amide Derivatives as Potent and Specific Pyruvate Dehydrogenase Kinase (PDHK) Inhibitors

Cho, H., Shin, I., Cho, K., Yoon, H., Yoo, E. K., Kim, M. J., Park, S., Lee, I. K., Kim, N. D. & Sim, T., 2019 Sep 26, In : Journal of Medicinal Chemistry. 62, 18, p. 8461-8479 19 p.

Research output: Contribution to journalArticle

1 Citation (Scopus)

Preparation of a Multiple-Targeting NIR-Based Fluorogenic Probe and Its Application for Selective Cancer Cell Imaging

Li, H., Lee, C. H. & Shin, I., 2019 Jun 21, In : Organic Letters. 21, 12, p. 4628-4631 4 p.

Research output: Contribution to journalArticle

2 Citations (Scopus)

Raman-Based in Situ Monitoring of Changes in Molecular Signatures during Mitochondrially Mediated Apoptosis

Shin, H. J., Lee, J. H., Kim, Y. D., Shin, I., Sim, T. & Lim, D. K., 2019 May 6, In : ACS Omega. 4, 5, p. 8188-8195 8 p.

Research output: Contribution to journalArticle

Open Access
1 Citation (Scopus)

Trifunctional Fluorogenic Probes for Fluorescence Imaging and Isolation of Glycosidases in Cells

Hyun, J. Y., Park, S. H., Park, C. W., Kim, H. B., Cho, J. W. & Shin, I., 2019 Jun 21, In : Organic Letters. 21, 12, p. 4439-4442 4 p.

Research output: Contribution to journalArticle

2 Citations (Scopus)
2018

A Glycoengineered Enzyme with Multiple Mannose-6-Phosphates Is Internalized into Diseased Cells to Restore Its Activity in Lysosomes

Hyun, J. Y., Kim, S., Lee, H. S. & Shin, I., 2018 Oct 18, In : Cell Chemical Biology. 25, 10, p. 1255-1267.e8

Research output: Contribution to journalArticle

8 Citations (Scopus)

Analysis of binding properties of pathogens and toxins using multivalent glycan microarrays

Kim, H. S., Hyun, J. Y., Park, S. H. & Shin, I., 2018, In : RSC Advances. 8, 27, p. 14898-14905 8 p.

Research output: Contribution to journalArticle

3 Citations (Scopus)

Carbohydrate microarrays containing glycosylated fluorescent probes for assessment of glycosidase activities

Hyun, J. Y., Kang, N. R. & Shin, I., 2018 Feb 16, In : Organic Letters. 20, 4, p. 1240-1243 4 p.

Research output: Contribution to journalArticle

7 Citations (Scopus)

First SAR Study for Overriding NRAS Mutant Driven Acute Myeloid Leukemia

Cho, H., Shin, I., Ju, E., Choi, S., Hur, W., Kim, H., Hong, E., Kim, N. D., Choi, H. G., Gray, N. S. & Sim, T., 2018 Sep 27, In : Journal of Medicinal Chemistry. 61, 18, p. 8353-8383 31 p.

Research output: Contribution to journalArticle

1 Citation (Scopus)

Subcellular Hsp70 Inhibitors Promote Cancer Cell Death via Different Mechanisms

Park, S. H., Baek, K. H., Shin, I. & Shin, I., 2018 Oct 18, In : Cell Chemical Biology. 25, 10, p. 1242-1254.e8

Research output: Contribution to journalArticle

9 Citations (Scopus)
2017

Anti-leukemia activity of a Hsp70 inhibitor and its hybrid molecules

Park, S. H., Kim, W. J., Li, H., Seo, W., Park, S. H., Kim, H., Shin, S. C., Zuiderweg, E. R. P., Kim, E. E. K., Sim, T., Kim, N. K. & Shin, I., 2017 Dec 1, In : Scientific reports. 7, 1, 3537.

Research output: Contribution to journalArticle

5 Citations (Scopus)

A synthetic ion transporter that disrupts autophagy and induces apoptosis by perturbing cellular chloride concentrations

Busschaert, N., Park, S. H., Baek, K. H., Choi, Y. P., Park, J., Howe, E. N. W., Hiscock, J. R., Karagiannidis, L. E., Marques, I., Félix, V., Namkung, W., Sessler, J. L., Gale, P. A. & Shin, I., 2017 Jul 1, In : Nature chemistry. 9, 7, p. 667-675 9 p.

Research output: Contribution to journalArticle

93 Citations (Scopus)

Carbohydrate Analogue Microarrays for Identification of Lectin-Selective Ligands

Hyun, J. Y., Park, C. W., Liu, Y., Kwon, D., Park, S. H., Park, S., Pai, J. & Shin, I., 2017 Jun 19, In : ChemBioChem. 18, 12, p. 1077-1082 6 p.

Research output: Contribution to journalArticle

6 Citations (Scopus)

Identification of a novel 5-amino-3-(5-cyclopropylisoxazol-3-yl)-1-isopropyl-1H-pyrazole-4-carboxamide as a specific RET kinase inhibitor

Yoon, H., Shin, I., Nam, Y., Kim, N. D., Lee, K. B. & Sim, T., 2017, In : European Journal of Medicinal Chemistry. 125, p. 1145-1155 11 p.

Research output: Contribution to journalArticle

8 Citations (Scopus)

Structural Revision of Baulamycin A and Structure-Activity Relationships of Baulamycin A Derivatives

Sengupta, S., Bae, M., Oh, D. C., Dash, U., Kim, H. J., Song, W. Y., Shin, I. & Sim, T., 2017 Dec 15, In : Journal of Organic Chemistry. 82, 24, p. 12947-12966 20 p.

Research output: Contribution to journalArticle

4 Citations (Scopus)

Suppression of Sin3A activity promotes differentiation of pluripotent cells into functional neurons

Halder, D., Lee, C. H., Hyun, J. Y., Chang, G. E., Cheong, E. & Shin, I., 2017 Mar 17, In : Scientific reports. 7, 44818.

Research output: Contribution to journalArticle

6 Citations (Scopus)

The Glycan Microarray Story from Construction to Applications

Hyun, J. Y., Pai, J. & Shin, I., 2017 Apr 18, In : Accounts of Chemical Research. 50, 4, p. 1069-1078 10 p.

Research output: Contribution to journalArticle

23 Citations (Scopus)
2016

A potent and selective small molecule inhibitor of sirtuin 1 promotes differentiation of pluripotent P19 cells into functional neurons

Kim, B. S., Lee, C. H., Chang, G. E., Cheong, E. & Shin, I., 2016 Sep 29, In : Scientific reports. 6, 34324.

Research output: Contribution to journalArticle

16 Citations (Scopus)

Carbohydrate microarrays for screening functional glycans

Pai, J., Hyun, J. Y., Jeong, J., Loh, S., Cho, E. H., Kang, Y. S. & Shin, I., 2016 Mar 1, In : Chemical Science. 7, 3, p. 2084-2093 10 p.

Research output: Contribution to journalArticle

12 Citations (Scopus)

Highly sensitive and selective bioluminescence based ozone probes and their applications to detect ambient ozone

Nam, Y., Kim, B. S. & Shin, I., 2016 Jan 1, In : Chemical Communications. 52, 6, p. 1128-1130 3 p.

Research output: Contribution to journalArticle

8 Citations (Scopus)

Screening of Pre-miRNA-155 Binding Peptides for Apoptosis Inducing Activity Using Peptide Microarrays

Pai, J., Hyun, S., Hyun, J. Y., Park, S. H., Kim, W. J., Bae, S. H., Kim, N. K., Yu, J. & Shin, I., 2016 Jan 27, In : Journal of the American Chemical Society. 138, 3, p. 857-867 11 p.

Research output: Contribution to journalArticle

33 Citations (Scopus)

Small molecules that allosterically inhibit p21-activated kinase activity by binding to the regulatory p21-binding domain

Kim, D. J., Choi, C. K., Lee, C. S., Park, M. H., Tian, X., Kim, N. D., Lee, K. I., Choi, J. K., Ahn, J. H., Shin, E. Y., Shin, I. & Kim, E. G., 2016 Apr 29, In : Experimental & molecular medicine. 48, p. e229

Research output: Contribution to journalArticle

10 Citations (Scopus)
2015

A small molecule inhibitor for ATPase activity of Hsp70 and Hsc70 enhances the immune response to protein antigens

Baek, K. H., Zhang, H., Lee, B. R., Kwon, Y. G., Ha, S. J. & Shin, I., 2015 Dec 3, In : Scientific reports. 5, 17642.

Research output: Contribution to journalArticle

7 Citations (Scopus)

A small molecule inhibitor of ATPase activity of HSP70 induces apoptosis and has antitumor activities

Ko, S. K., Kim, J., Na, D. C., Park, S., Park, S. H., Hyun, J. Y., Baek, K. H., Kim, N. D., Kim, N. K., Park, Y. N., Song, K. & Shin, I., 2015 Mar 19, In : Chemistry and Biology. 22, 3, p. 391-403 13 p., 3008.

Research output: Contribution to journalArticle

42 Citations (Scopus)

Combining Suppression of Stemness with Lineage-Specific Induction Leads to Conversion of Pluripotent Cells into Functional Neurons

Halder, D., Chang, G. E., De, D., Cheong, E., Kim, K. K. & Shin, I., 2015 Nov 19, In : Chemistry and Biology. 22, 11, p. 1512-1520 9 p.

Research output: Contribution to journalArticle

7 Citations (Scopus)
10 Citations (Scopus)

Probing Cell-Surface Carbohydrate Binding Proteins with Dual-Modal Glycan-Conjugated Nanoparticles

Park, S., Kim, G. H., Park, S. H., Pai, J., Rathwell, D., Park, J. Y., Kang, Y. S. & Shin, I., 2015 May 13, In : Journal of the American Chemical Society. 137, 18, p. 5961-5968 8 p.

Research output: Contribution to journalArticle

30 Citations (Scopus)

Probing the effect of an inhibitor of an ATPase domain of Hsc70 on clathrin-mediated endocytosis

Cho, H. J., Kim, G. H., Park, S. H., Hyun, J. Y., Kim, N. K. & Shin, I., 2015 Jan 14, In : Molecular BioSystems. 11, 10, p. 2763-2769 7 p.

Research output: Contribution to journalArticle

8 Citations (Scopus)

Synthetic aminopyrrolic receptors have apoptosis inducing activity

Park, S. H., Choi, Y. P., Park, J., Share, A., Francesconi, O., Nativi, C., Namkung, W., Sessler, J. L., Roelens, S. & Shin, I., 2015 Jan 1, In : Chemical Science. 6, 12, p. 7284-7292 9 p.

Research output: Contribution to journalArticle

14 Citations (Scopus)

Synthetic small molecules that induce neuronal differentiation in neuroblastoma and fibroblast cells

Halder, D., Kim, G. H. & Shin, I., 2015 Apr 2, In : Molecular BioSystems. 11, 10, p. 2727-2737 11 p.

Research output: Contribution to journalArticle

9 Citations (Scopus)
2014

Imidazole-based small molecules that promote neurogenesis in pluripotent cells

Kim, G. H., Halder, D., Park, J., Namkung, W. & Shin, I., 2014 Aug 25, In : Angewandte Chemie - International Edition. 53, 35, p. 9271-9274 4 p.

Research output: Contribution to journalArticle

20 Citations (Scopus)

Selective homocysteine turn-on fluorescent probes and their bioimaging applications

Lee, H. Y., Choi, Y. P., Kim, S., Yoon, T., Guo, Z., Lee, S., Swamy, K. M. K., Kim, G., Lee, J. Y., Shin, I. & Yoon, J., 2014 Jun 3, In : Chemical Communications. 50, 53, p. 6967-6969 3 p.

Research output: Contribution to journalArticle

105 Citations (Scopus)

Synthesis of a highly Zn 2+-selective cyanine-based probe and its use for tracing endogenous zinc ions in cells and organisms

Guo, Z., Kim, G. H., Yoon, J. & Shin, I., 2014 Jun, In : Nature Protocols. 9, 6, p. 1245-1254 10 p.

Research output: Contribution to journalArticle

64 Citations (Scopus)

Synthetic ion transporters can induce apoptosis by facilitating chloride anion transport into cells

Ko, S. K., Kim, S. K., Share, A., Lynch, V. M., Park, J., Namkung, W., Van Rossom, W., Busschaert, N., Gale, P. A., Sessler, J. L. & Shin, I., 2014 Oct 1, In : Nature chemistry. 6, 10, p. 885-892 8 p.

Research output: Contribution to journalArticle

175 Citations (Scopus)
2013

Carbohydrate chemistry

Shin, I. & Soo Kima, K., 2013 Apr 29, In : Chemical Society reviews. 42, 10, p. 4267-4269 3 p.

Research output: Contribution to journalArticle

6 Citations (Scopus)

Carbohydrate microarrays

Park, S., Gildersleeve, J. C., Blixt, O. & Shin, I., 2013 Apr 29, In : Chemical Society reviews. 42, 10, p. 4310-4326 17 p.

Research output: Contribution to journalArticle

171 Citations (Scopus)

Dual-labeled glycoclusters: Synthesis and their application in monitoring lectin-mediated endocytosis

Tian, X., Baek, K. H. & Shin, I., 2013 May 1, In : Molecular BioSystems. 9, 5, p. 978-986 9 p.

Research output: Contribution to journalArticle

3 Citations (Scopus)

Dual-targeting delivery system for selective cancer cell death and imaging

Tian, X., Baek, K. H. & Shin, I., 2013 Mar 1, In : Chemical Science. 4, 3, p. 947-956 10 p.

Research output: Contribution to journalArticle

23 Citations (Scopus)

Highly selective ratiometric fluorescent probe for Au3+ and its application to bioimaging

Young Choi, J., Kim, G. H., Guo, Z., Yeon Lee, H., Swamy, K. M. K., Pai, J., Shin, S., Shin, I. & Yoon, J., 2013 Nov 5, In : Biosensors and Bioelectronics. 49, p. 438-441 4 p.

Research output: Contribution to journalArticle

53 Citations (Scopus)

Rhodamine cyclic hydrazide as a fluorescent probe for the detection of hydroxyl radicals

Kim, M., Ko, S. K., Kim, H., Shin, I. & Tae, J., 2013 Aug 13, In : Chemical Communications. 49, 72, p. 7959-7961 3 p.

Research output: Contribution to journalArticle

40 Citations (Scopus)
2012

A cyanine-based fluorescent sensor for detecting endogenous zinc ions in live cells and organisms

Guo, Z., Kim, G. H., Shin, I. & Yoon, J., 2012 Nov 1, In : Biomaterials. 33, 31, p. 7818-7827 10 p.

Research output: Contribution to journalArticle

133 Citations (Scopus)

Analysis of density-dependent binding of glycans by lectins using carbohydrate microarrays

Tian, X., Pai, J. & Shin, I., 2012 Sep 1, In : Chemistry - An Asian Journal. 7, 9, p. 2052-2060 9 p.

Research output: Contribution to journalArticle

16 Citations (Scopus)

Autophagy-regulating small molecules and their therapeutic applications

Baek, K. H., Park, J. & Shin, I., 2012 Mar 23, In : Chemical Society reviews. 41, 8, p. 3245-3263 19 p.

Research output: Contribution to journalArticle

58 Citations (Scopus)

Cardiosulfa Induces Heart Deformation in Zebrafish through the AhR-Mediated, CYP1A-Independent Pathway

Ko, S. K. & Shin, I., 2012 Jul 9, In : ChemBioChem. 13, 10, p. 1483-1489 7 p.

Research output: Contribution to journalArticle

9 Citations (Scopus)

Cobalt-catalyzed asymmetric addition of silylacetylenes to oxa- and azabenzonorbornadienes

Shin, I., 2012 May 21, In : Chemical Communications. 48, 48, p. 5956-5967 2 p.

Research output: Contribution to journalArticle

Cobalt-catalyzed asymmetric addition of silylacetylenes to oxa- and azabenzonorbornadienes

Guo, Z., Shin, I. & Yoon, J., 2012 May 21, In : Chemical Communications. 48, 48, p. 5956-5967 12 p.

Research output: Contribution to journalArticle

1 Citation (Scopus)