• 1256 Citations
  • 17 h-Index
20062018
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Research Output 2006 2018

  • 1256 Citations
  • 17 h-Index
  • 22 Article
  • 2 Short survey
  • 1 Comment/debate
  • 1 Editorial
2018
5 Citations (Scopus)

Erratum: The SS18-SSX Oncoprotein Hijacks KDM2B-PRC1.1 to Drive Synovial Sarcoma (Cancer Cell (2018) 33(3) (527–541.e8) (S1535610818300187) (10.1016/j.ccell.2018.01.018))

Banito, A., Li, X., Laporte, A. N., Roe, J-S., Sanchez-Vega, F., Huang, C. H., Dancsok, A. R., Hatzi, K., Chen, C. C., Tschaharganeh, D. F., Chandwani, R., Tasdemir, N., Jones, K. B., Capecchi, M. R., Vakoc, C. R., Schultz, N., Ladanyi, M., Nielsen, T. O. & Lowe, S. W., 2018 Aug 13, In : Cancer Cell. 34, 2, p. 346-348 3 p.

Research output: Contribution to journalComment/debate

Synovial Sarcoma
Oncogene Proteins
Western Blotting
Neoplasms
Immunoprecipitation
21 Citations (Scopus)

The SS18-SSX Oncoprotein Hijacks KDM2B-PRC1.1 to Drive Synovial Sarcoma

Banito, A., Li, X., Laporte, A. N., Roe, J-S., Sanchez-Vega, F., Huang, C. H., Dancsok, A. R., Hatzi, K., Chen, C. C., Tschaharganeh, D. F., Chandwani, R., Tasdemir, N., Jones, K. B., Capecchi, M. R., Vakoc, C. R., Schultz, N., Ladanyi, M., Nielsen, T. O. & Lowe, S. W., 2018 Mar 12, In : Cancer Cell. 33, 3, p. 527-541.e8

Research output: Contribution to journalArticle

Synovial Sarcoma
Polycomb Repressive Complex 1
Oncogene Proteins
Histone Demethylases
Genes
2017
67 Citations (Scopus)

Enhancer Reprogramming Promotes Pancreatic Cancer Metastasis

Roe, J-S., Hwang, C. I., Somerville, T. D. D., Milazzo, J. P., Lee, E. J., Da Silva, B., Maiorino, L., Tiriac, H., Young, C. M., Miyabayashi, K., Filippini, D., Creighton, B., Burkhart, R. A., Buscaglia, J. M., Kim, E. J., Grem, J. L., Lazenby, A. J., Grunkemeyer, J. A., Hollingsworth, M. A., Grandgenett, P. M. & 4 others, Egeblad, M., Park, Y., Tuveson, D. A. & Vakoc, C. R., 2017 Aug 24, In : Cell. 170, 5, p. 875-888.e20

Research output: Contribution to journalArticle

Transcription
Pancreatic Neoplasms
Adenocarcinoma
Chemical activation
Neoplasm Metastasis
15 Citations (Scopus)

Harnessing BET Inhibitor Sensitivity Reveals AMIGO2 as a Melanoma Survival Gene

Fontanals-Cirera, B., Hasson, D., Vardabasso, C., Di Micco, R., Agrawal, P., Chowdhury, A., Gantz, M., de Pablos-Aragoneses, A., Morgenstern, A., Wu, P., Filipescu, D., Valle-Garcia, D., Darvishian, F., Roe, J-S., Davies, M. A., Vakoc, C. R., Hernando, E. & Bernstein, E., 2017 Nov 16, In : Molecular Cell. 68, 4, p. 731-744.e9

Research output: Contribution to journalArticle

Melanoma
Survival
Genes
Transcriptional Regulatory Elements
Nevus
2016
52 Citations (Scopus)

BET Bromodomain Inhibition Releases the Mediator Complex from Select cis-Regulatory Elements

Bhagwat, A. S., Roe, J. S., Mok, B. Y. L., Hohmann, A. F., Shi, J. & Vakoc, C. R., 2016 Apr 19, In : Cell Reports. 15, 3, p. 519-530 12 p.

Research output: Contribution to journalArticle

Mediator Complex
Acute Myeloid Leukemia
Genes
Myeloid Cells
Therapeutic Uses
76 Citations (Scopus)

BRD4 connects enhancer remodeling to senescence immune surveillance

Tasdemir, N., Banito, A., Roe, J-S., Alonso-Curbelo, D., Camiolo, M., Tschaharganeh, D. F., Huang, C. H., Aksoy, O., Bolden, J. E., Chen, C. C., Fennell, M., Thapar, V., Chicas, A., Vakoc, C. R. & Lowe, S. W., 2016 Jun 1, In : Cancer Discovery. 6, 6, p. 613-629 17 p.

Research output: Contribution to journalArticle

Phenotype
Oncogenes
Chromatin
Paracrine Communication
Genes
51 Citations (Scopus)

Sensitivity and engineered resistance of myeloid leukemia cells to BRD9 inhibition

Hohmann, A. F., Martin, L. J., Minder, J. L., Roe, J-S., Shi, J., Steurer, S., Bader, G., McConnell, D., Pearson, M., Gerstberger, T., Gottschamel, T., Thompson, D., Suzuki, Y., Koegl, M. & Vakoc, C. R., 2016 Sep 1, In : Nature Chemical Biology. 12, 9, p. 672-679 8 p.

Research output: Contribution to journalArticle

Myeloid Leukemia
Myeloid Cells
Alleles
Acute Myeloid Leukemia
Chromatin Assembly and Disassembly
5 Citations (Scopus)

The essential transcriptional function of BRD4 in acute myeloid leukemia

Roe, J-S. & Vakoc, C. R., 2016 Jan 1, In : Cold Spring Harbor Symposia on Quantitative Biology. 81, 1, p. 61-66 6 p.

Research output: Contribution to journalArticle

Acute Myeloid Leukemia
Transcription
Chromatin
Proteins
Protein Transport
2015
133 Citations (Scopus)

BET Bromodomain Inhibition Suppresses the Function of Hematopoietic Transcription Factors in Acute Myeloid Leukemia

Roe, J-S., Mercan, F., Rivera, K., Pappin, D. J. & Vakoc, C. R., 2015 Jun 18, In : Molecular Cell. 58, 6, p. 1028-1039 12 p.

Research output: Contribution to journalArticle

Acute Myeloid Leukemia
Transcription Factors
Chromatin
Leukemia
p300-CBP Transcription Factors
51 Citations (Scopus)

NSD3-Short Is an Adaptor Protein that Couples BRD4 to the CHD8 Chromatin Remodeler

Shen, C., Ipsaro, J. J., Shi, J., Milazzo, J. P., Wang, E., Roe, J-S., Suzuki, Y., Pappin, D. J., Joshua-Tor, L. & Vakoc, C. R., 2015 Dec 17, In : Molecular Cell. 60, 6, p. 847-859 13 p.

Research output: Contribution to journalArticle

Acute Myeloid Leukemia
Chromatin
Methyltransferases
Leukemia
Proteins
1 Citation (Scopus)

OGFOD1 is required for breast cancer cell proliferation and is associated with poor prognosis in breast cancer

Kim, J. H., Lee, S. M., Lee, J. H., Chun, S., Kang, B. H., Kwak, S., Roe, J-S., Kim, T. W., Kim, H., Kim, W. H., Cho, E. J. & Youn, H. D., 2015 Jan 1, In : Oncotarget. 6, 23, p. 19528-19541 14 p.

Research output: Contribution to journalArticle

Cell Proliferation
Breast Neoplasms
Prolyl Hydroxylases
Oxygenases
Computational Biology
29 Citations (Scopus)

TGF-β/smad signaling through DOCK4 facilitates lung adenocarcinoma metastasis

Yu, J. R., Tai, Y., Jin, Y., Hammell, M. C., Wilkinson, J. E., Roe, J-S., Vakoc, C. R. & Van Aelst, L., 2015 Jan 1, In : Genes and Development. 29, 3, p. 250-261 12 p.

Research output: Contribution to journalArticle

Neoplasm Metastasis
Epithelial-Mesenchymal Transition
Cell Movement
Neoplasms
Adenocarcinoma of lung
11 Citations (Scopus)

The transcriptional cofactor TRIM33 prevents apoptosis in B lymphoblastic leukemia by deactivating a single enhancer

Wang, E., Kawaoka, S., Roe, J-S., Shi, J., Hohmann, A. F., Xu, Y., Bhagwat, A. S., Suzuki, Y., Kinney, J. B. & Vakoc, C. R., 2015 Apr 28, In : eLife. 4, p. e06377

Research output: Contribution to journalArticle

Precursor Cell Lymphoblastic Leukemia-Lymphoma
Transcription Factors
Cells
B-Cell Leukemia
Apoptosis
11 Citations (Scopus)

The transcriptional cofactor TRIM33 prevents apoptosis in B lymphoblastic leukemia by deactivating a single enhancer

Wang, E., Kawaoka, S., Roe, J. S., Shi, J., Hohmann, A. F., Xu, Y., Bhagwat, A. S., Kinney, J. B. & Vakoc, C. R., 2015 Apr 28, In : eLife. 2015, 4, e06377.

Research output: Contribution to journalArticle

Precursor Cell Lymphoblastic Leukemia-Lymphoma
Transcription Factors
Cells
B-Cell Leukemia
Apoptosis
187 Citations (Scopus)

Transcriptional plasticity promotes primary and acquired resistance to BET inhibition

Rathert, P., Roth, M., Neumann, T., Muerdter, F., Roe, J-S., Muhar, M., Deswal, S., Cerny-Reiterer, S., Peter, B., Jude, J., Hoffmann, T., Boryn, L. M., Axelsson, E., Schweifer, N., Tontsch-Grunt, U., Dow, L. E., Gianni, D., Pearson, M., Valent, P., Stark, A. & 3 others, Kraut, N., Vakoc, C. R. & Zuber, J., 2015 Sep 24, In : Nature. 525, 7570, p. 543-547 5 p.

Research output: Contribution to journalArticle

Leukemia
Proteins
Acute Myeloid Leukemia
Chromatin
Chromatin Immunoprecipitation
2014
17 Citations (Scopus)

C/EBPα: Critical at the origin of leukemic transformation

Roe, J-S. & Vakoc, C. R., 2014 Jan 1, In : Journal of Experimental Medicine. 211, 1, p. 1-4 4 p.

Research output: Contribution to journalShort survey

Acute Myeloid Leukemia
Oncogene Proteins
Transcription Factors
Myeloid Progenitor Cells
Hematologic Neoplasms
2013
1 Citation (Scopus)

Oncogene interference through targeting of chromatin regulators

Roe, J-S. & Vakoc, C. R., 2013 May 15, In : Cell Cycle. 12, 10, p. 1475-1476 2 p.

Research output: Contribution to journalEditorial

Myeloid-Lymphoid Leukemia Protein
Ubiquitin-Protein Ligases
Oncogenes
Acute Myeloid Leukemia
Chromatin
49 Citations (Scopus)

P53 regulates glucose metabolism by miR-34a

Kim, H. R., Roe, J-S., Lee, J. E., Cho, E. J. & Youn, H. D., 2013 Jul 26, In : Biochemical and Biophysical Research Communications. 437, 2, p. 225-231 7 p.

Research output: Contribution to journalArticle

MicroRNAs
Metabolism
Glucose
Hexokinase
Glycolysis
16 Citations (Scopus)

Phosphorylation and ubiquitination-dependent degradation of CABIN1 releases p53 for transactivation upon genotoxic stress

Choi, S. Y., Jang, H., Roe, J-S., Kim, S. T., Cho, E. J. & Youn, H. D., 2013 Feb 1, In : Nucleic acids research. 41, 4, p. 2180-2190 11 p.

Research output: Contribution to journalArticle

Ubiquitination
Transcriptional Activation
DNA Damage
Phosphorylation
Ubiquitin
184 Citations (Scopus)

Role of SWI/SNF in acute leukemia maintenance and enhancer-mediated Myc regulation

Shi, J., Whyte, W. A., Zepeda-Mendoza, C. J., Milazzo, J. P., Shen, C., Roe, J-S., Minder, J. L., Mercan, F., Wang, E., Eckersley-Maslin, M. A., Campbell, A. E., Kawaoka, S., Shareef, S., Zhu, Z., Kendall, J., Muhar, M., Haslinger, C., Yu, M., Roeder, R. G., Wigler, M. H. & 5 others, Blobel, G. A., Zuber, J., Spector, D. L., Young, R. A. & Vakoc, C. R., 2013 Dec 15, In : Genes and Development. 27, 24, p. 2648-2662 15 p.

Research output: Contribution to journalArticle

Leukemia
Maintenance
Chromatin
Neoplasms
Chromatin Assembly and Disassembly
2012
24 Citations (Scopus)

A p53-inducible microRNA-34a downregulates Ras signaling by targeting IMPDH

Kim, H. R., Roe, J-S., Lee, J. E., Hwang, I. Y., Cho, E. J. & Youn, H. D., 2012 Feb 24, In : Biochemical and Biophysical Research Communications. 418, 4, p. 682-688 7 p.

Research output: Contribution to journalArticle

IMP Dehydrogenase
Biosynthesis
MicroRNAs
Down-Regulation
Cells
7 Citations (Scopus)

pVHL-mediated transcriptional repression of c-Myc by recruitment of histone deacetylases

Hwang, I. Y., Roe, J-S., Seol, J. H., Kim, H. R., Cho, E. J. & Youn, H. D., 2012 Feb 1, In : Molecules and cells. 33, 2, p. 195-201 7 p.

Research output: Contribution to journalArticle

Histone Deacetylases
Renal Cell Carcinoma
Acetylation
Genetic Promoter Regions
Histones
2011
20 Citations (Scopus)

Phosphorylation of von Hippel-Lindau protein by checkpoint kinase 2 regulates p53 transactivation

Roe, J-S., Kim, H. R., Hwang, I. Y., Ha, N. C., Kim, S. T., Cho, E. J. & Youn, H. D., 2011 Nov 15, In : Cell Cycle. 10, 22, p. 3920-3928 9 p.

Research output: Contribution to journalArticle

Checkpoint Kinase 2
Protein Kinases
Transcriptional Activation
DNA Damage
Phosphorylation
20 Citations (Scopus)

Von Hippel-Lindau protein promotes Skp2 destabilization on DNA damage

Roe, J-S., Kim, H. R., Hwang, I. Y., Cho, E. J. & Youn, H. D., 2011 Jul 14, In : Oncogene. 30, 28, p. 3127-3138 12 p.

Research output: Contribution to journalArticle

S-Phase Kinase-Associated Proteins
DNA Damage
von Hippel-Lindau Disease
S Phase
Renal Cell Carcinoma
2006
168 Citations (Scopus)

p53 Stabilization and Transactivation by a von Hippel-Lindau Protein

Roe, J-S., Kim, H., Lee, S. M., Kim, S. T., Cho, E. J. & Youn, H. D., 2006 May 5, In : Molecular Cell. 22, 3, p. 395-405 11 p.

Research output: Contribution to journalArticle

Transcriptional Activation
Von Hippel-Lindau Tumor Suppressor Protein
von Hippel-Lindau Disease
Neoplasms
Proteins
35 Citations (Scopus)

The positive regulation of p53 by the tumor suppressor VHL

Roe, J-S. & Youn, H. D., 2006 Sep 15, In : Cell Cycle. 5, 18, p. 2054-2056 3 p.

Research output: Contribution to journalShort survey

DNA Damage
Von Hippel-Lindau Tumor Suppressor Protein
Neoplasms
Germ-Line Mutation
Ubiquitination