• 2229 Citations
  • 26 h-Index
19982020

Research output per year

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Research Output

  • 2229 Citations
  • 26 h-Index
  • 61 Article
  • 8 Review article
  • 2 Short survey
  • 1 Comment/debate
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Article
2020

Deubiquitylation and stabilization of Notch1 intracellular domain by ubiquitin-specific protease 8 enhance tumorigenesis in breast cancer

Shin, S., Kim, K., Kim, H. R., Ylaya, K., Do, S. I., Hewitt, S. M., Park, H. S., Roe, J. S., Chung, J. Y. & Song, J., 2020 Apr 1, In : Cell Death and Differentiation. 27, 4, p. 1341-1354 14 p.

Research output: Contribution to journalArticle

2019

Absence of Cytosolic 2-Cys Prx Subtypes I and II Exacerbates TNF-α-Induced Apoptosis via Different Routes

Lee, S., Lee, J. Y., Lee, E. W., Park, S., Kang, D. H., Min, C., Lee, D. J., Kang, D., Song, J., Kwon, J. & Kang, S. W., 2019 Feb 19, In : Cell Reports. 26, 8, p. 2194-2211.e6

Research output: Contribution to journalArticle

Open Access
3 Citations (Scopus)

Quantitative proteomic analyses reveal that GPX4 downregulation during myocardial infarction contributes to ferroptosis in cardiomyocytes

Park, T. J., Park, J. H., Lee, G. S., Lee, J. Y., Shin, J. H., Kim, M. W., Kim, Y. S., Kim, J. Y., Oh, K. J., Han, B. S., Kim, W. K., Ahn, Y., Moon, J. H., Song, J., Bae, K. H., Kim, D. H., Lee, E. W. & Lee, S. C., 2019 Nov 1, In : Cell Death and Disease. 10, 11, 835.

Research output: Contribution to journalArticle

Open Access
3 Citations (Scopus)
2018

Cytoplasmic pro-apoptotic function of the tumor suppressor p73 is mediated through a modified mode of recognition of the anti-apoptotic regulator Bcl-XL

Yoon, M. K., Kim, B. Y., Lee, J. Y., Ha, J. H., Kim, S. A., Lee, D. H., Lee, M. S., Lee, M. K., Choi, J. S., Cho, J. H., Kim, J. H., Kim, S., Song, J., Park, S. G., Park, B. C., Bae, K. H., Choi, S. U. & Chi, S. W., 2018 Dec 21, In : Journal of Biological Chemistry. 293, 51, p. 19546-19558 13 p.

Research output: Contribution to journalArticle

4 Citations (Scopus)

Dual loss of USP10 and p14ARF protein expression is associated with poor prognosis in patients with small intestinal adenocarcinoma

Song, J. S., Yi, J. M., Cho, H., Choi, C. H., Park, Y., Chung, E. J., Song, J., Chung, J. Y. & Hong, S. M., 2018 Oct 1, In : Tumor Biology. 40, 10

Research output: Contribution to journalArticle

4 Citations (Scopus)

K6 linked polyubiquitylation of FADD by CHIP prevents death inducing signaling complex formation suppressing cell death

Seo, J., Lee, E. W., Shin, J., Seong, D., Nam, Y. W., Jeong, M., Lee, S. H., Lee, C. & Song, J., 2018 Sep 6, In : Oncogene. 37, 36, p. 4994-5006 13 p.

Research output: Contribution to journalArticle

11 Citations (Scopus)

Loss of the E3 ubiquitin ligase MKRN1 represses diet-induced metabolic syndrome through AMPK activation

Lee, M. S., Han, H. J., Han, S. Y., Kim, I. Y., Chae, S., Lee, C. S., Kim, S. E., Yoon, S. G., Park, J. W., Kim, J. H., Shin, S., Jeong, M., Ko, A., Lee, H. Y., Oh, K. J., Lee, Y. H., Bae, K. H., Koo, S. H., Kim, J. W., Seong, J. K. & 2 others, Hwang, D. & Song, J., 2018 Dec 1, In : Nature communications. 9, 1, 3404.

Research output: Contribution to journalArticle

14 Citations (Scopus)

Oncogene-induced senescence mediated by c-Myc requires USP10 dependent deubiquitination and stabilization of p14ARF

Ko, A., Han, S. Y., Choi, C. H., Cho, H., Lee, M. S., Kim, S. Y., Song, J. S., Hong, K. M., Lee, H. W., Hewitt, S. M., Chung, J. Y. & Song, J., 2018 Jun 1, In : Cell Death and Differentiation. 25, 6, p. 1050-1062 13 p.

Research output: Contribution to journalArticle

20 Citations (Scopus)

Targeting Mitochondrial Oxidative Phosphorylation Abrogated Irinotecan Resistance in NSCLC

Lee, S., Lee, J. S., Seo, J., Lee, S. H., Kang, J. H., Song, J. & Kim, S. Y., 2018 Dec 1, In : Scientific reports. 8, 1, 15707.

Research output: Contribution to journalArticle

6 Citations (Scopus)

Ubiquitylation and degradation of adenomatous polyposis coli by MKRN1 enhances Wnt/β-catenin signaling

Lee, H. K., Lee, E. W., Seo, J., Jeong, M., Lee, S. H., Kim, S. Y., Jho, E. H., Choi, C. H., Chung, J. Y. & Song, J., 2018 Aug 2, In : Oncogene. 37, 31, p. 4273-4286 14 p.

Research output: Contribution to journalArticle

8 Citations (Scopus)
2017

C-terminus of HSC70-Interacting Protein (CHIP) Inhibits Adipocyte Differentiation via Ubiquitin- and Proteasome-Mediated Degradation of PPARγ

Kim, J. H., Shin, S., Seo, J., Lee, E. W., Jeong, M., Lee, M. S., Han, H. J. & Song, J., 2017 Jan 6, In : Scientific reports. 7, 40023.

Research output: Contribution to journalArticle

4 Citations (Scopus)

Glatiramer acetate attenuates the activation of CD4 + T cells by modulating STAT1 and â'3 signaling in glia

Ahn, Y. H., Jeon, S. B., Chang, C. Y., Goh, E. A., Kim, S. S., Kim, H. J., Song, J. & Park, E. J., 2017 Jan 17, In : Scientific reports. 7, 40484.

Research output: Contribution to journalArticle

5 Citations (Scopus)

Molecular chaperone HSP90 is necessary to prevent cellular senescence via lysosomal degradation of p14ARF

Han, S. Y., Ko, A., Kitano, H., Choi, C. H., Lee, M. S., Seo, J., Fukuoka, J., Kim, S. Y., Hewitt, S. M., Chung, J. Y. & Song, J., 2017 Jan 15, In : Cancer Research. 77, 2, p. 343-354 12 p.

Research output: Contribution to journalArticle

8 Citations (Scopus)

Sorafenib tosylate inhibits directly necrosome complex formation and protects in mouse models of inflammation and tissue injury

Martens, S., Jeong, M., Tonnus, W., Feldmann, F., Hofmans, S., Goossens, V., Takahashi, N., Bräsen, J. H., Lee, E. W., Van der Veken, P., Joossens, J., Augustyns, K., Fulda, S., Linkermann, A., Song, J. & Vandenabeele, P., 2017 Jun 29, In : Cell death & disease. 8, 6, p. e2904

Research output: Contribution to journalArticle

29 Citations (Scopus)

USP8 suppresses death receptor-mediated apoptosis by enhancing FLIP L stability

Jeong, M., Lee, E. W., Seong, D., Seo, J., Kim, J. H., Grootjans, S., Kim, S. Y., Vandenabeele, P. & Song, J., 2017 Jan 26, In : Oncogene. 36, 4, p. 458-470 13 p.

Research output: Contribution to journalArticle

19 Citations (Scopus)
2016

Activation of nuclear PTEN by inhibition of Notch signaling induces G2/M cell cycle arrest in gastric cancer

Kim, S. J., Lee, H. W., Baek, J. H., Cho, Y. H., Kang, H. G., Jeong, J. S., Song, J., Park, H. S. & Chun, K. H., 2016 Jan 14, In : Oncogene. 35, 2, p. 251-260 10 p.

Research output: Contribution to journalArticle

44 Citations (Scopus)

CHIP controls necroptosis through ubiquitylation-and lysosome-dependent degradation of RIPK3

Seo, J., Lee, E. W., Sung, H., Seong, D., Dondelinger, Y., Shin, J., Jeong, M., Lee, H. K., Kim, J. H., Han, S. Y., Lee, C., Seong, J. K., Vandenabeele, P. & Song, J., 2016 Feb 25, In : Nature Cell Biology. 18, 3, p. 291-302 12 p.

Research output: Contribution to journalArticle

53 Citations (Scopus)

Dual targeting of glutaminase 1 and thymidylate synthase elicits death synergistically in NSCLC

Lee, J. S., Kang, J. H., Lee, S. H., Hong, D., Son, J., Hong, K. M., Song, J. & Kim, S. Y., 2016 Jan 1, In : Cell Death and Disease. 7, 12, e2511.

Research output: Contribution to journalArticle

12 Citations (Scopus)

New role of E3 ubiquitin ligase in the regulation of necroptosis

Seo, J., Lee, E. W. & Song, J., 2016 May 1, In : BMB reports. 49, 5, p. 247-248 2 p.

Research output: Contribution to journalArticle

3 Citations (Scopus)

Targeting the WEE1 kinase as a molecular targeted therapy for gastric cancer

Kim, H. Y., Cho, Y., Kang, H. G., Yim, Y. S., Kim, S. J., Song, J. & Chun, K. H., 2016 Jan 1, In : Oncotarget. 7, 31, p. 49902-49916 15 p.

Research output: Contribution to journalArticle

19 Citations (Scopus)

USP11: A key regulator of cIAP2 stability and sensitivity to SMAC mimetics

Lee, E. W. & Song, J., 2016 May 3, In : Molecular and Cellular Oncology. 3, 3, e1029829.

Research output: Contribution to journalArticle

4 Citations (Scopus)
2015

Camptothecin and topotecan inhibit adipocyte differentiation by inducing degradation of PPARγ

Kim, J. H., Jeong, M., Lee, S. S. & Song, J., 2015 Jul 13, In : Biochemical and Biophysical Research Communications. 463, 4, p. 1122-1128 7 p.

Research output: Contribution to journalArticle

11 Citations (Scopus)

Galectin-3 activates PPARγ and supports white adipose tissue formation and high-fat diet-induced obesity

Baek, J. H., Kim, S. J., Kang, H. G., Lee, H. W., Kim, J. H., Hwang, K. A., Song, J. & Chun, K. H., 2015 Jan 1, In : Endocrinology. 156, 1, p. 147-156 10 p.

Research output: Contribution to journalArticle

35 Citations (Scopus)

PI3K/AKT activation induces PTEN ubiquitination and destabilization accelerating tumourigenesis

Lee, M. S., Jeong, M. H., Lee, H. W., Han, H. J., Ko, A., Hewitt, S. M., Kim, J. H., Chun, K. H., Chung, J. Y., Lee, C., Cho, H. & Song, J., 2015 Jul 17, In : Nature communications. 6, 7769.

Research output: Contribution to journalArticle

67 Citations (Scopus)

Targeting Notch signaling by γ-secretase inhibitor I enhances the cytotoxic effect of 5-FU in gastric cancer

Lee, H. W., Kim, S. J., Choi, I. J., Song, J. & Chun, K. H., 2015 Aug 25, In : Clinical and Experimental Metastasis. 32, 6, p. 593-603 11 p.

Research output: Contribution to journalArticle

22 Citations (Scopus)

USP11-dependent selective cIAP2 deubiquitylation and stabilization determine sensitivity to Smac mimetics

Lee, E. W., Seong, D., Seo, J., Jeong, M., Lee, H. K. & Song, J., 2015 Sep 11, In : Cell Death and Differentiation. 22, 9, p. 1463-1476 14 p.

Research output: Contribution to journalArticle

30 Citations (Scopus)
2014

Ablation of galectin-3 induces p27 KIP1-dependent premature senescence without oncogenic stress

Kim, S. J., Lee, H. W., Gu Kang, H., La, S. H., Choi, I. J., Ro, J. Y., Bresalier, R. S., Song, J. & Chun, K. H., 2014 Nov 1, In : Cell Death and Differentiation. 21, 11, p. 1769-1779 11 p.

Research output: Contribution to journalArticle

19 Citations (Scopus)

Magnetic iron oxide nanoparticles induce autophagy preceding apoptosis through mitochondrial damage and ER stress in RAW264.7 cells

Park, E. J., Choi, D. H., Kim, Y., Lee, E. W., Song, J., Cho, M. H., Kim, J. H. & Kim, S. W., 2014 Dec, In : Toxicology in Vitro. 28, 8, p. 1402-1412 11 p.

Research output: Contribution to journalArticle

62 Citations (Scopus)

Oleanolic acid regulates NF-κB signaling by suppressing MafK expression in RAW 264.7 cells

Hwang, Y. J., Song, J., Kim, H. R. & Hwang, K. A., 2014 Jan 1, In : BMB reports. 47, 9, p. 524-529 6 p.

Research output: Contribution to journalArticle

22 Citations (Scopus)

P42 Ebp1 regulates the proteasomal degradation of the p85 regulatory subunit of PI3K by recruiting a chaperone-E3 ligase complex HSP70/CHIP

Ko, H. R., Kim, C. K., Lee, S. B., Song, J., Lee, K. H., Kim, K. K., Park, K. W., Cho, S. W. & Ahn, J. Y., 2014 Mar, In : Cell Death and Disease. 5, 3, e1131.

Research output: Contribution to journalArticle

23 Citations (Scopus)

Suppression of PPARγ through MKRN1-mediated ubiquitination and degradation prevents adipocyte differentiation

Kim, J. H., Park, K. W., Lee, E. W., Jang, W. S., Seo, J., Shin, S., Hwang, K. A. & Song, J., 2014 Apr 1, In : Cell Death and Differentiation. 21, 4, p. 594-603 10 p.

Research output: Contribution to journalArticle

48 Citations (Scopus)

SWCNTs induced autophagic cell death in human bronchial epithelial cells

Park, E. J., Zahari, N. E. M., Lee, E. W., Song, J., Lee, J. H., Cho, M. H. & Kim, J. H., 2014 Apr 1, In : Toxicology in Vitro. 28, 3, p. 442-450 9 p.

Research output: Contribution to journalArticle

22 Citations (Scopus)
2013

Anti-cancer effect of a quinoxaline derivative GK13 as a transglutaminase 2 inhibitor

Lee, S. H., Kim, N., Kim, S. J., Song, J., Gong, Y. D. & Kim, S. Y., 2013 Aug 1, In : Journal of cancer research and clinical oncology. 139, 8, p. 1279-1294 16 p.

Research output: Contribution to journalArticle

27 Citations (Scopus)

MafK positively regulates NF-κB activity by enhancing CBP-mediated p65 acetylation

Hwang, Y. J., Lee, E. W., Song, J., Kim, H. R., Jun, Y. C. & Hwang, K. A., 2013 Nov 28, In : Scientific reports. 3, 3242.

Research output: Contribution to journalArticle

28 Citations (Scopus)

Stabilization of p21 (Cip1/WAF1) following Tip60-dependent acetylation is required for p21-mediated DNA damage response

Lee, M. S., Seo, J., Choi, D. Y., Lee, E. W., Ko, A., Ha, N. C., Bok Yoon, J., Lee, H. W., Pyo Kim, K. & Song, J., 2013 Apr 1, In : Cell Death and Differentiation. 20, 4, p. 620-629 10 p.

Research output: Contribution to journalArticle

23 Citations (Scopus)
2012

Acceleration of Gastric Tumorigenesis Through MKRN1-Mediated Posttranslational Regulation of p14ARF

Ko, A., Shin, J. Y., Seo, J., Lee, K. D., Lee, E. W., Lee, M. S., Lee, H. W., Choi, I. J., Jeong, J. S., Chun, K. H. & Song, J., 2012 Nov 7, In : Journal of the National Cancer Institute. 104, 21, p. 1660-1672 13 p.

Research output: Contribution to journalArticle

34 Citations (Scopus)
4 Citations (Scopus)

Ei24-deficiency attenuates protein kinase Cα signaling and skin carcinogenesis in mice

Devkota, S., Sung, Y. H., Choi, J. M., Lee, J., Ha, N. Y., Kim, H., Cho, B., Song, J. & Lee, H. W., 2012 Nov 1, In : International Journal of Biochemistry and Cell Biology. 44, 11, p. 1887-1896 10 p.

Research output: Contribution to journalArticle

13 Citations (Scopus)

STAT3 silencing enhances the efficacy of the HSV.tk suicide gene in gastrointestinal cancer therapy

Ahn, Y. H., Yi, H., Shin, J. Y., Lee, K. D., Shin, S. P., Lee, S. J., Song, J. & Chun, K. H., 2012 Apr 1, In : Clinical and Experimental Metastasis. 29, 4, p. 359-369 11 p.

Research output: Contribution to journalArticle

17 Citations (Scopus)

Ubiquitination and degradation of the FADD adaptor protein regulate death receptor-mediated apoptosis and necroptosis

Lee, E. W., Kim, J. H., Ahn, Y. H., Seo, J., Ko, A., Jeong, M., Kim, S. J., Ro, J. Y., Park, K. M., Lee, H. W., Park, E. J., Chun, K. H. & Song, J., 2012 Aug 15, In : Nature communications. 3, 978.

Research output: Contribution to journalArticle

61 Citations (Scopus)
2010

Hdm2 negatively regulates telomerase activity by functioning as an E3 ligase of hTERT

Oh, W., Lee, E. W., Lee, D., Yang, M. R., Ko, A., Yoon, C. H., Lee, H. W., Bae, Y. S., Choi, C. Y. & Song, J., 2010 Jul 1, In : Oncogene. 29, 28, p. 4101-4112 12 p.

Research output: Contribution to journalArticle

24 Citations (Scopus)

MKRN1 induces degradation of West Nile virus capsid protein by functioning as an E3 ligase

Ko, A., Lee, E. W., Yeh, J. Y., Yang, M. R., Oh, W., Moon, J. S. & Song, J., 2010 Jan 1, In : Journal of Virology. 84, 1, p. 426-436 11 p.

Research output: Contribution to journalArticle

24 Citations (Scopus)
2009

Differential regulation of p53 and p21 by MKRN1 E3 ligase controls cell cycle arrest and apoptosis

Lee, E. W., Lee, M. S., Camus, S., Ghim, J., Yang, M. R., Oh, W., Ha, N. C., Lane, D. P. & Song, J., 2009 Jul 22, In : EMBO Journal. 28, 14, p. 2100-2113 14 p.

Research output: Contribution to journalArticle

90 Citations (Scopus)

Jab1 has negative effects on p53-mediated genotoxic stresses

Lee, E. W., Lee, S. & Song, J., 2009 May, In : BMB reports. 42, 5, p. 299-303 5 p.

Research output: Contribution to journalArticle

1 Citation (Scopus)

PML-IV functions as a negative regulator of telomerase by interacting with TERT

Oh, W., Ghim, J., Lee, E. W., Yang, M. R., Kim, E. T., Ahn, J. H. & Song, J., 2009 Aug 1, In : Journal of cell science. 122, 15, p. 2613-2622 10 p.

Research output: Contribution to journalArticle

26 Citations (Scopus)
2008

Ikaros negatively regulates inducible nitric oxide synthase expression in macrophages: Involvement of Ikaros phosphorylation by casein kinase 2

Cho, S. J., Huh, J. E., Song, J., Rhee, D. K. & Pyo, S., 2008 Oct 1, In : Cellular and Molecular Life Sciences. 65, 20, p. 3290-3303 14 p.

Research output: Contribution to journalArticle

16 Citations (Scopus)

West Nile virus capsid protein induces p53-mediated apoptosis via the sequestration of HDM2 to the nucleolus

Yang, M. R., Lee, S. R., Oh, W., Lee, E. W., Yeh, J. Y., Nah, J. J., Joo, Y. S., Shin, J., Lee, H. W., Pyo, S. & Song, J., 2008 Jan 1, In : Cellular Microbiology. 10, 1, p. 165-176 12 p.

Research output: Contribution to journalArticle

67 Citations (Scopus)
2006

Hsp70 functions as a negative regulator of West Nile virus capsid protein through direct interaction

Oh, W. K. & Song, J., 2006 Sep 8, In : Biochemical and Biophysical Research Communications. 347, 4, p. 994-1000 7 p.

Research output: Contribution to journalArticle

19 Citations (Scopus)

Jab1 induces the cytoplasmic localization and degradation of p53 in coordination with Hdm2

Oh, W., Lee, E. W., Young, H. S., Yang, M. R., Ghim, J., Lee, H. W. & Song, J., 2006 Jun 23, In : Journal of Biological Chemistry. 281, 25, p. 17457-17465 9 p.

Research output: Contribution to journalArticle

72 Citations (Scopus)

Jab1 mediates cytoplasmic localization and degradation of West Nile virus capsid protein

Oh, W., Yang, M. R., Lee, E. W., Park, K. M., Pyo, S., Yang, J. S., Lee, H. W. & Song, J., 2006 Oct 6, In : Journal of Biological Chemistry. 281, 40, p. 30166-30174 9 p.

Research output: Contribution to journalArticle

51 Citations (Scopus)