• 3814 Citations
  • 33 h-Index
1990 …2020

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Article
2020

A mixed micellar formulation for the transdermal delivery of an Indirubin analog

Seo, S. H., Kim, E., Joo, Y., Lee, J., Oh, K. T., Hwang, S. J. & Choi, K. Y., 2020 Feb, In : Pharmaceutics. 12, 2, 175.

Research output: Contribution to journalArticle

Open Access

A mutant KRAS-induced factor REG4 promotes cancer stem cell properties via Wnt/β-catenin signaling

Hwang, J. H., Yoon, J., Cho, Y. H., Cha, P. H., Park, J. C. & Choi, K. Y., 2020 May 15, In : International Journal of Cancer. 146, 10, p. 2877-2890 14 p.

Research output: Contribution to journalArticle

1 Citation (Scopus)

Small molecule-induced simultaneous destabilization of β-catenin and RAS is an effective molecular strategy to suppress stemness of colorectal cancer cells

Cho, Y. H., Ro, E. J., Yoon, J. S., Kwak, D. K., Cho, J., Kang, D. W., Lee, H. Y. & Choi, K. Y., 2020 Mar 6, In : Cell Communication and Signaling. 18, 1, 38.

Research output: Contribution to journalArticle

Open Access
2019

A Ras destabilizer KYA1797K overcomes the resistance of EGFR tyrosine kinase inhibitor in KRAS-mutated non-small cell lung cancer

Park, J., Cho, Y. H., Shin, W. J., Lee, S. K., Lee, J. H., Kim, T., Cha, P. H., Yang, J. S., Cho, J., Min, D. S., Han, G., Lee, H. Y. & Choi, K. Y., 2019 Dec 1, In : Scientific reports. 9, 1, 648.

Research output: Contribution to journalArticle

6 Citations (Scopus)

A therapeutic strategy for chemotherapy-resistant gastric cancer via destabilization of both β-catenin and ras

Ryu, W. J., Lee, J. E., Cho, Y. H., Lee, G., Seo, M. K., Lee, S. K., Hwang, J. H., Min, D. S., Noh, S. H., Paik, S., Kim, S., Cheong, J. H. & Choi, K. Y., 2019 Apr, In : Cancers. 11, 4, 496.

Research output: Contribution to journalArticle

Open Access
1 Citation (Scopus)

CXXC5 mediates growth plate senescence and is a target for enhancement of longitudinal bone growth

Choi, S., Kim, H. Y., Cha, P. H., Seo, S. H., Lee, C., Choi, Y., Shin, W., Heo, Y., Han, G., Lee, W. & Choi, K. Y., 2019 Jan 1, In : Life Science Alliance. 2, 2, e201800254.

Research output: Contribution to journalArticle

Open Access
2 Citations (Scopus)

Indirubin-3′-oxime stimulates chondrocyte maturation and longitudinal bone growth via activation of the Wnt/β-catenin pathway

Choi, S., Cha, P. H., Kim, H. Y. & Choi, K. Y., 2019 Sep 1, In : Experimental and Molecular Medicine. 51, 9, 104.

Research output: Contribution to journalArticle

WDR76 degrades RAS and suppresses cancer stem cell activation in colorectal cancer

Ro, E. J., Cho, Y. H., Jeong, W. J., Park, J. C., Min, D. S. & Choi, K. Y., 2019 Jul 30, In : Cell Communication and Signaling. 17, 1, 88.

Research output: Contribution to journalArticle

Open Access
2 Citations (Scopus)

WDR76 is a RAS binding protein that functions as a tumor suppressor via RAS degradation

Jeong, W. J., Park, J. C., Kim, W. S., Ro, E. J., Jeon, S. H., Lee, S. K., Park, Y. N., Min, D. S. & Choi, K. Y., 2019 Dec 1, In : Nature communications. 10, 1, 295.

Research output: Contribution to journalArticle

5 Citations (Scopus)

WDR76 mediates obesity and hepatic steatosis via HRas destabilization

Park, J. C., Jeong, W. J., Seo, S. H. & Choi, K. Y., 2019 Dec 1, In : Scientific reports. 9, 1, 19676.

Research output: Contribution to journalArticle

Open Access
2018

A small molecule approach to degrade RAS with EGFR repression is a potential therapy for KRAS mutation-driven colorectal cancer resistance to cetuximab

Lee, S. K., Cho, Y. H., Cha, P. H., Yoon, J. S., Ro, E. J., Jeong, W. J., Park, J., Kim, H., Il Kim, T., Min, D. S., Han, G. & Choi, K. Y., 2018 Nov 1, In : Experimental and Molecular Medicine. 50, 11, 153.

Research output: Contribution to journalArticle

3 Citations (Scopus)

Discovery of a small-molecule inhibitor of Dvl–CXXC5 interaction by computational approaches

Ma, S., Choi, J., Jin, X., Kim, H. Y., Yun, J. H., Lee, W., Choi, K. Y. & No, K. T., 2018 May 1, In : Journal of Computer-Aided Molecular Design. 32, 5, p. 643-655 13 p.

Research output: Contribution to journalArticle

4 Citations (Scopus)

Identification of Ras-degrading small molecules that inhibit the transformation of colorectal cancer cells independent of β-catenin signaling

Shin, W., Lee, S. K., Hwang, J. H., Park, J. C., Cho, Y. H., Ro, E. J., Song, Y., Seo, H. R. & Choi, K. Y., 2018 Jun 1, In : Experimental and Molecular Medicine. 50, 6, 71.

Research output: Contribution to journalArticle

4 Citations (Scopus)

Transcutaneous implantation of valproic acid-encapsulated dissolving microneedles induces hair regrowth

Fakhraei Lahiji, S., Seo, S. H., Kim, S., Dangol, M., Shim, J., Li, C. G., Ma, Y., Lee, C., Kang, G., Yang, H., Choi, K. Y. & Jung, H., 2018 Jun, In : Biomaterials. 167, p. 69-79 11 p.

Research output: Contribution to journalArticle

9 Citations (Scopus)

β-Catenin-RAS interaction serves as a molecular switch for RAS degradation via GSK3β

Lee, S. K., Jeong, W. J., Cho, Y. H., Cha, P. H., Yoon, J. S., Ro, E. J., Choi, S., Oh, J. M., Heo, Y., Kim, H., Min, D. S., Han, G., Lee, W. & Choi, K. Y., 2018 Dec, In : EMBO Reports. 19, 12, e46060.

Research output: Contribution to journalArticle

4 Citations (Scopus)
2017

Crystal structure of the PDZ domain of mouse Dishevelled 1 and its interaction with CXXC5

Lee, I., Choi, S., Yun, J. H., Seo, S. H., Choi, S., Choi, K. Y. & Lee, W., 2017 Apr 8, In : Biochemical and Biophysical Research Communications. 485, 3, p. 584-590 7 p.

Research output: Contribution to journalArticle

3 Citations (Scopus)

MicroRNA-320a and microRNA-4496 attenuate Helicobacter pylori cytotoxin-associated gene A (CagA)-induced cancer-initiating potential and chemoresistance by targeting β-catenin and ATP-binding cassette, subfamily G, member 2

Kang, D. W., Yang, E. S., Noh, Y. N., Hwang, W. C., Jo, S. Y., Suh, Y. A., Park, W. S., Choi, K. Y. & Min, D. S., 2017 Apr 1, In : Journal of Pathology. 241, 5, p. 614-625 12 p.

Research output: Contribution to journalArticle

7 Citations (Scopus)

Phospholipase D1 acts through Akt/TopBP1 and RB1 to regulate the E2F1-dependent apoptotic program in cancer cells

Kang, D. W., Lee, S. W., Hwang, W. C., Lee, B. H., Choi, Y. S., Suh, Y. A., Choi, K. Y. & Min, D. S., 2017 Jan 1, In : Cancer Research. 77, 1, p. 142-152 11 p.

Research output: Contribution to journalArticle

4 Citations (Scopus)

Phospholipase D1 inhibition linked to upregulation of ICAT blocks colorectal cancer growth hyperactivated by Wnt/β-catenin and PI3K/Akt signaling

Kang, D. W., Lee, B. H., Suh, Y. A., Choi, Y. S., Jang, S. J., Kim, Y. M., Choi, K. Y. & Min, D. S., 2017 Dec 1, In : Clinical Cancer Research. 23, 23, p. 7340-7350 11 p.

Research output: Contribution to journalArticle

8 Citations (Scopus)

Stabilization of Sur8 via PKCα/δ degradation promotes transformation and migration of colorectal cancer cells

Lee, K. H., Jeong, W. J., Cha, P. H., Lee, S. K., Min, D. S. & Choi, K. Y., 2017 Jan 1, In : Oncotarget. 8, 70, p. 115596-115608 13 p.

Research output: Contribution to journalArticle

1 Citation (Scopus)

Targeting of CXXC5 by a Competing Peptide Stimulates Hair Regrowth and Wound-Induced Hair Neogenesis

Lee, S. H., Seo, S. H., Lee, D. H., Pi, L. Q., Lee, W. S. & Choi, K. Y., 2017 Nov, In : Journal of Investigative Dermatology. 137, 11, p. 2260-2269 10 p.

Research output: Contribution to journalArticle

17 Citations (Scopus)
2016

CXXC5 plays a role as a transcription activator for myelin genes on oligodendrocyte differentiation

Kim, M. Y., Kim, H. Y., Hong, J., Kim, D., Lee, H., Cheong, E., Lee, Y., Roth, J., Kim, D. G., Min, D. S. & Choi, K. Y., 2016 Mar 1, In : Glia. 64, 3, p. 350-362 13 p.

Research output: Contribution to journalArticle

10 Citations (Scopus)

Identification of small-molecule compounds targeting the dishevelled PDZ domain by virtual screening and binding studies

Choi, J., Ma, S. L., Kim, H. Y., Yun, J. H., Heo, J. N., Lee, W., Choi, K. Y. & No, K. T., 2016 Jan 1, In : Bioorganic and Medicinal Chemistry. 24, 15, p. 3259-3266 8 p.

Research output: Contribution to journalArticle

4 Citations (Scopus)

KY1022, a small molecule destabilizing Ras via targeting the Wnt/β-catenin pathway, inhibits development of metastatic colorectal cancer

Cho, Y. H., Cha, P. H., Kaduwal, S., Park, J. C., Lee, S. K., Yoon, J. S., Shin, W., Kim, H., Ro, E. J., Koo, K. H., Park, K. S., Han, G. & Choi, K. Y., 2016 Jan 1, In : Oncotarget. 7, 49, p. 81727-81740 14 p.

Research output: Contribution to journalArticle

19 Citations (Scopus)

Polygonum aviculare L. And its active compounds, quercitrin hydrate, caffeic acid, and rutin, activate the Wnt/β-catenin pathway and induce cutaneous wound healing

Seo, S. H., Lee, S. H., Cha, P. H., Kim, M. Y., Min, D. S. & Choi, K. Y., 2016 May 1, In : Phytotherapy Research. 30, 5, p. 848-854 7 p.

Research output: Contribution to journalArticle

7 Citations (Scopus)
5 Citations (Scopus)

Retinoic-acid-mediated HRas stabilization induces neuronal differentiation of neural stem cells during brain development

Park, J. C., Jeong, W. J., Kim, M. Y., Min, D. S. & Choi, K. Y., 2016 Jan 1, In : Journal of cell science. 129, 15, p. 2997-3007 11 p.

Research output: Contribution to journalArticle

10 Citations (Scopus)
1 Citation (Scopus)

Small-molecule binding of the axin RGS domain promotes β-catenin and Ras degradation

Cha, P. H., Cho, Y. H., Lee, S. K., Lee, J., Jeong, W. J., Moon, B. S., Yun, J. H., Yang, J. S., Choi, S., Yoon, J., Kim, H. Y., Kim, M. Y., Kaduwal, S., Lee, W., Min, D. S., Kim, H., Han, G. & Choi, K. Y., 2016 Aug 1, In : Nature Chemical Biology. 12, 8, p. 593-600 8 p.

Research output: Contribution to journalArticle

25 Citations (Scopus)

Small molecule inhibitors of the Dishevelled-CXXC5 interaction are new drug candidates for bone anabolic osteoporosis therapy

Kim, H. Y., Choi, S., Yoon, J. H., Lim, H. J., Lee, H., Choi, J., Ro, E. J., Heo, J. N., Lee, W., No, K. T. & Choi, K. Y., 2016 Apr 1, In : EMBO Molecular Medicine. 8, 4, p. 375-387 13 p.

Research output: Contribution to journalArticle

14 Citations (Scopus)

STAT3 potentiates SIAH-1 mediated proteasomal degradation of β-Catenin in human embryonic kidney cells

Shin, M., Yi, E. H., Kim, B. H., Shin, J. C., Park, J. Y., Cho, C. H., Park, J. W., Choi, K. Y. & Ye, S. K., 2016 Nov 1, In : Molecules and cells. 39, 11, p. 821-826 6 p.

Research output: Contribution to journalArticle

3 Citations (Scopus)

Sur8 mediates tumorigenesis and metastasis in colorectal cancer

Lee, Y. M., Kaduwal, S., Lee, K. H., Park, J. C., Jeong, W. J. & Choi, K. Y., 2016 Jul 29, In : Experimental & molecular medicine. 48, 7, p. e249

Research output: Contribution to journalArticle

5 Citations (Scopus)
2015

CXXC5 is a negative-feedback regulator of the Wnt/β-catenin pathway involved in osteoblast differentiation

Kim, H. Y., Yoon, J. Y., Yun, J. H., Cho, K. W., Lee, S. H., Rhee, Y. M., Jung, H. S., Lim, H. J., Lee, H., Choi, J., Heo, J. N., Lee, W., No, K. T., Min, D. & Choi, K. Y., 2015 Jun 1, In : Cell Death and Differentiation. 22, 6, p. 912-920 9 p.

Research output: Contribution to journalArticle

28 Citations (Scopus)

Euodia sutchuenensis Dode extract stimulates osteoblast differentiation via Wnt/β-catenin pathway activation

Hwang, J. H., Cha, P. H., Han, G., Bach, T. T. H., Min, D. S. I. & Choi, K. Y., 2015 Jan 1, In : Experimental & molecular medicine. 47, p. e152

Research output: Contribution to journalArticle

14 Citations (Scopus)

K-Ras stabilization by estrogen via PKCδ is involved in endometrial tumorigenesis

Koo, K. H., Jeong, W. J., Cho, Y. H., Park, J. C., Min, D. S. & Choi, K. Y., 2015 Jan 1, In : Oncotarget. 6, 25, p. 21328-21340 13 p.

Research output: Contribution to journalArticle

12 Citations (Scopus)

NNC 55-0396, a T-type Ca2+ channel inhibitor, inhibits angiogenesis via suppression of hypoxia-inducible factor-1α signal transduction

Kim, K. H., Kim, D., Park, J. Y., Jung, H. J., Cho, Y. H., Kim, H. K., Han, J., Choi, K. Y. & Kwon, H. J., 2015 May 1, In : Journal of Molecular Medicine. 93, 5, p. 499-509 11 p.

Research output: Contribution to journalArticle

18 Citations (Scopus)

N-nicotinoyl tyramine, a novel niacinamide derivative, inhibits melanogenesis by suppressing MITF gene expression

Kim, B., Lee, S. H., Choi, K. Y. & Kim, H. S., 2015 Jul 1, In : European Journal of Pharmacology. 764, p. 1-8 8 p.

Research output: Contribution to journalArticle

9 Citations (Scopus)

Phospholipase D2 promotes degradation of hypoxia-inducible factor-1α independent of lipase activity

Park, M. H., Bae, S. S., Choi, K. Y. & Min, D. S., 2015 Jan 1, In : Experimental and Molecular Medicine. 47, 11, e196.

Research output: Contribution to journalArticle

2 Citations (Scopus)

Sur8/Shoc2 promotes cell motility and metastasis through activation of Ras-PI3K signaling

Kaduwal, S., Jeong, W. J., Park, J. C., Lee, K. H., Lee, Y. M., Jeon, S. H., Lim, Y. B., Min, D. S. & Choi, K. Y., 2015 Jan 1, In : Oncotarget. 6, 32, p. 33091-33105 15 p.

Research output: Contribution to journalArticle

17 Citations (Scopus)

Targeting phospholipase D1 attenuates intestinal tumorigenesis by controlling β-catenin signaling in cancer-initiating cells

Kang, D. W. O., Choi, C. Y. E., Cho, Y. H., Tian, H., Di Paolo, G., Choi, K. Y. & Min, D. S. I., 2015 Jul 27, In : The Journal of experimental medicine. 212, 8, p. 1219-1237 19 p.

Research output: Contribution to journalArticle

22 Citations (Scopus)

The Dishevelled-binding protein CXXC5 negatively regulates cutaneous wound healing

Lee, S. H., Kim, M. Y., Kim, H. Y., Lee, Y. M., Kim, H., Nam, K. A., Roh, M. R., Min, D. S., Chung, K. Y. & Choi, K. Y., 2015 Jan 1, In : Journal of Experimental Medicine. 212, 7, p. 1061-1080 20 p.

Research output: Contribution to journalArticle

24 Citations (Scopus)
3 Citations (Scopus)
2014

CXXC5 is a transcriptional activator of Flk-1 and mediates bone morphogenic protein-induced endothelial cell differentiation and vessel formation

Kim, H. Y., Yang, D. H., Shin, S. W., Kim, M. Y., Yoon, J. H., Kim, S., Park, H. C., Kang, D. W., Min, D., Hur, M. W. & Choi, K. Y., 2014 Feb, In : FASEB Journal. 28, 2, p. 615-626 12 p.

Research output: Contribution to journalArticle

20 Citations (Scopus)

Hovenia dulcis Thunb extract and its ingredient methyl vanillate Activate Wnt/β-catenin pathway and increase bone mass in growing or ovariectomized mice

Cha, P. H., Shin, W., Zahoor, M., Kim, H. Y., Min, D. S. & Choi, K. Y., 2014 Jan 22, In : PloS one. 9, 1, e85546.

Research output: Contribution to journalArticle

17 Citations (Scopus)
8 Citations (Scopus)
15 Citations (Scopus)

Inhibition of phospholipase D2 induces autophagy in colorectal cancer cells

Hwang, W. C., Kim, M. K., Song, J. H., Choi, K. Y. & Min, D. S., 2014 Jan 1, In : Experimental and Molecular Medicine. 46, 12, e124.

Research output: Contribution to journalArticle

7 Citations (Scopus)

Phospholipase D1 protein coordinates dynamic assembly of HIF-1α-PHD-VHL to regulate HIF-1α stability

Park, M. H., Choi, K. Y., Jung, Y. & Min, D. S., 2014 Jan 1, In : Oncotarget. 5, 23, p. 11857-11872 16 p.

Research output: Contribution to journalArticle

9 Citations (Scopus)

Phospholipase D-mediated autophagic regulation is a potential target for cancer therapy

Jang, Y. H., Choi, K. Y. & Min, D. S., 2014 Apr 1, In : Cell Death and Differentiation. 21, 4, p. 533-546 14 p.

Research output: Contribution to journalArticle

21 Citations (Scopus)

Role of oncogenic K-Ras in cancer stem cell activation by aberrant wnt/β-catenin signaling

Moon, B. S., Jeong, W. J., Park, J., Kim, T. I., Min, D. S. & Choi, K. Y., 2014 Feb 1, In : Journal of the National Cancer Institute. 106, 2

Research output: Contribution to journalArticle

85 Citations (Scopus)