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Research Output 1989 2019

  • 4087 Citations
  • 37 h-Index
  • 44 Article
  • 13 Review article
  • 1 Short survey
2019

Liver disease-associated keratin 8 and 18 mutations modulate keratin acetylation and methylation

Jang, K. H., Yoon, H. N., Lee, J., Yi, H., Park, S. Y., Lee, S. Y., Lim, Y., Lee, H. J., Cho, J. W., Paik, Y-K., Hancock, W. S. & Ku, N., 2019 Aug 1, In : FASEB journal : official publication of the Federation of American Societies for Experimental Biology. 33, 8, p. 9030-9043 14 p.

Research output: Contribution to journalArticle

Keratin-8
Keratin-18
Acetylation
Methylation
Keratins
2018
4 Citations (Scopus)

Intermediate filaments: The sweet side of vimentin

Snider, N. T., Ku, N. & Omary, M. B., 2018 Mar 7, In : eLife. 7, e35336.

Research output: Contribution to journalArticle

Glycosylation
Intermediate Filaments
Chlamydia
Vimentin
Bacteria
1 Citation (Scopus)

The role of keratins in the digestive system: lessons from transgenic mouse models

Yi, H., Yoon, H. N., Kim, S. & Ku, N., 2018 Oct 1, In : Histochemistry and Cell Biology. 150, 4, p. 351-359 9 p.

Research output: Contribution to journalReview article

Digestive System
Keratins
Transgenic Mice
Type II Keratin
Type I Keratin
2017
2 Citations (Scopus)

A mutation in keratin 18 that causes caspase-digestion resistance protects homozygous transgenic mice from hepatic apoptosis and injury

Yoon, H. N., Yoon, S. Y., Hong, J. H. & Ku, N., 2017 Aug 1, In : Journal of cell science. 130, 15, p. 2541-2550 10 p.

Research output: Contribution to journalArticle

Keratin-18
Caspases
Transgenic Mice
Digestion
Apoptosis
2016
26 Citations (Scopus)

Keratins: Biomarkers and modulators of apoptotic and necrotic cell death in the liver

Ku, N., Strnad, P., Bantel, H. & Omary, M. B., 2016 Jan 1, In : Hepatology. 64, 3, p. 966-976 11 p.

Research output: Contribution to journalReview article

Keratins
Cell Death
Biomarkers
Liver
Apoptosis
2014
18 Citations (Scopus)

Mutation of caspase-digestion sites in keratin 18 interferes with filament reorganization, and predisposes to hepatocyte necrosis and loss of membrane integrity

Weerasinghe, S. V. W., Ku, N., Altshuler, P. J., Kwan, R. & Omary, M. B., 2014 Jan 1, In : Journal of cell science. 127, 7, p. 1464-1475 12 p.

Research output: Contribution to journalArticle

Keratin-18
Caspases
Digestion
Hepatocytes
Necrosis
2013
5 Citations (Scopus)

Intermediate filaments of the lung

Yi, H. & Ku, N., 2013 Jul 1, In : Histochemistry and cell biology. 140, 1, p. 65-69 5 p.

Research output: Contribution to journalReview article

Intermediate Filaments
Lung Diseases
Lung
Intermediate Filament Proteins
Animal Models
7 Citations (Scopus)

Predisposition to apoptosis in keratin 8-null liver is related to inactivation of NF-κB and SAPKs but not decreased c-Flip

Lee, J., Jang, K. H., Kim, H., Lim, Y., Kim, S., Yoon, H. N., Chung, I. K., Roth, J. & Ku, N., 2013 Jul 15, In : Biology Open. 2, 7, p. 695-702 8 p.

Research output: Contribution to journalArticle

Keratin-8
keratin
Heat-Shock Proteins
mitogen-activated protein kinase
Liver
2012
27 Citations (Scopus)

Keratins: Markers and modulators of liver disease

Strnad, P., Paschke, S., Jang, K. H. & Ku, N., 2012 May 1, In : Current Opinion in Gastroenterology. 28, 3, p. 209-216 8 p.

Research output: Contribution to journalReview article

Keratins
Liver Diseases
Tumor Biomarkers
Mallory Bodies
Alcoholic Fatty Liver
2010
8 Citations (Scopus)

Characterization of in vivo keratin 19 phosphorylation on tyrosine-391

Zhou, Q., Snider, N. T., Liao, J., Li, D. H., Hong, A., Ku, N., Cartwright, C. A. & Bishr Omary, M., 2010 Nov 17, In : PloS one. 5, 10, e13538.

Research output: Contribution to journalArticle

Keratin-19
Phosphorylation
keratin
Keratins
Tyrosine
81 Citations (Scopus)

Cytoskeletal keratin glycosylation protects epithelial tissue from injury

Ku, N., Toivola, D. M., Strnad, P. & Omary, M. B., 2010 Sep 1, In : Nature Cell Biology. 12, 9, p. 876-885 10 p.

Research output: Contribution to journalArticle

Keratins
Glycosylation
Epithelium
Wounds and Injuries
Apoptosis
2009
167 Citations (Scopus)

Toward unraveling the complexity of simple epithelial keratins in human disease

Omary, M. B., Ku, N., Strnad, P. & Hanada, S., 2009 Jul 1, In : Journal of Clinical Investigation. 119, 7, p. 1794-1805 12 p.

Research output: Contribution to journalReview article

Keratins
Liver Diseases
Mallory Bodies
Keratin-7
Cytoskeleton
2007
25 Citations (Scopus)

Keratin 18 overexpression but not phosphorylation or filament organization blocks mouse mallory body formation

Harada, M., Strnad, P., Resurreccion, E. Z., Ku, N. & Omary, M. B., 2007 Jan 1, In : Hepatology. 45, 1, p. 88-96 9 p.

Research output: Contribution to journalArticle

Mallory Bodies
Keratin-18
Phosphorylation
Keratins
Liver
111 Citations (Scopus)

Keratins let liver live: Mutations predispose to liver disease and crosslinking generates Mallory-Denk bodies

Ku, N., Strnad, P., Zhong, B. H., Tao, G. Z. & Omary, M. B., 2007 Nov 1, In : Hepatology. 46, 5, p. 1639-1649 11 p.

Research output: Contribution to journalReview article

Mallory Bodies
Keratins
Liver Diseases
Mutation
Liver
2006
118 Citations (Scopus)

A disease- and phosphorylation-related nonmechanical function for keratin 8

Ku, N. & Omary, M. B., 2006 Jul 3, In : Journal of Cell Biology. 174, 1, p. 115-125 11 p.

Research output: Contribution to journalArticle

Keratin-8
Phosphorylation
Serine
Phosphotransferases
Wounds and Injuries
15 Citations (Scopus)

Bispecific and human disease-related anti-keratin rabbit monoclonal antibodies

Tao, G. Z., Nakamichi, I., Ku, N., Wang, J., Frolkis, M., Gong, X., Zhu, W., Pytela, R. & Omary, M. B., 2006 Feb 15, In : Experimental Cell Research. 312, 4, p. 411-422 12 p.

Research output: Contribution to journalArticle

Keratins
Monoclonal Antibodies
Epitopes
Rabbits
Antibodies
11 Citations (Scopus)

Cell biology: Skin care by keratins

Omary, M. B. & Ku, N., 2006 May 18, In : Nature. 441, 7091, p. 296-297 2 p.

Research output: Contribution to journalShort survey

14-3-3 Proteins
Skin Care
Keratins
Wound Healing
Protein Kinases
14 Citations (Scopus)

Denaturing temperature selection may underestimate keratin mutation detection by DHPLC

Strnad, P., Lienau, T. C., Tao, G. Z., Ku, N., Magin, T. M. & Omary, M. B., 2006 May 1, In : Human Mutation. 27, 5, p. 444-452 9 p.

Research output: Contribution to journalArticle

Keratins
Mutation
Temperature
Exons
Liver Diseases
200 Citations (Scopus)

'Heads and tails' of intermediate filament phosphorylation: multiple sites and functional insights

Omary, M. B., Ku, N., Tao, G. Z., Toivola, D. M. & Liao, J., 2006 Jul 1, In : Trends in Biochemical Sciences. 31, 7, p. 383-394 12 p.

Research output: Contribution to journalReview article

Phosphorylation
Intermediate Filaments
Head
Tissue
Phosphoproteins
2005
53 Citations (Scopus)

Keratins as susceptibility genes for end-stage liver disease

Ku, N., Lim, J. K., Krams, S. M., Esquivel, C. O., Keeffe, E. B., Wright, T. L., Parry, D. A. D. & Omary, M. B., 2005 Jan 1, In : Gastroenterology. 129, 3, p. 885-893 9 p.

Research output: Contribution to journalArticle

Keratin-8
End Stage Liver Disease
Keratins
Keratin-18
Genes
2004
67 Citations (Scopus)

Keratin 8 and 18 hyperphosphorylation is a marker of progression of human liver disease

Toivola, D. M., Ku, N., Resurreccion, E. Z., Nelson, D. R., Wright, T. L. & Omary, M. B., 2004 Aug 1, In : Hepatology. 40, 2, p. 459-466 8 p.

Research output: Contribution to journalArticle

Keratin-8
Keratin-18
Keratins
Liver Diseases
Hepacivirus
41 Citations (Scopus)

Raf-1 activation disrupts its binding to keratins during cell stress

Ku, N., Fu, H. & Omary, M. B., 2004 Aug 16, In : Journal of Cell Biology. 166, 4, p. 479-485 7 p.

Research output: Contribution to journalArticle

14-3-3 Proteins
Keratin-3
Keratins
raf Kinases
Keratin-8
61 Citations (Scopus)

Studying simple epithelial keratins in cells and tissues

Ku, N., Toivola, D. M., Zhou, Q., Tao, G. Z., Zhong, B. & Omary, M. B., 2004 Dec 1, In : Methods in cell biology. 2004, 78, p. 489-517 29 p.

Research output: Contribution to journalReview article

Liver Regeneration
Post Translational Protein Processing
Caspases
Keratins
Gallbladder
2003
82 Citations (Scopus)

Keratin 8 and 18 mutations are risk factors for developing liver disease of multiple etiologies

Ku, N., Darling, J. M., Krams, S. M., Esquivel, C. O., Keeffe, E. B., Sibley, R. K., Lee, Y. M., Wright, T. L. & Omary, M. B., 2003 May 13, In : Proceedings of the National Academy of Sciences of the United States of America. 100, 10, p. 6063-6068 6 p.

Research output: Contribution to journalArticle

Keratin-8
Keratin-18
Liver Diseases
Mutation
Blood Banks
80 Citations (Scopus)

Keratin mutation in transgenic mice predisposes to Fas but not TNF-induced apoptosis and massive liver injury

Ku, N., Soetikno, R. M. & Omary, M. B., 2003 May 1, In : Hepatology. 37, 5, p. 1006-1014 9 p.

Research output: Contribution to journalArticle

Keratins
Transgenic Mice
Tumor Necrosis Factor-alpha
Apoptosis
Mutation
2002
100 Citations (Scopus)

Keratin 8 phosphorylation by p38 kinase regulates cellular keratin filament reorganization. Modulation by a keratin 1-like disease-causing mutation

Ku, N., Azhar, S. & Bishr Omary, M., 2002 Mar 29, In : Journal of Biological Chemistry. 277, 13, p. 10775-10782 8 p.

Research output: Contribution to journalArticle

Keratin-1
Keratin-8
Phosphorylation
Keratins
Phosphotransferases
124 Citations (Scopus)

Keratin binding to 14-3-3 proteins modulates keratin filaments and hepatocyte mitotic progression

Ku, N., Michie, S., Resurreccion, E. Z., Broome, R. L. & Omary, M. B., 2002 Apr 2, In : Proceedings of the National Academy of Sciences of the United States of America. 99, 7, p. 4373-4378 6 p.

Research output: Contribution to journalArticle

14-3-3 Proteins
Keratins
Hepatocytes
Mitosis
Epithelium
131 Citations (Scopus)

Keratins: Guardians of the liver

Omary, M. B., Ku, N. & Toivola, D. M., 2002 Jan 1, In : Hepatology. 35, 2, p. 251-257 7 p.

Research output: Contribution to journalArticle

Keratins
Liver
2001
72 Citations (Scopus)

Effect of Mutation and Phosphorylation of Type I Keratins on Their Caspase-mediated Degradation

Ku, N. & Omary, M. B., 2001 Jul 20, In : Journal of Biological Chemistry. 276, 29, p. 26792-26798 7 p.

Research output: Contribution to journalArticle

Type I Keratin
Phosphorylation
Caspases
Degradation
Mutation
127 Citations (Scopus)

Keratin 8 mutations in patients with cryptogenic liver disease

Ku, N., Gish, R., Wright, T. L. & Omary, M. B., 2001 May 24, In : New England Journal of Medicine. 344, 21, p. 1580-1587 8 p.

Research output: Contribution to journalArticle

Keratin-8
Liver Diseases
Mutation
Keratin-18
Keratins
2000
24 Citations (Scopus)

Effects of keratin filament disruption on exocrine pancreas-stimulated secretion and susceptibility to injury

Toivola, D. M., Ku, N., Ghori, N., Lowe, A. W., Michie, S. A. & Omary, M. B., 2000 Mar 15, In : Experimental Cell Research. 255, 2, p. 156-170 15 p.

Research output: Contribution to journalArticle

Exocrine Pancreas
Keratins
Keratin-18
Wounds and Injuries
Acinar Cells
132 Citations (Scopus)

Keratins turn over by ubiquitination in a phosphorylation-modulated fashion

Ku, N. & Omary, M. B., 2000 May 1, In : Journal of Cell Biology. 149, 3, p. 547-552 6 p.

Research output: Contribution to journalArticle

Ubiquitination
Keratins
Phosphorylation
Intermediate Filament Proteins
Proteasome Endopeptidase Complex
1999
188 Citations (Scopus)

Characterization of distinct early assembly units of different intermediate filament proteins

Herrmann, H., Häner, M., Brettel, M., Ku, N. & Aebi, U., 1999 Mar 12, In : Journal of Molecular Biology. 286, 5, p. 1403-1420 18 p.

Research output: Contribution to journalArticle

Intermediate Filament Proteins
Vimentin
Desmin
Keratin-8
Keratin-18
165 Citations (Scopus)

The cytoskeleton of digestive epithelia in health and disease

Ku, N., Zhou, X., Toivola, D. M. & Omary, M. B., 1999 Dec 1, In : American Journal of Physiology - Gastrointestinal and Liver Physiology. 277, 6 40-6

Research output: Contribution to journalReview article

Intermediate Filaments
Cytoskeleton
Epithelium
Health
Proteins
1998
170 Citations (Scopus)

Keratin modifications and solubility properties in epithelial cells and in vitro.

Omary, M. B., Ku, N., Liao, J. & Price, D., 1998 Jan 1, In : Sub-Cellular Biochemistry. 31, p. 105-140 36 p.

Research output: Contribution to journalReview article

Keratins
Solubility
Epithelial Cells
Phosphorylation
Serine
84 Citations (Scopus)

Mutation of a major keratin phosphorylation site predisposes to hepatotoxic injury in transgenic mice

Ku, N., Michie, S. A., Soetikno, R. M., Resurreccion, E. Z., Broome, R. L. & Bishr Omary, M., 1998 Dec 28, In : Journal of Cell Biology. 143, 7, p. 2023-2032 10 p.

Research output: Contribution to journalArticle

Keratins
Transgenic Mice
Phosphorylation
Mutation
Keratin-8
175 Citations (Scopus)

Phosphorylation of human keratin 18 serine 33 regulates binding to 14-3-3 proteins

Ku, N., Liao, J. & Omary, M. B., 1998 Apr 1, In : EMBO Journal. 17, 7, p. 1892-1906 15 p.

Research output: Contribution to journalArticle

14-3-3 Proteins
Keratin-18
Phosphorylation
Serine
Keratins
61 Citations (Scopus)

Protein phosphatase inhibition in normal and keratin 8/18 assembly- incompetent mouse strains supports a functional role of keratin intermediate filaments in preserving hepatocyte integrity

Toivola, D. M., Omary, M. B., Ku, N., Peltola, O., Baribault, H. & Eriksson, J. E., 1998 Jul 13, In : Hepatology. 28, 1, p. 116-128 13 p.

Research output: Contribution to journalArticle

Keratin-8
Keratin-18
Intermediate Filaments
Phosphoprotein Phosphatases
Keratins
1997
193 Citations (Scopus)

Apoptosis generates stable fragments of human type I keratins

Ku, N., Liao, J. & Omary, M. B., 1997 Dec 26, In : Journal of Biological Chemistry. 272, 52, p. 33197-33203 7 p.

Research output: Contribution to journalArticle

Type I Keratin
Keratins
Apoptosis
Phosphorylation
Caspases
86 Citations (Scopus)

Intermediate filament proteins of the liver: Emerging disease association and functions

Omary, M. B. & Ku, N., 1997 Jan 1, In : Hepatology. 25, 5, p. 1043-1048 6 p.

Research output: Contribution to journalReview article

Intermediate Filament Proteins
Intermediate Filaments
Keratins
Liver Diseases
Liver
93 Citations (Scopus)

Mutation of human keratin 18 in association with cryptogenic cirrhosis

Ku, N., Wright, T. L., Terrault, N. A., Gish, R. & Omary, M. B., 1997 Jan 1, In : Journal of Clinical Investigation. 99, 1, p. 19-23 5 p.

Research output: Contribution to journalArticle

Keratin-18
Mutation
Liver
Keratin-8
Chronic Hepatitis
86 Citations (Scopus)
Keratin-8
Phosphorylation
Epidermal Growth Factor
Serine
Tail
99 Citations (Scopus)

Stress, apoptosis, and mitosis induce phosphorylation of human keratin 8 at Ser-73 in tissues and cultured cells

Liao, J., Ku, N. & Omary, M. B., 1997 Aug 5, In : Journal of Biological Chemistry. 272, 28, p. 17565-17573 9 p.

Research output: Contribution to journalArticle

Keratin-8
Phosphorylation
Mitosis
Cultured Cells
HT29 Cells
1996
90 Citations (Scopus)

Implications of intermediate filament protein phosphorylation

Ku, N., Liao, J., Chou, C. F. & Omary, M. B., 1996 Dec 1, In : Cancer and Metastasis Reviews. 15, 4, p. 429-444 16 p.

Research output: Contribution to journalReview article

Intermediate Filament Proteins
Phosphorylation
Post Translational Protein Processing
Solubility
Membrane Proteins
102 Citations (Scopus)

Susceptibility to hepatotoxicity in transgenic mice that express a dominant-negative human keratin 18 mutant

Ku, N., Michie, S. A., Soetikno, R. M., Resurreccion, E. Z., Broome, R. L., Oshima, R. G. & Omary, M. B., 1996 Aug 15, In : Journal of Clinical Investigation. 98, 4, p. 1034-1046 13 p.

Research output: Contribution to journalArticle

Keratin-18
Transgenic Mice
Keratins
Griseofulvin
Hepatocytes
24 Citations (Scopus)

Two-dimensional gel analysis of glandular keratin intermediate filament phosphorylation

Liao, J., Ku, N. & Omary, M. B., 1996 Jan 1, In : Electrophoresis. 17, 11, p. 1671-1676 6 p.

Research output: Contribution to journalReview article

Intermediate Filaments
Electrophoresis, Gel, Two-Dimensional
Keratins
Gels
Phosphorylation
1995
133 Citations (Scopus)

Chronic hepatitis, hepatocyte fragility, and increased soluble phosphoglycokeratins in transgenic mice expressing a keratin 18 conserved arginine mutant

Ku, N., Michie, S., Oshima, R. G. & Omary, M. B., 1995 Dec 1, In : Journal of Cell Biology. 131, 5, p. 1303-1314 12 p.

Research output: Contribution to journalArticle

Keratin-18
Chronic Hepatitis
Transgenic Mice
Arginine
Hepatocytes
71 Citations (Scopus)

Dynamics of human keratin 18 phosphorylation: Polarized distribution of phosphorylated keratins in simple epithelial tissues

Liao, J., Lowthert, L. A., Ku, N., Fernandez, R. & Omary, M. B., 1995 Dec 1, In : Journal of Cell Biology. 131, 5, p. 1291-1301 11 p.

Research output: Contribution to journalArticle

Keratin-18
Keratins
Epithelium
Phosphorylation
Cell Cycle
38 Citations (Scopus)

Empigen BB: A useful detergent for solubilization and biochemical analysis of keratins

Lowthert, L. A., Ku, N., Liao, J., Coulombe, P. A. & Omary, M. B., 1995 Jan 5, In : Biochemical and Biophysical Research Communications. 206, 1, p. 370-379 10 p.

Research output: Contribution to journalArticle

Keratins
Detergents
Intermediate Filament Proteins
empigen BB
Vimentin
56 Citations (Scopus)

Identification and mutational analysis of the glycosylation sites of human keratin 18

Ku, N. & Omary, M. B., 1995 Jan 1, In : Journal of Biological Chemistry. 270, 20, p. 11820-11827 8 p.

Research output: Contribution to journalArticle

Keratin-18
Glycosylation
Glycopeptides
Keratins
Serine