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Research Output 1989 2019

  • 4091 Citations
  • 37 h-Index
  • 44 Article
  • 13 Review article
  • 1 Short survey
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Article
2019

Liver disease-associated keratin 8 and 18 mutations modulate keratin acetylation and methylation

Jang, K. H., Yoon, H. N., Lee, J., Yi, H., Park, S. Y., Lee, S. Y., Lim, Y., Lee, H. J., Cho, J. W., Paik, Y-K., Hancock, W. S. & Ku, N., 2019 Aug 1, In : FASEB journal : official publication of the Federation of American Societies for Experimental Biology. 33, 8, p. 9030-9043 14 p.

Research output: Contribution to journalArticle

Keratin-8
Keratin-18
Acetylation
Methylation
Keratins
2018
5 Citations (Scopus)

Intermediate filaments: The sweet side of vimentin

Snider, N. T., Ku, N. & Omary, M. B., 2018 Mar 7, In : eLife. 7, e35336.

Research output: Contribution to journalArticle

Glycosylation
Intermediate Filaments
Chlamydia
Vimentin
Bacteria
2017
2 Citations (Scopus)

A mutation in keratin 18 that causes caspase-digestion resistance protects homozygous transgenic mice from hepatic apoptosis and injury

Yoon, H. N., Yoon, S. Y., Hong, J. H. & Ku, N., 2017 Aug 1, In : Journal of cell science. 130, 15, p. 2541-2550 10 p.

Research output: Contribution to journalArticle

Keratin-18
Caspases
Transgenic Mice
Digestion
Apoptosis
2014
18 Citations (Scopus)

Mutation of caspase-digestion sites in keratin 18 interferes with filament reorganization, and predisposes to hepatocyte necrosis and loss of membrane integrity

Weerasinghe, S. V. W., Ku, N., Altshuler, P. J., Kwan, R. & Omary, M. B., 2014 Jan 1, In : Journal of cell science. 127, 7, p. 1464-1475 12 p.

Research output: Contribution to journalArticle

Keratin-18
Caspases
Digestion
Hepatocytes
Necrosis
2013
7 Citations (Scopus)

Predisposition to apoptosis in keratin 8-null liver is related to inactivation of NF-κB and SAPKs but not decreased c-Flip

Lee, J., Jang, K. H., Kim, H., Lim, Y., Kim, S., Yoon, H. N., Chung, I. K., Roth, J. & Ku, N., 2013 Jul 15, In : Biology Open. 2, 7, p. 695-702 8 p.

Research output: Contribution to journalArticle

Keratin-8
keratin
Heat-Shock Proteins
mitogen-activated protein kinase
Liver
2010
8 Citations (Scopus)

Characterization of in vivo keratin 19 phosphorylation on tyrosine-391

Zhou, Q., Snider, N. T., Liao, J., Li, D. H., Hong, A., Ku, N., Cartwright, C. A. & Bishr Omary, M., 2010 Nov 17, In : PloS one. 5, 10, e13538.

Research output: Contribution to journalArticle

Keratin-19
Phosphorylation
keratin
Keratins
Tyrosine
81 Citations (Scopus)

Cytoskeletal keratin glycosylation protects epithelial tissue from injury

Ku, N., Toivola, D. M., Strnad, P. & Omary, M. B., 2010 Sep 1, In : Nature Cell Biology. 12, 9, p. 876-885 10 p.

Research output: Contribution to journalArticle

Keratins
Glycosylation
Epithelium
Wounds and Injuries
Apoptosis
2007
25 Citations (Scopus)

Keratin 18 overexpression but not phosphorylation or filament organization blocks mouse mallory body formation

Harada, M., Strnad, P., Resurreccion, E. Z., Ku, N. & Omary, M. B., 2007 Jan 1, In : Hepatology. 45, 1, p. 88-96 9 p.

Research output: Contribution to journalArticle

Mallory Bodies
Keratin-18
Phosphorylation
Keratins
Liver
2006
118 Citations (Scopus)

A disease- and phosphorylation-related nonmechanical function for keratin 8

Ku, N. & Omary, M. B., 2006 Jul 3, In : Journal of Cell Biology. 174, 1, p. 115-125 11 p.

Research output: Contribution to journalArticle

Keratin-8
Phosphorylation
Serine
Phosphotransferases
Wounds and Injuries
15 Citations (Scopus)

Bispecific and human disease-related anti-keratin rabbit monoclonal antibodies

Tao, G. Z., Nakamichi, I., Ku, N., Wang, J., Frolkis, M., Gong, X., Zhu, W., Pytela, R. & Omary, M. B., 2006 Feb 15, In : Experimental Cell Research. 312, 4, p. 411-422 12 p.

Research output: Contribution to journalArticle

Keratins
Monoclonal Antibodies
Epitopes
Rabbits
Antibodies
14 Citations (Scopus)

Denaturing temperature selection may underestimate keratin mutation detection by DHPLC

Strnad, P., Lienau, T. C., Tao, G. Z., Ku, N., Magin, T. M. & Omary, M. B., 2006 May 1, In : Human Mutation. 27, 5, p. 444-452 9 p.

Research output: Contribution to journalArticle

Keratins
Mutation
Temperature
Exons
Liver Diseases
2005
53 Citations (Scopus)

Keratins as susceptibility genes for end-stage liver disease

Ku, N., Lim, J. K., Krams, S. M., Esquivel, C. O., Keeffe, E. B., Wright, T. L., Parry, D. A. D. & Omary, M. B., 2005 Jan 1, In : Gastroenterology. 129, 3, p. 885-893 9 p.

Research output: Contribution to journalArticle

Keratin-8
End Stage Liver Disease
Keratins
Keratin-18
Genes
2004
67 Citations (Scopus)

Keratin 8 and 18 hyperphosphorylation is a marker of progression of human liver disease

Toivola, D. M., Ku, N., Resurreccion, E. Z., Nelson, D. R., Wright, T. L. & Omary, M. B., 2004 Aug 1, In : Hepatology. 40, 2, p. 459-466 8 p.

Research output: Contribution to journalArticle

Keratin-8
Keratin-18
Keratins
Liver Diseases
Hepacivirus
41 Citations (Scopus)

Raf-1 activation disrupts its binding to keratins during cell stress

Ku, N., Fu, H. & Omary, M. B., 2004 Aug 16, In : Journal of Cell Biology. 166, 4, p. 479-485 7 p.

Research output: Contribution to journalArticle

14-3-3 Proteins
Keratin-3
Keratins
raf Kinases
Keratin-8
2003
82 Citations (Scopus)

Keratin 8 and 18 mutations are risk factors for developing liver disease of multiple etiologies

Ku, N., Darling, J. M., Krams, S. M., Esquivel, C. O., Keeffe, E. B., Sibley, R. K., Lee, Y. M., Wright, T. L. & Omary, M. B., 2003 May 13, In : Proceedings of the National Academy of Sciences of the United States of America. 100, 10, p. 6063-6068 6 p.

Research output: Contribution to journalArticle

Keratin-8
Keratin-18
Liver Diseases
Mutation
Blood Banks
80 Citations (Scopus)

Keratin mutation in transgenic mice predisposes to Fas but not TNF-induced apoptosis and massive liver injury

Ku, N., Soetikno, R. M. & Omary, M. B., 2003 May 1, In : Hepatology. 37, 5, p. 1006-1014 9 p.

Research output: Contribution to journalArticle

Keratins
Transgenic Mice
Tumor Necrosis Factor-alpha
Apoptosis
Mutation
2002
100 Citations (Scopus)

Keratin 8 phosphorylation by p38 kinase regulates cellular keratin filament reorganization. Modulation by a keratin 1-like disease-causing mutation

Ku, N., Azhar, S. & Bishr Omary, M., 2002 Mar 29, In : Journal of Biological Chemistry. 277, 13, p. 10775-10782 8 p.

Research output: Contribution to journalArticle

Keratin-1
Keratin-8
Phosphorylation
Keratins
Phosphotransferases
125 Citations (Scopus)

Keratin binding to 14-3-3 proteins modulates keratin filaments and hepatocyte mitotic progression

Ku, N., Michie, S., Resurreccion, E. Z., Broome, R. L. & Omary, M. B., 2002 Apr 2, In : Proceedings of the National Academy of Sciences of the United States of America. 99, 7, p. 4373-4378 6 p.

Research output: Contribution to journalArticle

14-3-3 Proteins
Keratins
Hepatocytes
Mitosis
Epithelium
131 Citations (Scopus)

Keratins: Guardians of the liver

Omary, M. B., Ku, N. & Toivola, D. M., 2002 Jan 1, In : Hepatology. 35, 2, p. 251-257 7 p.

Research output: Contribution to journalArticle

Keratins
Liver
2001
72 Citations (Scopus)

Effect of Mutation and Phosphorylation of Type I Keratins on Their Caspase-mediated Degradation

Ku, N. & Omary, M. B., 2001 Jul 20, In : Journal of Biological Chemistry. 276, 29, p. 26792-26798 7 p.

Research output: Contribution to journalArticle

Type I Keratin
Phosphorylation
Caspases
Degradation
Mutation
127 Citations (Scopus)

Keratin 8 mutations in patients with cryptogenic liver disease

Ku, N., Gish, R., Wright, T. L. & Omary, M. B., 2001 May 24, In : New England Journal of Medicine. 344, 21, p. 1580-1587 8 p.

Research output: Contribution to journalArticle

Keratin-8
Liver Diseases
Mutation
Keratin-18
Keratins
2000
24 Citations (Scopus)

Effects of keratin filament disruption on exocrine pancreas-stimulated secretion and susceptibility to injury

Toivola, D. M., Ku, N., Ghori, N., Lowe, A. W., Michie, S. A. & Omary, M. B., 2000 Mar 15, In : Experimental Cell Research. 255, 2, p. 156-170 15 p.

Research output: Contribution to journalArticle

Exocrine Pancreas
Keratins
Keratin-18
Wounds and Injuries
Acinar Cells
132 Citations (Scopus)

Keratins turn over by ubiquitination in a phosphorylation-modulated fashion

Ku, N. & Omary, M. B., 2000 May 1, In : Journal of Cell Biology. 149, 3, p. 547-552 6 p.

Research output: Contribution to journalArticle

Ubiquitination
Keratins
Phosphorylation
Intermediate Filament Proteins
Proteasome Endopeptidase Complex
1999
188 Citations (Scopus)

Characterization of distinct early assembly units of different intermediate filament proteins

Herrmann, H., Häner, M., Brettel, M., Ku, N. & Aebi, U., 1999 Mar 12, In : Journal of Molecular Biology. 286, 5, p. 1403-1420 18 p.

Research output: Contribution to journalArticle

Intermediate Filament Proteins
Vimentin
Desmin
Keratin-8
Keratin-18
1998
84 Citations (Scopus)

Mutation of a major keratin phosphorylation site predisposes to hepatotoxic injury in transgenic mice

Ku, N., Michie, S. A., Soetikno, R. M., Resurreccion, E. Z., Broome, R. L. & Bishr Omary, M., 1998 Dec 28, In : Journal of Cell Biology. 143, 7, p. 2023-2032 10 p.

Research output: Contribution to journalArticle

Keratins
Transgenic Mice
Phosphorylation
Mutation
Keratin-8
175 Citations (Scopus)

Phosphorylation of human keratin 18 serine 33 regulates binding to 14-3-3 proteins

Ku, N., Liao, J. & Omary, M. B., 1998 Apr 1, In : EMBO Journal. 17, 7, p. 1892-1906 15 p.

Research output: Contribution to journalArticle

14-3-3 Proteins
Keratin-18
Phosphorylation
Serine
Keratins
61 Citations (Scopus)

Protein phosphatase inhibition in normal and keratin 8/18 assembly- incompetent mouse strains supports a functional role of keratin intermediate filaments in preserving hepatocyte integrity

Toivola, D. M., Omary, M. B., Ku, N., Peltola, O., Baribault, H. & Eriksson, J. E., 1998 Jul 13, In : Hepatology. 28, 1, p. 116-128 13 p.

Research output: Contribution to journalArticle

Keratin-8
Keratin-18
Intermediate Filaments
Phosphoprotein Phosphatases
Keratins
1997
193 Citations (Scopus)

Apoptosis generates stable fragments of human type I keratins

Ku, N., Liao, J. & Omary, M. B., 1997 Dec 26, In : Journal of Biological Chemistry. 272, 52, p. 33197-33203 7 p.

Research output: Contribution to journalArticle

Type I Keratin
Keratins
Apoptosis
Phosphorylation
Caspases
93 Citations (Scopus)

Mutation of human keratin 18 in association with cryptogenic cirrhosis

Ku, N., Wright, T. L., Terrault, N. A., Gish, R. & Omary, M. B., 1997 Jan 1, In : Journal of Clinical Investigation. 99, 1, p. 19-23 5 p.

Research output: Contribution to journalArticle

Keratin-18
Mutation
Liver
Keratin-8
Chronic Hepatitis
86 Citations (Scopus)
Keratin-8
Phosphorylation
Epidermal Growth Factor
Serine
Tail
99 Citations (Scopus)

Stress, apoptosis, and mitosis induce phosphorylation of human keratin 8 at Ser-73 in tissues and cultured cells

Liao, J., Ku, N. & Omary, M. B., 1997 Aug 5, In : Journal of Biological Chemistry. 272, 28, p. 17565-17573 9 p.

Research output: Contribution to journalArticle

Keratin-8
Phosphorylation
Mitosis
Cultured Cells
HT29 Cells
1996
102 Citations (Scopus)

Susceptibility to hepatotoxicity in transgenic mice that express a dominant-negative human keratin 18 mutant

Ku, N., Michie, S. A., Soetikno, R. M., Resurreccion, E. Z., Broome, R. L., Oshima, R. G. & Omary, M. B., 1996 Aug 15, In : Journal of Clinical Investigation. 98, 4, p. 1034-1046 13 p.

Research output: Contribution to journalArticle

Keratin-18
Transgenic Mice
Keratins
Griseofulvin
Hepatocytes
1995
134 Citations (Scopus)

Chronic hepatitis, hepatocyte fragility, and increased soluble phosphoglycokeratins in transgenic mice expressing a keratin 18 conserved arginine mutant

Ku, N., Michie, S., Oshima, R. G. & Omary, M. B., 1995 Dec 1, In : Journal of Cell Biology. 131, 5, p. 1303-1314 12 p.

Research output: Contribution to journalArticle

Keratin-18
Chronic Hepatitis
Transgenic Mice
Arginine
Hepatocytes
71 Citations (Scopus)

Dynamics of human keratin 18 phosphorylation: Polarized distribution of phosphorylated keratins in simple epithelial tissues

Liao, J., Lowthert, L. A., Ku, N., Fernandez, R. & Omary, M. B., 1995 Dec 1, In : Journal of Cell Biology. 131, 5, p. 1291-1301 11 p.

Research output: Contribution to journalArticle

Keratin-18
Keratins
Epithelium
Phosphorylation
Cell Cycle
38 Citations (Scopus)

Empigen BB: A useful detergent for solubilization and biochemical analysis of keratins

Lowthert, L. A., Ku, N., Liao, J., Coulombe, P. A. & Omary, M. B., 1995 Jan 5, In : Biochemical and Biophysical Research Communications. 206, 1, p. 370-379 10 p.

Research output: Contribution to journalArticle

Keratins
Detergents
Intermediate Filament Proteins
empigen BB
Vimentin
56 Citations (Scopus)

Identification and mutational analysis of the glycosylation sites of human keratin 18

Ku, N. & Omary, M. B., 1995 Jan 1, In : Journal of Biological Chemistry. 270, 20, p. 11820-11827 8 p.

Research output: Contribution to journalArticle

Keratin-18
Glycosylation
Glycopeptides
Keratins
Serine
1994
46 Citations (Scopus)

Expression, glycosylation, and phosphorylation of human keratins 8 and 18 in insect cells

Ku, N. & Omary, M. B., 1994 Jan 1, In : Experimental Cell Research. 211, 1, p. 24-35 12 p.

Research output: Contribution to journalArticle

Keratin-18
Glycosylation
Insects
Sf9 Cells
Phosphorylation
80 Citations (Scopus)
Keratin-18
Phosphotransferases
Phosphorylation
Peptides
Intermediate Filaments
1993
12 Citations (Scopus)

Cloning and tissue-specific expression of the gene for mouse C-reactive protein

Ku, N. & Mortensen, R. F., 1993 Jan 1, In : Biochemical Journal. 295, 2, p. 379-386 8 p.

Research output: Contribution to journalArticle

Hepatocyte Nuclear Factor 1
Cloning
C-Reactive Protein
Acute-Phase Proteins
Organism Cloning
16 Citations (Scopus)

The mouse C-reactive protein (CRP) gene is expressed in response to IL-1 but not IL-6

Ku, N. & Mortensen, R. F., 1993 Jan 1, In : Cytokine. 5, 4, p. 319-326 8 p.

Research output: Contribution to journalArticle

Interleukin-1
C-Reactive Protein
Interleukin-6
Genes
Acute-Phase Proteins
1990
29 Citations (Scopus)

IL-1 and IL-6 mediate increased production and synthesis by hepatocytes of acute-phase reactant mouse serum amyloid P-component (SAP)

Lin, B. F., Ku, N., Zahedi, K., Whitehead, A. S. & Mortensen, R. F., 1990 Jun 1, In : Inflammation. 14, 3, p. 297-313 17 p.

Research output: Contribution to journalArticle

Serum Amyloid P-Component
Acute-Phase Proteins
Interleukin-1
Hepatocytes
Interleukin-6
52 Citations (Scopus)

Regulation of cytokine-induced human C-reactive protein production by transforming growth factor-β1

Taylor, A. W., Ku, N. O. & Mortensen, R. F., 1990 Jan 1, In : Journal of Immunology. 145, 8, p. 2507-2513 7 p.

Research output: Contribution to journalArticle

Transforming Growth Factors
C-Reactive Protein
Cytokines
Interleukin-6
Interleukin-1
1989
2 Citations (Scopus)

Both Human IL‐1 and IL‐6 Induce Synthesis of C‐Reactive Protein (CRP) by the PLC/PRF/5 Hepatoma Cell Line

TAYLOR, ANDREW. W., Ku, N. & MORTENSEN, RICHARD. F., 1989 Jan 1, In : Annals of the New York Academy of Sciences. 557, 1, p. 532-533 2 p.

Research output: Contribution to journalArticle

Interleukin-1
C-Reactive Protein
Hepatocellular Carcinoma
Interleukin-6
Cell Line
2 Citations (Scopus)

Induction of Hepatocyte Synthesis of the Mouse Acute Phase Protein Serum Amyloid P‐Component (SAP) by IL‐1 and IL‐6

LIN, BIHFEN. F., Ku, N., ZAHEDI, KAMYAR., WHITEHEAD, ALEXANDER. S. & MORTENSEN, RICHARD. F., 1989 Jan 1, In : Annals of the New York Academy of Sciences. 557, 1, p. 534-535 2 p.

Research output: Contribution to journalArticle

Serum Amyloid P-Component
Acute-Phase Proteins
Interleukin-1
Hepatocytes
Interleukin-6