• 4184 Citations
  • 37 h-Index
1989 …2019

Research output per year

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Research Output

  • 4184 Citations
  • 37 h-Index
  • 45 Article
  • 13 Review article
  • 1 Short survey
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Article
2019

Keratins regulate Hsp70-mediated nuclear localization of p38 mitogen-activated protein kinase

Lee, S. Y., Kim, S., Lim, Y., Yoon, H. N. & Ku, N. O., 2019 Sep 26, In : Journal of cell science. 132, 18

Research output: Contribution to journalArticle

Open Access

Liver disease–associated keratin 8 and 18 mutations modulate keratin acetylation and methylation

Jang, K. H., Yoon, H. N., Lee, J., Yi, H., Park, S. Y., Lee, S. Y., Lim, Y., Lee, H. J., Cho, J. W., Paik, Y. K., Hancock, W. S. & Ku, N. O., 2019 Aug 1, In : FASEB Journal. 33, 8, p. 9030-9043 14 p.

Research output: Contribution to journalArticle

1 Citation (Scopus)
2018

Intermediate filaments: The sweet side of vimentin

Snider, N. T., Ku, N. O. & Omary, M. B., 2018 Mar 7, In : eLife. 7, e35336.

Research output: Contribution to journalArticle

8 Citations (Scopus)
2017

A mutation in keratin 18 that causes caspase-digestion resistance protects homozygous transgenic mice from hepatic apoptosis and injury

Yoon, H. N., Yoon, S. Y., Hong, J. H. & Ku, N. O., 2017 Aug 1, In : Journal of cell science. 130, 15, p. 2541-2550 10 p.

Research output: Contribution to journalArticle

2 Citations (Scopus)
2014

Mutation of caspase-digestion sites in keratin 18 interferes with filament reorganization, and predisposes to hepatocyte necrosis and loss of membrane integrity

Weerasinghe, S. V. W., Ku, N. O., Altshuler, P. J., Kwan, R. & Omary, M. B., 2014 Apr, In : Journal of cell science. 127, 7, p. 1464-1475 12 p.

Research output: Contribution to journalArticle

18 Citations (Scopus)
2013

Predisposition to apoptosis in keratin 8-null liver is related to inactivation of NF-κB and SAPKs but not decreased c-Flip

Lee, J., Jang, K. H., Kim, H., Lim, Y., Kim, S., Yoon, H. N., Chung, I. K., Roth, J. & Ku, N. O., 2013 Jul 15, In : Biology Open. 2, 7, p. 695-702 8 p.

Research output: Contribution to journalArticle

8 Citations (Scopus)
2010

Characterization of in vivo keratin 19 phosphorylation on tyrosine-391

Zhou, Q., Snider, N. T., Liao, J., Li, D. H., Hong, A., Ku, N. O., Cartwright, C. A. & Bishr Omary, M., 2010 Nov 17, In : PloS one. 5, 10, e13538.

Research output: Contribution to journalArticle

9 Citations (Scopus)

Cytoskeletal keratin glycosylation protects epithelial tissue from injury

Ku, N. O., Toivola, D. M., Strnad, P. & Omary, M. B., 2010 Sep 1, In : Nature Cell Biology. 12, 9, p. 876-885 10 p.

Research output: Contribution to journalArticle

83 Citations (Scopus)
2007

Keratin 18 overexpression but not phosphorylation or filament organization blocks mouse mallory body formation

Harada, M., Strnad, P., Resurreccion, E. Z., Ku, N. O. & Omary, M. B., 2007 Jan 1, In : Hepatology. 45, 1, p. 88-96 9 p.

Research output: Contribution to journalArticle

26 Citations (Scopus)
2006

A disease- and phosphorylation-related nonmechanical function for keratin 8

Ku, N. O. & Omary, M. B., 2006 Jul 3, In : Journal of Cell Biology. 174, 1, p. 115-125 11 p.

Research output: Contribution to journalArticle

122 Citations (Scopus)

Bispecific and human disease-related anti-keratin rabbit monoclonal antibodies

Tao, G. Z., Nakamichi, I., Ku, N. O., Wang, J., Frolkis, M., Gong, X., Zhu, W., Pytela, R. & Omary, M. B., 2006 Feb 15, In : Experimental Cell Research. 312, 4, p. 411-422 12 p.

Research output: Contribution to journalArticle

15 Citations (Scopus)

Denaturing temperature selection may underestimate keratin mutation detection by DHPLC

Strnad, P., Lienau, T. C., Tao, G. Z., Ku, N. O., Magin, T. M. & Omary, M. B., 2006 May 1, In : Human mutation. 27, 5, p. 444-452 9 p.

Research output: Contribution to journalArticle

14 Citations (Scopus)
2005

Keratins as susceptibility genes for end-stage liver disease

Ku, N. O., Lim, J. K., Krams, S. M., Esquivel, C. O., Keeffe, E. B., Wright, T. L., Parry, D. A. D. & Omary, M. B., 2005 Sep, In : Gastroenterology. 129, 3, p. 885-893 9 p.

Research output: Contribution to journalArticle

54 Citations (Scopus)
2004

Keratin 8 and 18 hyperphosphorylation is a marker of progression of human liver disease

Toivola, D. M., Ku, N. O., Resurreccion, E. Z., Nelson, D. R., Wright, T. L. & Omary, M. B., 2004 Aug 1, In : Hepatology. 40, 2, p. 459-466 8 p.

Research output: Contribution to journalArticle

69 Citations (Scopus)

Raf-1 activation disrupts its binding to keratins during cell stress

Ku, N. O., Fu, H. & Omary, M. B., 2004 Aug 16, In : Journal of Cell Biology. 166, 4, p. 479-485 7 p.

Research output: Contribution to journalArticle

42 Citations (Scopus)
2003

Keratin 8 and 18 mutations are risk factors for developing liver disease of multiple etiologies

Ku, N. O., Darling, J. M., Krams, S. M., Esquivel, C. O., Keeffe, E. B., Sibley, R. K., Lee, Y. M., Wright, T. L. & Omary, M. B., 2003 May 13, In : Proceedings of the National Academy of Sciences of the United States of America. 100, 10, p. 6063-6068 6 p.

Research output: Contribution to journalArticle

83 Citations (Scopus)

Keratin mutation in transgenic mice predisposes to Fas but not TNF-induced apoptosis and massive liver injury

Ku, N. O., Soetikno, R. M. & Omary, M. B., 2003 May 1, In : Hepatology. 37, 5, p. 1006-1014 9 p.

Research output: Contribution to journalArticle

81 Citations (Scopus)
2002

Keratin 8 phosphorylation by p38 kinase regulates cellular keratin filament reorganization. Modulation by a keratin 1-like disease-causing mutation

Ku, N. O., Azhar, S. & Bishr Omary, M., 2002 Mar 29, In : Journal of Biological Chemistry. 277, 13, p. 10775-10782 8 p.

Research output: Contribution to journalArticle

100 Citations (Scopus)

Keratin binding to 14-3-3 proteins modulates keratin filaments and hepatocyte mitotic progression

Ku, N. O., Michie, S., Resurreccion, E. Z., Broome, R. L. & Omary, M. B., 2002 Apr 2, In : Proceedings of the National Academy of Sciences of the United States of America. 99, 7, p. 4373-4378 6 p.

Research output: Contribution to journalArticle

129 Citations (Scopus)

Keratins: Guardians of the liver

Omary, M. B., Ku, N. O. & Toivola, D. M., 2002 Jan 1, In : Hepatology. 35, 2, p. 251-257 7 p.

Research output: Contribution to journalArticle

133 Citations (Scopus)
2001

Effect of Mutation and Phosphorylation of Type I Keratins on Their Caspase-mediated Degradation

Ku, N. O. & Omary, M. B., 2001 Jul 20, In : Journal of Biological Chemistry. 276, 29, p. 26792-26798 7 p.

Research output: Contribution to journalArticle

72 Citations (Scopus)

Keratin 8 mutations in patients with cryptogenic liver disease

Ku, N. O., Gish, R., Wright, T. L. & Omary, M. B., 2001 May 24, In : New England Journal of Medicine. 344, 21, p. 1580-1587 8 p.

Research output: Contribution to journalArticle

129 Citations (Scopus)
2000

Effects of keratin filament disruption on exocrine pancreas-stimulated secretion and susceptibility to injury

Toivola, D. M., Ku, N. O., Ghori, N., Lowe, A. W., Michie, S. A. & Omary, M. B., 2000 Mar 15, In : Experimental Cell Research. 255, 2, p. 156-170 15 p.

Research output: Contribution to journalArticle

24 Citations (Scopus)

Keratins turn over by ubiquitination in a phosphorylation-modulated fashion

Ku, N. O. & Omary, M. B., 2000 May 1, In : Journal of Cell Biology. 149, 3, p. 547-552 6 p.

Research output: Contribution to journalArticle

134 Citations (Scopus)
1999

Characterization of distinct early assembly units of different intermediate filament proteins

Herrmann, H., Häner, M., Brettel, M., Ku, N. O. & Aebi, U., 1999 Mar 12, In : Journal of Molecular Biology. 286, 5, p. 1403-1420 18 p.

Research output: Contribution to journalArticle

191 Citations (Scopus)
1998

Mutation of a major keratin phosphorylation site predisposes to hepatotoxic injury in transgenic mice

Ku, N. O., Michie, S. A., Soetikno, R. M., Resurreccion, E. Z., Broome, R. L. & Bishr Omary, M., 1998 Dec 28, In : Journal of Cell Biology. 143, 7, p. 2023-2032 10 p.

Research output: Contribution to journalArticle

85 Citations (Scopus)

Phosphorylation of human keratin 18 serine 33 regulates binding to 14-3-3 proteins

Ku, N. O., Liao, J. & Omary, M. B., 1998 Apr 1, In : EMBO Journal. 17, 7, p. 1892-1906 15 p.

Research output: Contribution to journalArticle

180 Citations (Scopus)

Protein phosphatase inhibition in normal and keratin 8/18 assembly- incompetent mouse strains supports a functional role of keratin intermediate filaments in preserving hepatocyte integrity

Toivola, D. M., Omary, M. B., Ku, N. O., Peltola, O., Baribault, H. & Eriksson, J. E., 1998 Jul 13, In : Hepatology. 28, 1, p. 116-128 13 p.

Research output: Contribution to journalArticle

61 Citations (Scopus)
1997

Apoptosis generates stable fragments of human type I keratins

Ku, N. O., Liao, J. & Omary, M. B., 1997 Dec 26, In : Journal of Biological Chemistry. 272, 52, p. 33197-33203 7 p.

Research output: Contribution to journalArticle

196 Citations (Scopus)

Mutation of human keratin 18 in association with cryptogenic cirrhosis

Ku, N. O., Wright, T. L., Terrault, N. A., Gish, R. & Omary, M. B., 1997 Jan 1, In : Journal of Clinical Investigation. 99, 1, p. 19-23 5 p.

Research output: Contribution to journalArticle

95 Citations (Scopus)
89 Citations (Scopus)

Stress, apoptosis, and mitosis induce phosphorylation of human keratin 8 at Ser-73 in tissues and cultured cells

Liao, J., Ku, N. O. & Omary, M. B., 1997 Aug 5, In : Journal of Biological Chemistry. 272, 28, p. 17565-17573 9 p.

Research output: Contribution to journalArticle

101 Citations (Scopus)
1996

Susceptibility to hepatotoxicity in transgenic mice that express a dominant-negative human keratin 18 mutant

Ku, N. O., Michie, S. A., Soetikno, R. M., Resurreccion, E. Z., Broome, R. L., Oshima, R. G. & Omary, M. B., 1996 Aug 15, In : Journal of Clinical Investigation. 98, 4, p. 1034-1046 13 p.

Research output: Contribution to journalArticle

103 Citations (Scopus)
1995

Chronic hepatitis, hepatocyte fragility, and increased soluble phosphoglycokeratins in transgenic mice expressing a keratin 18 conserved arginine mutant

Ku, N. O., Michie, S., Oshima, R. G. & Omary, M. B., 1995 Dec 1, In : Journal of Cell Biology. 131, 5, p. 1303-1314 12 p.

Research output: Contribution to journalArticle

134 Citations (Scopus)

Dynamics of human keratin 18 phosphorylation: Polarized distribution of phosphorylated keratins in simple epithelial tissues

Liao, J., Lowthert, L. A., Ku, N. O., Fernandez, R. & Omary, M. B., 1995 Dec 1, In : Journal of Cell Biology. 131, 5, p. 1291-1301 11 p.

Research output: Contribution to journalArticle

72 Citations (Scopus)

Empigen BB: A useful detergent for solubilization and biochemical analysis of keratins

Lowthert, L. A., Ku, N. O., Liao, J., Coulombe, P. A. & Omary, M. B., 1995 Jan 5, In : Biochemical and Biophysical Research Communications. 206, 1, p. 370-379 10 p.

Research output: Contribution to journalArticle

39 Citations (Scopus)

Identification and mutational analysis of the glycosylation sites of human keratin 18

Ku, N. O. & Omary, M. B., 1995 Jan 1, In : Journal of Biological Chemistry. 270, 20, p. 11820-11827 8 p.

Research output: Contribution to journalArticle

56 Citations (Scopus)
1994

Expression, glycosylation, and phosphorylation of human keratins 8 and 18 in insect cells

Ku, N. O. & Omary, M. B., 1994 Mar, In : Experimental Cell Research. 211, 1, p. 24-35 12 p.

Research output: Contribution to journalArticle

46 Citations (Scopus)
84 Citations (Scopus)
1993

Cloning and tissue-specific expression of the gene for mouse C-reactive protein

Ku, N. O. & Mortensen, R. F., 1993 Jan 1, In : Biochemical Journal. 295, 2, p. 379-386 8 p.

Research output: Contribution to journalArticle

12 Citations (Scopus)

The mouse C-reactive protein (CRP) gene is expressed in response to IL-1 but not IL-6

Ku, N. O. & Mortensen, R. F., 1993 Jan 1, In : Cytokine. 5, 4, p. 319-326 8 p.

Research output: Contribution to journalArticle

16 Citations (Scopus)
1990

IL-1 and IL-6 mediate increased production and synthesis by hepatocytes of acute-phase reactant mouse serum amyloid P-component (SAP)

Lin, B. F., Ku, N. O., Zahedi, K., Whitehead, A. S. & Mortensen, R. F., 1990 Jun 1, In : Inflammation. 14, 3, p. 297-313 17 p.

Research output: Contribution to journalArticle

29 Citations (Scopus)

Regulation of cytokine-induced human C-reactive protein production by transforming growth factor-β1

Taylor, A. W., Ku, N. O. & Mortensen, R. F., 1990 Jan 1, In : Journal of Immunology. 145, 8, p. 2507-2513 7 p.

Research output: Contribution to journalArticle

53 Citations (Scopus)
1989

Both Human IL‐1 and IL‐6 Induce Synthesis of C‐Reactive Protein (CRP) by the PLC/PRF/5 Hepatoma Cell Line

TAYLOR, ANDREW. W., KU, NAMON. O. & MORTENSEN, RICHARD. F., 1989 Jun, In : Annals of the New York Academy of Sciences. 557, 1, p. 532-533 2 p.

Research output: Contribution to journalArticle

2 Citations (Scopus)

Induction of Hepatocyte Synthesis of the Mouse Acute Phase Protein Serum Amyloid P‐Component (SAP) by IL‐1 and IL‐6

LIN, BIHFEN. F., KU, NAMON. O., ZAHEDI, KAMYAR., WHITEHEAD, ALEXANDER. S. & MORTENSEN, RICHARD. F., 1989 Jun, In : Annals of the New York Academy of Sciences. 557, 1, p. 534-535 2 p.

Research output: Contribution to journalArticle

2 Citations (Scopus)