• 5026 Citations
  • 33 h-Index
19982020

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2020

Peripheral natural killer cells and myeloid-derived suppressor cells correlate with anti-PD-1 responses in non-small cell lung cancer

Youn, J. I., Park, S. M., Park, S., Kim, G., Lee, H. J., Son, J., Hong, M. H., Ghaderpour, A., Baik, B., Islam, J., Choi, J. W., Lee, E. Y., Kim, H. R., Seo, S. U., Paik, S., Yoon, H. I., Jung, I., Xin, C. F., Jin, H. T., Cho, B. C. & 3 others, Seong, S. Y., Ha, S. J. & Kim, H. R., 2020 Dec 1, In : Scientific reports. 10, 1, 9050.

Research output: Contribution to journalArticle

Open Access

Single-cell transcriptome analysis reveals TOX as a promoting factor for T cell exhaustion and a predictor for anti-PD-1 responses in human cancer

Kim, K., Park, S., Park, S. Y., Kim, G., Park, S. M., Cho, J. W., Kim, D. H., Park, Y. M., Koh, Y. W., Kim, H. R., Ha, S. J. & Lee, I., 2020 Feb 28, In : Genome Medicine. 12, 1, 22.

Research output: Contribution to journalArticle

Open Access
1 Citation (Scopus)
2019

Biosynthesis of Nonimmunosuppressive FK506 Analogues with Antifungal Activity

Beom, J. Y., Jung, J. A., Lee, K. T., Hwangbo, A., Song, M. C., Lee, Y., Lee, S. J., Oh, J. H., Ha, S. J., Nam, S. J., Cheong, E., Bahn, Y. S. & Yoon, Y. J., 2019 Aug 23, In : Journal of Natural Products. 82, 8, p. 2078-2086 9 p.

Research output: Contribution to journalArticle

Open Access
2 Citations (Scopus)

CD160 serves as a negative regulator of NKT cells in acute hepatic injury

Kim, T. J., Park, G., Kim, J., Lim, S. A., Kim, J., Im, K., Shin, M. H., Fu, Y. X., Del Rio, M. L., Rodriguez-Barbosa, J. I., Yee, C., Suh, K. S., Kim, S. J., Ha, S. J. & Lee, K. M., 2019 Dec 1, In : Nature communications. 10, 1, 3258.

Research output: Contribution to journalArticle

Open Access
2 Citations (Scopus)

IL-15 generates IFN-γ-producing cells reciprocally expressing lymphoid-myeloid markers during dendritic cell differentiation

Kwon, K. W., Kim, S. J., Kim, H., Kim, W. S., Kang, S. M., Choi, E., Ha, S. J., Yoon, J. H. & Shin, S. J., 2019 Jan 1, In : International Journal of Biological Sciences. 15, 2, p. 464-480 17 p.

Research output: Contribution to journalArticle

1 Citation (Scopus)

Metabolic reprogramming by the excessive AMPK activation exacerbates antigen-specific memory CD8+ t cell differentiation after acute lymphocytic choriomeningitis virus infection

Son, J., Cho, Y. W., Woo, Y. J., Baek, Y. A., Kim, E. J., Cho, Y., Kim, J. Y., Kim, B. S., Song, J. J. & Ha, S. J., 2019 Apr, In : Immune Network. 19, 2, e11.

Research output: Contribution to journalArticle

Monocyte-derived dendritic cells dictate the memory differentiation of CD8+ T cells during acute infection

Shin, K. S., Jeon, I., Kim, B. S., Kim, I. K., Park, Y. J., Koh, C. H., Song, B., Lee, J. M., Lim, J., Bae, E. A., Seo, H., Ban, Y. H., Ha, S. J. & Kang, C. Y., 2019, In : Frontiers in Immunology. 10, AUG, 1887.

Research output: Contribution to journalArticle

Open Access

Structural Study of Monomethyl Fumarate-Bound Human GAPDH

Park, J. B., Park, H., Son, J., Ha, S. J. & Cho, H. S., 2019 Aug 31, In : Molecules and cells. 42, 8, p. 597-603 7 p.

Research output: Contribution to journalArticle

2 Citations (Scopus)

Sustained type I interferon reinforces NK cell–mediated cancer immunosurveillance during chronic virus infection

Oh, J. H., Kim, M. J., Choi, S. J., Ban, Y. H., Lee, H. K., Shin, E. C., Lee, K. M. & Ha, S. J., 2019 Apr, In : Cancer Immunology Research. 7, 4, p. 584-599 16 p.

Research output: Contribution to journalArticle

Open Access
4 Citations (Scopus)

The R229Q mutation of Rag2 does not characterize severe immunodeficiency in mice

Jin, Y., Lee, A., Oh, J. H., Lee, H. W. & Ha, S. J., 2019 Dec 1, In : Scientific reports. 9, 1, 4415.

Research output: Contribution to journalArticle

Open Access
1 Citation (Scopus)

Tumor microenvironment dictates regulatory T cell phenotype: Upregulated immune checkpoints reinforce suppressive function

Kim, H. R., Park, H. J., Son, J., Lee, J. G., Chung, K. Y., Cho, N. H., Shim, H. S., Park, S., Kim, G., In Yoon, H., Kim, H. G., Jung, Y. W., Cho, B. C., Park, S. Y., Rha, S. Y. & Ha, S. J., 2019 Dec 4, In : Journal for ImmunoTherapy of Cancer. 7, 1, 339.

Research output: Contribution to journalArticle

Open Access
3 Citations (Scopus)
2018

MicroRNA-150 controls differentiation of intraepithelial lymphocytes through TGF-β receptor II regulation

Seo, S. H., Jang, M. S., Kim, D. J., Kim, S. M., Oh, S. C., Jung, C. R., Park, Y., Ha, S. J., Jung, H., Park, Y. J., Yoon, S. R., Choi, I. & Kim, T. D., 2018 Apr, In : Journal of Allergy and Clinical Immunology. 141, 4, p. 1382-1394.e14

Research output: Contribution to journalArticle

2 Citations (Scopus)

Regulation of chitinase-3-like-1 in T cell elicits Th1 and cytotoxic responses to inhibit lung metastasis

Kim, D. H., Park, H. J., Lim, S., Koo, J. H., Lee, H. G., Choi, J. O., Oh, J. H., Ha, S. J., Kang, M. J., Lee, C. M., Lee, C. G., Elias, J. A. & Choi, J. M., 2018 Dec 1, In : Nature communications. 9, 1, 503.

Research output: Contribution to journalArticle

Open Access
17 Citations (Scopus)
2017

Concordance of programmed death-ligand 1 expression between primary and metastatic non-small cell lung cancer by immunohistochemistry and RNA in situ hybridization

Kim, H. R., Cha, Y. J., Hong, M. H., Gandhi, M., Levinson, S., Jung, I., Lee, J. G., Lee, C. Y., Cho, B. C., Ha, S. J. & Shim, H. S., 2017, In : Oncotarget. 8, 50, p. 87234-87243 10 p.

Research output: Contribution to journalArticle

7 Citations (Scopus)

Decreased ex vivo production of interferon-gamma is associated with severity and poor prognosis in patients with lupus

Ahn, S. S., Park, E. S., Shim, J. S., Ha, S. J., Kim, B. S., Jung, S. M., Lee, S. W., Park, Y. B. & Song, J. J., 2017 Aug 25, In : Arthritis Research and Therapy. 19, 1, 193.

Research output: Contribution to journalArticle

5 Citations (Scopus)

MicroRNA-150 modulates intracellular Ca 2+ levels in naïve CD8+ T cells by targeting TMEM20

Kim, T. D., Jung, H. R., Seo, S. H., Oh, S. C., Ban, Y., Tan, X., Min Kim, J., Hyun Lee, S., Koh, D. S., Jung, H., Park, Y. J., Ran Yoon, S., Doh, J., Ha, S. J., Choi, I. & Greenberg, P. D., 2017 Dec 1, In : Scientific reports. 7, 1, 2623.

Research output: Contribution to journalArticle

6 Citations (Scopus)

miR-150-Mediated Foxo1 Regulation Programs CD8+ T Cell Differentiation

Ban, Y. H., Oh, S. C., Seo, S. H., Kim, S. M., Choi, I. P., Greenberg, P. D., Chang, J., Kim, T. D. & Ha, S. J., 2017 Sep 12, In : Cell Reports. 20, 11, p. 2598-2611 14 p.

Research output: Contribution to journalArticle

13 Citations (Scopus)

Semi-functional quantitative flow cytometry assay for lymphocytic choriomeningitis virus titration

Ban, Y. H. & Ha, S. J., 2017 Oct, In : Immune Network. 17, 5, p. 307-316 10 p.

Research output: Contribution to journalArticle

TLR2 contributes to trigger immune response of pleural mesothelial cells against Mycobacterium bovis BCG and M. tuberculosis infection

Hwanga, E. H., Kim, T. H., Park, J. Y., Hong, J. J., Kim, D. H., Ha, S. J., Yang, S. J., Shin, S. J. & Park, J. H., 2017 Jul 1, In : Cytokine. 95, p. 80-87 8 p.

Research output: Contribution to journalArticle

2 Citations (Scopus)
2016

Altered biological potential and radioresponse of murine tumors in different microenvironments

Lee, I. J., Lee, E. J., Park, H., Kim, W., Ha, S. J., Shin, Y. K. & Seong, J., 2016 Apr 1, In : Cancer Research and Treatment. 48, 2, p. 727-737 11 p.

Research output: Contribution to journalArticle

1 Citation (Scopus)

Cell Type Preference of a Novel Human Derived Cell-Permeable Peptide dNP2 and TAT in Murine Splenic Immune Cells

Lim, S., Lee, J. A., Koo, J. H., Kang, T. G., Ha, S. J. & Choi, J. M., 2016 May 1, In : PloS one. 11, 5, e0155689.

Research output: Contribution to journalArticle

9 Citations (Scopus)

Cisplatin induces tolerogenic dendritic cells in response to TLR agonists via the abundant production of IL-10, thereby promoting Th2- and Tr1-biased T-cell immunity

Kim, W. S., Kim, H., Kwon, K. W., Im, S. H., Lee, B. R., Ha, S. J. & Shin, S. J., 2016 Jun 7, In : Oncotarget. 7, 23, p. 33765-33782 18 p.

Research output: Contribution to journalArticle

14 Citations (Scopus)

Combination of TLR1/2 and TLR3 ligands enhances CD4+ T cell longevity and antibody responses by modulating type i IFN production

Lee, B. R., Jeong, S. K., Ahn, B. C., Lee, B. J., Shin, S. J., Yum, J. S. & Ha, S. J., 2016 Sep 1, In : Scientific reports. 6, 32526.

Research output: Contribution to journalArticle

7 Citations (Scopus)

Effect of IL-4 on the development and function of memory-like CD8 T cells in the peripheral lymphoid tissues

Park, H. J., Lee, A., Lee, J. I., Park, S. H., Ha, S. J. & Jung, K. C., 2016, In : Immune Network. 16, 2, p. 126-133 8 p.

Research output: Contribution to journalArticle

7 Citations (Scopus)

PD-L1 expression on immune cells, but not on tumor cells, is a favorable prognostic factor for head and neck cancer patients

Kim, H. R., Ha, S. J., Hong, M. H., Heo, S. J., Koh, Y. W., Choi, E. C., Kim, E. K., Pyo, K. H., Jung, I., Seo, D., Choi, J., Cho, B. C. & Yoon, S. O., 2016 Nov 14, In : Scientific reports. 6, 36956.

Research output: Contribution to journalArticle

110 Citations (Scopus)
1 Citation (Scopus)
2015

AMI GO2, a novel membrane anchor of PDK1, controls cell survival and angiogenesis via Akt activation

Park, H., Lee, S., Shrestha, P., Kim, J., Park, J. A., Ko, Y., Ban, Y. H., Park, D. Y., Ha, S. J., Koh, G. Y., Hong, V. S., Mochizuki, N., Kim, Y. M., Lee, W. & Kwon, Y. G., 2015 Nov 1, In : Journal of Cell Biology. 211, 3, p. 619-637 19 p.

Research output: Contribution to journalArticle

23 Citations (Scopus)

A small molecule inhibitor for ATPase activity of Hsp70 and Hsc70 enhances the immune response to protein antigens

Baek, K. H., Zhang, H., Lee, B. R., Kwon, Y. G., Ha, S. J. & Shin, I., 2015 Dec 3, In : Scientific reports. 5, 17642.

Research output: Contribution to journalArticle

7 Citations (Scopus)

Diagnostic performance of a cytokine and IFN-γ-induced chemokine mRNA assay after mycobacterium tuberculosis-specific antigen stimulation in whole blood from infected individuals

Kim, S., Lee, H., Kim, H., Kim, Y., Cho, J. E., Jin, H., Kim, D. Y., Ha, S. J., Kang, Y. A., Cho, S. N. & Lee, H., 2015 Jan 1, In : Journal of Molecular Diagnostics. 17, 1, p. 90-99 10 p.

Research output: Contribution to journalArticle

9 Citations (Scopus)

Discrimination between active and latent tuberculosis based on ratio of antigen-specific to mitogen-induced IP-10 production

Jeong, Y. H., Hur, Y. G., Lee, H., Kim, S., Cho, J. E., Chang, J., Shin, S. J., Lee, H., Kang, Y. A., Cho, S. N. & Ha, S. J., 2015 Feb 1, In : Journal of Clinical Microbiology. 53, 2, p. 504-510 7 p.

Research output: Contribution to journalArticle

29 Citations (Scopus)

Identification of a subnuclear body involved in sequence-specific cytokine RNA processing

Lee, S., Lee, T. A., Lee, E., Kang, S., Park, A., Kim, S. W., Park, H. J., Yoon, J. H., Ha, S. J., Park, T., Lee, J. S., Cheon, J. H. & Park, B., 2015 Jan 5, In : Nature communications. 6, 5791.

Research output: Contribution to journalArticle

12 Citations (Scopus)

IL-4 Induced Innate CD8+ T Cells Control Persistent Viral Infection

Lee, A., Park, S. P., Park, C. H., Kang, B. H., Park, S. H., Ha, S. J. & Jung, K. C., 2015, In : PLoS Pathogens. 11, 10, e1005193.

Research output: Contribution to journalArticle

17 Citations (Scopus)

PD-1 upregulated on regulatory T cells during chronic virus infection enhances the suppression of CD8+ T cell immune response via the interaction with PD-L1 expressed on CD8+ T cells

Park, H. J., Park, J. S., Jeong, Y. H., Son, J., Ban, Y. H., Lee, B. H., Chen, L., Chang, J., Chung, D. H., Choi, I. & Ha, S. J., 2015 Jun 15, In : Journal of Immunology. 194, 12, p. 5801-5811 11 p.

Research output: Contribution to journalArticle

78 Citations (Scopus)
18 Citations (Scopus)
2014

Differentiation of antigen-specific T cells with limited functional capacity during Mycobacterium tuberculosis infection

Jeong, Y. H., Jeon, B. Y., Gu, S. H., Cho, S. N., Shin, S. J., Chang, J. & Ha, S. J., 2014 Jan 1, In : Infection and Immunity. 82, 1, p. 132-139 8 p.

Research output: Contribution to journalArticle

16 Citations (Scopus)

Direct endothelial junction restoration results in significant tumor vascular normalization and metastasis inhibition in mice

Agrawal, V., Maharjan, S., Kim, K., Kim, N. J., Son, J., Lee, K., Choi, H. J., Rho, S. S., Ahn, S., Won, M. H., Ha, S. J., Koh, G. Y., Kim, Y. M., Suh, Y. G. & Kwon, Y. G., 2014, In : Oncotarget. 5, 9, p. 2761-2777 17 p.

Research output: Contribution to journalArticle

28 Citations (Scopus)

Highly efficient gene knockout in mice and zebrafish with RNA-guided endonucleases

Sung, Y. H., Kim, J. M., Kim, H. T., Lee, J., Jeon, J., Jin, Y., Choi, J. H., Ban, Y. H., Ha, S. J., Kim, C. H., Lee, H. W. & Kim, J. S., 2014 Jan, In : Genome Research. 24, 1, p. 125-131 7 p.

Research output: Contribution to journalArticle

184 Citations (Scopus)

Inhibition of IL-17A suppresses enhanced-tumor growth in low dose pre-irradiated tumor beds

Lee, E. J., Park, H. J., Lee, I. J., Kim, W. W., Ha, S. J., Suh, Y. G. & Seong, J., 2014, In : PloS one. 9, 9, e106423.

Research output: Contribution to journalArticle

11 Citations (Scopus)
2013

A phase I trial of gefitinib and nimotuzumab in patients with advanced non-small cell lung cancer (NSCLC)

Kim, S. H., Shim, H. S., Cho, J., Jeong, J. H., Kim, S. M., Hong, Y. K., Sung, J. H., Ha, S. J., Kim, H. R., Chang, H., Kim, J. H., Tania, C. & Cho, B. C., 2013 Mar 1, In : Lung Cancer. 79, 3, p. 270-275 6 p.

Research output: Contribution to journalArticle

13 Citations (Scopus)

Egr2 induced during DC development acts as an intrinsic negative regulator of DC immunogenicity

Miah, M. A., Byeon, S. E., Ahmed, M. S., Yoon, C. H., Ha, S. J. & Bae, Y. S., 2013 Sep 1, In : European Journal of Immunology. 43, 9, p. 2484-2496 13 p.

Research output: Contribution to journalArticle

15 Citations (Scopus)

Fibroblast growth factor receptor 1 gene amplification is associated with poor survival and cigarette smoking dosage in patients with resected squamous cell lung cancer

Kim, H. R., Kim, D. J., Kang, D. R., Lee, J. G., Lim, S. M., Lee, C. Y., Rha, S. Y., Bae, M. K., Lee, Y. J., Kim, S. H., Ha, S. J., Soo, R. A., Chung, K. Y., Kim, J. H., Lee, J. H., Shim, H. S. & Cho, B. C., 2013 Feb 20, In : Journal of Clinical Oncology. 31, 6, p. 731-737 7 p.

Research output: Contribution to journalArticle

131 Citations (Scopus)

Interleukin-21 is a critical cytokine for the generation of virus-specific long-lived plasma cells

Rasheed, M. A. U., Latner, D. R., Aubert, R. D., Gourley, T., Spolski, R., Davis, C. W., Langley, W. A., Ha, S. J., Ye, L., Sarkar, S., Kalia, V., Konieczny, B. T., Leonard, W. J. & Ahmed, R., 2013 Jul, In : Journal of Virology. 87, 13, p. 7737-7746 10 p.

Research output: Contribution to journalArticle

66 Citations (Scopus)

Negative Regulation of Type I IFN Expression by OASL1 Permits Chronic Viral Infection and CD8+ T-Cell Exhaustion

Lee, M. S., Park, C. H., Jeong, Y. H., Kim, Y. J. & Ha, S. J., 2013 Jul, In : PLoS Pathogens. 9, 7, e1003478.

Research output: Contribution to journalArticle

33 Citations (Scopus)

PD-L1 blockade synergizes with IL-2 therapy in reinvigorating exhausted T cells

West, E. E., Jin, H. T., Rasheed, A. U., Penaloza-MacMaster, P., Ha, S. J., Tan, W. G., Youngblood, B., Freeman, G. J., Smith, K. A. & Ahmed, R., 2013 Jun 3, In : Journal of Clinical Investigation. 123, 6, p. 2604-2615 12 p.

Research output: Contribution to journalArticle

141 Citations (Scopus)

The impact of cigarette smoking on the frequency of and qualitative differences in KRAS mutations in Korean patients with lung adenocarcinoma

Kim, H. R., Ahn, J. R., Lee, J. G., Bang, D. H., Ha, S. J., Hong, Y. K., Kim, S. M., Nam, K. C., Rha, S. Y., Soo, R. A., Riely, G. J., Kim, J. H. & Cho, B. C., 2013 Jul, In : Yonsei medical journal. 54, 4, p. 865-874 10 p.

Research output: Contribution to journalArticle

15 Citations (Scopus)
2012

Activation of IL-6R/JAK1/STAT3 signaling induces De Novo resistance to irreversible EGFR inhibitors in non-small cell lung cancer with T790M resistance mutation

Kim, S. M., Kwon, O. J., Hong, Y. K., Kim, J. H., Solca, F., Ha, S. J., Soo, R. A., Christensen, J. G., Lee, J. H. & Cho, B. C., 2012 Oct, In : Molecular Cancer Therapeutics. 11, 10, p. 2254-2264 11 p.

Research output: Contribution to journalArticle

122 Citations (Scopus)

Distinct clinical features and outcomes in never-smokers with nonsmall cell lung cancer who harbor EGFR or KRAS mutations or ALK rearrangement

Kim, H. R., Shim, H. S., Chung, J. H., Lee, Y. J., Hong, Y. K., Rha, S. Y., Kim, S. H., Ha, S. J., Kim, S. K., Chung, K. Y., Soo, R., Kim, J. H. & Cho, B. C., 2012 Feb 1, In : Cancer. 118, 3, p. 729-739 11 p.

Research output: Contribution to journalArticle

102 Citations (Scopus)

High EGFR gene copy number and skin rash as predictive markers for EGFR tyrosine kinase inhibitors in patients with advanced squamous cell lung carcinoma

Lee, Y., Shim, H. S., Park, M. S., Kim, J. H., Ha, S. J., Kim, S. H. & Cho, B. C., 2012 Mar 15, In : Clinical Cancer Research. 18, 6, p. 1760-1768 9 p.

Research output: Contribution to journalArticle

45 Citations (Scopus)

Mind bomb-1 in dendritic cells is specifically required for notch-mediated t helper type 2 differentiation

Jeong, H. W., Kim, J. H., Kim, J. Y., Ha, S. J. & Kong, Y. Y., 2012 Apr 27, In : PloS one. 7, 4, e36359.

Research output: Contribution to journalArticle

10 Citations (Scopus)