• 2474 Citations
  • 28 h-Index
20022020

Research output per year

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Research Output

  • 2474 Citations
  • 28 h-Index
  • 65 Article
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Article
2020

A domino annulation approach to 3,4-diacylpyrrolo[1,2-a]pyrazines: decoration of pyrazine units

Dagar, A., Seo, Y., Namkung, W. & Kim, I., 2020 May 7, In : Organic and Biomolecular Chemistry. 18, 17, p. 3324-3333 10 p.

Research output: Contribution to journalArticle

Cytotoxic sesquiterpene glucosides from Fissistigma pallens

Thinh, N. S., Bich Thu, N. T., Ngoc, T. M., Khoi, N. M., Tai, B. H., Van Kiem, P., Van Minh, C., Nhiem, N. X., Seo, Y., Namkung, W., Park, S. J. & Kim, S. H., 2020 Apr, In : Phytochemistry. 172, 112255.

Research output: Contribution to journalArticle

1 Citation (Scopus)
1 Citation (Scopus)

Triterpenoid glycosides from the rhizomes of Allium ascalonicum and their anoctamin-1 inhibitory activity

Mai, N. T., Dung, D. T., Nga, T. T., Xuan, V. T., Doan, V. V., Tai, B. H., Nhiem, N. X., Yen, P. H., Kiem, P. V., Seo, Y., Namkung, W., Park, S. J. & Kim, S. H., 2020 Jan 1, (Accepted/In press) In : Natural Product Research.

Research output: Contribution to journalArticle

2019

Chemical constituents from Schisandra sphenanthera and their cytotoxic activity

Mai, N. T., Doan, V. V., Lan, H. T. T., Anh, B. T. M., Hoang, N. H., Tai, B. H., Nhiem, N. X., Yen, P. H., Park, S. J., Seo, Y., Namkung, W., Kim, S. H. & Kiem, P. V., 2019 Jan 1, (Accepted/In press) In : Natural Product Research.

Research output: Contribution to journalArticle

Discovery of cycloartane-type triterpene saponins from Mussaenda glabra

Thu, V. K., Bach, N. X., Anh, L. T., Trang, D. T., Nhiem, N. X., Tai, B. H., Van Kiem, P., Van Minh, C., Park, S. J., Seo, Y., Namkung, W. & Kim, S. H., 2019 Oct, In : Phytochemistry Letters. 33, p. 39-45 7 p.

Research output: Contribution to journalArticle

2 Citations (Scopus)

Novel pendrin inhibitor attenuates airway hyperresponsiveness and mucin expression in experimental murine asthma

Park, J., Lee, H. J., Song, D., Gi, M., Jo, S., Jeon, D. K., Seo, Y., Kim, B., Lee, H., Namkung, W., Han, G. & Choi, J. Y., 2019 Nov, In : Journal of Allergy and Clinical Immunology. 144, 5, p. 1425-1428.e12

Research output: Contribution to journalArticle

1 Citation (Scopus)

Quercetin 3-O-xyloside ameliorates acute pancreatitis in vitro via the reduction of ER stress and enhancement of apoptosis

Seo, J. Y., Pandey, R. P., Lee, J., Sohng, J. K., Namkung, W. & Park, Y. I., 2019 Mar 1, In : Phytomedicine. 55, p. 40-49 10 p.

Research output: Contribution to journalArticle

6 Citations (Scopus)

Rare KCNQ4 variants found in public databases underlie impaired channel activity that may contribute to hearing impairment

Jung, J., Lin, H., Koh, Y. I., Ryu, K., Lee, J. S., Rim, J. H., Choi, H. J., Lee, H. J., Kim, H. Y., Yu, S., Jin, H., Lee, J. H., Lee, M. G., Namkung, W., Choi, J. Y. & Gee, H. Y., 2019 Aug 1, In : Experimental and Molecular Medicine. 51, 8, 99.

Research output: Contribution to journalArticle

Open Access
2018

Synthesis and biological evaluation of novel Ani9 derivatives as potent and selective ANO1 inhibitors

Seo, Y., Kim, J., Chang, J., Kim, S. S., Namkung, W. & Kim, I., 2018 Dec 5, In : European Journal of Medicinal Chemistry. 160, p. 245-255 11 p.

Research output: Contribution to journalArticle

2 Citations (Scopus)
2017

A synthetic ion transporter that disrupts autophagy and induces apoptosis by perturbing cellular chloride concentrations

Busschaert, N., Park, S. H., Baek, K. H., Choi, Y. P., Park, J., Howe, E. N. W., Hiscock, J. R., Karagiannidis, L. E., Marques, I., Félix, V., Namkung, W., Sessler, J. L., Gale, P. A. & Shin, I., 2017 Jul 1, In : Nature chemistry. 9, 7, p. 667-675 9 p.

Research output: Contribution to journalArticle

90 Citations (Scopus)

Inhibition of ANO1 by luteolin and its cytotoxicity in human prostate cancer PC-3 cells

Seo, Y., Ryu, K., Park, J., Jeon, D. K., Jo, S., Lee, H. K. & Namkung, W., 2017 Mar, In : PloS one. 12, 3, e0174935.

Research output: Contribution to journalArticle

16 Citations (Scopus)

Synergistic mucus secretion by histamine and IL-4 through TMEM16A in airway epithelium

Kang, J. W., Lee, Y. H., Kang, M. J., Lee, H. J., Oh, R., Min, H. J., Namkung, W., Choi, J. Y., Lee, S. N., Kim, C. H., Yoon, J. H. & Cho, H. J., 2017 Sep, In : American Journal of Physiology - Lung Cellular and Molecular Physiology. 313, 3, p. L466-L476

Research output: Contribution to journalArticle

12 Citations (Scopus)
2016

Ani9, a novel potent small-molecule ANO1 inhibitor with negligible effect on ANO2

Seo, Y., Lee, H. K., Park, J., Jeon, D. K., Jo, S., Jo, M. & Namkung, W., 2016 May, In : PloS one. 11, 5, e0155771.

Research output: Contribution to journalArticle

44 Citations (Scopus)

Enzyme-Responsive Procarriers Capable of Transporting Chloride Ions across Lipid and Cellular Membranes

Choi, Y. R., Lee, B., Park, J., Namkung, W. & Jeong, K. S., 2016 Nov 30, In : Journal of the American Chemical Society. 138, 47, p. 15319-15322 4 p.

Research output: Contribution to journalArticle

12 Citations (Scopus)

Generation of ΔF508-CFTR T84 cell lines by CRISPR/Cas9-mediated genome editing

Chung, W. Y., Song, M., Park, J., Namkung, W., Lee, J., Kim, H., Lee, M. G. & Kim, J. Y., 2016 Dec 1, In : Biotechnology Letters. 38, 12, p. 2023-2034 12 p.

Research output: Contribution to journalArticle

3 Citations (Scopus)

Potentiation of Δf508- and G551D-CFTR-mediated Cl- current by novel hydroxypyrazolines

Park, J., Khloya, P., Seo, Y., Kumar, S., Lee, H. K., Jeon, D. K., Jo, S., Sharma, P. K. & Namkung, W., 2016 Feb, In : PloS one. 11, 2, e0149131.

Research output: Contribution to journalArticle

6 Citations (Scopus)
2015

Benzopyrimido-pyrrolo-oxazine-dione (R)-BPO-27 inhibits CFTR chloride channel gating by competition with ATP

Kim, Y., Anderson, M. O., Park, J., Lee, M. G., Namkung, W. & Verkman, A. S., 2015 Oct 1, In : Molecular pharmacology. 88, 4, p. 689-696 8 p.

Research output: Contribution to journalArticle

9 Citations (Scopus)

Inhibition of ANO1/TMEM16A chloride channel by idebenone and its cytotoxicity to cancer cell lines

Seo, Y., Park, J., Kim, M., Lee, H. K., Kim, J. H., Jeong, J. H. & Namkung, W., 2015 Jul 21, In : PloS one. 10, 7, e0133656.

Research output: Contribution to journalArticle

28 Citations (Scopus)

Synthetic aminopyrrolic receptors have apoptosis inducing activity

Park, S. H., Choi, Y. P., Park, J., Share, A., Francesconi, O., Nativi, C., Namkung, W., Sessler, J. L., Roelens, S. & Shin, I., 2015 Jan 1, In : Chemical Science. 6, 12, p. 7284-7292 9 p.

Research output: Contribution to journalArticle

14 Citations (Scopus)

Thick airway surface liquid volume and weak mucin expression in pendrin-deficient human airway epithelia

Lee, H. J., Yoo, J. E., Namkung, W., Cho, H. J., Kim, K., Kang, J. W., Yoon, J. H. & Choi, J. Y., 2015 Jan 1, In : Physiological Reports. 3, 8, e12480.

Research output: Contribution to journalArticle

15 Citations (Scopus)
2014

Anchored PDE4 regulates chloride conductance in wild-type and Δf508-CFTR human airway epithelia

Blanchard, E., Zlock, L., Lao, A., Mika, D., Namkung, W., Xie, M., Scheitrum, C., Gruenert, D. C., Verkman, A. S., Finkbeiner, W. E., Conti, M. & Richter, W., 2014 Feb, In : FASEB Journal. 28, 2, p. 791-801 11 p.

Research output: Contribution to journalArticle

11 Citations (Scopus)

Azobenzene-based chloride transporters with light-controllable activities

Choi, Y. R., Kim, G. C., Jeon, H. G., Park, J., Namkung, W. & Jeong, K. S., 2014 Nov 11, In : Chemical Communications. 50, 97, p. 15305-15308 4 p.

Research output: Contribution to journalArticle

22 Citations (Scopus)

Chloride channel inhibition by a red wine extract and a synthetic small molecule prevents rotaviral secretory diarrhoea in neonatal mice

Ko, E. A., Jin, B. J., Namkung, W., Ma, T., Thiagarajah, J. R. & Verkman, A. S., 2014 Jul, In : Gut. 63, 7, p. 1120-1129 10 p.

Research output: Contribution to journalArticle

39 Citations (Scopus)

Developmental changes of ENaC expression and function in the inner ear of pendrin knock-out mice as a perspective on the development of endolymphatic hydrops

Kim, B. G., Kim, J. Y., Kim, H. N., Bok, J., Namkung, W., Choi, J. Y. & Kim, S. H., 2014 Apr 21, In : PloS one. 9, 4, e95730.

Research output: Contribution to journalArticle

7 Citations (Scopus)

Imidazole-based small molecules that promote neurogenesis in pluripotent cells

Kim, G. H., Halder, D., Park, J., Namkung, W. & Shin, I., 2014 Aug 25, In : Angewandte Chemie - International Edition. 53, 35, p. 9271-9274 4 p.

Research output: Contribution to journalArticle

19 Citations (Scopus)

Shank2 mutant mice display a hypersecretory response to cholera toxin

Jung, E. S., Park, J., Gee, H. Y., Jung, J., Noh, S. H., Lee, J. S., Richter, W., Namkung, W. & Lee, M. G., 2014 Apr 15, In : Journal of Physiology. 592, 8, p. 1809-1821 13 p.

Research output: Contribution to journalArticle

2 Citations (Scopus)

Synthetic ion transporters can induce apoptosis by facilitating chloride anion transport into cells

Ko, S. K., Kim, S. K., Share, A., Lynch, V. M., Park, J., Namkung, W., Van Rossom, W., Busschaert, N., Gale, P. A., Sessler, J. L. & Shin, I., 2014 Oct 1, In : Nature chemistry. 6, 10, p. 885-892 8 p.

Research output: Contribution to journalArticle

167 Citations (Scopus)
2013

A comparison of Ypet and firefly luciferase as reporter proteins for high-throughput screening

Yoon, S. M., Namkung, W. & Lee, J., 2013 Dec 6, In : Bioscience, Biotechnology and Biochemistry. 77, 11, p. 2328-2330 3 p.

Research output: Contribution to journalArticle

3 Citations (Scopus)

Microfluidics platform for single-shot dose-response analysis of chloride channel-modulating compounds

Jin, B. J., Ko, E. A., Namkung, W. & Verkman, A. S., 2013 Oct 7, In : Lab on a chip. 13, 19, p. 3862-3867 6 p.

Research output: Contribution to journalArticle

7 Citations (Scopus)
12 Citations (Scopus)
2012

Fractionation of a herbal antidiarrheal medicine reveals Eugenol as an inhibitor of Ca2+-activated Cl- channel TMEM16A

Yao, Z., Namkung, W., Ko, E. A., Park, J., Tradtrantip, L. & Verkman, A. S., 2012 May 30, In : PloS one. 7, 5, e38030.

Research output: Contribution to journalArticle

29 Citations (Scopus)

Novel 5-substituted benzyloxy-2-arylbenzofuran-3-carboxylic acids as calcium activated chloride channel inhibitors

Kumar, S., Namkung, W., Verkman, A. S. & Sharma, P. K., 2012 Jul 15, In : Bioorganic and Medicinal Chemistry. 20, 14, p. 4237-4244 8 p.

Research output: Contribution to journalArticle

29 Citations (Scopus)
2011

Small-molecule activators of TMEM16A, a calcium-activated chloride channel, stimulate epithelial chloride secretion and intestinal contraction

Namkung, W., Yao, Z., Finkbeiner, W. E. & Verkman, A. S., 2011 Nov 1, In : FASEB Journal. 25, 11, p. 4048-4062 15 p.

Research output: Contribution to journalArticle

112 Citations (Scopus)

TMEM16A inhibitors reveal TMEM16A as a minor component of calcium-activated chloride channel conductance in airway and intestinal epithelial cells

Namkung, W., Phuan, P. W. & Verkman, A. S., 2011 Jan 21, In : Journal of Biological Chemistry. 286, 3, p. 2365-2374 10 p.

Research output: Contribution to journalArticle

229 Citations (Scopus)
2010

CFTR-adenylyl cyclase I association responsible for UTP activation of CFTR in well-differentiated primary human bronchial cell cultures

Namkung, W., Finkbeiner, W. E. & Verkman, A. S., 2010 Aug 1, In : Molecular Biology of the Cell. 21, 15, p. 2639-2648 10 p.

Research output: Contribution to journalArticle

43 Citations (Scopus)

Crofelemer, an antisecretory antidiarrheal proanthocyanidin oligomer extracted from Croton lechleri, targets two distinct intestinal chloride channels

Tradtrantip, L., Namkung, W. & Verkman, A. S., 2010 Jan 1, In : Molecular pharmacology. 77, 1, p. 69-78 10 p.

Research output: Contribution to journalArticle

79 Citations (Scopus)

Dynamic regulation of CFTR bicarbonate permeability by [Cl -]i and its role in pancreatic bicarbonate secretion

Park, H. W., Nam, J. H., Kim, J. Y., Namkung, W., Yoon, J. S., Lee, J. S., Kim, K. S., Venglovecz, V., Gray, M. A., Kim, K. H. & Lee, M. G., 2010, In : Gastroenterology. 139, 2, p. 620-631 12 p.

Research output: Contribution to journalArticle

120 Citations (Scopus)

Inhibition of Ca2+-activated Cl- channels by gallotannins as a possible molecular basis for health benefits of red wine and green tea

Namkung, W., Thiagarajah, J. R., Phuan, P. W. & Verkman, A. S., 2010 Nov 1, In : FASEB Journal. 24, 11, p. 4178-4186 9 p.

Research output: Contribution to journalArticle

126 Citations (Scopus)
2009

Airway surface liquid depth measured in ex vivo fragments of pig and human trachea: Dependence on Na+ and Cl- channel function

Song, Y., Namkung, W., Nielson, D. W., Lee, J. W., Finkbeiner, W. E. & Verkman, A. S., 2009 Dec 1, In : American Journal of Physiology - Lung Cellular and Molecular Physiology. 297, 6, p. L1131-L1140

Research output: Contribution to journalArticle

42 Citations (Scopus)

In situ measurement of airway surface liquid [K+] using a ratioable K+-sensitive fluorescent dye

Namkung, W., Song, Y., Mills, A. D., Padmawar, P., Finkbeiner, W. E. & Verkman, A. S., 2009 Jun 5, In : Journal of Biological Chemistry. 284, 23, p. 15916-15926 11 p.

Research output: Contribution to journalArticle

30 Citations (Scopus)

Nanomolar potency pyrimido-pyrrolo-quinoxalinedione CFTR inhibitor reduces cyst size in a polycystic kidney disease model

Tradtrantip, L., Sonawane, N. D., Wan, N. & Verkman, A. S., 2009 Oct 22, In : Journal of Medicinal Chemistry. 52, 20, p. 6447-6455 9 p.

Research output: Contribution to journalArticle

67 Citations (Scopus)

Synaptic Scaffolding Molecule Binds to and Regulates Vasoactive Intestinal Polypeptide Type-1 Receptor in Epithelial Cells

Gee, H. Y., Kim, Y. W., Jo, M. J., Namkung, W., Kim, J. Y., Park, H. W., Kim, K. S., Kim, H., Baba, A., Yang, J., Kim, E., Kim, K. H. & Lee, M. G., 2009 Aug, In : Gastroenterology. 137, 2, p. 607-617.e4

Research output: Contribution to journalArticle

24 Citations (Scopus)

The role of translation elongation factor eEF1A in intracellular alkalinization-induced tumor cell growth

Kim, J., Namkung, W., Yoon, J. S., Jo, M. J., Lee, S. H., Kim, K. H., Kim, J. Y. & Lee, M. G., 2009 Aug 1, In : Laboratory Investigation. 89, 8, p. 867-874 8 p.

Research output: Contribution to journalArticle

18 Citations (Scopus)
2008

Cell-based fluorescence screen for K+ channels and transporters using an extracellular triazacryptand-based K+ sensor

Namkung, W., Padmawar, P., Mills, A. D. & Verkman, A. S., 2008 Jun 25, In : Journal of the American Chemical Society. 130, 25, p. 7794-7795 2 p.

Research output: Contribution to journalArticle

54 Citations (Scopus)

Heterogeneity in the processing defect of SLC26A4 mutants

Yoon, J. S., Park, H. J., Yoo, S. Y., Namkung, W., Jo, M. J., Koo, S. K., Park, H. Y., Lee, W. S., Kim, K. H. & Lee, M. G., 2008 Jul 1, In : Journal of Medical Genetics. 45, 7, p. 411-419 9 p.

Research output: Contribution to journalArticle

66 Citations (Scopus)
21 Citations (Scopus)

Small-molecule screen identifies inhibitors of a human intestinal calcium-activated chloride channel

De La Fuente, R., Namkung, W., Mills, A. & Verkman, A. S., 2008 Mar 1, In : Molecular pharmacology. 73, 3, p. 758-768 11 p.

Research output: Contribution to journalArticle

128 Citations (Scopus)

α-aminoazaheterocyclic-methylglyoxal adducts do not inhibit cystic fibrosis transmembrane conductance regulator chloride channel activity

Sonawane, N. D., Zegarra-Moran, O., Namkung, W., Galietta, L. J. V. & Verkman, A. S., 2008 May 1, In : Journal of Pharmacology and Experimental Therapeutics. 325, 2, p. 529-535 7 p.

Research output: Contribution to journalArticle

3 Citations (Scopus)
2007

Dynamic regulation of cystic fibrosis transmembrane conductance regulator by competitive interactions of molecular adaptors

Ji, H. L., Richter, W., Namkung, W., Kyung, H. K., Kim, E., Conti, M. & Min, G. L., 2007 Apr 6, In : Journal of Biological Chemistry. 282, 14, p. 10414-10422 9 p.

Research output: Contribution to journalArticle

68 Citations (Scopus)