• 1646 Citations
  • 20 h-Index
1988 …2020

Research output per year

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Research Output

  • 1646 Citations
  • 20 h-Index
  • 50 Article
  • 2 Review article
  • 1 Book
  • 1 Chapter

A conserved arginine residue in the terminal protein domain of hepatitis B virus polymerase is critical for RNA pre-genome encapsidation

Shin, Y. C., Park, S. & Ryu, W. S., 2011 Aug, In : Journal of General Virology. 92, 8, p. 1809-1816 8 p.

Research output: Contribution to journalArticle

10 Citations (Scopus)

Activated ras oncogene collaborates with HBx gene of hepatitis B virus to transform cells by suppressing HBx-mediated apoptosis

Kim, Y. C., Song, K. S., Yoon, G., Nam, M. J. & Ryu, W. S., 2001 Jan 4, In : Oncogene. 20, 1, p. 16-23 8 p.

Research output: Contribution to journalArticle

73 Citations (Scopus)

A novel cis-acting element facilitates minus-strand DNA synthesis during reverse transcription of the hepatitis B virus genome

Shin, M. K., Lee, J. & Ryu, W. S., 2004 Jun, In : Journal of Virology. 78, 12, p. 6252-6262 11 p.

Research output: Contribution to journalArticle

19 Citations (Scopus)

A novel parvovirus isolated from Manchurian chipmunks

Yoo, B. C., Lee, D. H., Park, S. M., Park, J. W., Kim, C. Y., Lee, H. S., Seo, J. S., Park, K. J. & Ryu, W. S., 1999 Jan 20, In : Virology. 253, 2, p. 250-258 9 p.

Research output: Contribution to journalArticle

19 Citations (Scopus)

Assembly of hepatitis delta virus particles

Ryu, W. S., Bayer, M. & Taylor, J., 1992, In : Journal of Virology. 66, 4, p. 2310-2315 6 p.

Research output: Contribution to journalArticle

Open Access
140 Citations (Scopus)

Association of hepatitis C virus particles with immunoglobulin: A mechanism for persistent infection

Choo, S. H., So, H. S., Cho, J. M. & Ryu, W. S., 1995 Jan 1, In : Journal of General Virology. 76, 9, p. 2337-2341 5 p.

Research output: Contribution to journalArticle

53 Citations (Scopus)
6 Citations (Scopus)

Circularization of an RNA template via long-range base pairing is critical for hepadnaviral reverse transcription

Shin, M. K., Kim, J. H., Ryu, D. K. & Ryu, W. S., 2008 Feb 20, In : Virology. 371, 2, p. 362-373 12 p.

Research output: Contribution to journalArticle

5 Citations (Scopus)

Comparative analysis of antiviral efficacy of FDA-approved drugs against SARS-CoV-2 in human lung cells

Ko, M., Jeon, S., Ryu, W. S. & Kim, S., 2020, (Accepted/In press) In : Journal of Medical Virology.

Research output: Contribution to journalArticle

Open Access

DDB1 stimulates viral transcription of hepatitis B virus via HBx-independent mechanisms

Kim, W., Lee, S., Son, Y., Ko, C. & Ryu, W. S., 2016, In : Journal of Virology. 90, 21, p. 9644-9653 10 p.

Research output: Contribution to journalArticle

6 Citations (Scopus)

DDX3 DEAD-box RNA helicase inhibits hepatitis B virus reverse transcription by incorporation into Nucleocapsids

Wang, H., Kim, S. & Ryu, W. S., 2009 Jun, In : Journal of Virology. 83, 11, p. 5815-5824 10 p.

Research output: Contribution to journalArticle

74 Citations (Scopus)

DDX3 DEAD-box RNA helicase is a host factor that restricts hepatitis B virus replication at the transcriptional Level

Ko, C., Lee, S., Windisch, M. P. & Ryu, W. S., 2014, In : Journal of Virology. 88, 23, p. 13689-13698 10 p.

Research output: Contribution to journalArticle

44 Citations (Scopus)

Development of a novel hepatitis B virus encapsidation detection assay by viral nucleocapsid-captured quantitative RT-PCR

Ryu, D. K., Ahn, Y., Ryu, W. S. & Windisch, M. P., 2015 Nov, In : BioTechniques. 59, 5, p. 287-293 7 p.

Research output: Contribution to journalArticle

2 Citations (Scopus)

Development of transgenic chickens expressing enhanced green fluorescent protein

Kwon, M. S., Koo, B. C., Choi, B. R., Lee, H. T., Kim, Y. H., Ryu, W. S., Shim, H., Kim, J. H., Kim, N. H. & Kim, T., 2004 Jul 23, In : Biochemical and Biophysical Research Communications. 320, 2, p. 442-448 7 p.

Research output: Contribution to journalArticle

35 Citations (Scopus)

Effect of a Novel Saponin Adjuvant Derived from Quillaja saponaria on the Immune Response to Recombinant Hepatitis B Surface Antigen

So, H. S., Yoon, H. S., Choi, D. Y., Kwon, Y. S., Sung, J. H., Lee, T. G., Park, E. S., Cho, H. S., Lee, B. M., Cho, J. M. & Ryu, W. S., 1997 Apr 30, In : Molecules and cells. 7, 2, p. 178-186 9 p.

Research output: Contribution to journalArticle

17 Citations (Scopus)

Effect of S267F variant of NTCP on the patients with chronic hepatitis B

Lee, H. W., Park, H. J., Jin, B., Dezhbord, M., Kim, D. Y., Han, K. H., Ryu, W. S., Kim, S. & Ahn, S. H., 2017 Dec 1, In : Scientific reports. 7, 1, 17634.

Research output: Contribution to journalArticle

8 Citations (Scopus)

Efficient long-term amplification of hepatitis B virus isolates after infection of slow proliferating HepG2-NTCP cells

König, A., Yang, J., Jo, E., Park, K. H. P., Kim, H., Than, T. T., Song, X., Qi, X., Dai, X., Park, S., Shum, D., Ryu, W. S., Kim, J. H., Yoon, S. K., Park, J. Y., Ahn, S. H., Han, K. H., Gerlich, W. H. & Windisch, M. P., 2019 Aug, In : Journal of Hepatology. 71, 2, p. 289-300 12 p.

Research output: Contribution to journalArticle

Open Access
6 Citations (Scopus)

Emergence of YMDD motif mutant of hepatitis B virus during short-term lamivudine therapy in South Korea

Paik, Y. H., Chung, H. Y., Ryu, W. S., Lee, K. S., Lee, J. S., Kim, J. H., Lee, C. K., Chon, C. Y., Moon, Y. M. & Han, K. H., 2001, In : Journal of Hepatology. 35, 1, p. 92-98 7 p.

Research output: Contribution to journalArticle

34 Citations (Scopus)

Evidence that the 5'-end cap structure is essential for encapsidation of hepatitis B virus pregenomic RNA

Jeong, J. K., Yoon, G. S. & Ryu, W. S., 2000, In : Journal of Virology. 74, 12, p. 5502-5508 7 p.

Research output: Contribution to journalArticle

48 Citations (Scopus)

Expression from herpesvirus promoters does not relieve the intron requirement for cytoplasmic accumulation of human β-globin mRNA

Yu, X. M., Gelembiuk, G. W., Wang, C. Y., Ryu, W. S. & Mertz, J. E., 1991 Dec 25, In : Nucleic acids research. 19, 25, p. 7231-7234 4 p.

Research output: Contribution to journalArticle

11 Citations (Scopus)

Factors predictive of response to interferon-α therapy in hepatitis C virus type 1b infection

Yeh, B. I., Han, K. H., Lee, H. W., Sohn, J. H., Ryu, W. S., Yoon, D. J., Yoon, J., Kim, H. W., Kong, I. D., Chang, S. J. & Choi, J. W., 2002, In : Journal of Medical Virology. 66, 4, p. 481-487 7 p.

Research output: Contribution to journalArticle

20 Citations (Scopus)

Four conserved cysteine residues of the hepatitis B virus polymerase are critical for RNA pregenome encapsidation

Kim, S., Lee, J. & Ryu, W. S., 2009 Aug, In : Journal of Virology. 83, 16, p. 8032-8040 9 p.

Research output: Contribution to journalArticle

15 Citations (Scopus)

Genetic dissection of naturally occurring basal core promoter mutations of hepatitis B virus reveals a silent phenotype in the overlapping X gene

Hussain, Z., Jung, H. S., Ryu, D. K. & Ryu, W. S., 2009, In : Journal of General Virology. 90, 9, p. 2272-2281 10 p.

Research output: Contribution to journalArticle

9 Citations (Scopus)

HBx targeting to mitochondria and ROS generation are necessary but insufficient for HBV-induced cyclooxygenase-2 expression

Lim, W., Kwon, S. H., Cho, H., Kim, S., Lee, S., Ryu, W. S. & Cho, H., 2010 Apr, In : Journal of Molecular Medicine. 88, 4, p. 359-369 11 p.

Research output: Contribution to journalArticle

44 Citations (Scopus)

Hepatitis B virus genome recycling and de novo secondary infection events maintain stable cccDNA levels

Ko, C., Chakraborty, A., Chou, W. M., Hasreiter, J., Wettengel, J. M., Stadler, D., Bester, R., Asen, T., Zhang, K., Wisskirchen, K., McKeating, J. A., Ryu, W. S. & Protzer, U., 2018 Dec, In : Journal of Hepatology. 69, 6, p. 1231-1241 11 p.

Research output: Contribution to journalArticle

34 Citations (Scopus)

Hepatitis B virus polymerase blocks pattern recognition receptor signaling via interaction with DDX3: Implications for immune evasion

Wang, H. & Ryu, W. S., 2010 Jul, In : PLoS Pathogens. 6, 7, p. 1-11 11 p., e1000986.

Research output: Contribution to journalArticle

140 Citations (Scopus)

Hepatitis B virus polymerase suppresses translation of pregenomic RNA via a mechanism involving its interaction with 5′ stem-loop structure

Ryu, D. K., Kim, S. & Ryu, W. S., 2008 Mar 30, In : Virology. 373, 1, p. 112-123 12 p.

Research output: Contribution to journalArticle

23 Citations (Scopus)

Hepatitis B virus X protein enhances Myc stability by inhibiting SCF Skp2 ubiquitin E3 ligase-mediated Myc ubiquitination and contributes to oncogenesis

Lee, S., Kim, W., Ko, C. & Ryu, W. S., 2016 Apr 7, In : Oncogene. 35, 14, p. 1857-1867 11 p.

Research output: Contribution to journalArticle

19 Citations (Scopus)

Hepatitis B virus X protein is essential for the activation of Wnt/β-catenin signaling in hepatoma cells

Cha, M. Y., Kim, C. M., Park, Y. M. & Ryu, W. S., 2004 Jun, In : Hepatology. 39, 6, p. 1683-1693 11 p.

Research output: Contribution to journalArticle

178 Citations (Scopus)

Hepatitis delta virus mutant: Effect on RNA editing

Wu, T. T., Bichko, V. V., Ryu, W. S., Lemon, S. M. & Taylor, J. M., 1995 Nov, In : Journal of Virology. 69, 11, p. 7226-7231 6 p.

Research output: Contribution to journalArticle

Open Access
20 Citations (Scopus)

Hydrophobic residues of terminal protein domain of hepatitis B virus polymerase contribute to distinct steps in viral genome replication

Shin, Y. C., Ko, C. & Ryu, W. S., 2011 Dec 15, In : FEBS Letters. 585, 24, p. 3964-3968 5 p.

Research output: Contribution to journalArticle

11 Citations (Scopus)

Identification and characterization of a novel hepatitis B virus pregenomic RNA encapsidation inhibitor

Jo, E., Ryu, D. K., König, A., Park, S., Cho, Y., Park, S. H., Kim, T. H., Yoon, S. K., Ryu, W. S., Cechetto, J. & Windisch, M. P., 2020 Mar, In : Antiviral Research. 175, 104709.

Research output: Contribution to journalArticle

3 Citations (Scopus)
11 Citations (Scopus)

Inhibition of hepatitis B virus replication by ligand-mediated activation of RNase L

Park, I. H., Kwon, Y. C., Ryu, W. S. & Ahn, B. Y., 2014 Apr, In : Antiviral Research. 104, 1, p. 118-127 10 p.

Research output: Contribution to journalArticle

11 Citations (Scopus)

Insertion and deletion mutagenesis by overlap extension PCR

Lee, J., Shin, M. K., Ryu, D. K., Kim, S. & Ryu, W. S., 2010, In Vitro Mutagenesis Protocols: Third Edition. Jeff, B. (ed.). p. 137-146 10 p. (Methods in Molecular Biology; vol. 634).

Research output: Chapter in Book/Report/Conference proceedingChapter

41 Citations (Scopus)

Molecular aspects of hepatitis B viral infection and the viral carcinogenesis

Ryu, W. S., 2003 Jan 31, In : Journal of biochemistry and molecular biology. 36, 1, p. 138-143 6 p.

Research output: Contribution to journalReview article

Open Access
16 Citations (Scopus)

Molecular Virology of Human Pathogenic Viruses

Ryu, W. S., 2016 Apr 20, Elsevier Inc. 423 p.

Research output: Book/ReportBook

8 Citations (Scopus)

Monitoring antibody titers to recombinant core-NS3 fusion polypeptide is useful for evaluating hepatitis C virus infection and responses to interferon-alpha therapy

Park, Y. M., Byun, B. H., Choi, J. Y., Bae, S. H., Kim, B. S., So, H. S. & Ryu, W. S., 1999 Apr, In : Journal of Korean medical science. 14, 2, p. 165-170 6 p.

Research output: Contribution to journalReview article

3 Citations (Scopus)

Nucleotide sequence stability of the genome of hepatitis delta virus

Netter, H. J., Wu, T. T., Bockol, M., Cywinski, A., Ryu, W. S., Tennant, B. C. & Taylor, J. M., 1995 Mar, In : Journal of Virology. 69, 3, p. 1687-1692 6 p.

Research output: Contribution to journalArticle

Open Access
36 Citations (Scopus)

Polyadenylation is dispensable for encapsidation and reverse transcription of hepatitis B viral pregenomic RNA

Lee, H. J., Lee, J., Shin, M. K. & Ryu, W. S., 2008 Jun 30, In : Molecules and cells. 25, 4, p. 545-552 8 p.

Research output: Contribution to journalArticle

4 Citations (Scopus)

Presentation of the hydrophilic domains of hepatitis C viral E2 envelope glycoprotein on hepatitis B surface antigen particles

Lee, I. H., Kim, C. H. & Ryu, W. S., 1996 Oct, In : Journal of Medical Virology. 50, 2, p. 145-151 7 p.

Research output: Contribution to journalArticle

17 Citations (Scopus)

Proximity between the cap and 5′ ε stem-loop structure is critical for the suppression of pgRNA translation by the hepatitis B viral polymerase

Ryu, D. K., Ahn, B. Y. & Ryu, W. S., 2010 Oct, In : Virology. 406, 1, p. 56-64 9 p.

Research output: Contribution to journalArticle

8 Citations (Scopus)

Residues Arg703, Asp777, and Arg781 of the rnase H domain of hepatitis B virus polymerase are critical for viral DNA synthesis

Ko, C., Shin, Y. C., Park, W. J., Kim, S., Kim, J. & Ryua, W. S., 2014 Jan, In : Journal of Virology. 88, 1, p. 154-163 10 p.

Research output: Contribution to journalArticle

16 Citations (Scopus)

Ribonucleoprotein complexes of hepatitis delta virus

Ryu, W. S., Netter, H. J., Bayer, M. & Taylor, J., 1993, In : Journal of Virology. 67, 6, p. 3281-3287 7 p.

Research output: Contribution to journalArticle

Open Access
71 Citations (Scopus)
Open Access
75 Citations (Scopus)

Stimulation of hepatitis B virus genome replication by HBx is linked to both nuclear and cytoplasmic HBx expression

Cha, M. Y., Ryu, D. K., Jung, H. S., Chang, H. E. & Ryu, W. S., 2009, In : Journal of General Virology. 90, 4, p. 978-986 9 p.

Research output: Contribution to journalArticle

47 Citations (Scopus)

The FDA-approved drug irbesartan inhibits HBV-infection in HepG2 cells stably expressing sodium taurocholate co-transporting polypeptide

Ko, C., Park, W. J., Park, S., Kim, S., Windisch, M. P. & Ryu, W. S., 2015, In : Antiviral therapy. 20, 8, p. 835-842 8 p.

Research output: Contribution to journalArticle

34 Citations (Scopus)

The late spliced 19S and 16S RNAs of simian virus 40 can be synthesized from a common pool of transcripts

Good, P. J., Welch, R. C., Ryu, W. S. & Mertz, J. E., 1988, In : Journal of Virology. 62, 2, p. 563-571 9 p.

Research output: Contribution to journalArticle

Open Access
17 Citations (Scopus)

The roles of the delta antigen in the structure and replication of hepatitis delta virus

Taylor, J., Chao, M., Hsieh, S. Y. & Wang-Shick, R., 1991, In : Journal of Hepatology. 13, SUPPL. 4, p. S119-S120

Research output: Contribution to journalArticle

8 Citations (Scopus)