• 1508 Citations
  • 20 h-Index
1988 …2019
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Research Output 1988 2019

  • 1508 Citations
  • 20 h-Index
  • 48 Article
  • 2 Review article
  • 1 Book
  • 1 Chapter
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Article
2019
1 Citation (Scopus)

Characterization of the molecular events of covalently closed circular DNA synthesis in de novo Hepatitis B virus infection of human hepatoma cells

Dezhbord, M., Lee, S., Kim, W., Seong, B. L. & Ryu, W-S., 2019 Mar 1, In : Antiviral Research. 163, p. 11-18 8 p.

Research output: Contribution to journalArticle

Circular DNA
Virus Diseases
Hepatitis B virus
Hepatocellular Carcinoma
DNA

Efficient long-term amplification of hepatitis B virus isolates after infection of slow proliferating HepG2-NTCP cells

König, A., Yang, J., Jo, E., Park, K. H. P., Kim, H., Than, T. T., Song, X., Qi, X., Dai, X., Park, S., Shum, D., Ryu, W-S., Kim, J. H., Yoon, S. K., Park, J. Y., Ahn, S. H., Han, K., Gerlich, W. H. & Windisch, M. P., 2019 Aug 1, In : Journal of Hepatology. 71, 2, p. 289-300 12 p.

Research output: Contribution to journalArticle

Open Access
Hep G2 Cells
Hepatitis B virus
Infection
Hepatovirus
Cell Culture Techniques
2018
18 Citations (Scopus)

Hepatitis B virus genome recycling and de novo secondary infection events maintain stable cccDNA levels

Ko, C., Chakraborty, A., Chou, W. M., Hasreiter, J., Wettengel, J. M., Stadler, D., Bester, R., Asen, T., Zhang, K., Wisskirchen, K., McKeating, J. A., Ryu, W-S. & Protzer, U., 2018 Dec 1, In : Journal of Hepatology. 69, 6, p. 1231-1241 11 p.

Research output: Contribution to journalArticle

Recycling
Coinfection
Hepatitis B virus
Genome
Circular DNA
2017
7 Citations (Scopus)

Effect of S267F variant of NTCP on the patients with chronic hepatitis B

Lee, H. W., Park, H. J., Jin, B., Dezhbord, M., kim, D., Han, K., Ryu, W-S., Kim, S. & Ahn, S., 2017 Dec 1, In : Scientific reports. 7, 1, 17634.

Research output: Contribution to journalArticle

Chronic Hepatitis B
Hepatitis B virus
Virus Diseases
Virus Internalization
Fibrosis
2016
5 Citations (Scopus)

DDB1 stimulates viral transcription of hepatitis B virus via HBx-independent mechanisms

Kim, W., Lee, S., Son, Y., Ko, C. & Ryu, W-S., 2016 Jan 1, In : Journal of Virology. 90, 21, p. 9644-9653 10 p.

Research output: Contribution to journalArticle

Hepatitis B virus
Viral DNA
DNA replication
DNA Replication
transcription (genetics)
15 Citations (Scopus)

Hepatitis B virus X protein enhances Myc stability by inhibiting SCF Skp2 ubiquitin E3 ligase-mediated Myc ubiquitination and contributes to oncogenesis

Lee, S., Kim, W., Ko, C. & Ryu, W-S., 2016 Apr 7, In : Oncogene. 35, 14, p. 1857-1867 11 p.

Research output: Contribution to journalArticle

Cullin Proteins
Ubiquitin-Protein Ligases
Ubiquitination
Carcinogenesis
Oncogene Proteins
2015
1 Citation (Scopus)

Development of a novel hepatitis B virus encapsidation detection assay by viral nucleocapsid-captured quantitative RT-PCR

Ryu, D. K., Ahn, Y., Ryu, W-S. & Windisch, M. P., 2015 Nov 1, In : BioTechniques. 59, 5, p. 287-293 7 p.

Research output: Contribution to journalArticle

Nucleocapsid
Viruses
Hepatitis B virus
Assays
RNA
32 Citations (Scopus)

The FDA-approved drug irbesartan inhibits HBV-infection in HepG2 cells stably expressing sodium taurocholate co-transporting polypeptide

Ko, C., Park, W. J., Park, S., Kim, S., Windisch, M. P. & Ryu, W. S., 2015 Jan 1, In : Antiviral Therapy. 20, 8, p. 835-842 8 p.

Research output: Contribution to journalArticle

irbesartan
Taurocholic Acid
Hep G2 Cells
Peptides
Infection
2014
33 Citations (Scopus)

DDX3 DEAD-box RNA helicase is a host factor that restricts hepatitis B virus replication at the transcriptional Level

Ko, C., Lee, S., Windisch, M. P. & Ryu, W-S., 2014 Jan 1, In : Journal of Virology. 88, 23, p. 13689-13698 10 p.

Research output: Contribution to journalArticle

DEAD-box RNA Helicases
Hepatitis B virus
Virus Replication
virus replication
transcription (genetics)
9 Citations (Scopus)

Inhibition of hepatitis B virus replication by ligand-mediated activation of RNase L

Park, I. H., Kwon, Y. C., Ryu, W-S. & Ahn, B. Y., 2014 Apr 1, In : Antiviral Research. 104, 1, p. 118-127 10 p.

Research output: Contribution to journalArticle

Virus Replication
Hepatitis B virus
Ligands
Antiviral Agents
Interferons
10 Citations (Scopus)

Residues Arg703, Asp777, and Arg781 of the rnase H domain of hepatitis B virus polymerase are critical for viral DNA synthesis

Ko, C., Shin, Y. C., Park, W. J., Kim, S., Kim, J. & Ryu, W-S., 2014 Jan 1, In : Journal of Virology. 88, 1, p. 154-163 10 p.

Research output: Contribution to journalArticle

Ribonuclease H
Hepatitis B virus
Viral DNA
Reverse Transcription
mutants
2013
8 Citations (Scopus)

Topical administration of the pan-Src kinase inhibitors, dasatinib and LCB 03-0110, prevents allergic contact dermatitis in mice

Jung, S. H., Sun, X., Ryu, W-S. & Yang, B. S., 2013 Jan 1, In : British Journal of Dermatology. 168, 1, p. 112-119 8 p.

Research output: Contribution to journalArticle

Topical Administration
Allergic Contact Dermatitis
src-Family Kinases
Atrophy
Skin
2011
6 Citations (Scopus)

A conserved arginine residue in the terminal protein domain of hepatitis B virus polymerase is critical for RNA pre-genome encapsidation

Shin, Y. C., Park, S. & Ryu, W-S., 2011 Aug 1, In : Journal of General Virology. 92, 8, p. 1809-1816 8 p.

Research output: Contribution to journalArticle

Duck Hepatitis B Viruses
Hepatitis B virus
Arginine
Genome
RNA
8 Citations (Scopus)

Hydrophobic residues of terminal protein domain of hepatitis B virus polymerase contribute to distinct steps in viral genome replication

Shin, Y. C., Ko, C. & Ryu, W-S., 2011 Dec 15, In : FEBS Letters. 585, 24, p. 3964-3968 5 p.

Research output: Contribution to journalArticle

Viral Genome
Viruses
Hepatitis B virus
Genes
Isoleucine
2010
39 Citations (Scopus)

HBx targeting to mitochondria and ROS generation are necessary but insufficient for HBV-induced cyclooxygenase-2 expression

Lim, W., Kwon, S. H., Cho, H., Kim, S., Lee, S., Ryu, W-S. & Cho, H., 2010 Apr 1, In : Journal of Molecular Medicine. 88, 4, p. 359-369 11 p.

Research output: Contribution to journalArticle

Cyclooxygenase 2
Hepatitis B virus
Reactive Oxygen Species
Mitochondria
Calcium Signaling
129 Citations (Scopus)

Hepatitis B virus polymerase blocks pattern recognition receptor signaling via interaction with DDX3: Implications for immune evasion

Wang, H. & Ryu, W-S., 2010 Jul 1, In : PLoS Pathogens. 6, 7, p. 1-11 11 p., e1000986.

Research output: Contribution to journalArticle

Immune Evasion
Pattern Recognition Receptors
Hepatitis B virus
Phosphotransferases
Interferon Regulatory Factors
11 Citations (Scopus)

Incorporation of eukaryotic translation initiation factor eIF4E into viral nucleocapsids via interaction with hepatitis B virus polymerase

Kim, S., Wang, H. & Ryu, W-S., 2010 Jan 1, In : Journal of Virology. 84, 1, p. 52-58 7 p.

Research output: Contribution to journalArticle

Eukaryotic Initiation Factors
Nucleocapsid
ribonucleoproteins
nucleocapsid
Ribonucleoproteins
7 Citations (Scopus)

Proximity between the cap and 5′ ε stem-loop structure is critical for the suppression of pgRNA translation by the hepatitis B viral polymerase

Ryu, D. K., Ahn, B. Y. & Ryu, W-S., 2010 Oct 1, In : Virology. 406, 1, p. 56-64 9 p.

Research output: Contribution to journalArticle

Hepatitis B
Hepatitis B virus
RNA
Virology
Viral RNA
2009
68 Citations (Scopus)

DDX3 DEAD-box RNA helicase inhibits hepatitis B virus reverse transcription by incorporation into Nucleocapsids

Wang, H., Kim, S. & Ryu, W-S., 2009 Jun 1, In : Journal of Virology. 83, 11, p. 5815-5824 10 p.

Research output: Contribution to journalArticle

DEAD-box RNA Helicases
Nucleocapsid
nucleocapsid
reverse transcription
Hepatitis B virus
13 Citations (Scopus)

Four conserved cysteine residues of the hepatitis B virus polymerase are critical for RNA pregenome encapsidation

Kim, S., Lee, J. & Ryu, W-S., 2009 Aug 1, In : Journal of Virology. 83, 16, p. 8032-8040 9 p.

Research output: Contribution to journalArticle

Hepatitis B virus
DNA-Directed RNA Polymerases
Cysteine
cysteine
RNA
9 Citations (Scopus)

Genetic dissection of naturally occurring basal core promoter mutations of hepatitis B virus reveals a silent phenotype in the overlapping X gene

Hussain, Z., Jung, H. S., Ryu, D. K. & Ryu, W-S., 2009 Oct 5, In : Journal of General Virology. 90, 9, p. 2272-2281 10 p.

Research output: Contribution to journalArticle

Overlapping Genes
Viral Genome
Hepatitis B virus
Dissection
Phenotype
45 Citations (Scopus)

Stimulation of hepatitis B virus genome replication by HBx is linked to both nuclear and cytoplasmic HBx expression

Cha, M. Y., Ryu, D. K., Jung, H. S., Chang, H. E. & Ryu, W-S., 2009 Jun 29, In : Journal of General Virology. 90, 4, p. 978-986 9 p.

Research output: Contribution to journalArticle

Viral Genome
Virus Replication
Hepatitis B virus
Genome
Nuclear Export Signals
2008
5 Citations (Scopus)

Circularization of an RNA template via long-range base pairing is critical for hepadnaviral reverse transcription

Shin, M. K., Kim, J. H., Ryu, D. K. & Ryu, W-S., 2008 Feb 20, In : Virology. 371, 2, p. 362-373 12 p.

Research output: Contribution to journalArticle

Base Pairing
Reverse Transcription
RNA
DNA
Mutation
22 Citations (Scopus)

Hepatitis B virus polymerase suppresses translation of pregenomic RNA via a mechanism involving its interaction with 5′ stem-loop structure

Ryu, D. K., Kim, S. & Ryu, W-S., 2008 Mar 30, In : Virology. 373, 1, p. 112-123 12 p.

Research output: Contribution to journalArticle

Hepatitis B virus
RNA
Hepadnaviridae
Proteins
Polyribosomes
4 Citations (Scopus)

Polyadenylation is dispensable for encapsidation and reverse transcription of hepatitis B viral pregenomic RNA

Lee, H. J., Lee, J., Shin, M. K. & Ryu, W. S., 2008 Jun 30, In : Molecules and Cells. 25, 4, p. 545-552 8 p.

Research output: Contribution to journalArticle

Polyadenylation
Poly A
Viral RNA
Hepatitis B
Reverse Transcription
2006
13 Citations (Scopus)

Turnover of hepatitis B virus X protein is facilitated by Hdj1, a human Hsp40/DnaJ protein

Sohn, S. Y., Kim, J. H., Baek, K. W., Ryu, W-S. & Ahn, B. Y., 2006 Sep 1, In : Biochemical and Biophysical Research Communications. 347, 3, p. 764-768 5 p.

Research output: Contribution to journalArticle

HSP40 Heat-Shock Proteins
Viruses
Hepatitis B virus
Hepatocellular Carcinoma
Viral Core Proteins
2004
18 Citations (Scopus)

A novel cis-acting element facilitates minus-strand DNA synthesis during reverse transcription of the hepatitis B virus genome

Shin, M. K., Lee, J. & Ryu, W-S., 2004 Jun 1, In : Journal of Virology. 78, 12, p. 6252-6262 11 p.

Research output: Contribution to journalArticle

reverse transcription
Hepatitis B virus
Reverse Transcription
Genome
Nucleotides
34 Citations (Scopus)

Development of transgenic chickens expressing enhanced green fluorescent protein

Kwon, M. S., Koo, B. C., Choi, B. R., Lee, H. T., Kim, Y. H., Ryu, W-S., Shim, H., Kim, J. H., Kim, N. H. & Kim, T., 2004 Jul 23, In : Biochemical and Biophysical Research Communications. 320, 2, p. 442-448 7 p.

Research output: Contribution to journalArticle

Chickens
Fluorescence
Viruses
Retroviridae
Gene expression
170 Citations (Scopus)

Hepatitis B virus X protein is essential for the activation of Wnt/β-catenin signaling in hepatoma cells

Cha, M. Y., Kim, C. M., Park, Y. M. & Ryu, W-S., 2004 Jun 1, In : Hepatology. 39, 6, p. 1683-1693 11 p.

Research output: Contribution to journalArticle

Catenins
Hepatocellular Carcinoma
Hepatitis B virus
hepatitis B virus X protein
Viral Regulatory and Accessory Proteins
7 Citations (Scopus)

Three novel cis-acting elements required for efficient plus-strand DNA synthesis of the hepatitis B virus genome

Lee, J., Shin, M. K., Lee, H. J., Yoon, G. & Ryu, W-S., 2004 Jul 1, In : Journal of Virology. 78, 14, p. 7455-7464 10 p.

Research output: Contribution to journalArticle

Circular DNA
Hepatitis B virus
circular DNA
Genome
Hepadnaviridae
65 Citations (Scopus)

Versatile PCR-mediated insertion or deletion mutagenesis

Lee, J., Lee, H. J., Shin, M. K. & Ryu, W. S., 2004 Mar 1, In : BioTechniques. 36, 3, p. 398-400 3 p.

Research output: Contribution to journalArticle

Catalytic RNA
Mutagenesis
Insertional Mutagenesis
Viral Genome
Polymerase chain reaction
2002
20 Citations (Scopus)

Factors predictive of response to interferon-α therapy in hepatitis C virus type 1b infection

Yeh, B. I., Han, K., Lee, H. W., Sohn, J. H., Ryu, W-S., Yoon, D. J., Yoon, J., Kim, H. W., Kong, I., Chang, S. J. & Choi, J. W., 2002 Mar 19, In : Journal of Medical Virology. 66, 4, p. 481-487 7 p.

Research output: Contribution to journalArticle

Virus Diseases
Hepacivirus
Interferons
Therapeutics
Viral Load
Transcriptome
Hepatitis B virus
Hepatocellular Carcinoma
Genes
Carcinogenesis
2001
72 Citations (Scopus)

Activated ras oncogene collaborates with HBx gene of hepatitis B virus to transform cells by suppressing HBx-mediated apoptosis

Kim, Y. C., Song, K. S., Yoon, G., Nam, M. J. & Ryu, W-S., 2001 Jan 4, In : Oncogene. 20, 1, p. 16-23 8 p.

Research output: Contribution to journalArticle

ras Genes
Hepatitis B virus
Apoptosis
Genes
Rodentia
34 Citations (Scopus)

Emergence of YMDD motif mutant of hepatitis B virus during short-term lamivudine therapy in South Korea

Paik, Y. H., Chung, H. Y., Ryu, W-S., Lee, K. S., Lee, J. S., Kim, J. H., Lee, C. K., Chon, C. Y., Moon, Y. M. & Han, K., 2001 Jul 25, In : Journal of Hepatology. 35, 1, p. 92-98 7 p.

Research output: Contribution to journalArticle

Republic of Korea
Lamivudine
Hepatitis B virus
Polymerase Chain Reaction
Therapeutics
2000
48 Citations (Scopus)

Evidence that the 5'-end cap structure is essential for encapsidation of hepatitis B virus pregenomic RNA

Jeong, J. K., Yoon, G. S. & Ryu, W-S., 2000 Jun 22, In : Journal of Virology. 74, 12, p. 5502-5508 7 p.

Research output: Contribution to journalArticle

Hepatitis B virus
RNA
DNA-directed DNA polymerase
DNA-Directed DNA Polymerase
position effect (genetics)
1999
19 Citations (Scopus)

A novel parvovirus isolated from Manchurian chipmunks

Yoo, B. C., Lee, D. H., Park, S. M., Park, J. W., Kim, C. Y., Lee, H. S., Seo, J. S., Park, K. J. & Ryu, W-S., 1999 Jan 20, In : Virology. 253, 2, p. 250-258 9 p.

Research output: Contribution to journalArticle

Sciuridae
Parvovirus
Erythrovirus
Open Reading Frames
Hepatitis B Surface Antigens
1997
17 Citations (Scopus)

Effect of a Novel Saponin Adjuvant Derived from Quillaja saponaria on the Immune Response to Recombinant Hepatitis B Surface Antigen

So, H. S., Yoon, H. S., Choi, D. Y., Kwon, Y. S., Sung, J. H., Lee, T. G., Park, E. S., Cho, H. S., Lee, B. M., Cho, J. M. & Ryu, W-S., 1997 Apr 30, In : Molecules and Cells. 7, 2, p. 178-186 9 p.

Research output: Contribution to journalArticle

Quillaja
Saponins
Hepatitis B Surface Antigens
HIV Envelope Protein gp120
Antigens
1996
16 Citations (Scopus)

Presentation of the hydrophilic domains of hepatitis C viral E2 envelope glycoprotein on hepatitis B surface antigen particles

Lee, I. H., Kim, C. H. & Ryu, W-S., 1996 Oct 1, In : Journal of Medical Virology. 50, 2, p. 145-151 7 p.

Research output: Contribution to journalArticle

Hepatitis C
Hepatitis B Surface Antigens
Hepatitis B virus
Glycoproteins
Hepacivirus
1995
53 Citations (Scopus)

Association of hepatitis C virus particles with immunoglobulin: A mechanism for persistent infection

Choo, S. H., So, H. S., Cho, J. M. & Ryu, W-S., 1995 Jan 1, In : Journal of General Virology. 76, 9, p. 2337-2341 5 p.

Research output: Contribution to journalArticle

Hepacivirus
Virion
Immunoglobulin A
Infection
Virus Diseases
19 Citations (Scopus)

Hepatitis delta virus mutant: Effect on RNA editing

Wu, T. T., Bichko, V. V., Ryu, W. S., Lemon, S. M. & Taylor, J. M., 1995 Jan 1, In : Journal of Virology. 69, 11, p. 7226-7231 6 p.

Research output: Contribution to journalArticle

Hepatitis delta virus
RNA Editing
Hepatitis Delta Virus
RNA editing
mutants
35 Citations (Scopus)

Nucleotide sequence stability of the genome of hepatitis delta virus

Netter, H. J., Wu, T. T., Bockol, M., Cywinski, A., Ryu, W. S., Tennant, B. C. & Taylor, J. M., 1995 Jan 1, In : Journal of Virology. 69, 3, p. 1687-1692 6 p.

Research output: Contribution to journalArticle

Hepatitis delta virus
Hepatitis Delta Virus
Genomic Instability
nucleotide sequences
genome
1993
63 Citations (Scopus)

Ribonucleoprotein complexes of hepatitis delta virus

Ryu, W. S., Netter, H. J., Bayer, M. & Taylor, J., 1993 Jan 1, In : Journal of Virology. 67, 6, p. 3281-3287 7 p.

Research output: Contribution to journalArticle

Hepatitis delta virus
Hepatitis Delta Virus
ribonucleoproteins
Ribonucleoproteins
Hepatitis delta Antigens
1992
129 Citations (Scopus)

Assembly of hepatitis delta virus particles

Ryu, W. S., Bayer, M. & Taylor, J., 1992 Jan 1, In : Journal of Virology. 66, 4, p. 2310-2315 6 p.

Research output: Contribution to journalArticle

Hepatitis delta virus
Hepatitis Delta Virus
virion
Virion
Hepatitis B virus
1991
11 Citations (Scopus)

Expression from herpesvirus promoters does not relieve the intron requirement for cytoplasmic accumulation of human β-globin mRNA

Yu, X. M., Gelembiuk, G. W., Wang, C. Y., Ryu, W-S. & Mertz, J. E., 1991 Dec 25, In : Nucleic acids research. 19, 25, p. 7231-7234 4 p.

Research output: Contribution to journalArticle

Globins
Herpesviridae
Introns
Messenger RNA
Cytoplasm
8 Citations (Scopus)

The roles of the delta antigen in the structure and replication of hepatitis delta virus

Taylor, J., Chao, M., Hsieh, S. Y. & Ryu, W-S., 1991 Jan 1, In : Journal of Hepatology. 13, SUPPL. 4

Research output: Contribution to journalArticle

Hepatitis delta Antigens
Hepatitis Delta Virus
Amino Acids
Genome
Terminator Codon
1989
74 Citations (Scopus)
Simian virus 40
Introns
Cytoplasm
cytoplasm
Haplorhini
1988
17 Citations (Scopus)

The late spliced 19S and 16S RNAs of simian virus 40 can be synthesized from a common pool of transcripts

Good, P. J., Welch, R. C., Ryu, W. S. & Mertz, J. E., 1988 Jan 1, In : Journal of Virology. 62, 2, p. 563-571 9 p.

Research output: Contribution to journalArticle

Simian virus 40
RNA Viruses
RNA
RNA Splice Sites
Introns