• 695 Citations
  • 9 h-Index
20062018
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Research Output 2006 2018

  • 695 Citations
  • 9 h-Index
  • 10 Article
  • 1 Short survey
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Article
2018
6 Citations (Scopus)

Accelerated Aging and Clearance of Host Anti-inflammatory Enzymes by Discrete Pathogens Fuels Sepsis

Yang, W. H., Heithoff, D. M., Aziz, P. V., Haslund-Gourley, B., Westman, J. S., Narisawa, S., Pinkerton, A. B., Millán, J. L., Nizet, V., Mahan, M. J. & Marth, J. D., 2018 Oct 10, In : Cell Host and Microbe. 24, 4, p. 500-513.e5

Research output: Contribution to journalArticle

Neuraminidase
Sepsis
Anti-Inflammatory Agents
Alkaline Phosphatase
Enzymes
2017
15 Citations (Scopus)

Recurrent infection progressively disables host protection against intestinal inflammation

Yang, W. H., Heithoff, D. M., Aziz, P. V., Sperandio, M., Nizet, V., Mahan, M. J. & Marth, J. D., 2017 Dec 22, In : Science. 358, 6370, eaao5610.

Research output: Contribution to journalArticle

Alkaline Phosphatase
Inflammation
Infection
Toll-Like Receptor 4
Salmonella enterica
2015
40 Citations (Scopus)

An intrinsic mechanism of secreted protein aging and turnover

Yang, W. H., Aziz, P. V., Heithoff, D. M., Mahan, M. J., Smith, J. W. & Marth, J. D., 2015 Nov 3, In : Proceedings of the National Academy of Sciences of the United States of America. 112, 44, p. 13657-13662 6 p.

Research output: Contribution to journalArticle

Open Access
Polysaccharides
Proteins
Glycoside Hydrolases
Neuraminidase
Lectins
2012
53 Citations (Scopus)

Biosynthesis of the major brain gangliosides GD1a and GT1b

Sturgill, E. R., Aoki, K., Lopez, P. H. H., Colacurcio, D., Vajn, K., Lorenzini, I., Majić, S., Yang, W. H., Heffer, M., Tiemeyer, M., Marth, J. D. & Schnaar, R. L., 2012 Oct 1, In : Glycobiology. 22, 10, p. 1289-1301 13 p.

Research output: Contribution to journalArticle

Open Access
Gangliosides
Biosynthesis
Brain
beta-galactoside alpha-2,3-sialyltransferase
Galactose
43 Citations (Scopus)

Coordinated roles of ST3Gal-VI and ST3Gal-IV sialyltransferases in the synthesis of selectin ligands

Yang, W. H., Nussbaum, C., Grewal, P. K., Marth, J. D. & Sperandio, M., 2012 Aug 2, In : Blood. 120, 5, p. 1015-1026 12 p.

Research output: Contribution to journalArticle

Open Access
beta-galactoside alpha-2,3-sialyltransferase
Sialyltransferases
Selectins
E-Selectin
P-Selectin
2010
12 Citations (Scopus)

O-GlcNAcylation regulates hyperglycemia-induced GPX1 activation

Yang, W. H., Park, S. Y., Ji, S., Kang, J. G., Kim, J. E., Song, H., Mook-Jung, I., Choe, K. M. & Cho, J. W., 2010 Jan 1, In : Biochemical and Biophysical Research Communications. 391, 1, p. 756-761 6 p.

Research output: Contribution to journalArticle

Hyperglycemia
Chemical activation
nitazoxanide
Glycosylation
Oxidative stress
103 Citations (Scopus)

Snail1 is stabilized by O-GlcNAc modification in hyperglycaemic condition

Park, S. Y., Kim, H. S., Kim, N. H., Ji, S., Cha, S. Y., Kang, J. G., Ota, I., Shimada, K., Konishi, N., Nam, H. W., Hong, S. W., Yang, W. H., Roth, J., Yook, J. I. & Cho, J. W., 2010 Nov 17, In : EMBO Journal. 29, 22, p. 3787-3796 10 p.

Research output: Contribution to journalArticle

Phosphorylation
Epithelial-Mesenchymal Transition
Cadherins
Glycogen Synthase Kinase 3
Degradation
2008
131 Citations (Scopus)

NFκB activation is associated with its O-GlcNAcylation state under hyperglycemic conditions

Won, H. Y., Sang, Y. P., Hyung, W. N., Do, H. K., Jeong, G. K., Eun, S. K., Yu, S. K., Hyun, C. L., Kwan, S. K. & Cho, J. W., 2008 Nov 11, In : Proceedings of the National Academy of Sciences of the United States of America. 105, 45, p. 17345-17350 6 p.

Research output: Contribution to journalArticle

Acetylglucosamine
Post Translational Protein Processing
Acetylation
Transcriptional Activation
Transcription Factors
2006
24 Citations (Scopus)

Heat shock protein 60 modified with O-linked N-acetylglucosamine is involved in pancreatic β-cell death under hyperglycemic conditions

Kim, H. S., Kim, E. M., Lee, J., Yang, W. H., Park, T. Y., Kim, Y. M. & Cho, J. W., 2006 Apr 17, In : FEBS Letters. 580, 9, p. 2311-2316 6 p.

Research output: Contribution to journalArticle

Chaperonin 60
Acetylglucosamine
Cell death
Cell Death
Chaperonins
267 Citations (Scopus)

Modification of p53 with O-linked N-acetylglucosamine regulates p53 activity and stability

Yang, W. H., Kim, J. E., Nam, H. W., Ju, J. W., Kim, H. S., Kim, Y. S. & Cho, J. W., 2006 Oct 1, In : Nature Cell Biology. 8, 10, p. 1074-1083 10 p.

Research output: Contribution to journalArticle

Acetylglucosamine
Ubiquitination
Ubiquitin
Proteolysis
Phosphates