• 1342 Citations
  • 20 h-Index
20022019

Research output per year

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Research Output

2019

A small molecule Nec-1 directly induces amyloid clearance in the brains of aged APP/PS1 mice

Yang, S. H., Shin, J., Shin, N. N., Hwang, J-H., Hong, S-C., Park, K., Lee, J. W., Lee, S., Baek, S., Kim, K., Cho, I. & Kim, Y., 2019 Mar 12, In : Scientific reports. 9, 1, p. 4183

Research output: Contribution to journalArticle

2 Citations (Scopus)

Comparative analyses of plasma amyloid-b levels in heterogeneous and monomerized states by interdigitated microelectrode sensor system

Kim, Y. S., Yoo, Y. K., Kim, H. Y., Roh, J. H., Kim, J., Baek, S., Lee, J. C., Kim, H. J., Chae, M. S., Jeong, D., Park, D., Lee, S., Jang, H. C., Kim, K., Lee, J. H., Byun, B. H., Park, S. Y., Ha, J. H., Lee, K. C., Cho, W. W. & 4 others, Kim, J. S., Koh, J. Y., Lim, S. M. & Hwang, K. S., 2019 Jan 1, In : Science Advances. 5, 4, eaav1388.

Research output: Contribution to journalArticle

Open Access
6 Citations (Scopus)

Comparative analyses of plasma amyloid-β levels in heterogeneous and monomerized states by interdigitated microelectrode sensor system

Kim, Y., Yoo, Y. K., Kim, H. Y., Roh, J. H., Kim, J., Baek, S., Lee, J. C., Kim, H. J., Chae, M-S., Jeong, D., Park, D., Lee, S., Jang, H., Kim, K., Lee, J. H., Byun, B. H., Park, S. Y., Ha, J. H., Lee, K. C., Cho, W. W. & 4 others, Kim, J-S., Koh, J-Y., Lim, S. M. & Hwang, K. S., 2019 Apr 17, In : Science Advances. 5, 4, p. eaav1388

Research output: Contribution to journalArticle

Diagnosis of Alzheimer’s disease utilizing amyloid and tau as fluid biomarkers

Lee, J. C., Kim, S. J., Hong, S. & Kim, Y. S., 2019 May 1, In : Experimental and Molecular Medicine. 51, 5, 53.

Research output: Contribution to journalReview article

Open Access
13 Citations (Scopus)

Dielectrophoresis-based filtration effect and detection of amyloid beta in plasma for Alzheimer's disease diagnosis

Kim, H. J., Park, D., Baek, S. Y., Yang, S. H., Kim, Y. S., Lim, S. M., Kim, J. & Hwang, K. S., 2019 Mar 1, In : Biosensors and Bioelectronics. 128, p. 166-175 10 p.

Research output: Contribution to journalArticle

3 Citations (Scopus)

Fluorescence Chemicals to Detect Insoluble and Soluble Amyloid-β Aggregates

Lee, D., Kim, S. M., Kim, H. Y. & Kim, Y., 2019 Jun 19, In : ACS Chemical Neuroscience. 10, 6, p. 2647-2657 11 p.

Research output: Contribution to journalReview article

2 Citations (Scopus)

Fluorescent 1,4-Naphthoquinones to Visualize Diffuse and Dense-Core Amyloid Plaques in APP/PS1 Transgenic Mouse Brains

Neo Shin, N., Jeon, H., Jung, Y., Baek, S., Lee, S., Yoo, H. C., Bae, G. H., Park, K., Yang, S. H., Han, J. M., Kim, I. & Kim, Y., 2019 Jun 19, In : ACS Chemical Neuroscience. 10, 6, p. 3031-3044 14 p.

Research output: Contribution to journalArticle

2 Citations (Scopus)

Fluorescent 1,4-Naphthoquinones To Visualize Diffuse and Dense-Core Amyloid Plaques in APP/PS1 Transgenic Mouse Brains

Neo Shin, N., Jeon, H., Jung, Y., Baek, S., Lee, S., Yoo, H. C., Bae, G. H., Park, K., Yang, S-H., Han, J. M., Kim, I. & Kim, Y., 2019 Apr 24, In : ACS Chemical Neuroscience.

Research output: Contribution to journalArticle

Frontiers in Probing Alzheimer's Disease Biomarkers with Fluorescent Small Molecules

Jun, Y. W., Cho, S. W., Jung, J., Huh, Y., Kim, Y., Kim, D. & Ahn, K. H., 2019 Feb 27, In : ACS Central Science. 5, 2, p. 209-217 9 p.

Research output: Contribution to journalReview article

6 Citations (Scopus)

Preventive approach for overcoming dementia

Lee, H. Y., Kim, D. W., Lee, W., Kim, H. Y. & Kim, Y. S., 2019 Aug 1, In : Archives of pharmacal research. 42, 8, p. 647-657 11 p.

Research output: Contribution to journalReview article

2018

Four-week individual caging of male ICR mice alters body composition without change in body mass

Shin, J., Woo, J., Cho, Y., Choi, Y. H., Shin, N. N. & Kim, Y., 2018 Dec 1, In : Scientific reports. 8, 1, 1331.

Research output: Contribution to journalArticle

Identification of Plasma Membrane Glycoproteins Specific to Human Glioblastoma Multiforme Cells Using Lectin Arrays and LC-MS/MS

Park, Y. E., Yeom, J., Kim, Y. S., Lee, H. J., Han, K. C., Lee, S. T., Lee, C. & Lee, J. E., 2018 Jan, In : Proteomics. 18, 1, 1700302.

Research output: Contribution to journalArticle

3 Citations (Scopus)

Multifunctionalized reduced graphene oxide biosensors for simultaneous monitoring of structural changes in amyloid-β 40

Jeong, D., Kim, J., Chae, M. S., Lee, W., Yang, S. H., Kim, Y., Kim, S. M., Lee, J. S., Lee, J. H., Choi, J., Yoon, D. S. & Hwang, K. S., 2018 Jun, In : Sensors (Switzerland). 18, 6, 1738.

Research output: Contribution to journalArticle

3 Citations (Scopus)

Peptide-nanoparticle conjugates: a next generation of diagnostic and therapeutic platforms?

Jeong, W-J., Bu, J., Kubiatowicz, L. J., Chen, S. S., Kim, Y. & Hong, S., 2018 Dec 12, In : Nano Convergence. 5, 1, p. 38

Research output: Contribution to journalReview article

17 Citations (Scopus)

TNF-α increases the intrinsic excitability of cerebellar Purkinje cells through elevating glutamate release in Bergmann Glia

Shim, H. G., Jang, S-S., Kim, S. H., Hwang, E. M., Min, J. O., Kim, H. Y., Kim, Y. S., Ryu, C., Chung, G., Kim, Y., Yoon, B-E. & Kim, S. J., 2018 Aug 2, In : Scientific Reports. 8, 1, p. 11589

Research output: Contribution to journalArticle

2 Citations (Scopus)
2017

A highly sensitive plasma-based amyloid-β detection system through medium-changing and noise cancellation system for early diagnosis of the Alzheimer's disease

Yoo, Y. K., Kim, J., Kim, G., Kim, Y. S., Kim, H. Y., Lee, S., Cho, W. W., Kim, S., Lee, S. M., Lee, B. C., Lee, J. H. & Hwang, K. S., 2017 Dec 1, In : Scientific reports. 7, 1, 8882.

Research output: Contribution to journalArticle

16 Citations (Scopus)

Enhancing surface functionality of reduced graphene oxide biosensors by oxygen plasma treatment for Alzheimer's disease diagnosis

Chae, M. S., Kim, J., Jeong, D., Kim, Y. S., Roh, J. H., Lee, S. M., Heo, Y., Kang, J. Y., Lee, J. H., Yoon, D. S., Kim, T. G., Chang, S. T. & Hwang, K. S., 2017 Jun 15, In : Biosensors and Bioelectronics. 92, p. 610-617 8 p.

Research output: Contribution to journalArticle

31 Citations (Scopus)

Nec-1 alleviates cognitive impairment with reduction of Aβ and tau abnormalities in APP/PS1 mice

Yang, S. H., Lee, D. K., Shin, J., Lee, S., Baek, S., Kim, J., Jung, H., Hah, J. M. & Kim, Y. S., 2017 Jan 1, In : EMBO Molecular Medicine. 9, 1, p. 61-77 17 p.

Research output: Contribution to journalArticle

31 Citations (Scopus)

Preliminary PET Study of 18F-FC119S in Normal and Alzheimer's Disease Models

Oh, S. J., Kim, M. H., Han, S. J., Kang, K. J., Ko, I. O., Kim, Y., Park, J. A., Choi, J. Y., Lee, K. C., Chi, D. Y., Lee, Y. J. & Kim, K. M., 2017 Sep 5, In : Molecular Pharmaceutics. 14, 9, p. 3114-3120 7 p.

Research output: Contribution to journalArticle

4 Citations (Scopus)

Taurine-carbohydrate derivative stimulates fibrillogenesis of amyloid-β and reduce Alzheimer-like behaviors

Kim, H. Y., Yang, S. H., Yoon, J., Jang, H. C., Baek, S., Shin, J., Kim, S. H. & Kim, Y. S., 2017 Jan 1, In : Advances in Experimental Medicine and Biology. 975, p. 225-232 8 p.

Research output: Contribution to journalArticle

2 Citations (Scopus)

Taurine directly binds to oligomeric amyloid-β and recovers cognitive deficits in Alzheimer model mice

Jang, H. C., Lee, S., Choi, S. L., Kim, H. Y., Baek, S. & Kim, Y. S., 2017 Jan 1, In : Advances in experimental medicine and biology. 975, p. 233-241 9 p.

Research output: Contribution to journalArticle

12 Citations (Scopus)
2016

Age-dependent inverse correlations in CSF and plasma amyloid-β(1-42) concentrations prior to amyloid plaque deposition in the brain of 3xTg-AD mice

Cho, S. M., Lee, S., Yang, S. H., Kim, H. Y., Lee, M. J., Kim, H. V., Kim, J., Baek, S., Yun, J., Kim, D., Kim, Y. K., Cho, Y., Woo, J., Kim, T. S. & Kim, Y. S., 2016 Feb 2, In : Scientific reports. 6, 20185.

Research output: Contribution to journalArticle

12 Citations (Scopus)

Cell surface GRP78 as a biomarker and target for suppressing glioma cells

Kang, B. R., Yang, S. H., Chung, B. R., Kim, W. & Kim, Y. S., 2016 Oct 7, In : Scientific reports. 6, 34922.

Research output: Contribution to journalArticle

9 Citations (Scopus)

Corrigendum: EPPS rescues hippocampus-dependent cognitive deficits in APP/PS1 mice by disaggregation of amyloid-β oligomers and plaques

Kim, H. Y., Kim, H. V., Jo, S., Lee, C. J., Choi, S. Y., Kim, D. J. & Kim, Y. S., 2016 Feb 15, In : Nature communications. 7, 10755.

Research output: Contribution to journalComment/debate

4 Citations (Scopus)

Intracerebroventricular injection of amyloid-# peptides in normal mice to acutely induce alzheimer-like cognitive deficits

Kim, H. Y., Lee, D. K., Chung, B. R., Kim, H. V. & Kim, Y., 2016 Feb 24, In : Journal of Visualized Experiments. 2016, 109, e53308.

Research output: Contribution to journalArticle

32 Citations (Scopus)

Multifunctional Photonics Nanoparticles for Crossing the Blood–Brain Barrier and Effecting Optically Trackable Brain Theranostics

Singh, A., Kim, W., Kim, Y., Jeong, K., Kang, C. S., Kim, Y. S., Koh, J., Mahajan, S. D., Prasad, P. N. & Kim, S., 2016 Oct 18, In : Advanced Functional Materials. 26, 39, p. 7057-7066 10 p.

Research output: Contribution to journalArticle

29 Citations (Scopus)

Rapid and sustained cognitive recovery in APP/PS1 transgenic mice by co-administration of EPPS and donepezil

Kim, H. Y., Kim, H. V., Lee, D. K., Yang, S. H. & Kim, Y. S., 2016 Oct 31, In : Scientific reports. 6, 34165.

Research output: Contribution to journalArticle

3 Citations (Scopus)

Wafer-scale high-resolution patterning of reduced graphene oxide films for detection of low concentration biomarkers in plasma

Kim, J., Chae, M. S., Lee, S. M., Jeong, D., Lee, B. C., Lee, J. H., Kim, Y., Chang, S. T. & Hwang, K. S., 2016 Oct 8, In : Scientific reports. 6, 31276.

Research output: Contribution to journalArticle

17 Citations (Scopus)
2015

Abnormalities of plasma cytokines and spleen in senile APP/PS1/Tau transgenic mouse model

Yang, S. H., Kim, J., Lee, M. J. & Kim, Y., 2015 Oct 27, In : Scientific reports. 5, 15703.

Research output: Contribution to journalArticle

8 Citations (Scopus)

Amyloid-β Oligomers May Impair SNARE-Mediated Exocytosis by Direct Binding to Syntaxin 1a

Yang, Y., Kim, J., Kim, H. Y., Ryoo, N., Lee, S., Kim, Y. S., Rhim, H. & Shin, Y. K., 2015 Aug 25, In : Cell Reports. 12, 8, p. 1244-1251 8 p., 1940.

Research output: Contribution to journalArticle

20 Citations (Scopus)

Anti-amyloidogenic approach to access amyloid-β(1-42) in Fmoc solid-phase synthesis

Lee, S. & Kim, Y. S., 2015 Aug 1, In : Bulletin of the Korean Chemical Society. 36, 8, p. 2147-2149 3 p.

Research output: Contribution to journalArticle

3 Citations (Scopus)

Bis-styrylnaphthalene and bis-styrylnaphthyridine derivatives with high binding affinity to β-amyloid fibrils

Lee, Y. R., Kim, Y. S. & Yoo, K. H., 2015 Jan 20, In : Bulletin of the Korean Chemical Society. 36, 1, p. 413-416 4 p.

Research output: Contribution to journalArticle

CR6-interacting factor 1 is a key regulator in Aβ-induced mitochondrial disruption and pathogenesis of Alzheimer's disease

Byun, J., Son, S. M., Cha, M. Y., Shong, M., Hwang, Y. J., Kim, Y., Ryu, H., Moon, M., Kim, K. S. & Mook-Jung, I., 2015 Jun 1, In : Cell Death and Differentiation. 22, 6, p. 959-973 15 p.

Research output: Contribution to journalArticle

19 Citations (Scopus)

EPPS rescues hippocampus-dependent cognitive deficits in APP/PS1 mice by disaggregation of amyloid-β oligomers and plaques

Kim, H. Y., Kim, H. V., Jo, S., Lee, C. J., Choi, S. Y., Kim, D. J. & Kim, Y., 2015 Dec 8, In : Nature communications. 6, 8997.

Research output: Contribution to journalArticle

45 Citations (Scopus)

Immunotherapeutic approaches against amyloid-β in drug discovery for alzheimer’s disease

Yang, S. H., Kim, J. & Kim, Y. S., 2015 Jan 1, Aging Mechanisms: Longevity, Metabolism, and Brain Aging. Springer Japan, p. 395-415 21 p.

Research output: Chapter in Book/Report/Conference proceedingChapter

Real-time imaging of glioblastoma using bioluminescence in a U-87 MG xenograft model mouse

Kim, W., Kang, B. R., Kim, H. Y., Cho, S. M., Lee, Y. D., Kim, S., Kim, J. Y., Kim, D. J. & Kim, Y. S., 2015 Jan 1, In : Journal of the Korean Society for Applied Biological Chemistry. 58, 2, p. 243-248 6 p.

Research output: Contribution to journalArticle

3 Citations (Scopus)

Real-time imaging reveals glioblastoma suppression effects of curcumin in mouse brains

Kim, W., Kim, H. Y., Woo, J., Rhim, H. J., Bo, R. K., Lee, Y. D., Kim, S., Kim, J. Y., Choi, E. J., Kim, K. S., Kim, D. J. & Kim, Y. S., 2015 May 1, In : Bulletin of the Korean Chemical Society. 36, 5, p. 1528-1531 4 p.

Research output: Contribution to journalArticle

1 Citation (Scopus)
2014

Aminostyrylbenzofuran directly reduces oligomeric amyloid-β and reverses cognitive deficits in Alzheimer transgenic mice

Lee, S. H., Kim, Y. S., Kim, H. Y., Kim, Y. H., Kim, M. S., Kong, J. Y., Lee, M. H., Kim, D. J. & Ahn, Y. G., 2014 Apr 23, In : PloS one. 9, 4, e95733.

Research output: Contribution to journalArticle

9 Citations (Scopus)

Correlations of amyloid-β concentrations between CSF and plasma in acute Alzheimer mouse model

Cho, S. M., Kim, H. V., Lee, S., Kim, H. Y., Kim, W., Kim, T. S., Kim, D. J. & Kim, Y. S., 2014 Oct 27, In : Scientific reports. 4, 6777.

Research output: Contribution to journalArticle

23 Citations (Scopus)

Detection and quantification of plasma amyloid-β by selected reaction monitoring mass spectrometry

Kim, J. S., Ahn, H. S., Cho, S. M., Lee, J. E., Kim, Y. S. & Lee, C., 2014 Aug 20, In : Analytica Chimica Acta. 840, p. 1-9 9 p.

Research output: Contribution to journalArticle

19 Citations (Scopus)

GABA from reactive astrocytes impairs memory in mouse models of Alzheimer's disease

Jo, S., Yarishkin, O., Hwang, Y. J., Chun, Y. E., Park, M., Woo, D. H., Bae, J. Y., Kim, T., Lee, J., Chun, H., Park, H. J., Lee, D. Y., Hong, J., Kim, H. Y., Oh, S. J., Park, S. J., Lee, H., Yoon, B. E., Kim, Y., Jeong, Y. & 8 others, Shim, I., Bae, Y. C., Cho, J., Kowall, N. W., Ryu, H., Hwang, E., Kim, D. & Lee, C. J., 2014 Aug, In : Nature Medicine. 20, 8, p. 886-896 11 p.

Research output: Contribution to journalReview article

247 Citations (Scopus)

Glial GABA, synthesized by monoamine oxidase B, mediates tonic inhibition

Yoon, B. E., Woo, J., Chun, Y. E., Chun, H., Jo, S., Bae, J. Y., An, H., Min, J. O., Oh, S. J., Han, K. S., Kim, H. Y., Kim, T., Kim, Y. S., Bae, Y. C. & Lee, C. J., 2014 Jan 1, In : Journal of Physiology. 592, 22, p. 4951-4968 18 p.

Research output: Contribution to journalArticle

46 Citations (Scopus)

Taurine in drinking water recovers learning and memory in the adult APP/PS1 mouse model of Alzheimer's disease

Kim, H. Y., Kim, H. V., Yoon, J. H., Kang, B. R., Cho, S. M., Lee, S., Kim, J. Y., Kim, J. W., Cho, Y., Woo, J. & Kim, Y. S., 2014 Dec 12, In : Scientific reports. 4, 7467.

Research output: Contribution to journalArticle

51 Citations (Scopus)
2013

2-Phenylbenzofuran derivatives alleviate mitochondrial damage via the inhibition of β-amyloid aggregation

Lee, Y. S., Kim, H. Y., Youn, H. M., Seo, J. H., Kim, Y. & Shin, K. J., 2013 Nov 1, In : Bioorganic and Medicinal Chemistry Letters. 23, 21, p. 5882-5886 5 p.

Research output: Contribution to journalArticle

4 Citations (Scopus)

Amelioration of Alzheimer's disease by neuroprotective effect of sulforaphane in animal model

Kim, H. V., Kim, H. Y., Ehrlich, H. Y., Choi, S. Y., Kim, D. J. & Kim, Y. S., 2013 Mar 1, In : Amyloid. 20, 1, p. 7-12 6 p.

Research output: Contribution to journalArticle

74 Citations (Scopus)

Bimolecular fluorescence complementation; Lighting-up tau-tau interaction in living cells

Tak, H. J., Haque, M. M., Kim, M. J., Lee, J. H., Baik, J. H., Kim, Y. S., Kim, D. J., Grailhe, R. & Kim, Y. K., 2013 Dec 2, In : PloS one. 8, 12, e81682.

Research output: Contribution to journalArticle

28 Citations (Scopus)

Reactive cyanine fluorescence dyes indicating ph perturbation of biomolecules

Park, J. W., Kim, D. J., Lee, K. J. & Kim, Y. S., 2013 Jan 20, In : Bulletin of the Korean Chemical Society. 34, 1, p. 287-290 4 p.

Research output: Contribution to journalArticle

3 Citations (Scopus)

Therapeutic and pharmacokinetic characterizations of an anti-amyloidogenic bis-styrylbenzene derivative for Alzheimer's disease treatment

Byeon, S. R., Kim, H. V., Jeon, M., Ahn, Y. G., Kim, M. S., Kong, J. Y., Kim, H. Y., Kim, Y. S. & Kim, D. J., 2013 Jun 1, In : Bioorganic and Medicinal Chemistry Letters. 23, 11, p. 3467-3469 3 p.

Research output: Contribution to journalArticle

5 Citations (Scopus)

Wide-ranged fluorescent molecular weight size markers for electrophoresis

Park, J. W., Kim, M. J., Lee, K. J. & Kim, Y. S., 2013 Jan 20, In : Bulletin of the Korean Chemical Society. 34, 1, p. 29-30 2 p.

Research output: Contribution to journalLetter

2012

Efficient access to highly pure β-amyloid peptide by optimized solid-phase synthesis

Choi, J. W., Kim, H. Y., Jeon, M., Kim, D. J. & Kim, Y., 2012 Sep 1, In : Amyloid. 19, 3, p. 133-137 5 p.

Research output: Contribution to journalArticle

13 Citations (Scopus)