α-Glycosidase inhibitory activity of hexagalloylglucose from the galls of Quercus infectoria

Jae Kwan Hwang, Tae Wook Kong, Nam In Baek, Yu Ryang Pyun

Research output: Contribution to journalArticle

63 Citations (Scopus)

Abstract

Hexagalloylglucose (3-O-digalloyl-1,2,4,6-tetra-O-galloyl-β-D-glucose), which was isolated from the methanol extract of the galls of Quercus infectoria, significantly inhibited α-glycosidases such as sucrase, maltase and isomaltase. Its inhibitory activity was comparable to acarbose being used as a hypoglycemic agent, while the inhibitory activity on α-amylase was approximately 10 times lower than that of acarbose. The results indicate that, when compared to acarbose, hexagalloylglucose might reduce the side effects by reducing inhibition of α-amylase.

Original languageEnglish
Pages (from-to)273-274
Number of pages2
JournalPlanta Medica
Volume66
Issue number3
DOIs
Publication statusPublished - 2000

All Science Journal Classification (ASJC) codes

  • Analytical Chemistry
  • Molecular Medicine
  • Pharmacology
  • Pharmaceutical Science
  • Drug Discovery
  • Complementary and alternative medicine
  • Organic Chemistry

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