α-Ionone attenuates high-fat diet-induced skeletal muscle wasting in mice

Via activation of cAMP signaling

Tao Tong, Minji Kim, Taesun Park

Research output: Contribution to journalArticle

1 Citation (Scopus)

Abstract

Skeletal muscle atrophy is a common and debilitating condition that lacks a pharmacological therapy. Our aim was to investigate the potential of α-ionone, a naturally occurring flavoring agent, in preventing muscle atrophy and to delineate the mechanisms involved. We found that α-ionone not only stimulated myogenesis but also attenuated palmitic-acid-induced atrophy of cultured skeletal myotubes, as evidenced by an increased myotube diameter and length, fusion index, and cellular protein content. These beneficial actions of α-ionone were abrogated by cAMP inhibitor. The antiatrophic effects of α-ionone on cultured myotubes were confirmed in a corresponding mouse model. The skeletal muscle mass, muscle protein content, myofiber diameter, and muscle strength were greater in α-ionone-treated mice than in untreated animals fed high-fat diet. Furthermore, α-ionone increased cAMP concentration and enhanced its downstream PKA-CREB signaling in skeletal muscle of mice fed high-fat diet. Thus, α-ionone is a promising agent that may enhance skeletal muscle mass and strength.

Original languageEnglish
Pages (from-to)1167-1178
Number of pages12
JournalFood and Function
Volume10
Issue number2
DOIs
Publication statusPublished - 2019 Feb 1

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Norisoprenoids
norisoprenoids
High Fat Diet
high fat diet
skeletal muscle
Skeletal Muscle
mice
Skeletal Muscle Fibers
muscular atrophy
Muscular Atrophy
Muscle Strength
Flavoring Agents
protein content
muscle strength
Palmitic Acid
Muscle Development
Muscle Proteins
muscle development
flavorings
muscle protein

All Science Journal Classification (ASJC) codes

  • Food Science

Cite this

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abstract = "Skeletal muscle atrophy is a common and debilitating condition that lacks a pharmacological therapy. Our aim was to investigate the potential of α-ionone, a naturally occurring flavoring agent, in preventing muscle atrophy and to delineate the mechanisms involved. We found that α-ionone not only stimulated myogenesis but also attenuated palmitic-acid-induced atrophy of cultured skeletal myotubes, as evidenced by an increased myotube diameter and length, fusion index, and cellular protein content. These beneficial actions of α-ionone were abrogated by cAMP inhibitor. The antiatrophic effects of α-ionone on cultured myotubes were confirmed in a corresponding mouse model. The skeletal muscle mass, muscle protein content, myofiber diameter, and muscle strength were greater in α-ionone-treated mice than in untreated animals fed high-fat diet. Furthermore, α-ionone increased cAMP concentration and enhanced its downstream PKA-CREB signaling in skeletal muscle of mice fed high-fat diet. Thus, α-ionone is a promising agent that may enhance skeletal muscle mass and strength.",
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α-Ionone attenuates high-fat diet-induced skeletal muscle wasting in mice : Via activation of cAMP signaling. / Tong, Tao; Kim, Minji; Park, Taesun.

In: Food and Function, Vol. 10, No. 2, 01.02.2019, p. 1167-1178.

Research output: Contribution to journalArticle

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