α-ionone protects against UVB-induced photoaging in human dermal fibroblasts

Tao Tong, Jinju Park, Youna Moon, Wesuk Kang, Taesun Park

Research output: Contribution to journalArticle

Abstract

Ultraviolet (UV) light-induced wrinkle formation is a major dermatological problem and is associated with alteration in collagen. Here, we investigated the potential of α-ionone, a naturally occurring aromatic compound, in regulation of UVB-induced photoaging in human Hs68 dermal fibroblasts and identified the mechanisms involved.We found that in human dermal fibroblasts, α-ionone inhibited UVB-induced loss of collagen. α-Ionone upregulated the molecules participating in the TGF-β-SMAD pathway (TGF-β1, phospho-SMAD2/3, Col1A1, and Col1A2), but downregulated the molecules involved in the MAPK-AP-1 signaling pathway (phospho-p38, phospho-JNK, phospho-ERK, phospho-c-Fos, phospho-c-Jun, MMP1, MMP3, and MMP9), in human dermal fibroblasts. α-Ionone treatment also increased hyaluronic acid contents, and this effect was accompanied by an upregulation of mRNA expression of genes (HAS1 and HAS2) involved in hyaluronic acid synthesis. Thus, α-ionone is effective in the prevention of UVB-induced decrease of collagen and hyaluronic acid in human dermal fibroblasts. We propose that α-ionone may prove beneficial for the prevention of UV-induced wrinkle formation and skin damage.

Original languageEnglish
Article number1804
JournalMolecules
Volume24
Issue number9
DOIs
Publication statusPublished - 2019 Jan 1

Fingerprint

Norisoprenoids
fibroblasts
Fibroblasts
collagens
Skin
Hyaluronic Acid
acids
Collagen
aromatic compounds
ultraviolet radiation
genes
molecules
Molecules
Aromatic compounds
Transcription Factor AP-1
Ultraviolet Rays
damage
Up-Regulation
Down-Regulation
synthesis

All Science Journal Classification (ASJC) codes

  • Analytical Chemistry
  • Chemistry (miscellaneous)
  • Molecular Medicine
  • Pharmaceutical Science
  • Drug Discovery
  • Physical and Theoretical Chemistry
  • Organic Chemistry

Cite this

Tong, Tao ; Park, Jinju ; Moon, Youna ; Kang, Wesuk ; Park, Taesun. / α-ionone protects against UVB-induced photoaging in human dermal fibroblasts. In: Molecules. 2019 ; Vol. 24, No. 9.
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α-ionone protects against UVB-induced photoaging in human dermal fibroblasts. / Tong, Tao; Park, Jinju; Moon, Youna; Kang, Wesuk; Park, Taesun.

In: Molecules, Vol. 24, No. 9, 1804, 01.01.2019.

Research output: Contribution to journalArticle

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