α-Mangostin ameliorates hepatic steatosis and insulin resistance by inhibition C-C chemokine receptor 2

Hong Min Kim, You Mi Kim, Ji Hye Huh, Eun Soo Lee, Mi Hye Kwon, Bo Ra Lee, Hyun Jeong Ko, Choon Hee Chung

Research output: Contribution to journalArticle

6 Citations (Scopus)

Abstract

Obesity induces various metabolic diseases such as dyslipidemia, nonalcoholic fatty liver disease (NAFLD), and type 2 diabetes. Fat expansion in adipose tissue induces adipose tissue dysfunction and inflammation, insulin resistance, and other metabolic syndromes. α- Mangostin (α-MG) has been previously studied for its anti-cancer, anti-inflammatory, and antioxidant activities. In this study, we investigated the effects of α-MG on adipose tissue inflammation and hepatic steatosis. We categorized study animals into four groups: regular diet control mice, RD mice treated with α-MG, high fat diet-induced obese mice, and HFD mice treated with α-MG. α-MG treatment significantly reduced not only the body, liver, and fat weights, but also plasma glucose, insulin, and triglyceride levels in HFD mice. Additionally, adiponectin levels of α-MG-treated mice were significantly higher than those of control HFD mice. Immunohistochemistry of liver and adipose tissue showed that CD11c expression was reduced in α-MG fed obese mice. α-MG treatment of HFD mice down-regulated the adipose-associated inflammatory cytokines and CCR2 in both liver and adipose tissue. Moreover, glucose tolerance and insulin sensitivity were significantly improved in α-MG fed obese mice. α-Mangostin ameliorates adipose inflammation and hepatic steatosis in HFDinduced obese mice.

Original languageEnglish
Article numbere0179204
JournalPloS one
Volume12
Issue number6
DOIs
Publication statusPublished - 2017 Jun 1

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CC Chemokines
Chemokine Receptors
fatty liver
insulin resistance
Insulin Resistance
Liver
Obese Mice
Insulin
Tissue
Adipose Tissue
mice
Fats
Nutrition
adipose tissue
Inflammation
Glucose
Adiponectin
inflammation
Medical problems
liver

All Science Journal Classification (ASJC) codes

  • Biochemistry, Genetics and Molecular Biology(all)
  • Agricultural and Biological Sciences(all)

Cite this

Kim, Hong Min ; Kim, You Mi ; Huh, Ji Hye ; Lee, Eun Soo ; Kwon, Mi Hye ; Lee, Bo Ra ; Ko, Hyun Jeong ; Chung, Choon Hee. / α-Mangostin ameliorates hepatic steatosis and insulin resistance by inhibition C-C chemokine receptor 2. In: PloS one. 2017 ; Vol. 12, No. 6.
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α-Mangostin ameliorates hepatic steatosis and insulin resistance by inhibition C-C chemokine receptor 2. / Kim, Hong Min; Kim, You Mi; Huh, Ji Hye; Lee, Eun Soo; Kwon, Mi Hye; Lee, Bo Ra; Ko, Hyun Jeong; Chung, Choon Hee.

In: PloS one, Vol. 12, No. 6, e0179204, 01.06.2017.

Research output: Contribution to journalArticle

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