α-Synuclein enhances dopamine D2 receptor signaling

Sung Jae Kim, Sung Yul Kim, Young Soon Na, Hyun Jung Lee, Kwang Chul Chung, Ja Hyun Baik

Research output: Contribution to journalArticle

5 Citations (Scopus)

Abstract

Parkinson's disease (PD) is characterized by a selective loss of dopamine-producing neurons in the substantia nigra (SN), which in turn results in dopamine depletion in the striatum, and the presence of neuronal cytoplasmic inclusions known as Lewy bodies (LBs). α-Synuclein is a presynaptic protein that accumulates abnormally in LBs and is seen predominantly in cases of dementia with LBs. Although the central role of α-synuclein in neurodegeneration has been previously demonstrated by the discovery of missense α-synuclein mutations in familial PD, the specific mechanism by which α-synuclein contributes to these diseases remains unclear. In the present study, we examined whether α-synuclein affects the downstream signaling of dopamine D2 receptor (D2R). In CHO cells stably transfected with D2Rs, α-synuclein enhanced dopamine D2-agonist-mediated inhibition of adenylate cyclase, which consequently affected its downstream cAMP-responsive element (CRE)-mediated gene transcription, while C-terminal deletion mutant of α-synuclein did not. Our study suggests that the α-synuclein enhances the dopamine-mediated intracellular signaling pathways by D2R, thus provide a possible mechanism in presynaptic regulation of the synaptic homeostasis in the dopaminergic neurotransmission.

Original languageEnglish
Pages (from-to)5-9
Number of pages5
JournalBrain Research
Volume1124
Issue number1
DOIs
Publication statusPublished - 2006 Dec 8

Fingerprint

Synucleins
Dopamine D2 Receptors
Lewy Bodies
Parkinson Disease
Dopamine
Lewy Body Disease
CHO Cells
Dopaminergic Neurons
Inclusion Bodies
Dopamine Agonists
Substantia Nigra
Missense Mutation
Adenylyl Cyclases
Synaptic Transmission
Homeostasis

All Science Journal Classification (ASJC) codes

  • Neuroscience(all)
  • Molecular Biology
  • Developmental Biology
  • Clinical Neurology

Cite this

Jae Kim, S., Yul Kim, S., Na, Y. S., Lee, H. J., Chung, K. C., & Baik, J. H. (2006). α-Synuclein enhances dopamine D2 receptor signaling. Brain Research, 1124(1), 5-9. https://doi.org/10.1016/j.brainres.2006.09.079
Jae Kim, Sung ; Yul Kim, Sung ; Na, Young Soon ; Lee, Hyun Jung ; Chung, Kwang Chul ; Baik, Ja Hyun. / α-Synuclein enhances dopamine D2 receptor signaling. In: Brain Research. 2006 ; Vol. 1124, No. 1. pp. 5-9.
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Jae Kim, S, Yul Kim, S, Na, YS, Lee, HJ, Chung, KC & Baik, JH 2006, 'α-Synuclein enhances dopamine D2 receptor signaling', Brain Research, vol. 1124, no. 1, pp. 5-9. https://doi.org/10.1016/j.brainres.2006.09.079

α-Synuclein enhances dopamine D2 receptor signaling. / Jae Kim, Sung; Yul Kim, Sung; Na, Young Soon; Lee, Hyun Jung; Chung, Kwang Chul; Baik, Ja Hyun.

In: Brain Research, Vol. 1124, No. 1, 08.12.2006, p. 5-9.

Research output: Contribution to journalArticle

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