β 1-and β 2-Adrenergic stimulation-induced electrogenic transport by human endolymphatic sac epithelium and its clinical implications

Bo Gyung Kim, Jin Young Kim, Jinsei Jung, In Seok Moon, Joo Heon Yoon, Jae Young Choi, Sung Huhn Kim

Research output: Contribution to journalArticle

3 Citations (Scopus)

Abstract

The endolymphatic sac (ES) is a cystic structure of the inner ear connected to the cochlea and vestibule, which plays a role in regulating ion homeostasis in inner ear fluid. Disruption of ion homeostasis can cause inner ear disorders with hearing loss and dizziness, such as Meniere's disease. Herein, we found, for the first time, functional evidence for the involvement of β 1-and β 2-Adrenergic receptors in apical electrogenic ion transport by human ES epithelium by using electrophysiological/pharmacological and molecular biological methods, which were dependent on K + and Cl â ' ion transport. The apical electrogenic transport was absent or very weak in ES epithelia of patients with Meniere's disease. These results suggested that adrenergic stimulation via β 1-and β 2-Adrenergic receptors in the human ES was involved in regulation of inner ear fluid ion homeostasis and impairment of this response could be a pathological mechanism of Meniere's disease.

Original languageEnglish
Article number42217
JournalScientific reports
Volume7
DOIs
Publication statusPublished - 2017 Feb 6

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Endolymphatic Sac
Inner Ear
Adrenergic Agents
Meniere Disease
Epithelium
Homeostasis
Ion Transport
Ions
Adrenergic Receptors
Cochlea
Dizziness
Hearing Loss
Pharmacology

All Science Journal Classification (ASJC) codes

  • General

Cite this

Kim, Bo Gyung ; Kim, Jin Young ; Jung, Jinsei ; Moon, In Seok ; Yoon, Joo Heon ; Choi, Jae Young ; Kim, Sung Huhn. / β 1-and β 2-Adrenergic stimulation-induced electrogenic transport by human endolymphatic sac epithelium and its clinical implications. In: Scientific reports. 2017 ; Vol. 7.
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β 1-and β 2-Adrenergic stimulation-induced electrogenic transport by human endolymphatic sac epithelium and its clinical implications. / Kim, Bo Gyung; Kim, Jin Young; Jung, Jinsei; Moon, In Seok; Yoon, Joo Heon; Choi, Jae Young; Kim, Sung Huhn.

In: Scientific reports, Vol. 7, 42217, 06.02.2017.

Research output: Contribution to journalArticle

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