ω-Transaminase-catalyzed asymmetric synthesis of unnatural amino acids using isopropylamine as an amino donor

Eul Soo Park, Joo Young Dong, jong shik shin

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Abstract

Isopropylamine is an ideal amino donor for reductive amination of carbonyl compounds by ω-transaminase (ω-TA) owing to its cheapness and high volatility of a ketone product. Here we developed asymmetric synthesis of unnatural amino acids via ω-TA-catalyzed amino group transfer between α-keto acids and isopropylamine.

Original languageEnglish
Pages (from-to)6929-6933
Number of pages5
JournalOrganic and Biomolecular Chemistry
Volume11
Issue number40
DOIs
Publication statusPublished - 2013 Oct 28

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All Science Journal Classification (ASJC) codes

  • Biochemistry
  • Physical and Theoretical Chemistry
  • Organic Chemistry

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