15-deoxy-Δ,12,14-prostaglandin J2 suppresses nuclear factor-κB-mediated apoptosis of helicobacter pylori-infected gastric epithelial cells

Boram Cha, Kyung Hwan Kim, Hyeyoung Kim

Research output: Chapter in Book/Report/Conference proceedingConference contribution

3 Citations (Scopus)

Abstract

Helicobacter pylori deregulates the genes that control homeostasis between apoptosis and cell proliferation of gastric epithelial cells. Nuclear factor-κB (NF-κB) has an important role in H. pylori-induced apoptosis in gastric epithelial cells. The peroxisome proliferator-activated receptor-γ ligand 15-deoxy-Δ12,14-prostaglandin J 2 (15d-PGJ2) regulates growth and the signaling cascade in H. pylori-infected gastric epithelial cells. In the present study, we determined whether 15d-PGJ2 inhibits apoptosis by regulating apoptotic gene expression and NF-κB activation in gastric epithelial cells infected with CagA+, VacA+ H. pylori in a Korean isolate (HP99). 15d-PGJ 2 was found to inhibit H. pylori-induced DNA fragmentation and cell death. 15d-PGJ2 induced downregulation of proapoptotic Bax and upregulation of antiapoptotic Bcl-2 as well as suppression of NF-κB activation caused by H. pylori in gastric epithelial cells. The results suggest that 15d-PGJ2 inhibits apoptotic cell death by inhibiting NF-κB activation and apoptotic gene expression in gastric epithelial cells.

Original languageEnglish
Title of host publicationNatural Compounds and Their Role in Apoptotic Cell Signaling Pathways
PublisherBlackwell Publishing Inc.
Pages457-463
Number of pages7
ISBN (Print)9781573317375
DOIs
Publication statusPublished - 2009 Aug

Publication series

NameAnnals of the New York Academy of Sciences
Volume1171
ISSN (Print)0077-8923
ISSN (Electronic)1749-6632

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All Science Journal Classification (ASJC) codes

  • Neuroscience(all)
  • Biochemistry, Genetics and Molecular Biology(all)
  • History and Philosophy of Science

Cite this

Cha, B., Kim, K. H., & Kim, H. (2009). 15-deoxy-Δ,12,14-prostaglandin J2 suppresses nuclear factor-κB-mediated apoptosis of helicobacter pylori-infected gastric epithelial cells. In Natural Compounds and Their Role in Apoptotic Cell Signaling Pathways (pp. 457-463). (Annals of the New York Academy of Sciences; Vol. 1171). Blackwell Publishing Inc.. https://doi.org/10.1111/j.1749-6632.2009.04706.x