15-deoxy-Δ,12,14-prostaglandin J2 suppresses nuclear factor-κB-mediated apoptosis of helicobacter pylori-infected gastric epithelial cells

Boram Cha, Kyung Hwan Kim, Hyeyoung Kim

Research output: Chapter in Book/Report/Conference proceedingConference contribution

4 Citations (Scopus)


Helicobacter pylori deregulates the genes that control homeostasis between apoptosis and cell proliferation of gastric epithelial cells. Nuclear factor-κB (NF-κB) has an important role in H. pylori-induced apoptosis in gastric epithelial cells. The peroxisome proliferator-activated receptor-γ ligand 15-deoxy-Δ12,14-prostaglandin J 2 (15d-PGJ2) regulates growth and the signaling cascade in H. pylori-infected gastric epithelial cells. In the present study, we determined whether 15d-PGJ2 inhibits apoptosis by regulating apoptotic gene expression and NF-κB activation in gastric epithelial cells infected with CagA+, VacA+ H. pylori in a Korean isolate (HP99). 15d-PGJ 2 was found to inhibit H. pylori-induced DNA fragmentation and cell death. 15d-PGJ2 induced downregulation of proapoptotic Bax and upregulation of antiapoptotic Bcl-2 as well as suppression of NF-κB activation caused by H. pylori in gastric epithelial cells. The results suggest that 15d-PGJ2 inhibits apoptotic cell death by inhibiting NF-κB activation and apoptotic gene expression in gastric epithelial cells.

Original languageEnglish
Title of host publicationNatural Compounds and Their Role in Apoptotic Cell Signaling Pathways
PublisherBlackwell Publishing Inc.
Number of pages7
ISBN (Print)9781573317375
Publication statusPublished - 2009 Aug

Publication series

NameAnnals of the New York Academy of Sciences
ISSN (Print)0077-8923
ISSN (Electronic)1749-6632

All Science Journal Classification (ASJC) codes

  • Neuroscience(all)
  • Biochemistry, Genetics and Molecular Biology(all)
  • History and Philosophy of Science


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