15-deoxy-Δ,12,14-prostaglandin J2 suppresses nuclear factor-κB-mediated apoptosis of helicobacter pylori-infected gastric epithelial cells

Boram Cha; Kyung Hwan Kim; Hyeyoung Kim

doi:10.1111/j.1749-6632.2009.04706.x

15-deoxy-Δ,^12,14-prostaglandin J₂ suppresses nuclear factor-κB-mediated apoptosis of helicobacter pylori-infected gastric epithelial cells

Boram Cha, Kyung Hwan Kim, Hyeyoung Kim

Department of Food and Nutrition

Research output: Chapter in Book/Report/Conference proceeding › Conference contribution

4 Citations (Scopus)

Abstract

Helicobacter pylori deregulates the genes that control homeostasis between apoptosis and cell proliferation of gastric epithelial cells. Nuclear factor-κB (NF-κB) has an important role in H. pylori-induced apoptosis in gastric epithelial cells. The peroxisome proliferator-activated receptor-γ ligand 15-deoxy-Δ^12,14-prostaglandin J ₂ (15d-PGJ₂) regulates growth and the signaling cascade in H. pylori-infected gastric epithelial cells. In the present study, we determined whether 15d-PGJ₂ inhibits apoptosis by regulating apoptotic gene expression and NF-κB activation in gastric epithelial cells infected with CagA+, VacA+ H. pylori in a Korean isolate (HP99). 15d-PGJ ₂ was found to inhibit H. pylori-induced DNA fragmentation and cell death. 15d-PGJ₂ induced downregulation of proapoptotic Bax and upregulation of antiapoptotic Bcl-2 as well as suppression of NF-κB activation caused by H. pylori in gastric epithelial cells. The results suggest that 15d-PGJ₂ inhibits apoptotic cell death by inhibiting NF-κB activation and apoptotic gene expression in gastric epithelial cells.

Original language	English
Title of host publication	Natural Compounds and Their Role in Apoptotic Cell Signaling Pathways
Publisher	Blackwell Publishing Inc.
Pages	457-463
Number of pages	7
ISBN (Print)	9781573317375
DOIs	https://doi.org/10.1111/j.1749-6632.2009.04706.x
Publication status	Published - 2009 Aug

Publication series

Name	Annals of the New York Academy of Sciences
Volume	1171
ISSN (Print)	0077-8923
ISSN (Electronic)	1749-6632

All Science Journal Classification (ASJC) codes

Neuroscience(all)
Biochemistry, Genetics and Molecular Biology(all)
History and Philosophy of Science

Access to Document

10.1111/j.1749-6632.2009.04706.x

Cite this

Cha, B., Kim, K. H., & Kim, H. (2009). 15-deoxy-Δ,^12,14-prostaglandin J₂ suppresses nuclear factor-κB-mediated apoptosis of helicobacter pylori-infected gastric epithelial cells. In Natural Compounds and Their Role in Apoptotic Cell Signaling Pathways (pp. 457-463). (Annals of the New York Academy of Sciences; Vol. 1171). Blackwell Publishing Inc.. https://doi.org/10.1111/j.1749-6632.2009.04706.x

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title = "15-deoxy-Δ,12,14-prostaglandin J2 suppresses nuclear factor-κB-mediated apoptosis of helicobacter pylori-infected gastric epithelial cells",

abstract = "Helicobacter pylori deregulates the genes that control homeostasis between apoptosis and cell proliferation of gastric epithelial cells. Nuclear factor-κB (NF-κB) has an important role in H. pylori-induced apoptosis in gastric epithelial cells. The peroxisome proliferator-activated receptor-γ ligand 15-deoxy-Δ12,14-prostaglandin J 2 (15d-PGJ2) regulates growth and the signaling cascade in H. pylori-infected gastric epithelial cells. In the present study, we determined whether 15d-PGJ2 inhibits apoptosis by regulating apoptotic gene expression and NF-κB activation in gastric epithelial cells infected with CagA+, VacA+ H. pylori in a Korean isolate (HP99). 15d-PGJ 2 was found to inhibit H. pylori-induced DNA fragmentation and cell death. 15d-PGJ2 induced downregulation of proapoptotic Bax and upregulation of antiapoptotic Bcl-2 as well as suppression of NF-κB activation caused by H. pylori in gastric epithelial cells. The results suggest that 15d-PGJ2 inhibits apoptotic cell death by inhibiting NF-κB activation and apoptotic gene expression in gastric epithelial cells.",

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Cha, B, Kim, KH & Kim, H 2009, 15-deoxy-Δ,^12,14-prostaglandin J₂ suppresses nuclear factor-κB-mediated apoptosis of helicobacter pylori-infected gastric epithelial cells. in Natural Compounds and Their Role in Apoptotic Cell Signaling Pathways. Annals of the New York Academy of Sciences, vol. 1171, Blackwell Publishing Inc., pp. 457-463. https://doi.org/10.1111/j.1749-6632.2009.04706.x

15-deoxy-Δ,^12,14-prostaglandin J₂ suppresses nuclear factor-κB-mediated apoptosis of helicobacter pylori-infected gastric epithelial cells. / Cha, Boram; Kim, Kyung Hwan; Kim, Hyeyoung.

Natural Compounds and Their Role in Apoptotic Cell Signaling Pathways. Blackwell Publishing Inc., 2009. p. 457-463 (Annals of the New York Academy of Sciences; Vol. 1171).

Research output: Chapter in Book/Report/Conference proceeding › Conference contribution

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