2-[2-Substituted-3-(3,4-dichlorobenzylamino)propylamino]-1H-quinolin-4-ones as Staphylococcus aureus methionyl-tRNA synthetase inhibitors

Farhanullah, Taehee Kang, Eun Jung Yoon, Eun Chil Choi, Sunghoon Kim, Jeewoo Lee

Research output: Contribution to journalArticlepeer-review

22 Citations (Scopus)

Abstract

New analogues of 2-[2-substituted-3-(3,4-dichlorobenzylamino)propylamino]quinolin-4-ones, 26a, 26b, 31a-e, 34, 35, 38 and 40, have been synthesized and evaluated against Staphylococcus aureus methionyl-tRNA synthetase. All of the synthesized compounds were less active than the reference compound 2. The compounds were also screened against various strains of S. aureus and Enterococci for their antibacterial activities. Among the compounds, 26b, 31c and 31e displayed significant inhibitory properties against various strains of Enterococci compared to compound 2.

Original languageEnglish
Pages (from-to)239-250
Number of pages12
JournalEuropean Journal of Medicinal Chemistry
Volume44
Issue number1
DOIs
Publication statusPublished - 2009 Jan

Bibliographical note

Funding Information:
This work was supported by a Grant (03-PJ2-PG4-BD02-0001) from the Ministry of Health and Welfare, Republic of Korea and by the Korea Science and Engineering Foundation (KOSEF) grant funded by the Korean Government (MOST) (R17-2007-020-01000-0).

All Science Journal Classification (ASJC) codes

  • Pharmacology
  • Drug Discovery
  • Organic Chemistry

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