2-Aminophenylpyrimidines as Novel Inhibitors of Aminoacyl-tRNA Synthetase Interacting Multifunctional Protein 2 (AIMP2)-DX2 for Lung Cancer Treatment

Sunghoon Kim, Seungbeom Lee, Dae Gyu Kim, Kyeojin Kim, Taewoo Kim, Semi Lim, Hyejin Kong, Young-Ger Suh

Research output: Contribution to journalArticlepeer-review

2 Citations (Scopus)

Abstract

Aminoacyl-tRNA synthetase interacting multifunctional proteins (AIMPs) have recently been considered novel therapeutic targets in several cancers. In this publication we report the development of novel 2-aminophenylpyrimidines as new AIMP2-DX2 inhibitors. In particular, aminophenylpyrimidine 3 not only exhibited promising in vitro and in vivo potency but also exerted selective inhibition of H460 and A549 cells and AIMP2-DX2 rather than WI-26 cells and AIMP2. Aminophenylpyrimidine 3 offers possible therapeutic potential in the treatment of lung cancer.
Original languageEnglish
Pages (from-to)3908-3914
JournalJournal of Medicinal Chemistry
Volume63
Issue number8
DOIs
Publication statusPublished - 2020 Apr 23

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