3D-printed polycaprolactone scaffold mixed with β-tricalcium phosphate as a bone regenerative material in rabbit calvarial defects

Hyung Chul Pae, Joo Hyun Kang, Jae Kook Cha, Jung Seok Lee, Jeong Won Paik, Ui Won Jung, Byung Hoon Kim, Seong Ho Choi

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36 Citations (Scopus)


Defect-specific bone regeneration using 3-dimensional (3D) printing of block bone has been developed. Polycaprolactone (PCL) is biocompatible polymer that can be used as 3D scaffold. The aim of this study is to assess the biocompatibility and osteogenic efficacy of 3D printed PCL scaffold and to evaluate the effectiveness of β-tricalcium phosphate (β-TCP) addition in PCL scaffold. In this work, four circular defects (diameter: 8 mm) in rabbit calvarium were randomly assigned to (1) negative control (control), (2) PCL block (PCL), (3) PCL mixed with 10 wt% β-TCP (PCL/β-TCP), and (4) PCL/β-TCP plus collagen membrane (PCL/β-TCP + M). Animals were euthanized at 2 (n = 5) and 8 weeks (n = 5). Results indicated that in micro-CT, PCL/β-TCP + M showed the highest total augmented volume and new bone volume at 8 weeks, but there was no significant difference among four groups. Histomorphometrically, PCL, PCL/β-TCP, and PCL/β-TCP + M showed the significantly higher total augmented area compared to the control. PCL/β-TCP + M showed the highest new bone area but not statistically higher than the control. New bone formation deep inside the scaffold was observed only in β-TCP added scaffold. PCL showed high biocompatibility with great volume maintenance. Addition of β-TCP to PCL seemed to increase hydrophilicity and osteoconductivity. Developments in 3D-printed PCL material are expected.

Original languageEnglish
Pages (from-to)1254-1263
Number of pages10
JournalJournal of Biomedical Materials Research - Part B Applied Biomaterials
Issue number4
Publication statusPublished - 2019 May

Bibliographical note

Funding Information:
Correspondence to: S.-H. Choi; e-mail: shchoi726@yuhs.ac Contract grant sponsor: National Research Foundation of Korea; contract grant number: NRF-2017R1A2B4002782

Publisher Copyright:
© 2018 Wiley Periodicals, Inc.

All Science Journal Classification (ASJC) codes

  • Biomaterials
  • Biomedical Engineering


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