3D-printed transmembrane glycoprotein cancer biomarker aptasensor

Agustín G. Crevillen; Carmen C. Mayorga-Martinez; Jaroslav Zelenka; Silvie Rimpelová; Tomáš Ruml; Martin Pumera

doi:10.1016/j.apmt.2021.101153

3D-printed transmembrane glycoprotein cancer biomarker aptasensor

Agustín G. Crevillen, Carmen C. Mayorga-Martinez, Jaroslav Zelenka, Silvie Rimpelová, Tomáš Ruml, Martin Pumera

Department of Chemical and Biomolecular Engineering

Research output: Contribution to journal › Article › peer-review

6 Citations (Scopus)

Abstract

Point-of-care, easy to manufacture, and low cost detection of cancer biomarkers is crucial for fighting the early stage disease. 3D printing allows delocalized printing at remote locations with updates/upgrades available globally via electronic files. Mucin 1 (MUC1) is a protein that is overexpressed in a number of epithelial cancers and is a key factor in advancement of the disease. Here we show the simple point-of-care 3D printing fabrication of a MUC1 aptasensor using a nanocarbon/polymer filament. Efficacy of the 3D-printed aptasensor is demonstrated by monitoring the expression and release of MUC1 in breast cancer cell cultures. Such a simple, low cost, and easy to locally fabricate cancer biosensor will have a large impact on the field of cancer diagnostics.

Original language	English
Article number	101153
Journal	Applied Materials Today
Volume	24
DOIs	https://doi.org/10.1016/j.apmt.2021.101153
Publication status	Published - 2021 Sep

Bibliographical note

Funding Information:
This work was supported by the project Advanced Functional Nanorobots (Reg. No. CZ.02.1.01/0.0/0.0/15_003/0000444 financed by the EFRR). AGC acknowledges the fellowship from Jose Castillejo program. The project was supported by Ministry of Education, Youth and Sports (Czech Republic) grant LL2002 under ERC CZ program. This work was supported by the funds from the Ministry of Health of the Czech Republic ( NU21-08-00407 ).

Publisher Copyright:
© 2021

All Science Journal Classification (ASJC) codes

Materials Science(all)

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

Access to Document

10.1016/j.apmt.2021.101153

Cite this

@article{b636bc027c1549389be07e7d6c998c6a,

title = "3D-printed transmembrane glycoprotein cancer biomarker aptasensor",

abstract = "Point-of-care, easy to manufacture, and low cost detection of cancer biomarkers is crucial for fighting the early stage disease. 3D printing allows delocalized printing at remote locations with updates/upgrades available globally via electronic files. Mucin 1 (MUC1) is a protein that is overexpressed in a number of epithelial cancers and is a key factor in advancement of the disease. Here we show the simple point-of-care 3D printing fabrication of a MUC1 aptasensor using a nanocarbon/polymer filament. Efficacy of the 3D-printed aptasensor is demonstrated by monitoring the expression and release of MUC1 in breast cancer cell cultures. Such a simple, low cost, and easy to locally fabricate cancer biosensor will have a large impact on the field of cancer diagnostics.",

author = "Crevillen, {Agust{\'i}n G.} and Mayorga-Martinez, {Carmen C.} and Jaroslav Zelenka and Silvie Rimpelov{\'a} and Tom{\'a}{\v s} Ruml and Martin Pumera",

note = "Funding Information: This work was supported by the project Advanced Functional Nanorobots (Reg. No. CZ.02.1.01/0.0/0.0/15_003/0000444 financed by the EFRR). AGC acknowledges the fellowship from Jose Castillejo program. The project was supported by Ministry of Education, Youth and Sports (Czech Republic) grant LL2002 under ERC CZ program. This work was supported by the funds from the Ministry of Health of the Czech Republic ( NU21-08-00407 ). Publisher Copyright: {\textcopyright} 2021",

year = "2021",

month = sep,

doi = "10.1016/j.apmt.2021.101153",

language = "English",

volume = "24",

journal = "Applied Materials Today",

issn = "2352-9407",

publisher = "Elsevier BV",

}

TY - JOUR

T1 - 3D-printed transmembrane glycoprotein cancer biomarker aptasensor

AU - Crevillen, Agustín G.

AU - Mayorga-Martinez, Carmen C.

AU - Zelenka, Jaroslav

AU - Rimpelová, Silvie

AU - Ruml, Tomáš

AU - Pumera, Martin

N1 - Funding Information: This work was supported by the project Advanced Functional Nanorobots (Reg. No. CZ.02.1.01/0.0/0.0/15_003/0000444 financed by the EFRR). AGC acknowledges the fellowship from Jose Castillejo program. The project was supported by Ministry of Education, Youth and Sports (Czech Republic) grant LL2002 under ERC CZ program. This work was supported by the funds from the Ministry of Health of the Czech Republic ( NU21-08-00407 ). Publisher Copyright: © 2021

PY - 2021/9

Y1 - 2021/9

N2 - Point-of-care, easy to manufacture, and low cost detection of cancer biomarkers is crucial for fighting the early stage disease. 3D printing allows delocalized printing at remote locations with updates/upgrades available globally via electronic files. Mucin 1 (MUC1) is a protein that is overexpressed in a number of epithelial cancers and is a key factor in advancement of the disease. Here we show the simple point-of-care 3D printing fabrication of a MUC1 aptasensor using a nanocarbon/polymer filament. Efficacy of the 3D-printed aptasensor is demonstrated by monitoring the expression and release of MUC1 in breast cancer cell cultures. Such a simple, low cost, and easy to locally fabricate cancer biosensor will have a large impact on the field of cancer diagnostics.

AB - Point-of-care, easy to manufacture, and low cost detection of cancer biomarkers is crucial for fighting the early stage disease. 3D printing allows delocalized printing at remote locations with updates/upgrades available globally via electronic files. Mucin 1 (MUC1) is a protein that is overexpressed in a number of epithelial cancers and is a key factor in advancement of the disease. Here we show the simple point-of-care 3D printing fabrication of a MUC1 aptasensor using a nanocarbon/polymer filament. Efficacy of the 3D-printed aptasensor is demonstrated by monitoring the expression and release of MUC1 in breast cancer cell cultures. Such a simple, low cost, and easy to locally fabricate cancer biosensor will have a large impact on the field of cancer diagnostics.

UR - http://www.scopus.com/inward/record.url?scp=85120742823&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=85120742823&partnerID=8YFLogxK

U2 - 10.1016/j.apmt.2021.101153

DO - 10.1016/j.apmt.2021.101153

M3 - Article

AN - SCOPUS:85120742823

VL - 24

JO - Applied Materials Today

JF - Applied Materials Today

SN - 2352-9407

M1 - 101153

ER -

3D-printed transmembrane glycoprotein cancer biomarker aptasensor

Abstract

Bibliographical note

All Science Journal Classification (ASJC) codes

UN SDGs

Access to Document

Other files and links

Fingerprint

Cite this