3D-printed transmembrane glycoprotein cancer biomarker aptasensor

Agustín G. Crevillen, Carmen C. Mayorga-Martinez, Jaroslav Zelenka, Silvie Rimpelová, Tomáš Ruml, Martin Pumera

Research output: Contribution to journalArticlepeer-review

3 Citations (Scopus)

Abstract

Point-of-care, easy to manufacture, and low cost detection of cancer biomarkers is crucial for fighting the early stage disease. 3D printing allows delocalized printing at remote locations with updates/upgrades available globally via electronic files. Mucin 1 (MUC1) is a protein that is overexpressed in a number of epithelial cancers and is a key factor in advancement of the disease. Here we show the simple point-of-care 3D printing fabrication of a MUC1 aptasensor using a nanocarbon/polymer filament. Efficacy of the 3D-printed aptasensor is demonstrated by monitoring the expression and release of MUC1 in breast cancer cell cultures. Such a simple, low cost, and easy to locally fabricate cancer biosensor will have a large impact on the field of cancer diagnostics.

Original languageEnglish
Article number101153
JournalApplied Materials Today
Volume24
DOIs
Publication statusPublished - 2021 Sep

Bibliographical note

Funding Information:
This work was supported by the project Advanced Functional Nanorobots (Reg. No. CZ.02.1.01/0.0/0.0/15_003/0000444 financed by the EFRR). AGC acknowledges the fellowship from Jose Castillejo program. The project was supported by Ministry of Education, Youth and Sports (Czech Republic) grant LL2002 under ERC CZ program. This work was supported by the funds from the Ministry of Health of the Czech Republic ( NU21-08-00407 ).

Publisher Copyright:
© 2021

All Science Journal Classification (ASJC) codes

  • Materials Science(all)

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