5-Arylamino-2-methyl-4,7-dioxobenzothiazoles as inhibitors of cyclin-dependent kinase 4 and cytotoxic agents

Chung Kyu Ryu, Hye Young Kang, Sang Kook Lee, Kyung Ae Nam, Chang Yong Hong, Won Gil Ko, Byung Hoon Lee

Research output: Contribution to journalArticle

38 Citations (Scopus)

Abstract

5-Arylamino-2-methyl-4,7-dioxobenzothiazoles were synthesized as inhibitors of cyclin-dependent kinase 4 (CDK4) and cytotoxic agents. Most of the 4,7-dioxobenzothiazoles exhibited selective inhibitory activities for the CDK4 and cytotoxic potential against human cancer cell lines. (C) 2000 Elsevier Science Ltd. All rights reserved.

Original languageEnglish
Pages (from-to)461-464
Number of pages4
JournalBioorganic and Medicinal Chemistry Letters
Volume10
Issue number5
DOIs
Publication statusPublished - 2000 Mar 6

All Science Journal Classification (ASJC) codes

  • Biochemistry
  • Molecular Medicine
  • Molecular Biology
  • Pharmaceutical Science
  • Drug Discovery
  • Clinical Biochemistry
  • Organic Chemistry

Fingerprint Dive into the research topics of '5-Arylamino-2-methyl-4,7-dioxobenzothiazoles as inhibitors of cyclin-dependent kinase 4 and cytotoxic agents'. Together they form a unique fingerprint.

  • Cite this