5 nm Silver Nanoparticles Amplify Clinical Features of Atopic Dermatitis in Mice by Activating Mast Cells

Han Goo Kang, Seungjae Kim, Kwang Hoon Lee, Shan Jin, Seo Hyeong Kim, Kangtaek Lee, Hyungjoon Jeon, Young Geon Song, Sang Won Lee, Jinwon Seo, Soomin Park, In Hong Choi

Research output: Contribution to journalArticlepeer-review

21 Citations (Scopus)


The triggering effect of silver nanoparticles (NPs) on the induction of allergic reactions is evaluated, by studying the activation of mast cells and the clinical features of atopic dermatitis in a mouse model. Granule release is induced in RBL-2H3 mast cells by 5 nm, but not 100 nm silver NPs. Increases in the levels of reactive oxygen species (hydrogen peroxide and mitochondrial superoxide) and intracellular Ca++ in mast cells are induced by 5 nm silver NPs. In a mouse model of atopic dermatitis induced by a mite allergen, the skin lesions are more severe and appear earlier in mice treated simultaneously with 5 nm silver NPs and allergen compared with mice treated with allergen alone or 100 nm silver NPs and allergen. The histological findings reveal that number of tryptase-positive mast cells and total IgE levels in the serum increase in mice treated with 5 nm silver NPs and allergen. The results in this study indicate that cotreatment with 5 nm silver NPs stimulates mast cell degranulation and induces earlier and more severe clinical alterations in allergy-prone individuals.

Original languageEnglish
Article number1602363
Issue number9
Publication statusPublished - 2017 Mar 7

Bibliographical note

Funding Information:
H.K. and S.K. contributed equally to this work. This research was supported by NRF-2012R1A4A1029061. There are no conflicts of interest.

Publisher Copyright:
© 2016 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim

All Science Journal Classification (ASJC) codes

  • Biotechnology
  • Biomaterials
  • Chemistry(all)
  • Materials Science(all)


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