5′-porphyrin-oligonucleotide conjugates: Neutral porphyrin-DNA interactions

Milan Balaz, Jay D. Steinkruger, George A. Ellestad, Nina Berova

Research output: Contribution to journalArticlepeer-review

44 Citations (Scopus)


(Chemical Equation Presented) Incorporation of hydrophilic tetraarylporphyrin phosphoramidites into the 5′-termimus of the DNA as well as noncharged porphyrin-DNA interactions have been studied. Porphyrin-modified oligonucleotides show lower melting temperatures than their unmodified analogues. Single-stranded DNA interacts more strongly with porphyrin and causes more intense chiral disturbance in the porphyrin environment than the corresponding double strand.

Original languageEnglish
Pages (from-to)5613-5616
Number of pages4
JournalOrganic Letters
Issue number25
Publication statusPublished - 2005 Dec 8

All Science Journal Classification (ASJC) codes

  • Biochemistry
  • Physical and Theoretical Chemistry
  • Organic Chemistry


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