(Chemical Equation Presented) Incorporation of hydrophilic tetraarylporphyrin phosphoramidites into the 5′-termimus of the DNA as well as noncharged porphyrin-DNA interactions have been studied. Porphyrin-modified oligonucleotides show lower melting temperatures than their unmodified analogues. Single-stranded DNA interacts more strongly with porphyrin and causes more intense chiral disturbance in the porphyrin environment than the corresponding double strand.
|Number of pages||4|
|Publication status||Published - 2005 Dec 8|
All Science Journal Classification (ASJC) codes
- Physical and Theoretical Chemistry
- Organic Chemistry