5′-porphyrin-oligonucleotide conjugates: Neutral porphyrin-DNA interactions

Milan Balaz; Jay D. Steinkruger; George A. Ellestad; Nina Berova

doi:10.1021/ol0522992

5′-porphyrin-oligonucleotide conjugates: Neutral porphyrin-DNA interactions

Milan Balaz, Jay D. Steinkruger, George A. Ellestad, Nina Berova

Integrated Sciences and Engineering Division

Research output: Contribution to journal › Article › peer-review

44 Citations (Scopus)

Abstract

(Chemical Equation Presented) Incorporation of hydrophilic tetraarylporphyrin phosphoramidites into the 5′-termimus of the DNA as well as noncharged porphyrin-DNA interactions have been studied. Porphyrin-modified oligonucleotides show lower melting temperatures than their unmodified analogues. Single-stranded DNA interacts more strongly with porphyrin and causes more intense chiral disturbance in the porphyrin environment than the corresponding double strand.

Original language	English
Pages (from-to)	5613-5616
Number of pages	4
Journal	Organic Letters
Volume	7
Issue number	25
DOIs	https://doi.org/10.1021/ol0522992
Publication status	Published - 2005 Dec 8

All Science Journal Classification (ASJC) codes

Biochemistry
Physical and Theoretical Chemistry
Organic Chemistry

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10.1021/ol0522992

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AU - Ellestad, George A.

AU - Berova, Nina

PY - 2005/12/8

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5′-porphyrin-oligonucleotide conjugates: Neutral porphyrin-DNA interactions

Abstract

All Science Journal Classification (ASJC) codes

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