[6]-Gingerol, a pungent ingredient of ginger, inhibits angiogenesis in vitro and in vivo

Eok Cheon Kim, Jeong Ki Min, Tae Yoon Kim, Shin Jeong Lee, Hyun Ok Yang, Sanghwa Han, Young Myeong Kim, Young Guen Kwon

Research output: Contribution to journalArticlepeer-review

219 Citations (Scopus)

Abstract

[6]-Gingerol, a pungent ingredient of ginger (Zingiber officinale Roscoe, Zingiberaceae), has anti-bacterial, anti-inflammatory, and anti-tumor-promoting activities. Here, we describe its novel anti-angiogenic activity in vitro and in vivo. In vitro, [6]-gingerol inhibited both the VEGF- and bFGF-induced proliferation of human endothelial cells and caused cell cycle arrest in the G1 phase. It also blocked capillary-like tube formation by endothelial cells in response to VEGF, and strongly inhibited sprouting of endothelial cells in the rat aorta and formation of new blood vessel in the mouse cornea in response to VEGF. Moreover, i.p. administration, without reaching tumor cytotoxic blood levels, to mice receiving i.v. injection of B16F10 melanoma cells, reduced the number of lung metastasis, with preservation of apparently healthy behavior. Taken together, these results demonstrate that [6]-gingerol inhibits angiogenesis and may be useful in the treatment of tumors and other angiogenesis-dependent diseases.

Original languageEnglish
Pages (from-to)300-308
Number of pages9
JournalBiochemical and Biophysical Research Communications
Volume335
Issue number2
DOIs
Publication statusPublished - 2005 Sep 23

Bibliographical note

Funding Information:
This work supported by a Vascular System Research Center Grant from KOSEF and a grant (PF0320503-00) from the Plant Diversity Research Center of the 21st Century Frontier Research Program, Ministry of Science and Technology, Republic of Korea.

All Science Journal Classification (ASJC) codes

  • Biophysics
  • Biochemistry
  • Molecular Biology
  • Cell Biology

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