7-oxostaurosporine selectively inhibits the mycelial form of Candida albicans

Eui Il Hwang, Bong Sik Yun, Sang Han Lee, Soo Kie Kim, Se Jin Lim, Sung Uk Kim

Research output: Contribution to journalArticle

3 Citations (Scopus)

Abstract

In the course of screening for specific inhibitors against the mycelial form of Candida albicans from natural resources, we have isolated and identified A6792-1 from Streptomyces sp. A6792 by using several chromatographies. By spectral analyses, this compound was determined as 7-oxostaurosporine, having a structure of staurosporine aglycon moiety. 7-Oxostaurosporine exhibited a selective growth inhibitory activity against the mycelial form of Candida spp. up to 100 μg/disc in bioassay. It also exhibited a specific antifungal activity against the mycelial form of Candida spp. including C. krusei, C. albicans, C. tropicalis, and C. lusitaniae with MICs ranging from 3.1 to 25 μg/ml. 7-Oxostaurosporine demonstrated no in vivo toxicity in SPF ICR mice. Therefore, this compound may have a considerable potential as an antifungal agent based on the preferential inhibition against growth of the mycelial form of Candida spp., dimorphic fungi.

Original languageEnglish
Pages (from-to)1067-1070
Number of pages4
JournalJournal of microbiology and biotechnology
Volume14
Issue number5
Publication statusPublished - 2004 Oct 1

Fingerprint

Candida albicans
Candida
Inbred ICR Mouse
Staurosporine
Antifungal Agents
Streptomyces
Growth
Biological Assay
Chromatography
Fungi
7-oxostaurosporine

All Science Journal Classification (ASJC) codes

  • Biotechnology
  • Applied Microbiology and Biotechnology

Cite this

Hwang, E. I., Yun, B. S., Lee, S. H., Kim, S. K., Lim, S. J., & Kim, S. U. (2004). 7-oxostaurosporine selectively inhibits the mycelial form of Candida albicans. Journal of microbiology and biotechnology, 14(5), 1067-1070.
Hwang, Eui Il ; Yun, Bong Sik ; Lee, Sang Han ; Kim, Soo Kie ; Lim, Se Jin ; Kim, Sung Uk. / 7-oxostaurosporine selectively inhibits the mycelial form of Candida albicans. In: Journal of microbiology and biotechnology. 2004 ; Vol. 14, No. 5. pp. 1067-1070.
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Hwang, EI, Yun, BS, Lee, SH, Kim, SK, Lim, SJ & Kim, SU 2004, '7-oxostaurosporine selectively inhibits the mycelial form of Candida albicans', Journal of microbiology and biotechnology, vol. 14, no. 5, pp. 1067-1070.

7-oxostaurosporine selectively inhibits the mycelial form of Candida albicans. / Hwang, Eui Il; Yun, Bong Sik; Lee, Sang Han; Kim, Soo Kie; Lim, Se Jin; Kim, Sung Uk.

In: Journal of microbiology and biotechnology, Vol. 14, No. 5, 01.10.2004, p. 1067-1070.

Research output: Contribution to journalArticle

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AU - Kim, Sung Uk

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