7-oxostaurosporine selectively inhibits the mycelial form of Candida albicans

Eui Il Hwang, Bong Sik Yun, Sang Han Lee, Soo Kie Kim, Se Jin Lim, Sung Uk Kim

Research output: Contribution to journalArticle

3 Citations (Scopus)

Abstract

In the course of screening for specific inhibitors against the mycelial form of Candida albicans from natural resources, we have isolated and identified A6792-1 from Streptomyces sp. A6792 by using several chromatographies. By spectral analyses, this compound was determined as 7-oxostaurosporine, having a structure of staurosporine aglycon moiety. 7-Oxostaurosporine exhibited a selective growth inhibitory activity against the mycelial form of Candida spp. up to 100 μg/disc in bioassay. It also exhibited a specific antifungal activity against the mycelial form of Candida spp. including C. krusei, C. albicans, C. tropicalis, and C. lusitaniae with MICs ranging from 3.1 to 25 μg/ml. 7-Oxostaurosporine demonstrated no in vivo toxicity in SPF ICR mice. Therefore, this compound may have a considerable potential as an antifungal agent based on the preferential inhibition against growth of the mycelial form of Candida spp., dimorphic fungi.

Original languageEnglish
Pages (from-to)1067-1070
Number of pages4
JournalJournal of microbiology and biotechnology
Volume14
Issue number5
Publication statusPublished - 2004 Oct 1

All Science Journal Classification (ASJC) codes

  • Biotechnology
  • Applied Microbiology and Biotechnology

Fingerprint Dive into the research topics of '7-oxostaurosporine selectively inhibits the mycelial form of Candida albicans'. Together they form a unique fingerprint.

  • Cite this

    Hwang, E. I., Yun, B. S., Lee, S. H., Kim, S. K., Lim, S. J., & Kim, S. U. (2004). 7-oxostaurosporine selectively inhibits the mycelial form of Candida albicans. Journal of microbiology and biotechnology, 14(5), 1067-1070.