Abstract
6-Chloro-7-(substituted-phenyl)amino-5,8-isoquinolinediones (3a-3u) and 7-(substituted-phenyl)amino-5,8-isoquinolinediones (4a-4d) were synthesized by nucleophilic substitution of 6,7-dichloro-5,8-isoquinolinedione (8) and 5,8-isoquinolinedione (9) with appropriate arylamines. The quinones 3a-3u and 4a-4d were evaluated for in vitro cytotoxic activities against five solid tumor cell lines such as A549, SK-OV-3, SK-MEL-2, XF498 and HCT-15. Among them, 3c, 3d, 3f and 3h exhibited potent activities against the cell lines HCT-15 and SK-MEL-2.
| Original language | English |
|---|---|
| Pages (from-to) | 40-49 |
| Number of pages | 10 |
| Journal | Medicinal Chemistry Research |
| Volume | 10 |
| Issue number | 1 |
| Publication status | Published - 2000 Jan 1 |
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All Science Journal Classification (ASJC) codes
- Organic Chemistry
- Drug Discovery
Cite this
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7-(Substituted-phenyl)amino-5,8-isoquinolinediones : Synthesis and cytotoxic activities on cancer cell lines. / Ryu, Chung Kyu; Lee, In Kyung; Jung, Sung Hee; Kang, Hye Young; Lee, Chong Ock.
In: Medicinal Chemistry Research, Vol. 10, No. 1, 01.01.2000, p. 40-49.Research output: Contribution to journal › Article
TY - JOUR
T1 - 7-(Substituted-phenyl)amino-5,8-isoquinolinediones
T2 - Synthesis and cytotoxic activities on cancer cell lines
AU - Ryu, Chung Kyu
AU - Lee, In Kyung
AU - Jung, Sung Hee
AU - Kang, Hye Young
AU - Lee, Chong Ock
PY - 2000/1/1
Y1 - 2000/1/1
N2 - 6-Chloro-7-(substituted-phenyl)amino-5,8-isoquinolinediones (3a-3u) and 7-(substituted-phenyl)amino-5,8-isoquinolinediones (4a-4d) were synthesized by nucleophilic substitution of 6,7-dichloro-5,8-isoquinolinedione (8) and 5,8-isoquinolinedione (9) with appropriate arylamines. The quinones 3a-3u and 4a-4d were evaluated for in vitro cytotoxic activities against five solid tumor cell lines such as A549, SK-OV-3, SK-MEL-2, XF498 and HCT-15. Among them, 3c, 3d, 3f and 3h exhibited potent activities against the cell lines HCT-15 and SK-MEL-2.
AB - 6-Chloro-7-(substituted-phenyl)amino-5,8-isoquinolinediones (3a-3u) and 7-(substituted-phenyl)amino-5,8-isoquinolinediones (4a-4d) were synthesized by nucleophilic substitution of 6,7-dichloro-5,8-isoquinolinedione (8) and 5,8-isoquinolinedione (9) with appropriate arylamines. The quinones 3a-3u and 4a-4d were evaluated for in vitro cytotoxic activities against five solid tumor cell lines such as A549, SK-OV-3, SK-MEL-2, XF498 and HCT-15. Among them, 3c, 3d, 3f and 3h exhibited potent activities against the cell lines HCT-15 and SK-MEL-2.
UR - http://www.scopus.com/inward/record.url?scp=0033913872&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=0033913872&partnerID=8YFLogxK
M3 - Article
VL - 10
SP - 40
EP - 49
JO - Medicinal Chemistry Research
JF - Medicinal Chemistry Research
SN - 1054-2523
IS - 1
ER -