7-(Substituted-phenyl)amino-5,8-isoquinolinediones

Synthesis and cytotoxic activities on cancer cell lines

Chung Kyu Ryu, In Kyung Lee, Sung Hee Jung, Hye Young Kang, Chong Ock Lee

Research output: Contribution to journalArticle

8 Citations (Scopus)

Abstract

6-Chloro-7-(substituted-phenyl)amino-5,8-isoquinolinediones (3a-3u) and 7-(substituted-phenyl)amino-5,8-isoquinolinediones (4a-4d) were synthesized by nucleophilic substitution of 6,7-dichloro-5,8-isoquinolinedione (8) and 5,8-isoquinolinedione (9) with appropriate arylamines. The quinones 3a-3u and 4a-4d were evaluated for in vitro cytotoxic activities against five solid tumor cell lines such as A549, SK-OV-3, SK-MEL-2, XF498 and HCT-15. Among them, 3c, 3d, 3f and 3h exhibited potent activities against the cell lines HCT-15 and SK-MEL-2.

Original languageEnglish
Pages (from-to)40-49
Number of pages10
JournalMedicinal Chemistry Research
Volume10
Issue number1
Publication statusPublished - 2000 Jan 1

Fingerprint

Quinones
Tumor Cell Line
Cells
Cell Line
Tumors
Neoplasms
Substitution reactions
In Vitro Techniques

All Science Journal Classification (ASJC) codes

  • Organic Chemistry
  • Drug Discovery

Cite this

Ryu, Chung Kyu ; Lee, In Kyung ; Jung, Sung Hee ; Kang, Hye Young ; Lee, Chong Ock. / 7-(Substituted-phenyl)amino-5,8-isoquinolinediones : Synthesis and cytotoxic activities on cancer cell lines. In: Medicinal Chemistry Research. 2000 ; Vol. 10, No. 1. pp. 40-49.
@article{0d85e1469974454ebc6081ed9cf8441b,
title = "7-(Substituted-phenyl)amino-5,8-isoquinolinediones: Synthesis and cytotoxic activities on cancer cell lines",
abstract = "6-Chloro-7-(substituted-phenyl)amino-5,8-isoquinolinediones (3a-3u) and 7-(substituted-phenyl)amino-5,8-isoquinolinediones (4a-4d) were synthesized by nucleophilic substitution of 6,7-dichloro-5,8-isoquinolinedione (8) and 5,8-isoquinolinedione (9) with appropriate arylamines. The quinones 3a-3u and 4a-4d were evaluated for in vitro cytotoxic activities against five solid tumor cell lines such as A549, SK-OV-3, SK-MEL-2, XF498 and HCT-15. Among them, 3c, 3d, 3f and 3h exhibited potent activities against the cell lines HCT-15 and SK-MEL-2.",
author = "Ryu, {Chung Kyu} and Lee, {In Kyung} and Jung, {Sung Hee} and Kang, {Hye Young} and Lee, {Chong Ock}",
year = "2000",
month = "1",
day = "1",
language = "English",
volume = "10",
pages = "40--49",
journal = "Medicinal Chemistry Research",
issn = "1054-2523",
publisher = "Birkhause Boston",
number = "1",

}

7-(Substituted-phenyl)amino-5,8-isoquinolinediones : Synthesis and cytotoxic activities on cancer cell lines. / Ryu, Chung Kyu; Lee, In Kyung; Jung, Sung Hee; Kang, Hye Young; Lee, Chong Ock.

In: Medicinal Chemistry Research, Vol. 10, No. 1, 01.01.2000, p. 40-49.

Research output: Contribution to journalArticle

TY - JOUR

T1 - 7-(Substituted-phenyl)amino-5,8-isoquinolinediones

T2 - Synthesis and cytotoxic activities on cancer cell lines

AU - Ryu, Chung Kyu

AU - Lee, In Kyung

AU - Jung, Sung Hee

AU - Kang, Hye Young

AU - Lee, Chong Ock

PY - 2000/1/1

Y1 - 2000/1/1

N2 - 6-Chloro-7-(substituted-phenyl)amino-5,8-isoquinolinediones (3a-3u) and 7-(substituted-phenyl)amino-5,8-isoquinolinediones (4a-4d) were synthesized by nucleophilic substitution of 6,7-dichloro-5,8-isoquinolinedione (8) and 5,8-isoquinolinedione (9) with appropriate arylamines. The quinones 3a-3u and 4a-4d were evaluated for in vitro cytotoxic activities against five solid tumor cell lines such as A549, SK-OV-3, SK-MEL-2, XF498 and HCT-15. Among them, 3c, 3d, 3f and 3h exhibited potent activities against the cell lines HCT-15 and SK-MEL-2.

AB - 6-Chloro-7-(substituted-phenyl)amino-5,8-isoquinolinediones (3a-3u) and 7-(substituted-phenyl)amino-5,8-isoquinolinediones (4a-4d) were synthesized by nucleophilic substitution of 6,7-dichloro-5,8-isoquinolinedione (8) and 5,8-isoquinolinedione (9) with appropriate arylamines. The quinones 3a-3u and 4a-4d were evaluated for in vitro cytotoxic activities against five solid tumor cell lines such as A549, SK-OV-3, SK-MEL-2, XF498 and HCT-15. Among them, 3c, 3d, 3f and 3h exhibited potent activities against the cell lines HCT-15 and SK-MEL-2.

UR - http://www.scopus.com/inward/record.url?scp=0033913872&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=0033913872&partnerID=8YFLogxK

M3 - Article

VL - 10

SP - 40

EP - 49

JO - Medicinal Chemistry Research

JF - Medicinal Chemistry Research

SN - 1054-2523

IS - 1

ER -