7-(Substituted-phenyl)amino-5,8-isoquinolinediones: Synthesis and cytotoxic activities on cancer cell lines

Chung Kyu Ryu; In Kyung Lee; Sung Hee Jung; Hye Young Kang; Chong Ock Lee

7-(Substituted-phenyl)amino-5,8-isoquinolinediones: Synthesis and cytotoxic activities on cancer cell lines

Chung Kyu Ryu, In Kyung Lee, Sung Hee Jung, Hye Young Kang, Chong Ock Lee

Department of Pharmacy

Research output: Contribution to journal › Article › peer-review

8 Citations (Scopus)

Abstract

6-Chloro-7-(substituted-phenyl)amino-5,8-isoquinolinediones (3a-3u) and 7-(substituted-phenyl)amino-5,8-isoquinolinediones (4a-4d) were synthesized by nucleophilic substitution of 6,7-dichloro-5,8-isoquinolinedione (8) and 5,8-isoquinolinedione (9) with appropriate arylamines. The quinones 3a-3u and 4a-4d were evaluated for in vitro cytotoxic activities against five solid tumor cell lines such as A549, SK-OV-3, SK-MEL-2, XF498 and HCT-15. Among them, 3c, 3d, 3f and 3h exhibited potent activities against the cell lines HCT-15 and SK-MEL-2.

Original language	English
Pages (from-to)	40-49
Number of pages	10
Journal	Medicinal Chemistry Research
Volume	10
Issue number	1
Publication status	Published - 2000

All Science Journal Classification (ASJC) codes

Pharmacology, Toxicology and Pharmaceutics(all)
Organic Chemistry

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

Cite this

@article{0d85e1469974454ebc6081ed9cf8441b,

title = "7-(Substituted-phenyl)amino-5,8-isoquinolinediones: Synthesis and cytotoxic activities on cancer cell lines",

abstract = "6-Chloro-7-(substituted-phenyl)amino-5,8-isoquinolinediones (3a-3u) and 7-(substituted-phenyl)amino-5,8-isoquinolinediones (4a-4d) were synthesized by nucleophilic substitution of 6,7-dichloro-5,8-isoquinolinedione (8) and 5,8-isoquinolinedione (9) with appropriate arylamines. The quinones 3a-3u and 4a-4d were evaluated for in vitro cytotoxic activities against five solid tumor cell lines such as A549, SK-OV-3, SK-MEL-2, XF498 and HCT-15. Among them, 3c, 3d, 3f and 3h exhibited potent activities against the cell lines HCT-15 and SK-MEL-2.",

author = "Ryu, {Chung Kyu} and Lee, {In Kyung} and Jung, {Sung Hee} and Kang, {Hye Young} and Lee, {Chong Ock}",

year = "2000",

language = "English",

volume = "10",

pages = "40--49",

journal = "Medicinal Chemistry Research",

issn = "1054-2523",

publisher = "Birkhause Boston",

number = "1",

}

TY - JOUR

T1 - 7-(Substituted-phenyl)amino-5,8-isoquinolinediones

T2 - Synthesis and cytotoxic activities on cancer cell lines

AU - Ryu, Chung Kyu

AU - Lee, In Kyung

AU - Jung, Sung Hee

AU - Kang, Hye Young

AU - Lee, Chong Ock

PY - 2000

Y1 - 2000

N2 - 6-Chloro-7-(substituted-phenyl)amino-5,8-isoquinolinediones (3a-3u) and 7-(substituted-phenyl)amino-5,8-isoquinolinediones (4a-4d) were synthesized by nucleophilic substitution of 6,7-dichloro-5,8-isoquinolinedione (8) and 5,8-isoquinolinedione (9) with appropriate arylamines. The quinones 3a-3u and 4a-4d were evaluated for in vitro cytotoxic activities against five solid tumor cell lines such as A549, SK-OV-3, SK-MEL-2, XF498 and HCT-15. Among them, 3c, 3d, 3f and 3h exhibited potent activities against the cell lines HCT-15 and SK-MEL-2.

AB - 6-Chloro-7-(substituted-phenyl)amino-5,8-isoquinolinediones (3a-3u) and 7-(substituted-phenyl)amino-5,8-isoquinolinediones (4a-4d) were synthesized by nucleophilic substitution of 6,7-dichloro-5,8-isoquinolinedione (8) and 5,8-isoquinolinedione (9) with appropriate arylamines. The quinones 3a-3u and 4a-4d were evaluated for in vitro cytotoxic activities against five solid tumor cell lines such as A549, SK-OV-3, SK-MEL-2, XF498 and HCT-15. Among them, 3c, 3d, 3f and 3h exhibited potent activities against the cell lines HCT-15 and SK-MEL-2.

UR - http://www.scopus.com/inward/record.url?scp=0033913872&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=0033913872&partnerID=8YFLogxK

M3 - Article

AN - SCOPUS:0033913872

VL - 10

SP - 40

EP - 49

JO - Medicinal Chemistry Research

JF - Medicinal Chemistry Research

SN - 1054-2523

IS - 1

ER -

7-(Substituted-phenyl)amino-5,8-isoquinolinediones: Synthesis and cytotoxic activities on cancer cell lines

Abstract

All Science Journal Classification (ASJC) codes

UN SDGs

Other files and links

Fingerprint

Cite this