8p11 myeloproliferative syndrome preceded by t(8;9)(p11;q33), CEP110/FGFR1 fusion transcript

morphologic, molecular, and cytogenetic characterization of myeloid neoplasms associated with eosinophilia and FGFR1 abnormality

Tae Sung Park, Jaewoo Song, Jinseok Kim, Woo Ick Yang, Sungwook Song, Sue Jung Kim, Borum Suh, Jong Rak Choi

Research output: Contribution to journalArticle

24 Citations (Scopus)

Abstract

We report a rare case of t(8;9)(p11;q33) in a patient with 8p11 myeloproliferative syndrome (EMS) that was preceded by centrosomal protein 110kDa (CEP110; previously CEP1)/fibroblast growth factor receptor 1 (FGFR1) fusion transcript. A 36-year-old man was brought to Severance Hospital with a nasopharyngeal mass and eosinophilia. Biopsy of the left tonsil and nasopharynx revealed diffuse infiltration of atypical lymphoid cells, and he was diagnosed with precursor T-cell lymphoma with hypereosinophilic syndrome. Two months later, chromosome study revealed a 46,XY,t(8;9)(p11;q33) karyotype, and the CEP110/FGFR1 fusion transcript was detected by reverse transcription-polymerase chain reaction (RT-PCR) in both this and the previous bone marrow specimen. Timely molecular and cytogenetic tests are of value for diagnosis and treatment of the newly classified "myeloid neoplasms associated with clonal eosinophilic disorders" (according to 2008 World Health Organization criteria).

Original languageEnglish
Pages (from-to)93-99
Number of pages7
JournalCancer genetics and cytogenetics
Volume181
Issue number2
DOIs
Publication statusPublished - 2008 Jan 1

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Receptor, Fibroblast Growth Factor, Type 1
Eosinophilia
Cytogenetics
Hypereosinophilic Syndrome
Nasopharynx
T-Cell Lymphoma
Palatine Tonsil
Karyotype
Reverse Transcription
Neoplasms
Chromosomes
Bone Marrow
Lymphocytes
Biopsy
Polymerase Chain Reaction
Proteins
Therapeutics

All Science Journal Classification (ASJC) codes

  • Molecular Biology
  • Genetics
  • Cancer Research

Cite this

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title = "8p11 myeloproliferative syndrome preceded by t(8;9)(p11;q33), CEP110/FGFR1 fusion transcript: morphologic, molecular, and cytogenetic characterization of myeloid neoplasms associated with eosinophilia and FGFR1 abnormality",
abstract = "We report a rare case of t(8;9)(p11;q33) in a patient with 8p11 myeloproliferative syndrome (EMS) that was preceded by centrosomal protein 110kDa (CEP110; previously CEP1)/fibroblast growth factor receptor 1 (FGFR1) fusion transcript. A 36-year-old man was brought to Severance Hospital with a nasopharyngeal mass and eosinophilia. Biopsy of the left tonsil and nasopharynx revealed diffuse infiltration of atypical lymphoid cells, and he was diagnosed with precursor T-cell lymphoma with hypereosinophilic syndrome. Two months later, chromosome study revealed a 46,XY,t(8;9)(p11;q33) karyotype, and the CEP110/FGFR1 fusion transcript was detected by reverse transcription-polymerase chain reaction (RT-PCR) in both this and the previous bone marrow specimen. Timely molecular and cytogenetic tests are of value for diagnosis and treatment of the newly classified {"}myeloid neoplasms associated with clonal eosinophilic disorders{"} (according to 2008 World Health Organization criteria).",
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8p11 myeloproliferative syndrome preceded by t(8;9)(p11;q33), CEP110/FGFR1 fusion transcript : morphologic, molecular, and cytogenetic characterization of myeloid neoplasms associated with eosinophilia and FGFR1 abnormality. / Park, Tae Sung; Song, Jaewoo; Kim, Jinseok; Yang, Woo Ick; Song, Sungwook; Kim, Sue Jung; Suh, Borum; Choi, Jong Rak.

In: Cancer genetics and cytogenetics, Vol. 181, No. 2, 01.01.2008, p. 93-99.

Research output: Contribution to journalArticle

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AU - Park, Tae Sung

AU - Song, Jaewoo

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AU - Yang, Woo Ick

AU - Song, Sungwook

AU - Kim, Sue Jung

AU - Suh, Borum

AU - Choi, Jong Rak

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