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  • KwangHyub Han
2020

A Changing Paradigm for the Treatment of Intermediate-Stage Hepatocellular Carcinoma: Asia-Pacific Primary Liver Cancer Expert Consensus Statements

Kudo, M., Han, K. H., Ye, S. L., Zhou, J., Huang, Y. H., Lin, S. M., Wang, C. K., Ikeda, M., Chan, S. L., Choo, S. P., Miyayama, S. & Cheng, A. L., 2020 Jun 1, In : Liver Cancer. 9, 3, p. 245-260 16 p.

Research output: Contribution to journalArticle

Open Access
4 Citations (Scopus)

An observational study on long-term renal outcome in patients with chronic hepatitis B treated with tenofovir disoproxil fumarate

Lim, T. S., Lee, J. S., Kim, B. K., Lee, H. W., Jeon, M. Y., Kim, S. U., Park, J. Y., Kim, D. Y., Han, K. H. & Ahn, S. H., 2020 Mar 1, In : Journal of Viral Hepatitis. 27, 3, p. 316-322 7 p.

Research output: Contribution to journalArticle

1 Citation (Scopus)

A nomogram based on liver stiffness predicts postoperative complications in patients with hepatocellular carcinoma

Serenari, M., Han, K. H., Ravaioli, F., Kim, S. U., Cucchetti, A., Han, D. H., Odaldi, F., Ravaioli, M., Festi, D., Pinna, A. D. & Cescon, M., 2020, (Accepted/In press) In : Journal of Hepatology. 73, 4, p. 855-862 8 p.

Research output: Contribution to journalArticle

5 Citations (Scopus)

Association between liver fibrosis and appendicular skeletal muscle mass during antiviral therapy in chronic hepatitis B

Kim, K. H., Joo, D. J., Lee, Y. H., Kim, B. K., Park, J. Y., Kim, D. Y., Ahn, S. H., Han, K. H. & Kim, S. U., 2020, (Accepted/In press) In : Digestive and Liver Disease.

Research output: Contribution to journalArticle

A survey on transarterial chemoembolization refractoriness and a real-world treatment pattern for hepatocellular carcinoma in Korea

Lee, J. S., Kim, B. K., Kim, S. U., Park, J. Y., Ahn, S. H., Seong, J. S., Han, K. H. & Kim, D. Y., 2020 Jan, In : Clinical and Molecular Hepatology. 26, 1, p. 24-32 9 p.

Research output: Contribution to journalArticle

Open Access
4 Citations (Scopus)

A tool to measure the impact of inaction toward elimination of hepatitis C: A case study in Korea

Won, Y. K., Kang, K. S., Gonzalez, Y. S., Razavi, H., Dugan, E., Han, K. H., Ahn, S. H., Jeon, M. Y. & Kim, D. Y., 2020 Apr 1, In : PloS one. 15, 4, e0232186.

Research output: Contribution to journalArticle

Open Access

Besifovir Dipivoxil Maleate 144-Week Treatment of Chronic Hepatitis B: An Open-Label Extensional Study of a Phase 3 Trial

Yim, H. J., Kim, W., Ahn, S. H., Yang, J. M., Jang, J. Y., Kweon, Y. O., Cho, Y. K., Kim, Y. J., Hong, G. Y., Kim, D. J., Jung, Y. K., Um, S. H., Sohn, J. H., Lee, J. W., Park, S. J., Lee, B. S., Kim, J. H., Kim, H. S., Yoon, S. K., Kim, M. Y. & 4 others, Lee, K. S., Lim, Y. S., Lee, W. S. & Han, K. H., 2020 Aug 1, In : The American journal of gastroenterology. 115, 8, p. 1217-1225 9 p.

Research output: Contribution to journalArticle

Open Access
1 Citation (Scopus)

Correction to: Natural History of Untreated HBeAg-Positive Chronic HBV Infection With Persistently Elevated HBV DNA but Normal Alanine Aminotransferase

Lee, H. W., Kim, E. H., Lee, J., Kim, S. U., Park, J. Y., Kim, Y., Ahn, S. H., Han, K. H. & Kim, B. K., 2020 May 1, In : Clinical and translational gastroenterology. 11, 5, p. e00183

Research output: Contribution to journalArticle

Open Access

Design and validation of risk prediction model for hepatocellular carcinoma development after sustained virological response in patients with chronic hepatitis C

Chun, H. S., Kim, B. K., Park, J. Y., Kim, D. Y., Ahn, S. H., Han, K. H., Lee, C. H., Lee, Y. B., Cho, E. J., Yu, S. J., Kim, Y. J., Yoon, J. H., Lee, J. H. & Kim, S. U., 2020, (Accepted/In press) In : European Journal of Gastroenterology and Hepatology. p. 378-385 8 p.

Research output: Contribution to journalArticle

3 Citations (Scopus)

Effects of transarterial chemoembolization on regulatory T cell and its subpopulations in patients with hepatocellular carcinoma

Park, H., Jung, J. H., Jung, M. K., Shin, E. C., Ro, S. W., Park, J. H., Kim, D. Y., Park, J. Y. & Han, K. H., 2020 Mar 1, In : Hepatology International. 14, 2, p. 249-258 10 p.

Research output: Contribution to journalArticle

Efficacy and Safety of Liver-Directed Concurrent Chemoradiotherapy and Sequential Sorafenib for Advanced Hepatocellular Carcinoma: A Prospective Phase 2 Trial

Kim, B. K., Kim, D. Y., Byun, H. K., Choi, H. J., Beom, S. H., Lee, H. W., Kim, S. U., Park, J. Y., Ahn, S. H., Seong, J. & Han, K. H., 2020 May 1, In : International Journal of Radiation Oncology Biology Physics. 107, 1, p. 106-115 10 p.

Research output: Contribution to journalArticle

Entecavir and tenofovir on renal function in patients with hepatitis B virus-related hepatocellular carcinoma

Jeon, M. Y., Lee, J. S., Lee, H. W., Kim, B. K., Park, J. Y., Kim, D. Y., Han, K. H., Ahn, S. H. & Kim, S. U., 2020 Sep 1, In : Journal of Viral Hepatitis. 27, 9, p. 932-940 9 p.

Research output: Contribution to journalArticle

Open Access

Establishment and validation of a risk prediction model in patients with hepatocellular carcinoma treated with transarterial radioembolization

Lee, J. S., Lee, H. A., Jeon, M. Y., Lim, T. S., Kim, B. K., Park, J. Y., Kim, D. Y., Ahn, S. H., Um, S. H., Han, K. H., Seo, Y. S. & Kim, S. U., 2020, (Accepted/In press) In : European Journal of Gastroenterology and Hepatology. p. 739-747 9 p.

Research output: Contribution to journalArticle

Extremely low risk of hepatocellular carcinoma development in patients with chronic hepatitis B in immune-tolerant phase

Lee, H. A., Lee, H. W., Kim, I. H., Park, S. Y., Sinn, D. H., Yu, J. H., Seo, Y. S., Um, S. H., Lee, J. I., Lee, K. S., Lee, C. H., Tak, W. Y., Kweon, Y. O., Kang, W., Paik, Y. H., Lee, J. W., Suh, S. J., Jung, Y. K., Kim, B. K., Park, J. Y. & 5 others, Kim, D. Y., Ahn, S. H., Han, K. H., Yim, H. J. & Kim, S. U., 2020 Jul 1, In : Alimentary Pharmacology and Therapeutics. 52, 1, p. 196-204 9 p.

Research output: Contribution to journalArticle

Open Access
5 Citations (Scopus)

Hepatocellular carcinoma risk steadily persists over time despite long-term antiviral therapy for hepatitis B: A multicenter study

Kim, S. U., Seo, Y. S., Lee, H. A., Kim, M. N., Lee, E. J., Shin, H. J., Lee, Y. R., Lee, H. W., Park, J. Y., Kim, D. Y., Ahn, S. H., Han, K. H., Um, S. H., Tak, W. Y., Kweon, Y. O., Kim, B. K. & Park, S. Y., 2020, In : Cancer Epidemiology Biomarkers and Prevention. 29, 4, p. 832-837 6 p.

Research output: Contribution to journalArticle

Open Access
3 Citations (Scopus)

High body mass index hinders fibrosis improvement in patients receiving long-term tenofovir therapy in hepatitis B virus-related cirrhosis

Chon, Y. E., Jung, K. S., Ha, Y., Kim, M. N., Lee, J. H., Hwang, S. G., Ahn, S. H., Kim, D. Y., Han, K. H. & Park, J. Y., 2020, (Accepted/In press) In : Journal of Viral Hepatitis.

Research output: Contribution to journalArticle

Open Access

HKR3 regulates cell cycle through the inhibition of hTERT in hepatocellular carcinoma cell lines

Choi, S. H., Cho, K. J., Yun, S. H., Jin, B., Lee, H. Y., Ro, S. W., Kim, D. Y., Ahn, S. H., Han, K. H. & Park, J. Y., 2020, In : Journal of Cancer. 11, 9, p. 2442-2452 11 p.

Research output: Contribution to journalArticle

Open Access
1 Citation (Scopus)

Liver diseases in the Asia-Pacific region: a Lancet Gastroenterology & Hepatology Commission

Sarin, S. K., Kumar, M., Eslam, M., George, J., Al Mahtab, M., Akbar, S. M. F., Jia, J., Tian, Q., Aggarwal, R., Muljono, D. H., Omata, M., Ooka, Y., Han, K. H., Lee, H. W., Jafri, W., Butt, A. S., Chong, C. H., Lim, S. G., Pwu, R. F. & Chen, D. S., 2020 Feb, In : The Lancet Gastroenterology and Hepatology. 5, 2, p. 167-228 62 p.

Research output: Contribution to journalReview article

Open Access
10 Citations (Scopus)

Natural History of Untreated HBeAg-Positive Chronic HBV Infection With Persistently Elevated HBV DNA but Normal Alanine Aminotransferase

Lee, H. W., Kim, E. H., Lee, J., Kim, S. U., Park, J. Y., Kim, D. Y., Ahn, S. H., Han, K. H. & Kim, B. K., 2020 Mar 1, In : Clinical and translational gastroenterology. 11, 3, p. e00140

Research output: Contribution to journalArticle

Open Access
1 Citation (Scopus)

Nonalcoholic Fatty Liver Disease and Sarcopenia Are Independently Associated With Cardiovascular Risk

Han, E., Lee, Y. H., Kim, Y. D., Kim, B. K., Park, J. Y., Kim, D. Y., Ahn, S. H., Lee, B. W., Kang, E. S., Cha, B. S., Han, K. H., Nam, H. S., Heo, J. H. & Kim, S. U., 2020 Apr 1, In : The American journal of gastroenterology. 115, 4, p. 584-595 12 p.

Research output: Contribution to journalArticle

2 Citations (Scopus)

Outcomes of Long-term Treatment of Chronic HBV Infection With Entecavir or Other Agents From a Randomized Trial in 24 Countries

Hou, J. L., Zhao, W., Lee, C., Hann, H. W., Peng, C. Y., Tanwandee, T., Morozov, V., Klinker, H., Sollano, J. D., Streinu-Cercel, A., Cheinquer, H., Xie, Q., Wang, Y. M., Wei, L., Jia, J. D., Gong, G., Han, K. H., Cao, W., Cheng, M., Tang, X. & 17 others, Tan, D., Ren, H., Duan, Z., Tang, H., Gao, Z., Chen, S., Lin, S., Sheng, J., Chen, C., Shang, J., Han, T., Ji, Y., Niu, J., Sun, J., Chen, Y., Cooney, E. L. & Lim, S. G., 2020 Feb, In : Clinical Gastroenterology and Hepatology. 18, 2, p. 457-467.e21

Research output: Contribution to journalArticle

Open Access
8 Citations (Scopus)

Proposal of a New Risk Score for Patients Treated with Transarterial Chemoembolization due to Recurrent Hepatocellular Carcinoma after Curative Resection: A Multicenter Study

Jeon, M. Y., Kim, B. K., Park, J. Y., Kim, D. Y., Ahn, S. H., Han, K. H., Lee, J. H., Yu, S. J., Kim, Y. J., Yoon, J. H., Cho, E. J. & Kim, S. U., 2020 Jul 15, In : Gut and liver. 14, 4, p. 477-485 9 p.

Research output: Contribution to journalArticle

Open Access
1 Citation (Scopus)

Sarcopenia assessed using bioimpedance analysis is associated independently with significant liver fibrosis in patients with chronic liver diseases

Hyun Kim, K., Kyung Kim, B., Yong Park, J., Young Kim, D., Hoon Ahn, S., Han, K. H. & Kim, S. U., 2020 Jan 1, In : European journal of gastroenterology & hepatology. 32, 1, p. 58-65 8 p.

Research output: Contribution to journalArticle

Serum Wisteria floribunda agglutinin-positive human mac-2 binding protein level predicts recurrence of hepatitis b virus-related hepatocellular carcinoma after curative resection

Kim, H. S., Kim, S. U., Kim, B. K., Park, J. Y., Kim, D. Y., Ahn, S. H., Han, K. H., Park, Y. N., Han, D. H., Kim, K. S., Choi, J. S., Choi, G. H. & Kim, H. S., 2020 Jan, In : Clinical and Molecular Hepatology. 26, 1, p. 33-44 12 p.

Research output: Contribution to journalArticle

Open Access
3 Citations (Scopus)

Strahlentherapie-Dosiseskalation nach unvollständiger transarterieller Chemoembolisation bei hepatozellulärem Karzinom

Translated title of the contribution: Dose escalation in radiotherapy for incomplete transarterial chemoembolization of hepatocellular carcinomaByun, H. K., Kim, H. J., Im, Y. R., Kim, D. Y., Han, K. H. & Seong, J., 2020 Feb 1, In : Strahlentherapie und Onkologie. 196, 2, p. 132-141 10 p.

Research output: Contribution to journalArticle

2 Citations (Scopus)

The beginning of ending hepatitis C virus: A Summary of the 26th International Symposium on Hepatitis C Virus and Related Viruses

Shin, E. C., Han, J. W., Kang, W., Kato, T., Kim, S. J., Zhong, J., Kim, S., Park, S. H., Sung, P. S., Watashi, K., Park, J. Y., Windisch, M. P., Oh, J. W., Wakita, T., Han, K. H. & Jang, S. K., 2020, In : Viruses. 12, 3, 302.

Research output: Contribution to journalArticle

Open Access

Validation of the CAMD Score in Patients With Chronic Hepatitis B Virus Infection Receiving Antiviral Therapy

Kim, S. U., Seo, Y. S., Lee, H. A., Kim, M. N., Kim, E. H., Kim, H. Y., Lee, Y. R., Lee, H. W., Park, J. Y., Kim, D. Y., Ahn, S. H., Han, K. H., Hwang, S. G., Rim, K. S., Um, S. H., Tak, W. Y., Kweon, Y. O., Kim, B. K. & Park, S. Y., 2020 Mar, In : Clinical Gastroenterology and Hepatology. 18, 3, p. 693-699.e1

Research output: Contribution to journalArticle

3 Citations (Scopus)
2018

Combination of transient elastography and an enhanced liver fibrosis test to assess the degree of liver fibrosis in patients with chronic hepatitis B

Heo, J. Y., Kim, B. K., Park, J. Y., Kim, D. Y., Ahn, S. H., Kim, H. S., Park, Y. N., Han, K. H., Song, K. & Kim, S. U., 2018 Mar, In : Gut and liver. 12, 2, p. 190-200 11 p.

Research output: Contribution to journalArticle

2 Citations (Scopus)

Daclatasvir plus asunaprevir for the treatment of patients with hepatitis C virus genotype 1b infection: Real-world efficacy, changes in liver stiffness and fibrosis markers, and safety

Lee, H. W., Oh, S. R., Kim, D. Y., Jeong, Y., Kim, S., Kim, B. K., Kim, S. U., Kim, D. Y., Ahn, S. H., Han, K. H. & Park, J. Y., 2018 May, In : Gut and liver. 12, 3, p. 324-330 7 p.

Research output: Contribution to journalArticle

4 Citations (Scopus)

Downstaging with Localized Concurrent Chemoradiotherapy Can Identify Optimal Surgical Candidates in Hepatocellular Carcinoma with Portal Vein Tumor Thrombus

Chong, J. U., Choi, G. H., Han, D. H., Kim, K. S., Seong, J., Han, K. H. & Choi, J. S., 2018 Oct 1, In : Annals of surgical oncology. 25, 11, p. 3308-3315 8 p.

Research output: Contribution to journalArticle

6 Citations (Scopus)

Effects of Virologic Response to Treatment on Short- and Long-term Outcomes of Patients With Chronic Hepatitis B Virus Infection and Decompensated Cirrhosis

Jang, J. W., Choi, J. Y., Kim, Y. S., Yoo, J. J., Woo, H. Y., Choi, S. K., Jun, C. H., Lee, C. H., Sohn, J. H., Tak, W. Y., Lee, Y. R. & Han, K. H., 2018 Dec, In : Clinical Gastroenterology and Hepatology. 16, 12, p. 1954-1963.e3

Research output: Contribution to journalArticle

12 Citations (Scopus)

Evolution and persistence of resistance-associated substitutions of hepatitis C virus after direct-acting antiviral treatment failures

Jeong, Y., Jin, B., Lee, H. W., Park, H. J., Park, J. Y., Kim, D. Y., Han, K. H., Ahn, S. H. & Kim, S., 2018 Nov, In : Journal of Viral Hepatitis. 25, 11, p. 1251-1259 9 p.

Research output: Contribution to journalArticle

4 Citations (Scopus)

Feasibility of dynamic risk prediction for hepatocellular carcinoma development in patients with chronic hepatitis B

Jeon, M. Y., Lee, H. W., Kim, S. U., Kim, B. K., Park, J. Y., Kim, D. Y., Han, K. H. & Ahn, S. H., 2018 Apr, In : Liver International. 38, 4, p. 676-686 11 p.

Research output: Contribution to journalArticle

8 Citations (Scopus)
3 Citations (Scopus)

HCV phylogenetic signature and prevalence of pretreatment NS5A and NS5B NI-Resistance associated substitutions in HCV-Infected patients in Mainland China

Wei, L., Omata, M., Lim, Y. S., Xie, Q., Hou, J. L., Jia, J., Hedskog, C., Martin, R., Doehle, B., Yang, J., De-Oertel, S., Massetto, B., Kersey, K., Brainard, D. M., Svarovskaia, E., Mo, H., Han, K. H., Mizokami, M. & Duan, Z., 2018 Oct, In : Antiviral Research. 158, p. 178-184 7 p.

Research output: Contribution to journalArticle

9 Citations (Scopus)

Impact of controlled attenuation parameter on detecting fibrosis using liver stiffness measurement

Karlas, T., Petroff, D., Sasso, M., Fan, J. G., Mi, Y. Q., de Lédinghen, V., Kumar, M., Lupsor-Platon, M., Han, K. H., Cardoso, A. C., Ferraioli, G., Chan, W. K., Wong, V. W. S., Myers, R. P., Chayama, K., Friedrich-Rust, M., Beaugrand, M., Shen, F., Hiriart, J. B., Sarin, S. K. & 12 others, Badea, R., Lee, H. W., Marcellin, P., Filice, C., Mahadeva, S., Wong, G. L. H., Crotty, P., Masaki, K., Bojunga, J., Bedossa, P., Keim, V. & Wiegand, J., 2018 Apr, In : Alimentary Pharmacology and Therapeutics. 47, 7, p. 989-1000 12 p.

Research output: Contribution to journalArticle

20 Citations (Scopus)

Lenvatinib versus sorafenib in first-line treatment of patients with unresectable hepatocellular carcinoma: a randomised phase 3 non-inferiority trial

Kudo, M., Finn, R. S., Qin, S., Han, K. H., Ikeda, K., Piscaglia, F., Baron, A., Park, J. W., Han, G., Jassem, J., Blanc, J. F., Vogel, A., Komov, D., Evans, T. R. J., Lopez, C., Dutcus, C., Guo, M., Saito, K., Kraljevic, S., Tamai, T. & 2 others, Ren, M. & Cheng, A. L., 2018 Mar 24, In : The Lancet. 391, 10126, p. 1163-1173 11 p.

Research output: Contribution to journalArticle

738 Citations (Scopus)
10 Citations (Scopus)

Predictors of failure to detect early hepatocellular carcinoma in patients with chronic hepatitis B who received regular surveillance

Chon, Y. E., Jung, K. S., Kim, M. J., Choi, J. Y., An, C., Park, J. Y., Ahn, S. H., Kim, B. K., Kim, S. U., Park, H., Hwang, S. K., Rim, K. S., Han, K. H. & Kim, D. Y., 2018 Apr, In : Alimentary Pharmacology and Therapeutics. 47, 8, p. 1201-1212 12 p.

Research output: Contribution to journalArticle

3 Citations (Scopus)
10 Citations (Scopus)

Reproducibility of European Association for the Study of the Liver criteria and modified Response Evaluation Criteria in Solid Tumors in patients treated with sorafenib

Jeon, M. Y., Lee, H. W., Kim, B. K., Park, J. Y., Kim, D. Y., Ahn, S. H., Han, K. H., Baek, S. E., Kim, H. S., Kim, S. U. & Park, M. S., 2018 Sep, In : Liver International. 38, 9, p. 1655-1663 9 p.

Research output: Contribution to journalArticle

7 Citations (Scopus)

Responses are durable for up to 5 years after completion of peginterferon alfa-2a treatment in hepatitis B e antigen-positive patients

Chuang, W. L., Jia, J., Chan, H. L. Y., Han, K. H., Tanwandee, T., Tan, D., Chen, X., Gane, E., Piratvisuth, T., Chen, L., Xie, Q., Sung, J. J. Y., Messinger, D., Wat, C., Bakalos, G. & Liaw, Y. F., 2018 May, In : Alimentary Pharmacology and Therapeutics. 47, 9, p. 1306-1316 11 p.

Research output: Contribution to journalArticle

4 Citations (Scopus)

Safety and Efficacy of Transarterial Radioembolization Combined with Chemoembolization for Bilobar Hepatocellular Carcinoma: A Single-Center Retrospective Study

Kwon, J. H., Kim, G. M., Han, K., Won, J. Y., Kim, M. D., Lee, D. Y., Lee, J., Choi, W., Kim, Y. S., Kim, D. Y. & Han, K. H., 2018 Mar 1, In : Cardiovascular and interventional radiology. 41, 3, p. 459-465 7 p.

Research output: Contribution to journalArticle

2 Citations (Scopus)

Sarcopenia is associated with the risk of significant liver fibrosis in metabolically unhealthy subjects with chronic hepatitis B

Han, E., Lee, Y. H., Kim, B. K., Park, J. Y., Kim, D. Y., Ahn, S. H., Lee, B. W., Kang, E. S., Cha, B. S., Han, K. H. & Kim, S. U., 2018 Aug, In : Alimentary Pharmacology and Therapeutics. 48, 3, p. 300-312 13 p.

Research output: Contribution to journalArticle

8 Citations (Scopus)

Serotonin signals through a gut-liver axis to regulate hepatic steatosis

Choi, W., Namkung, J., Hwang, I., Kim, H., Lim, A., Park, H. J., Lee, H. W., Han, K. H., Park, S., Jeong, J. S., Bang, G., Kim, Y. H., Yadav, V. K., Karsenty, G., Ju, Y. S., Choi, C., Suh, J. M., Park, J. Y., Park, S. & Kim, H., 2018 Dec 1, In : Nature communications. 9, 1, 4824.

Research output: Contribution to journalArticle

23 Citations (Scopus)

Sofosbuvir and ledipasvir are associated with high sustained virologic response and improvement of health-related quality of life in East Asian patients with hepatitis C virus infection

Younossi, Z. M., Stepanova, M., Henry, L., Han, K. H., Ahn, S. H., Lim, Y. S., Chuang, W. L., Kao, J. H., Nguyen, K. V., Lai, C. L., Chan, H. L. Y. & Wei, L., 2018 Dec, In : Journal of Viral Hepatitis. 25, 12, p. 1429-1437 9 p.

Research output: Contribution to journalArticle

8 Citations (Scopus)

Staging for hepatocellular carcinoma in light of tumor heterogeneity: Time to change or update?

Kim, D. Y. & Han, K. H., 2018 Jun, In : Hepatology. 67, 6, p. 2076-2078 3 p.

Research output: Contribution to journalEditorial

1 Citation (Scopus)
6 Citations (Scopus)

The effect of interferon-free regimens on health-related quality of life in East Asian patients with chronic hepatitis C

Younossi, Z. M., Stepanova, M., Henry, L., Han, K. H., Ahn, S. H., Lim, Y. S., Chuang, W. L., Kao, J. H., Kinh, N., Lai, C. L., Yuen, M. F., Chan, H. L. Y. & Lai, W., 2018 Jul, In : Liver International. 38, 7, p. 1179-1187 9 p.

Research output: Contribution to journalArticle

10 Citations (Scopus)