A 2-h diagnostic protocol to assess patients with chest pain symptoms in the Asia-Pacific region (ASPECT): A prospective observational validation study

Martin Than; Louise Cullen; Christopher M. Reid; Swee Han Lim; Sally Aldous; Michael W. Ardagh; W. Frank Peacock; William A. Parsonage; Hiu Fai Ho; Hiu Fai Ko; Ravi R. Kasliwal; Manish Bansal; Sunarya Soerianata; Dayi Hu; Rongjing Ding; Qi Hua; Kang Seok-Min; Piyamitr Sritara; Ratchanee Sae-Lee; Te Fa Chiu; Kuang Chau Tsai; Fang Yeh Chu; Wei Kung Chen; Wen Han Chang; Dylan F. Flaws; Peter M. George; A. Mark Richards

doi:10.1016/S0140-6736(11)60310-3

A 2-h diagnostic protocol to assess patients with chest pain symptoms in the Asia-Pacific region (ASPECT): A prospective observational validation study

Martin Than, Louise Cullen, Christopher M. Reid, Swee Han Lim, Sally Aldous, Michael W. Ardagh, W. Frank Peacock, William A. Parsonage, Hiu Fai Ho, Hiu Fai Ko, Ravi R. Kasliwal, Manish Bansal, Sunarya Soerianata, Dayi Hu, Rongjing Ding, Qi Hua, Kang Seok-Min, Piyamitr Sritara, Ratchanee Sae-Lee, Te Fa ChiuKuang Chau Tsai, Fang Yeh Chu, Wei Kung Chen, Wen Han Chang, Dylan F. Flaws, Peter M. George, A. Mark Richards

Department of Internal Medicine

Research output: Contribution to journal › Article › peer-review

290 Citations (Scopus)

Abstract

Background Patients with chest pain contribute substantially to emergency department attendances, lengthy hospital stay, and inpatient admissions. A reliable, reproducible, and fast process to identify patients presenting with chest pain who have a low short-term risk of a major adverse cardiac event is needed to facilitate early discharge. We aimed to prospectively validate the safety of a predefined 2-h accelerated diagnostic protocol (ADP) to assess patients presenting to the emergency department with chest pain symptoms suggestive of acute coronary syndrome. Methods This observational study was undertaken in 14 emergency departments in nine countries in the Asia-Pacific region, in patients aged 18 years and older with at least 5 min of chest pain. The ADP included use of a structured pre-test probability scoring method (Thrombolysis in Myocardial Infarction [TIMI] score), electrocardiograph, and point-of-care biomarker panel of troponin, creatine kinase MB, and myoglobin. The primary endpoint was major adverse cardiac events within 30 days after initial presentation (including initial hospital attendance). This trial is registered with the Australia-New Zealand Clinical Trials Registry, number ACTRN12609000283279. Intepretation 3582 consecutive patients were recruited and completed 30-day follow-up. 421 (11·8) patients had a major adverse cardiac event. The ADP classified 352 (9·8) patients as low risk and potentially suitable for early discharge. A major adverse cardiac event occurred in three (0·9) of these patients, giving the ADP a sensitivity of 99·3 (95 CI 97·9-99·8), a negative predictive value of 99·1 (97·3-99·8), and a specificity of 11·0 (10·0-12·2). This novel ADP identifies patients at very low risk of a short-term major adverse cardiac event who might be suitable for early discharge. Such an approach could be used to decrease the overall observation periods and admissions for chest pain. The components needed for the implementation of this strategy are widely available. The ADP has the potential to affect health-service delivery worldwide. Funding Alere Medical (all countries), Queensland Emergency Medicine Research Foundation and National Health and Medical Research Council (Australia), Christchurch Cardio-Endocrine Research Group (New Zealand), Medquest Jaya Global (Indonesia), Science International (Hong Kong), Bio Laboratories Pte (Singapore), National Heart Foundation of New Zealand, and Progressive Group (Taiwan).

Original language	English
Pages (from-to)	1077-1084
Number of pages	8
Journal	The Lancet
Volume	377
Issue number	9771
DOIs	https://doi.org/10.1016/S0140-6736(11)60310-3
Publication status	Published - 2011

Bibliographical note

Funding Information:
MT, MB, SHL, RRK, and LC received grants and supplies by Alere Medical. MT, AMR, and LC received honoraria for previous speaking and lecturing from Alere Medical. MT, MB, AMR, SHL, RRK, LC, and W-KC received support for travel to meetings from Alere Medical. MT received provision of administrative support funds from Alere Medical. HFH and HFK received grants from Science International Corporation. HFH received support for travel from Science International Corporation. MWA received unrelated grants from HRCNZ. LC received grants from the Queensland Emergency research Foundation (QEMRF). SA received grants from the National Heart Foundation of New Zealand, and support for travel to meetings from the Christchurch Cardio-Endocrine Research Group. CMR received grants from the National Health and Medical Research Council. WAP has received grants from the QEMRF. He is a board member of Sanofi-Aventis, is a consultant for Hospira, and has been paid to give lectures for Sanofi-Aventis and Roche, all unrelated to this project. WFP has received consultancy payments from Alere for unrelated projects. SS received grants, support for travel to meetings, and fees for participation in review activities from Medquest Jaya Global. DH, RD, QH, KS-M, DFF, RS-L, SS, and PS received support from Alere to travel to meetings. T-FC, K-CT, F-YC, and W-HC received grants for nurses and support for travel from Progressive Group (Taiwan). PMG has received unrelated grants from the Health Research Council New Zealand, National Heart Foundation New Zealand, and National Health and Medical Research Council; and unrelated honoraria from Roche, AstraZenica, and Abbott Laboratories.

All Science Journal Classification (ASJC) codes

Medicine(all)

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10.1016/S0140-6736(11)60310-3

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Than, M., Cullen, L., Reid, C. M., Lim, S. H., Aldous, S., Ardagh, M. W., Peacock, W. F., Parsonage, W. A., Ho, H. F., Ko, H. F., Kasliwal, R. R., Bansal, M., Soerianata, S., Hu, D., Ding, R., Hua, Q., Seok-Min, K., Sritara, P., Sae-Lee, R., ... Richards, A. M. (2011). A 2-h diagnostic protocol to assess patients with chest pain symptoms in the Asia-Pacific region (ASPECT): A prospective observational validation study. The Lancet, 377(9771), 1077-1084. https://doi.org/10.1016/S0140-6736(11)60310-3

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title = "A 2-h diagnostic protocol to assess patients with chest pain symptoms in the Asia-Pacific region (ASPECT): A prospective observational validation study",

abstract = "Background Patients with chest pain contribute substantially to emergency department attendances, lengthy hospital stay, and inpatient admissions. A reliable, reproducible, and fast process to identify patients presenting with chest pain who have a low short-term risk of a major adverse cardiac event is needed to facilitate early discharge. We aimed to prospectively validate the safety of a predefined 2-h accelerated diagnostic protocol (ADP) to assess patients presenting to the emergency department with chest pain symptoms suggestive of acute coronary syndrome. Methods This observational study was undertaken in 14 emergency departments in nine countries in the Asia-Pacific region, in patients aged 18 years and older with at least 5 min of chest pain. The ADP included use of a structured pre-test probability scoring method (Thrombolysis in Myocardial Infarction [TIMI] score), electrocardiograph, and point-of-care biomarker panel of troponin, creatine kinase MB, and myoglobin. The primary endpoint was major adverse cardiac events within 30 days after initial presentation (including initial hospital attendance). This trial is registered with the Australia-New Zealand Clinical Trials Registry, number ACTRN12609000283279. Intepretation 3582 consecutive patients were recruited and completed 30-day follow-up. 421 (11·8) patients had a major adverse cardiac event. The ADP classified 352 (9·8) patients as low risk and potentially suitable for early discharge. A major adverse cardiac event occurred in three (0·9) of these patients, giving the ADP a sensitivity of 99·3 (95 CI 97·9-99·8), a negative predictive value of 99·1 (97·3-99·8), and a specificity of 11·0 (10·0-12·2). This novel ADP identifies patients at very low risk of a short-term major adverse cardiac event who might be suitable for early discharge. Such an approach could be used to decrease the overall observation periods and admissions for chest pain. The components needed for the implementation of this strategy are widely available. The ADP has the potential to affect health-service delivery worldwide. Funding Alere Medical (all countries), Queensland Emergency Medicine Research Foundation and National Health and Medical Research Council (Australia), Christchurch Cardio-Endocrine Research Group (New Zealand), Medquest Jaya Global (Indonesia), Science International (Hong Kong), Bio Laboratories Pte (Singapore), National Heart Foundation of New Zealand, and Progressive Group (Taiwan).",

author = "Martin Than and Louise Cullen and Reid, {Christopher M.} and Lim, {Swee Han} and Sally Aldous and Ardagh, {Michael W.} and Peacock, {W. Frank} and Parsonage, {William A.} and Ho, {Hiu Fai} and Ko, {Hiu Fai} and Kasliwal, {Ravi R.} and Manish Bansal and Sunarya Soerianata and Dayi Hu and Rongjing Ding and Qi Hua and Kang Seok-Min and Piyamitr Sritara and Ratchanee Sae-Lee and Chiu, {Te Fa} and Tsai, {Kuang Chau} and Chu, {Fang Yeh} and Chen, {Wei Kung} and Chang, {Wen Han} and Flaws, {Dylan F.} and George, {Peter M.} and Richards, {A. Mark}",

note = "Funding Information: MT, MB, SHL, RRK, and LC received grants and supplies by Alere Medical. MT, AMR, and LC received honoraria for previous speaking and lecturing from Alere Medical. MT, MB, AMR, SHL, RRK, LC, and W-KC received support for travel to meetings from Alere Medical. MT received provision of administrative support funds from Alere Medical. HFH and HFK received grants from Science International Corporation. HFH received support for travel from Science International Corporation. MWA received unrelated grants from HRCNZ. LC received grants from the Queensland Emergency research Foundation (QEMRF). SA received grants from the National Heart Foundation of New Zealand, and support for travel to meetings from the Christchurch Cardio-Endocrine Research Group. CMR received grants from the National Health and Medical Research Council. WAP has received grants from the QEMRF. He is a board member of Sanofi-Aventis, is a consultant for Hospira, and has been paid to give lectures for Sanofi-Aventis and Roche, all unrelated to this project. WFP has received consultancy payments from Alere for unrelated projects. SS received grants, support for travel to meetings, and fees for participation in review activities from Medquest Jaya Global. DH, RD, QH, KS-M, DFF, RS-L, SS, and PS received support from Alere to travel to meetings. T-FC, K-CT, F-YC, and W-HC received grants for nurses and support for travel from Progressive Group (Taiwan). PMG has received unrelated grants from the Health Research Council New Zealand, National Heart Foundation New Zealand, and National Health and Medical Research Council; and unrelated honoraria from Roche, AstraZenica, and Abbott Laboratories. ",

year = "2011",

doi = "10.1016/S0140-6736(11)60310-3",

language = "English",

volume = "377",

pages = "1077--1084",

journal = "The Lancet",

issn = "0140-6736",

publisher = "Elsevier Limited",

number = "9771",

}

Than, M, Cullen, L, Reid, CM, Lim, SH, Aldous, S, Ardagh, MW, Peacock, WF, Parsonage, WA, Ho, HF, Ko, HF, Kasliwal, RR, Bansal, M, Soerianata, S, Hu, D, Ding, R, Hua, Q, Seok-Min, K, Sritara, P, Sae-Lee, R, Chiu, TF, Tsai, KC, Chu, FY, Chen, WK, Chang, WH, Flaws, DF, George, PM & Richards, AM 2011, 'A 2-h diagnostic protocol to assess patients with chest pain symptoms in the Asia-Pacific region (ASPECT): A prospective observational validation study', The Lancet, vol. 377, no. 9771, pp. 1077-1084. https://doi.org/10.1016/S0140-6736(11)60310-3

TY - JOUR

T1 - A 2-h diagnostic protocol to assess patients with chest pain symptoms in the Asia-Pacific region (ASPECT)

T2 - A prospective observational validation study

AU - Than, Martin

AU - Cullen, Louise

AU - Reid, Christopher M.

AU - Lim, Swee Han

AU - Aldous, Sally

AU - Ardagh, Michael W.

AU - Peacock, W. Frank

AU - Parsonage, William A.

AU - Ho, Hiu Fai

AU - Ko, Hiu Fai

AU - Kasliwal, Ravi R.

AU - Bansal, Manish

AU - Soerianata, Sunarya

AU - Hu, Dayi

AU - Ding, Rongjing

AU - Hua, Qi

AU - Seok-Min, Kang

AU - Sritara, Piyamitr

AU - Sae-Lee, Ratchanee

AU - Chiu, Te Fa

AU - Tsai, Kuang Chau

AU - Chu, Fang Yeh

AU - Chen, Wei Kung

AU - Chang, Wen Han

AU - Flaws, Dylan F.

AU - George, Peter M.

AU - Richards, A. Mark

N1 - Funding Information: MT, MB, SHL, RRK, and LC received grants and supplies by Alere Medical. MT, AMR, and LC received honoraria for previous speaking and lecturing from Alere Medical. MT, MB, AMR, SHL, RRK, LC, and W-KC received support for travel to meetings from Alere Medical. MT received provision of administrative support funds from Alere Medical. HFH and HFK received grants from Science International Corporation. HFH received support for travel from Science International Corporation. MWA received unrelated grants from HRCNZ. LC received grants from the Queensland Emergency research Foundation (QEMRF). SA received grants from the National Heart Foundation of New Zealand, and support for travel to meetings from the Christchurch Cardio-Endocrine Research Group. CMR received grants from the National Health and Medical Research Council. WAP has received grants from the QEMRF. He is a board member of Sanofi-Aventis, is a consultant for Hospira, and has been paid to give lectures for Sanofi-Aventis and Roche, all unrelated to this project. WFP has received consultancy payments from Alere for unrelated projects. SS received grants, support for travel to meetings, and fees for participation in review activities from Medquest Jaya Global. DH, RD, QH, KS-M, DFF, RS-L, SS, and PS received support from Alere to travel to meetings. T-FC, K-CT, F-YC, and W-HC received grants for nurses and support for travel from Progressive Group (Taiwan). PMG has received unrelated grants from the Health Research Council New Zealand, National Heart Foundation New Zealand, and National Health and Medical Research Council; and unrelated honoraria from Roche, AstraZenica, and Abbott Laboratories.

PY - 2011

Y1 - 2011

N2 - Background Patients with chest pain contribute substantially to emergency department attendances, lengthy hospital stay, and inpatient admissions. A reliable, reproducible, and fast process to identify patients presenting with chest pain who have a low short-term risk of a major adverse cardiac event is needed to facilitate early discharge. We aimed to prospectively validate the safety of a predefined 2-h accelerated diagnostic protocol (ADP) to assess patients presenting to the emergency department with chest pain symptoms suggestive of acute coronary syndrome. Methods This observational study was undertaken in 14 emergency departments in nine countries in the Asia-Pacific region, in patients aged 18 years and older with at least 5 min of chest pain. The ADP included use of a structured pre-test probability scoring method (Thrombolysis in Myocardial Infarction [TIMI] score), electrocardiograph, and point-of-care biomarker panel of troponin, creatine kinase MB, and myoglobin. The primary endpoint was major adverse cardiac events within 30 days after initial presentation (including initial hospital attendance). This trial is registered with the Australia-New Zealand Clinical Trials Registry, number ACTRN12609000283279. Intepretation 3582 consecutive patients were recruited and completed 30-day follow-up. 421 (11·8) patients had a major adverse cardiac event. The ADP classified 352 (9·8) patients as low risk and potentially suitable for early discharge. A major adverse cardiac event occurred in three (0·9) of these patients, giving the ADP a sensitivity of 99·3 (95 CI 97·9-99·8), a negative predictive value of 99·1 (97·3-99·8), and a specificity of 11·0 (10·0-12·2). This novel ADP identifies patients at very low risk of a short-term major adverse cardiac event who might be suitable for early discharge. Such an approach could be used to decrease the overall observation periods and admissions for chest pain. The components needed for the implementation of this strategy are widely available. The ADP has the potential to affect health-service delivery worldwide. Funding Alere Medical (all countries), Queensland Emergency Medicine Research Foundation and National Health and Medical Research Council (Australia), Christchurch Cardio-Endocrine Research Group (New Zealand), Medquest Jaya Global (Indonesia), Science International (Hong Kong), Bio Laboratories Pte (Singapore), National Heart Foundation of New Zealand, and Progressive Group (Taiwan).

AB - Background Patients with chest pain contribute substantially to emergency department attendances, lengthy hospital stay, and inpatient admissions. A reliable, reproducible, and fast process to identify patients presenting with chest pain who have a low short-term risk of a major adverse cardiac event is needed to facilitate early discharge. We aimed to prospectively validate the safety of a predefined 2-h accelerated diagnostic protocol (ADP) to assess patients presenting to the emergency department with chest pain symptoms suggestive of acute coronary syndrome. Methods This observational study was undertaken in 14 emergency departments in nine countries in the Asia-Pacific region, in patients aged 18 years and older with at least 5 min of chest pain. The ADP included use of a structured pre-test probability scoring method (Thrombolysis in Myocardial Infarction [TIMI] score), electrocardiograph, and point-of-care biomarker panel of troponin, creatine kinase MB, and myoglobin. The primary endpoint was major adverse cardiac events within 30 days after initial presentation (including initial hospital attendance). This trial is registered with the Australia-New Zealand Clinical Trials Registry, number ACTRN12609000283279. Intepretation 3582 consecutive patients were recruited and completed 30-day follow-up. 421 (11·8) patients had a major adverse cardiac event. The ADP classified 352 (9·8) patients as low risk and potentially suitable for early discharge. A major adverse cardiac event occurred in three (0·9) of these patients, giving the ADP a sensitivity of 99·3 (95 CI 97·9-99·8), a negative predictive value of 99·1 (97·3-99·8), and a specificity of 11·0 (10·0-12·2). This novel ADP identifies patients at very low risk of a short-term major adverse cardiac event who might be suitable for early discharge. Such an approach could be used to decrease the overall observation periods and admissions for chest pain. The components needed for the implementation of this strategy are widely available. The ADP has the potential to affect health-service delivery worldwide. Funding Alere Medical (all countries), Queensland Emergency Medicine Research Foundation and National Health and Medical Research Council (Australia), Christchurch Cardio-Endocrine Research Group (New Zealand), Medquest Jaya Global (Indonesia), Science International (Hong Kong), Bio Laboratories Pte (Singapore), National Heart Foundation of New Zealand, and Progressive Group (Taiwan).

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UR - http://www.scopus.com/inward/citedby.url?scp=79953163991&partnerID=8YFLogxK

U2 - 10.1016/S0140-6736(11)60310-3

DO - 10.1016/S0140-6736(11)60310-3

M3 - Article

C2 - 21435709

AN - SCOPUS:79953163991

SN - 0140-6736

VL - 377

SP - 1077

EP - 1084

JO - The Lancet

JF - The Lancet

IS - 9771

ER -

A 2-h diagnostic protocol to assess patients with chest pain symptoms in the Asia-Pacific region (ASPECT): A prospective observational validation study

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