Although 2D materials such as graphenes, chalcogenides, and black phosphorus (BP) have been intensively studied for a wide range of future technological applications, the multiple harsh reactions and post-treatments required to produce exfoliated nanosheets (NSs) represent challenging barriers to their realization. In the present study, a batch-by-batch free route to produce BP NSs was demonstrated, and the NSs were employed as base materials for the chemo-phototherapy of breast cancer. Specifically, a single-pass catalytic conversion of an all-in-one precursor (red P, Au–Sn, and iodine) in a heated tubular reactor (at a 650 °C wall temperature for 15.5 s) continuously produced crumpled BP NSs, and the NS-laden gas stream was passed through an activated carbon-packed tube to remove the reacted gases. Subsequently, doxorubicin (D), poly-l-lysine (L), and hyaluronic acid (H) were incorporated without further purification of these NSs to form BP-DLH, which was then employed in both in vitro and in vivo chemo-phototherapies. The biocompatibility and near-infrared-induced photothermal activity of BP NSs facilitate targeted delivery to CD44-overexpressing breast cancer cells to assist in the therapeutic efficacy of D.
Bibliographical noteFunding Information:
This research was supported by Basic Science Research Program through the National Research Foundation of Korea (NRF) funded by the Ministry of Science, ICT and future Planning (NRF-2018R1A2A1A05020683). This work was also supported by the NRF of Korea Grant funded by the Korean Government (NRF-2018R1A2A2A05021143).
All Science Journal Classification (ASJC) codes
- Modelling and Simulation
- Materials Science(all)
- Condensed Matter Physics