A benzimidazolium-based organic trication: A selective fluorescent sensor for detecting cysteine in water

Amanpreet Singh, Ajnesh Singh, Narinder Singh, Doo Ok Jang

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A benzimidazolium- and imidazolium-based trication was developed as a fluorescence probe for cysteine (Cys). The probe exhibits fluorescence responses to Cys in water with high selectivity and a nano-molar detection limit. Such specificity towards Cys is based on differences in the hydrogen bonding of R1 with Cys, and it provides a method for detecting Cys in the presence of other analytes in a real biological system such as human serum. Density functional theory (DFT) calculations and 1H NMR titration confirmed the cavity-based recognition of Cys.

Original languageEnglish
Pages (from-to)72084-72089
Number of pages6
JournalRSC Advances
Issue number88
Publication statusPublished - 2015 Aug 20


All Science Journal Classification (ASJC) codes

  • Chemistry(all)
  • Chemical Engineering(all)

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