A biodegradable polymersome containing Bcl-xL siRNA and doxorubicin as a dual delivery vehicle for a synergistic anticancer effect

Hyun Ouk Kim, Eunjung Kim, Yonghee An, Jihye Choi, Eunji H.O. Jang, Eun Bi Choi, Aastha Kukreja, Myeong Hoon Kim, Byunghoon Kang, Dong Joo Kim, Jinsuck Suh, yongmin Huh, Seungjoo Haam

Research output: Contribution to journalArticle

36 Citations (Scopus)

Abstract

Combined cancer treatment via co-delivery of siRNAs and an anticancer drug can be a promising strategy due to the synergistic effect of simultaneously minimizing gene/drug administration. In this study, Bcl-xL siRNA and doxorubicin (DOX) are encapsulated into designed methoxy-poly(ethylene glycol)-block-poly(D,L-lactic acid) (mPEG-b-PLA) block copolymer polymersomes (PSomes). A study of the cytotoxicity of Bcl-xL siRNA and DOX co-encapsulated PSomes (CPSomes) shows more inhibited proliferation of MKN-45 and MKN-28 human gastric cancer cell lines than only gene- and drug-loaded ones. Consequently, these results demonstrate that co-delivery of genes and drugs using PSomes results in a synergistic efficacy and indicates the potential of PSomes as efficient nanocarriers for combined cancer therapy.

Original languageEnglish
Pages (from-to)745-754
Number of pages10
JournalMacromolecular Bioscience
Volume13
Issue number6
DOIs
Publication statusPublished - 2013 Jun 1

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Doxorubicin
Small Interfering RNA
Genes
Pharmaceutical Preparations
Oncology
Lactic acid
Cytotoxicity
Polyethylene glycols
Block copolymers
Cells
Stomach Neoplasms
Neoplasms
Cell Line
Therapeutics

All Science Journal Classification (ASJC) codes

  • Biotechnology
  • Bioengineering
  • Biomaterials
  • Polymers and Plastics
  • Materials Chemistry

Cite this

Kim, Hyun Ouk ; Kim, Eunjung ; An, Yonghee ; Choi, Jihye ; Jang, Eunji H.O. ; Choi, Eun Bi ; Kukreja, Aastha ; Kim, Myeong Hoon ; Kang, Byunghoon ; Kim, Dong Joo ; Suh, Jinsuck ; Huh, yongmin ; Haam, Seungjoo. / A biodegradable polymersome containing Bcl-xL siRNA and doxorubicin as a dual delivery vehicle for a synergistic anticancer effect. In: Macromolecular Bioscience. 2013 ; Vol. 13, No. 6. pp. 745-754.
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A biodegradable polymersome containing Bcl-xL siRNA and doxorubicin as a dual delivery vehicle for a synergistic anticancer effect. / Kim, Hyun Ouk; Kim, Eunjung; An, Yonghee; Choi, Jihye; Jang, Eunji H.O.; Choi, Eun Bi; Kukreja, Aastha; Kim, Myeong Hoon; Kang, Byunghoon; Kim, Dong Joo; Suh, Jinsuck; Huh, yongmin; Haam, Seungjoo.

In: Macromolecular Bioscience, Vol. 13, No. 6, 01.06.2013, p. 745-754.

Research output: Contribution to journalArticle

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AU - Kim, Hyun Ouk

AU - Kim, Eunjung

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AU - Choi, Jihye

AU - Jang, Eunji H.O.

AU - Choi, Eun Bi

AU - Kukreja, Aastha

AU - Kim, Myeong Hoon

AU - Kang, Byunghoon

AU - Kim, Dong Joo

AU - Suh, Jinsuck

AU - Huh, yongmin

AU - Haam, Seungjoo

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