A biomimetic ocular prosthesis system: emulating autonomic pupil and corneal reflections

Seongchan Kim; Yoon Young Choi; Taewan Kim; Yong Min Kim; Dong Hae Ho; Young Jin Choi; Dong Gue Roe; Ju Hee Lee; Joongpill Park; Ji Woong Choi; Jeong Won Kim; Jin Hong Park; Sae Byeok Jo; Hong Chul Moon; Sohee Jeong; Jeong Ho Cho

doi:10.1038/s41467-022-34448-6

A biomimetic ocular prosthesis system: emulating autonomic pupil and corneal reflections

Seongchan Kim, Yoon Young Choi, Taewan Kim, Yong Min Kim, Dong Hae Ho, Young Jin Choi, Dong Gue Roe, Ju Hee Lee, Joongpill Park, Ji Woong Choi, Jeong Won Kim, Jin Hong Park, Sae Byeok Jo, Hong Chul Moon, Sohee Jeong, Jeong Ho Cho

Department of Chemical and Biomolecular Engineering

Research output: Contribution to journal › Article › peer-review

1 Citation (Scopus)

Abstract

The human light modulation response allows humans to perceive objects clearly by receiving the appropriate amount of light from the environment. This paper proposes a biomimetic ocular prosthesis system that mimics the human light modulation response capable of pupil and corneal reflections. First, photoinduced synaptic properties of the quantum dot embedded photonic synapse and its biosimilar signal transmission is confirmed. Subsequently, the pupillary light reflex is emulated by incorporating the quantum dot embedded photonic synapse, electrochromic device, and CMOS components. Moreover, a solenoid-based eyelid is connected to the pupillary light reflex system to emulate the corneal reflex. The proposed ocular prosthesis system represents a platform for biomimetic prosthesis that can accommodate an appropriate amount of stimulus by self-regulating the intensity of external stimuli.

Original language	English
Article number	6760
Journal	Nature communications
Volume	13
Issue number	1
DOIs	https://doi.org/10.1038/s41467-022-34448-6
Publication status	Published - 2022 Dec

Bibliographical note

Funding Information:
J.H.C. was supported by Creative Materials Discovery Program through the National Research Foundation of Korea (NRF) funded by the Ministry of Science and ICT (NRF-2019M3D1A1078299), the Basic Science Program (NRF-2020R1A2C2007819) through the National Research Foundation (NRF) of Korea funded by the Ministry of Science and ICT, Korea, and the Technology Innovation Program (or Industrial Strategic Technology Development Program) (20021909, Development of H gas detection films (≤0.1%) and process technologies) funded by the Ministry of Trade, Industry & Energy (MOTIE, Korea). 2

Publisher Copyright:
© 2022, The Author(s).

All Science Journal Classification (ASJC) codes

Chemistry(all)
Biochemistry, Genetics and Molecular Biology(all)
General
Physics and Astronomy(all)

Access to Document

10.1038/s41467-022-34448-6

Cite this

@article{8aa016b36678449e882215e0268f11b4,

title = "A biomimetic ocular prosthesis system: emulating autonomic pupil and corneal reflections",

abstract = "The human light modulation response allows humans to perceive objects clearly by receiving the appropriate amount of light from the environment. This paper proposes a biomimetic ocular prosthesis system that mimics the human light modulation response capable of pupil and corneal reflections. First, photoinduced synaptic properties of the quantum dot embedded photonic synapse and its biosimilar signal transmission is confirmed. Subsequently, the pupillary light reflex is emulated by incorporating the quantum dot embedded photonic synapse, electrochromic device, and CMOS components. Moreover, a solenoid-based eyelid is connected to the pupillary light reflex system to emulate the corneal reflex. The proposed ocular prosthesis system represents a platform for biomimetic prosthesis that can accommodate an appropriate amount of stimulus by self-regulating the intensity of external stimuli.",

author = "Seongchan Kim and Choi, {Yoon Young} and Taewan Kim and Kim, {Yong Min} and Ho, {Dong Hae} and Choi, {Young Jin} and Roe, {Dong Gue} and Lee, {Ju Hee} and Joongpill Park and Choi, {Ji Woong} and Kim, {Jeong Won} and Park, {Jin Hong} and Jo, {Sae Byeok} and Moon, {Hong Chul} and Sohee Jeong and Cho, {Jeong Ho}",

note = "Funding Information: J.H.C. was supported by Creative Materials Discovery Program through the National Research Foundation of Korea (NRF) funded by the Ministry of Science and ICT (NRF-2019M3D1A1078299), the Basic Science Program (NRF-2020R1A2C2007819) through the National Research Foundation (NRF) of Korea funded by the Ministry of Science and ICT, Korea, and the Technology Innovation Program (or Industrial Strategic Technology Development Program) (20021909, Development of H gas detection films (≤0.1%) and process technologies) funded by the Ministry of Trade, Industry & Energy (MOTIE, Korea). 2 Publisher Copyright: {\textcopyright} 2022, The Author(s).",

year = "2022",

month = dec,

doi = "10.1038/s41467-022-34448-6",

language = "English",

volume = "13",

journal = "Nature Communications",

issn = "2041-1723",

publisher = "Nature Publishing Group",

number = "1",

}

TY - JOUR

T1 - A biomimetic ocular prosthesis system

T2 - emulating autonomic pupil and corneal reflections

AU - Kim, Seongchan

AU - Choi, Yoon Young

AU - Kim, Taewan

AU - Kim, Yong Min

AU - Ho, Dong Hae

AU - Choi, Young Jin

AU - Roe, Dong Gue

AU - Lee, Ju Hee

AU - Park, Joongpill

AU - Choi, Ji Woong

AU - Kim, Jeong Won

AU - Park, Jin Hong

AU - Jo, Sae Byeok

AU - Moon, Hong Chul

AU - Jeong, Sohee

AU - Cho, Jeong Ho

N1 - Funding Information: J.H.C. was supported by Creative Materials Discovery Program through the National Research Foundation of Korea (NRF) funded by the Ministry of Science and ICT (NRF-2019M3D1A1078299), the Basic Science Program (NRF-2020R1A2C2007819) through the National Research Foundation (NRF) of Korea funded by the Ministry of Science and ICT, Korea, and the Technology Innovation Program (or Industrial Strategic Technology Development Program) (20021909, Development of H gas detection films (≤0.1%) and process technologies) funded by the Ministry of Trade, Industry & Energy (MOTIE, Korea). 2 Publisher Copyright: © 2022, The Author(s).

PY - 2022/12

Y1 - 2022/12

N2 - The human light modulation response allows humans to perceive objects clearly by receiving the appropriate amount of light from the environment. This paper proposes a biomimetic ocular prosthesis system that mimics the human light modulation response capable of pupil and corneal reflections. First, photoinduced synaptic properties of the quantum dot embedded photonic synapse and its biosimilar signal transmission is confirmed. Subsequently, the pupillary light reflex is emulated by incorporating the quantum dot embedded photonic synapse, electrochromic device, and CMOS components. Moreover, a solenoid-based eyelid is connected to the pupillary light reflex system to emulate the corneal reflex. The proposed ocular prosthesis system represents a platform for biomimetic prosthesis that can accommodate an appropriate amount of stimulus by self-regulating the intensity of external stimuli.

AB - The human light modulation response allows humans to perceive objects clearly by receiving the appropriate amount of light from the environment. This paper proposes a biomimetic ocular prosthesis system that mimics the human light modulation response capable of pupil and corneal reflections. First, photoinduced synaptic properties of the quantum dot embedded photonic synapse and its biosimilar signal transmission is confirmed. Subsequently, the pupillary light reflex is emulated by incorporating the quantum dot embedded photonic synapse, electrochromic device, and CMOS components. Moreover, a solenoid-based eyelid is connected to the pupillary light reflex system to emulate the corneal reflex. The proposed ocular prosthesis system represents a platform for biomimetic prosthesis that can accommodate an appropriate amount of stimulus by self-regulating the intensity of external stimuli.

UR - http://www.scopus.com/inward/record.url?scp=85141470225&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=85141470225&partnerID=8YFLogxK

U2 - 10.1038/s41467-022-34448-6

DO - 10.1038/s41467-022-34448-6

M3 - Article

C2 - 36351937

AN - SCOPUS:85141470225

SN - 2041-1723

VL - 13

JO - Nature Communications

JF - Nature Communications

IS - 1

M1 - 6760

ER -

A biomimetic ocular prosthesis system: emulating autonomic pupil and corneal reflections

Abstract

Bibliographical note

All Science Journal Classification (ASJC) codes

Access to Document

Other files and links

Fingerprint

Cite this