A bioresorbable peripheral nerve stimulator for electronic pain block

Geumbee Lee, Emily Ray, Hong Joon Yoon, Sabrina Genovese, Yeon Sik Choi, Min Kyu Lee, Samet Şahin, Ying Yan, Hak Young Ahn, Amay J. Bandodkar, Joohee Kim, Minsu Park, Hanjun Ryu, Sung Soo Kwak, Yei Hwan Jung, Arman Odabas, Umang Khandpur, Wilson Z. Ray, Matthew R. MacEwan, John A. Rogers

Research output: Contribution to journalArticlepeer-review

4 Citations (Scopus)


Local electrical stimulation of peripheral nerves can block the propagation of action potentials, as an attractive alternative to pharmacological agents for the treatment of acute pain. Traditional hardware for such purposes, however, involves interfaces that can damage nerve tissue and, when used for temporary pain relief, that impose costs and risks due to requirements for surgical extraction after a period of need. Here, we introduce a bioresorbable nerve stimulator that enables electrical nerve block and associated pain mitigation without these drawbacks. This platform combines a collection of bioresorbable materials in architectures that support stable blocking with minimal adverse mechanical, electrical, or biochemical effects. Optimized designs ensure that the device disappears harmlessly in the body after a desired period of use. Studies in live animal models illustrate capabilities for complete nerve block and other key features of the technology. In certain clinically relevant scenarios, such approaches may reduce or eliminate the need for use of highly addictive drugs such as opioids.

Original languageEnglish
Article numbereabp9169
JournalScience Advances
Issue number40
Publication statusPublished - 2022 Oct

Bibliographical note

Funding Information:
We thank Y. Xu (Washington University, St. Louis) for the help in electrophysiology tests and N. Ghoreishi-Haack, E. Dempsey, I. Stepien, and C. Haney (Northwestern University) for the help in biocompatibility studies and imaging. This work was supported by the Querrey Simpson Institute for Bioelectronics. Histology services were provided by the Northwestern University Mouse Histology and Phenotyping Laboratory, which is supported by NCI P30-CA060553 awarded to the Robert H. Lurie Comprehensive Cancer Center. G.L. acknowledges support from the Korea Institute for Advancement of Technology grant funded by the Korea Government (MOTIE) [P0017305, Human Resource Development Program for Industrial Innovation (Global)]. Y.S.C. acknowledges support from the NIH (grant 1K99HL155844-01A1). S.Ş. acknowledges support from the Turkish Fulbright Commission under Fulbright Postdoctoral Program (FY-2020-TR-PD-10). M.R.M. acknowledges support from the Office of the Assistant Secretary of Defense for Health Affairs through the Peer Reviewed Orthopedic Research Program (award no. W81XWH-17-PRORP-ARA).

Publisher Copyright:
Copyright © 2022 The Authors, some rights reserved;

All Science Journal Classification (ASJC) codes

  • General


Dive into the research topics of 'A bioresorbable peripheral nerve stimulator for electronic pain block'. Together they form a unique fingerprint.

Cite this