A boronic acid-functionalized phthalocyanine with an aggregation-enhanced photodynamic effect for combating antibiotic-resistant bacteria

Eunhye Lee, Xingshu Li, Juwon Oh, Nahyun Kwon, Gyoungmi Kim, Dongho Kim, Juyoung Yoon

Research output: Contribution to journalArticlepeer-review

3 Citations (Scopus)

Abstract

Most existing photosensitizers (e.g., porphyrins) are often aggregated in aqueous solution because of their large conjugated molecular structures. This aggregation usually results in a lack or low levels of reactive oxygen species (ROS) generation due to aggregation-caused quenching, which severely hampers the application of photosensitizers in photodynamic therapy (PDT). Herein, we make an interesting finding that a boronic acid-functionalized phthalocyanine (PcN4-BA) displays an uncommon phenomenon, an aggregation-enhanced photodynamic effect. The combination of the ability to form uniform nanostructured self-assemblies in water, highly efficient ROS generation and boronic acid-induced targeting give PcN4-BA excellent performances in antimicrobial PDT.

Original languageEnglish
Pages (from-to)5735-5739
Number of pages5
JournalChemical Science
Volume11
Issue number22
DOIs
Publication statusPublished - 2020 Jun 14

Bibliographical note

Funding Information:
J. Y. is thankful for nancial support from the National Research Foundation of Korea (NRF), which is funded by the Korea government (MSIP) (No. 2012R1A3A2048814). D. K. is thankful for the Strategic Research (NRF-2016R1E1A1A01943379) through the National Research Foundation of Korea (NRF) funded by the Ministry of Science.

All Science Journal Classification (ASJC) codes

  • Chemistry(all)

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