A capacitive biosensor based on an interdigitated electrode with nanoislands

Ha Wook Jung, Young Wook Chang, Ga yeon Lee, Sungbo Cho, Min Jung Kang, Jae Chul Pyun

Research output: Contribution to journalArticle

35 Citations (Scopus)

Abstract

A capacitive biosensor based on an interdigitated electrode (IDE) with nanoislands was developed for label-free detection of antigen-antibody interactions. To enable sensitive capacitive detection of protein adsorption, the nanoislands were fabricated between finger electrodes of the IDE. The effect of the nanoislands on the sensitive capacitive measurement was estimated using horseradish peroxidase (HRP) as a model protein. Additionally, a parylene-A film was coated on the IDE with nanoislands to improve the efficiency of protein immobilization. By using HRP and hepatitis B virus surface antigen (HBsAg) as model analytes, the effect of the parylene-A film on the capacitive detection of protein adsorption was demonstrated.

Original languageEnglish
Pages (from-to)27-34
Number of pages8
JournalAnalytica Chimica Acta
Volume844
DOIs
Publication statusPublished - 2014 Sep 24

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Biosensing Techniques
Biosensors
Electrodes
electrode
protein
Horseradish Peroxidase
antigen
Adsorption
Proteins
adsorption
hepatitis
Surface Antigens
Hepatitis B Surface Antigens
Viruses
Hepatitis B virus
Immobilization
immobilization
Fingers
antibody
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All Science Journal Classification (ASJC) codes

  • Analytical Chemistry
  • Biochemistry
  • Environmental Chemistry
  • Spectroscopy

Cite this

Jung, Ha Wook ; Chang, Young Wook ; Lee, Ga yeon ; Cho, Sungbo ; Kang, Min Jung ; Pyun, Jae Chul. / A capacitive biosensor based on an interdigitated electrode with nanoislands. In: Analytica Chimica Acta. 2014 ; Vol. 844. pp. 27-34.
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A capacitive biosensor based on an interdigitated electrode with nanoislands. / Jung, Ha Wook; Chang, Young Wook; Lee, Ga yeon; Cho, Sungbo; Kang, Min Jung; Pyun, Jae Chul.

In: Analytica Chimica Acta, Vol. 844, 24.09.2014, p. 27-34.

Research output: Contribution to journalArticle

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