A capacitive biosensor based on an interdigitated electrode with nanoislands

Ha Wook Jung, Young Wook Chang, Ga yeon Lee, Sungbo Cho, Min Jung Kang, Jae Chul Pyun

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36 Citations (Scopus)

Abstract

A capacitive biosensor based on an interdigitated electrode (IDE) with nanoislands was developed for label-free detection of antigen-antibody interactions. To enable sensitive capacitive detection of protein adsorption, the nanoislands were fabricated between finger electrodes of the IDE. The effect of the nanoislands on the sensitive capacitive measurement was estimated using horseradish peroxidase (HRP) as a model protein. Additionally, a parylene-A film was coated on the IDE with nanoislands to improve the efficiency of protein immobilization. By using HRP and hepatitis B virus surface antigen (HBsAg) as model analytes, the effect of the parylene-A film on the capacitive detection of protein adsorption was demonstrated.

Original languageEnglish
Pages (from-to)27-34
Number of pages8
JournalAnalytica Chimica Acta
Volume844
DOIs
Publication statusPublished - 2014 Sep 24

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All Science Journal Classification (ASJC) codes

  • Analytical Chemistry
  • Biochemistry
  • Environmental Chemistry
  • Spectroscopy

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