A carcinoembryonic antigen-secreting adenocarcinoma arising in tailgut cyst: Clinical implications of carcinoembryonic antigen

Byoung Chul Cho, Nam Kyu Kim, Beom Jin Lim, Sang Ook Kang, Ju Hyuk Sohn, Jae Kyung Roh, Sang Tae Choi, Sung Ai Kim, Se Eun Park

Research output: Contribution to journalArticle

22 Citations (Scopus)

Abstract

Tailgut cysts (TGCs) are rare congenital cysts that occur in the retrorectal or presacral spaces. Although most tailgut cysts have been reported as benign, there have been at least 9 cases associated with malignant change. We report herein on an unusual case of a 40-year-old woman with a carcinoembryonic antigen (CEA)-producing adenocarcinoma arising within a TGC who underwent surgical resection and local radiation therapy. Despite the complete resection, metastatic adenocarcinoma developed five months after surgery. CEA-producing adenocarcinoma from a TGC is extremely rare and only two cases, including this case, have been reported in the English medical literature. Besides CEA, the serum levels of CA 19-9 became markedly elevated in this patient. Given that the serum CEA level decreased to the normal range after complete resection of tumor and that the tumor recurrence was associated with a rebound of the CEA serum level, our case shows that serial measurements of serum CEA can be used for treatment planning and for assessing the patient's treatment response for this rare disease.

Original languageEnglish
Pages (from-to)555-561
Number of pages7
JournalYonsei medical journal
Volume46
Issue number4
DOIs
Publication statusPublished - 2005 Aug 31

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Carcinoembryonic Antigen
Cysts
Adenocarcinoma
Serum
Rare Diseases
Neoplasms
Reference Values
Radiotherapy
Recurrence
Therapeutics

All Science Journal Classification (ASJC) codes

  • Medicine(all)

Cite this

Cho, Byoung Chul ; Kim, Nam Kyu ; Lim, Beom Jin ; Kang, Sang Ook ; Sohn, Ju Hyuk ; Roh, Jae Kyung ; Choi, Sang Tae ; Kim, Sung Ai ; Park, Se Eun. / A carcinoembryonic antigen-secreting adenocarcinoma arising in tailgut cyst : Clinical implications of carcinoembryonic antigen. In: Yonsei medical journal. 2005 ; Vol. 46, No. 4. pp. 555-561.
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A carcinoembryonic antigen-secreting adenocarcinoma arising in tailgut cyst : Clinical implications of carcinoembryonic antigen. / Cho, Byoung Chul; Kim, Nam Kyu; Lim, Beom Jin; Kang, Sang Ook; Sohn, Ju Hyuk; Roh, Jae Kyung; Choi, Sang Tae; Kim, Sung Ai; Park, Se Eun.

In: Yonsei medical journal, Vol. 46, No. 4, 31.08.2005, p. 555-561.

Research output: Contribution to journalArticle

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AU - Cho, Byoung Chul

AU - Kim, Nam Kyu

AU - Lim, Beom Jin

AU - Kang, Sang Ook

AU - Sohn, Ju Hyuk

AU - Roh, Jae Kyung

AU - Choi, Sang Tae

AU - Kim, Sung Ai

AU - Park, Se Eun

PY - 2005/8/31

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N2 - Tailgut cysts (TGCs) are rare congenital cysts that occur in the retrorectal or presacral spaces. Although most tailgut cysts have been reported as benign, there have been at least 9 cases associated with malignant change. We report herein on an unusual case of a 40-year-old woman with a carcinoembryonic antigen (CEA)-producing adenocarcinoma arising within a TGC who underwent surgical resection and local radiation therapy. Despite the complete resection, metastatic adenocarcinoma developed five months after surgery. CEA-producing adenocarcinoma from a TGC is extremely rare and only two cases, including this case, have been reported in the English medical literature. Besides CEA, the serum levels of CA 19-9 became markedly elevated in this patient. Given that the serum CEA level decreased to the normal range after complete resection of tumor and that the tumor recurrence was associated with a rebound of the CEA serum level, our case shows that serial measurements of serum CEA can be used for treatment planning and for assessing the patient's treatment response for this rare disease.

AB - Tailgut cysts (TGCs) are rare congenital cysts that occur in the retrorectal or presacral spaces. Although most tailgut cysts have been reported as benign, there have been at least 9 cases associated with malignant change. We report herein on an unusual case of a 40-year-old woman with a carcinoembryonic antigen (CEA)-producing adenocarcinoma arising within a TGC who underwent surgical resection and local radiation therapy. Despite the complete resection, metastatic adenocarcinoma developed five months after surgery. CEA-producing adenocarcinoma from a TGC is extremely rare and only two cases, including this case, have been reported in the English medical literature. Besides CEA, the serum levels of CA 19-9 became markedly elevated in this patient. Given that the serum CEA level decreased to the normal range after complete resection of tumor and that the tumor recurrence was associated with a rebound of the CEA serum level, our case shows that serial measurements of serum CEA can be used for treatment planning and for assessing the patient's treatment response for this rare disease.

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