A case-control study of multiple system atrophy in Korean patients

Joo Hyun Seo, Seok Woo Yong, Sook K. Song, Ji E. Lee, Young H. Sohn, philhyu Lee

Research output: Contribution to journalArticle

16 Citations (Scopus)

Abstract

A few case-control studies of multiple system atrophy (MSA) have been reported in Western populations. In this study, we included various epidemiological factors to evaluate whether the risk factors for MSA differed in Korean and Western populations. A total of 100 consecutive MSA patients and 104 controls at two referral hospitals participated. Information was obtained through face-to-face interviews using a structured questionnaire: history of living area, occupational history, food habits, alcohol and tobacco consumption, and use of drugs. Odds ratios and 95% confident intervals (OR [95% CI]) were computed using logistic regression. The multivariate logistic regression analysis revealed that use of antihypertensive medication (OR = 0.30 [0.12-0.78]) and vitamins (OR = 0.30 [0.14-0.64]) and consumption of meat and poultry (OR = 0.27 [0.13-0.56]) were associated with decreasing risk for MSA, whereas use of herbal medications (OR = 3.17 [1.28-7.84]) was associated with increasing risk for MSA. In univariate analysis adjusted for age, sex, education level, and recruitment center, use of aspirin (OR = 0.21 [0.07-0.61]) and coffee consumption (OR = 0.44 [0.23-0.84]) were significantly less frequent in MSA patients than in controls, whereas heavy smoking (≥40 pack-years) was significantly more prevalent in MSA patients than in controls (OR = 3.44 [1.05-11.23]). There was no difference in living area, participation in farming, or exposure to agrichemicals and solvents between groups. This study showed that MSA in Korea is characterized by risk factors that are both similar to and different from those affecting Western populations and that herbal medicines constitute a new MSA risk factor for the Korean population.

Original languageEnglish
Pages (from-to)1953-1959
Number of pages7
JournalMovement Disorders
Volume25
Issue number12
DOIs
Publication statusPublished - 2010 Sep 15

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Multiple System Atrophy
Case-Control Studies
Tobacco Use
Population
Logistic Models
Agrochemicals
Sex Education
Herbal Medicine
Coffee
Feeding Behavior
Poultry
Korea
Agriculture
Vitamins
Alcohol Drinking
Meat
Antihypertensive Agents
Aspirin
Referral and Consultation
Smoking

All Science Journal Classification (ASJC) codes

  • Neurology
  • Clinical Neurology

Cite this

Seo, J. H., Yong, S. W., Song, S. K., Lee, J. E., Sohn, Y. H., & Lee, P. (2010). A case-control study of multiple system atrophy in Korean patients. Movement Disorders, 25(12), 1953-1959. https://doi.org/10.1002/mds.23185
Seo, Joo Hyun ; Yong, Seok Woo ; Song, Sook K. ; Lee, Ji E. ; Sohn, Young H. ; Lee, philhyu. / A case-control study of multiple system atrophy in Korean patients. In: Movement Disorders. 2010 ; Vol. 25, No. 12. pp. 1953-1959.
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Seo, JH, Yong, SW, Song, SK, Lee, JE, Sohn, YH & Lee, P 2010, 'A case-control study of multiple system atrophy in Korean patients', Movement Disorders, vol. 25, no. 12, pp. 1953-1959. https://doi.org/10.1002/mds.23185

A case-control study of multiple system atrophy in Korean patients. / Seo, Joo Hyun; Yong, Seok Woo; Song, Sook K.; Lee, Ji E.; Sohn, Young H.; Lee, philhyu.

In: Movement Disorders, Vol. 25, No. 12, 15.09.2010, p. 1953-1959.

Research output: Contribution to journalArticle

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AB - A few case-control studies of multiple system atrophy (MSA) have been reported in Western populations. In this study, we included various epidemiological factors to evaluate whether the risk factors for MSA differed in Korean and Western populations. A total of 100 consecutive MSA patients and 104 controls at two referral hospitals participated. Information was obtained through face-to-face interviews using a structured questionnaire: history of living area, occupational history, food habits, alcohol and tobacco consumption, and use of drugs. Odds ratios and 95% confident intervals (OR [95% CI]) were computed using logistic regression. The multivariate logistic regression analysis revealed that use of antihypertensive medication (OR = 0.30 [0.12-0.78]) and vitamins (OR = 0.30 [0.14-0.64]) and consumption of meat and poultry (OR = 0.27 [0.13-0.56]) were associated with decreasing risk for MSA, whereas use of herbal medications (OR = 3.17 [1.28-7.84]) was associated with increasing risk for MSA. In univariate analysis adjusted for age, sex, education level, and recruitment center, use of aspirin (OR = 0.21 [0.07-0.61]) and coffee consumption (OR = 0.44 [0.23-0.84]) were significantly less frequent in MSA patients than in controls, whereas heavy smoking (≥40 pack-years) was significantly more prevalent in MSA patients than in controls (OR = 3.44 [1.05-11.23]). There was no difference in living area, participation in farming, or exposure to agrichemicals and solvents between groups. This study showed that MSA in Korea is characterized by risk factors that are both similar to and different from those affecting Western populations and that herbal medicines constitute a new MSA risk factor for the Korean population.

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