Histologic changes can be involved in resistance to anticancer drugs. Transformation to small cell lung carcinoma (SCLC) following treatment with EGFR tyrosine kinase inhibitors has been reported in patients with EGFR-mutant lung adenocarcinoma. Herein, we report a case of ALK-rearranged lung adenocarcinoma with SCLC-like histology in a metastatic abdominal nodule that was resistant to crizotinib therapy.
Bibliographical notePublisher Copyright:
© 2016 International Association for the Study of Lung Cancer. Published by Elsevier Inc. All rights reserved.
All Science Journal Classification (ASJC) codes
- Pulmonary and Respiratory Medicine