A case of ALK-rearranged adenocarcinoma with small cell carcinoma-like transformation and resistance to crizotinib

Yoon Jin Cha, Byoung Chul Cho, Hye Ryun Kim, Hye Jeong Lee, Hyo Sup Shim

Research output: Contribution to journalArticle

35 Citations (Scopus)

Abstract

Histologic changes can be involved in resistance to anticancer drugs. Transformation to small cell lung carcinoma (SCLC) following treatment with EGFR tyrosine kinase inhibitors has been reported in patients with EGFR-mutant lung adenocarcinoma. Herein, we report a case of ALK-rearranged lung adenocarcinoma with SCLC-like histology in a metastatic abdominal nodule that was resistant to crizotinib therapy.

Original languageEnglish
Pages (from-to)e55-e58
JournalJournal of Thoracic Oncology
Volume11
Issue number5
DOIs
Publication statusPublished - 2016 Jan 1

All Science Journal Classification (ASJC) codes

  • Oncology
  • Pulmonary and Respiratory Medicine

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