A case of black thyroid associated with hyalinizing trabecular tumor

Sang Wook Kang, Soon Won Hong, Pyo Ju Yeon, Jong Ju Jeong, Tae Yon Sung, Seung Chul Lee, Yong Sang Lee, Kee Hyun Nam, Woong Youn Chung, Hang-Seok Chang, Cheong Soo Park

Research output: Contribution to journalArticle

5 Citations (Scopus)

Abstract

Black thyroid is an uncommon phenomenon of black pigmentation of thyroid parenchyma induced by chronic minocycline therapy. Thyroid tumors associated with black pigmented thyroid are rare. We describe here a 42-year-old woman with a black thyroid associated with hyalinizing trabecular tumor (HTT). The patient presented with a palpable left-sided thyroid nodule. She had taken minocycline for aphthous stomatitis and an oral ulcer for 9 years. The findings of fine needle aspiration biopsy and BRAF mutation analysis suggested a papillary carcinoma. The patient underwent a near-total thyroidectomy with central compartment node dissection. The surgical specimen showed a diffuse black thyroid and a 2-cm non-pigmented, well-circumscribed nodule in the left thyroid. Histopathologically, numerous black pigmented follicular epithelial cells and colloid were seen throughout the thyroid parenchyma, and the nodule was composed of elongated, polygonal cells in trabecular arrangement and dense hyaline stromas. The tumor cells showed a strong positive cytoplasmic reaction to Ki 67. All of these findings suggested a HTT, or a hyalinizing trabecular variant of papillary carcinoma, arising in a black thyroid. To our knowledge, this is the first case of black thyroid associated with HTT.

Original languageEnglish
Pages (from-to)1109-1112
Number of pages4
JournalEndocrine Journal
Volume55
Issue number6
DOIs
Publication statusPublished - 2008 Dec 1

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Thyroid Gland
Neoplasms
Minocycline
Thyroid Nodule
Papillary Carcinoma
Oral Ulcer
Aphthous Stomatitis
Hyalin
Thyroidectomy
Pigmentation
Colloids
Fine Needle Biopsy
Dissection
Epithelial Cells
Mutation

All Science Journal Classification (ASJC) codes

  • Endocrinology, Diabetes and Metabolism
  • Endocrinology

Cite this

Kang, S. W., Hong, S. W., Yeon, P. J., Jeong, J. J., Sung, T. Y., Lee, S. C., ... Park, C. S. (2008). A case of black thyroid associated with hyalinizing trabecular tumor. Endocrine Journal, 55(6), 1109-1112. https://doi.org/10.1507/endocrj.K08E-191
Kang, Sang Wook ; Hong, Soon Won ; Yeon, Pyo Ju ; Jeong, Jong Ju ; Sung, Tae Yon ; Lee, Seung Chul ; Lee, Yong Sang ; Nam, Kee Hyun ; Chung, Woong Youn ; Chang, Hang-Seok ; Park, Cheong Soo. / A case of black thyroid associated with hyalinizing trabecular tumor. In: Endocrine Journal. 2008 ; Vol. 55, No. 6. pp. 1109-1112.
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Kang, SW, Hong, SW, Yeon, PJ, Jeong, JJ, Sung, TY, Lee, SC, Lee, YS, Nam, KH, Chung, WY, Chang, H-S & Park, CS 2008, 'A case of black thyroid associated with hyalinizing trabecular tumor', Endocrine Journal, vol. 55, no. 6, pp. 1109-1112. https://doi.org/10.1507/endocrj.K08E-191

A case of black thyroid associated with hyalinizing trabecular tumor. / Kang, Sang Wook; Hong, Soon Won; Yeon, Pyo Ju; Jeong, Jong Ju; Sung, Tae Yon; Lee, Seung Chul; Lee, Yong Sang; Nam, Kee Hyun; Chung, Woong Youn; Chang, Hang-Seok; Park, Cheong Soo.

In: Endocrine Journal, Vol. 55, No. 6, 01.12.2008, p. 1109-1112.

Research output: Contribution to journalArticle

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AU - Hong, Soon Won

AU - Yeon, Pyo Ju

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AU - Lee, Seung Chul

AU - Lee, Yong Sang

AU - Nam, Kee Hyun

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AU - Chang, Hang-Seok

AU - Park, Cheong Soo

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N2 - Black thyroid is an uncommon phenomenon of black pigmentation of thyroid parenchyma induced by chronic minocycline therapy. Thyroid tumors associated with black pigmented thyroid are rare. We describe here a 42-year-old woman with a black thyroid associated with hyalinizing trabecular tumor (HTT). The patient presented with a palpable left-sided thyroid nodule. She had taken minocycline for aphthous stomatitis and an oral ulcer for 9 years. The findings of fine needle aspiration biopsy and BRAF mutation analysis suggested a papillary carcinoma. The patient underwent a near-total thyroidectomy with central compartment node dissection. The surgical specimen showed a diffuse black thyroid and a 2-cm non-pigmented, well-circumscribed nodule in the left thyroid. Histopathologically, numerous black pigmented follicular epithelial cells and colloid were seen throughout the thyroid parenchyma, and the nodule was composed of elongated, polygonal cells in trabecular arrangement and dense hyaline stromas. The tumor cells showed a strong positive cytoplasmic reaction to Ki 67. All of these findings suggested a HTT, or a hyalinizing trabecular variant of papillary carcinoma, arising in a black thyroid. To our knowledge, this is the first case of black thyroid associated with HTT.

AB - Black thyroid is an uncommon phenomenon of black pigmentation of thyroid parenchyma induced by chronic minocycline therapy. Thyroid tumors associated with black pigmented thyroid are rare. We describe here a 42-year-old woman with a black thyroid associated with hyalinizing trabecular tumor (HTT). The patient presented with a palpable left-sided thyroid nodule. She had taken minocycline for aphthous stomatitis and an oral ulcer for 9 years. The findings of fine needle aspiration biopsy and BRAF mutation analysis suggested a papillary carcinoma. The patient underwent a near-total thyroidectomy with central compartment node dissection. The surgical specimen showed a diffuse black thyroid and a 2-cm non-pigmented, well-circumscribed nodule in the left thyroid. Histopathologically, numerous black pigmented follicular epithelial cells and colloid were seen throughout the thyroid parenchyma, and the nodule was composed of elongated, polygonal cells in trabecular arrangement and dense hyaline stromas. The tumor cells showed a strong positive cytoplasmic reaction to Ki 67. All of these findings suggested a HTT, or a hyalinizing trabecular variant of papillary carcinoma, arising in a black thyroid. To our knowledge, this is the first case of black thyroid associated with HTT.

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Kang SW, Hong SW, Yeon PJ, Jeong JJ, Sung TY, Lee SC et al. A case of black thyroid associated with hyalinizing trabecular tumor. Endocrine Journal. 2008 Dec 1;55(6):1109-1112. https://doi.org/10.1507/endocrj.K08E-191