A Case of Crohn's Disease Showing Favorable Response to Induction and Maintenance Therapy with Methotrexate after Failure of Anti-tumor Necrosis Factor Therapy

Jung R.an Choi, Gak W.on Yun, Yoo M.i. Park, Jie H.yun Kim, Young H.oon Youn, Hyo J.in Park, Jae J.un Park

Research output: Contribution to journalArticle

Abstract

Thanks to the introduction of immumomodulators and biologics, therapeutic approaches in Crohn's disease have changed significantly during the past decade. Although new biologic therapy has dramatically improved the treatment of Crohn's disease, a substantial number of patients are refractory to these therapies or lose their initial response. Methotrexate (MTX) is a structural analogue of folic acid that can competitively inhibit the binding of dihydrofolic acid to the enzyme dihydrofolate reductase and has been widely used as immunomodulator in rheumatology area for patients with rheumatoid arthritis and psoriasis. Although MTX has also been shown to be an effective agent for remission induction and maintenance of remission in Crohn's disease, the use of MTX in Crohn's disease has not yet been reported in Korea. Herein, we report a case of Crohn's disease patient who was successfully treated with MTX after treatment failure with thiopurine and anti-tumor necrosis factor.

Original languageEnglish
Pages (from-to)231-236
Number of pages6
JournalThe Korean journal of gastroenterology = Taehan Sohwagi Hakhoe chi
Volume66
Issue number4
DOIs
Publication statusPublished - 2015 Oct 1

Fingerprint

Methotrexate
Crohn Disease
Tumor Necrosis Factor-alpha
Remission Induction
Therapeutics
Tetrahydrofolate Dehydrogenase
Biological Therapy
Immunologic Factors
Rheumatology
Korea
Biological Products
Treatment Failure
Psoriasis
Folic Acid
Rheumatoid Arthritis
Maintenance
Acids
Enzymes

All Science Journal Classification (ASJC) codes

  • Medicine(all)

Cite this

@article{0a7b828065d74b129bce319053c71ace,
title = "A Case of Crohn's Disease Showing Favorable Response to Induction and Maintenance Therapy with Methotrexate after Failure of Anti-tumor Necrosis Factor Therapy",
abstract = "Thanks to the introduction of immumomodulators and biologics, therapeutic approaches in Crohn's disease have changed significantly during the past decade. Although new biologic therapy has dramatically improved the treatment of Crohn's disease, a substantial number of patients are refractory to these therapies or lose their initial response. Methotrexate (MTX) is a structural analogue of folic acid that can competitively inhibit the binding of dihydrofolic acid to the enzyme dihydrofolate reductase and has been widely used as immunomodulator in rheumatology area for patients with rheumatoid arthritis and psoriasis. Although MTX has also been shown to be an effective agent for remission induction and maintenance of remission in Crohn's disease, the use of MTX in Crohn's disease has not yet been reported in Korea. Herein, we report a case of Crohn's disease patient who was successfully treated with MTX after treatment failure with thiopurine and anti-tumor necrosis factor.",
author = "Choi, {Jung R.an} and Yun, {Gak W.on} and Park, {Yoo M.i.} and Kim, {Jie H.yun} and Youn, {Young H.oon} and Park, {Hyo J.in} and Park, {Jae J.un}",
year = "2015",
month = "10",
day = "1",
doi = "10.4166/kjg.2015.66.4.231",
language = "English",
volume = "66",
pages = "231--236",
journal = "The Korean journal of gastroenterology = Taehan Sohwagi Hakhoe chi",
issn = "1598-9992",
publisher = "Korean Society of Gastroenterology",
number = "4",

}

A Case of Crohn's Disease Showing Favorable Response to Induction and Maintenance Therapy with Methotrexate after Failure of Anti-tumor Necrosis Factor Therapy. / Choi, Jung R.an; Yun, Gak W.on; Park, Yoo M.i.; Kim, Jie H.yun; Youn, Young H.oon; Park, Hyo J.in; Park, Jae J.un.

In: The Korean journal of gastroenterology = Taehan Sohwagi Hakhoe chi, Vol. 66, No. 4, 01.10.2015, p. 231-236.

Research output: Contribution to journalArticle

TY - JOUR

T1 - A Case of Crohn's Disease Showing Favorable Response to Induction and Maintenance Therapy with Methotrexate after Failure of Anti-tumor Necrosis Factor Therapy

AU - Choi, Jung R.an

AU - Yun, Gak W.on

AU - Park, Yoo M.i.

AU - Kim, Jie H.yun

AU - Youn, Young H.oon

AU - Park, Hyo J.in

AU - Park, Jae J.un

PY - 2015/10/1

Y1 - 2015/10/1

N2 - Thanks to the introduction of immumomodulators and biologics, therapeutic approaches in Crohn's disease have changed significantly during the past decade. Although new biologic therapy has dramatically improved the treatment of Crohn's disease, a substantial number of patients are refractory to these therapies or lose their initial response. Methotrexate (MTX) is a structural analogue of folic acid that can competitively inhibit the binding of dihydrofolic acid to the enzyme dihydrofolate reductase and has been widely used as immunomodulator in rheumatology area for patients with rheumatoid arthritis and psoriasis. Although MTX has also been shown to be an effective agent for remission induction and maintenance of remission in Crohn's disease, the use of MTX in Crohn's disease has not yet been reported in Korea. Herein, we report a case of Crohn's disease patient who was successfully treated with MTX after treatment failure with thiopurine and anti-tumor necrosis factor.

AB - Thanks to the introduction of immumomodulators and biologics, therapeutic approaches in Crohn's disease have changed significantly during the past decade. Although new biologic therapy has dramatically improved the treatment of Crohn's disease, a substantial number of patients are refractory to these therapies or lose their initial response. Methotrexate (MTX) is a structural analogue of folic acid that can competitively inhibit the binding of dihydrofolic acid to the enzyme dihydrofolate reductase and has been widely used as immunomodulator in rheumatology area for patients with rheumatoid arthritis and psoriasis. Although MTX has also been shown to be an effective agent for remission induction and maintenance of remission in Crohn's disease, the use of MTX in Crohn's disease has not yet been reported in Korea. Herein, we report a case of Crohn's disease patient who was successfully treated with MTX after treatment failure with thiopurine and anti-tumor necrosis factor.

UR - http://www.scopus.com/inward/record.url?scp=84973407958&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=84973407958&partnerID=8YFLogxK

U2 - 10.4166/kjg.2015.66.4.231

DO - 10.4166/kjg.2015.66.4.231

M3 - Article

C2 - 26493510

AN - SCOPUS:84973407958

VL - 66

SP - 231

EP - 236

JO - The Korean journal of gastroenterology = Taehan Sohwagi Hakhoe chi

JF - The Korean journal of gastroenterology = Taehan Sohwagi Hakhoe chi

SN - 1598-9992

IS - 4

ER -